5 minutes with Haw Yang, Chemical Science Associate Editor

Get to know our Editor-in-Chief and all of our Associate Editors on this blog over the coming months!
Read on to get acquainted with Chem Sci Associate Editor Haw Yang.

Haw-201308_px180.jpgHaw Yang is Associate Professor of Chemistry and Director of Graduate Studies at Princeton University, USA.  Haw and his experimental physical chemistry group work on single-molecule chemical dynamics and develop new single-molecule- and single-nanoparticle-based methods for the study of complex systems.  His team’s ultimate goal is to arrive at a level of understanding that affords a quantitative prediction of the dynamics and how they contribute to systems behaviour.

Haw serves as one of Chemical Science’s Associate Editors, handling submissions in physical chemistry.

Who or what inspired you to study physical chemistry?

Madame Curie.  I really didn’t know who she was until, as a kid, I watched a movie about her, based on her daughter’s autobiography.  That movie left a very strong impression on me because I saw her dedication and her passion for science.  And she did it, not for personal gain, but for humankind – for years, she used her discovery to cure cancer.  She went from doing fundamental research to helping humanity, and that left an enduring mark on me.

She was also very good at maths and physics and chemistry, and – because I’m a geek – this impressed me enormously, which is another reason why she became my heroine.

For you, what is the biggest and most important unanswered question in the chemical sciences?

The quantitative prediction of complex systems behaviour from first-principles understanding of atomistic and molecular actions.

Outside of science, what would your dream job be?

As I said, I’ve been a nerd, a geek, since I was a kid – I’ve never been any good at anything else.  So, if I hadn’t been able to get a job in this profession, I would have been doomed! (Laughs)

So this – what I’m doing now – is my dream job.  If I had to do it all again, I would do it exactly the same way – I would come to Princeton, and do what I’m doing right now. People pay me to do what I enjoy doing; not everyone can have this kind of career! I feel extremely lucky. This is the dream.

What do you consider the most fulfilling part of your job?

To see my students and post-docs do extremely well, do something really creative after they leave my group – and to have them still remember me!  (Laughs)  That’s really awesome.  Sometimes I get emails or postcards from former students out of the blue, and I’d say, wow, I did not expect this.

“For me, the cello is a fitting instrument – it would let me be alone and be quiet, and at the same time, do something creative” – Haw Yang (Image © Shutterstock)

Making new discoveries in the lab – I don’t often get to do that anymore, but when I was still in the lab, I knew I was the first in the world to see those results and interpret them – that was extremely fulfilling.  And these days, I take joy in doing experiments that people have been telling me are impossible to do.  (Laughs)  I love a challenge, I love to change the way people think.

Which musical instrument do you, or wish you could, play?

I wish that I could learn to play cello – it’s on my to-do list when I get the time.  I guess I’m hitting that age when I’d like something more quiet, more introspective, and the cello has that quality, especially if one can play Bach’s unaccompanied cello concertos – those are my favourites.  In this line of work, we’re alone most of the time, and we think a lot – that is, if we’re lucky, we get time to think.  So for me, the cello is a fitting instrument – it would let me be alone and be quiet, and at the same time, do something creative.

Fire, earth, water, or air?

Water.

Describe Chemical Science in three words.

Breaking status quo

Your personal message to Chem Sci authors and readers?

What always gets me excited is original physical chemistry, broadly defined. It could be a new and relevant physical chemistry problem that’s well articulated, an ingenious approach that definitely answers an outstanding question, an innovative technique that enables new experiments to solve problems that matter, or a conceptual breakthrough that inspires new thinking.

We scientists are in the business of breaking the status quo, and we should do so with high scientific rigour.  I strongly believe scientists must never do work which merely repeats what is already known, for the sake of hype, of joining the bandwagon, or aiming to please.

So, if you agree with me that ground-breaking substance and genuine originality are more important than hype, I invite you to submit your most creative papers to Chemical Science – your work could help define the future of physical chemistry!

Haw Yang and our dynamic international team of Associate Editors make direct decisions on the content of Chemical Science and actively drive its scientific development – submit your best and most innovative work to any of their Editorial Offices.

Read Haw Yang’s latest article in Chemical Science:

Harnessing thermal fluctuations for purposeful activities: the manipulation of single micro-swimmers by adaptive photon nudging
Bian Qian, Daniel Montiel, Andreas Bregulla, Frank Cichos and Haw Yang
Chem. Sci., 2013,4, 1420-1429
DOI: 10.1039/C2SC21263C, Edge Article

Our Associate Editors Haw Yang, Kopin Liu and Kazunari Domen have selected their recommended physical chemistry papers on Chemical Science read their Editors’ Choice selection today and find out why they think these are must-reads!

Online collection: Physical chemistry

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A cytochrome from scratch

Jennifer Newton writes about a HOT Chemical Science article for Chemistry World

Artificial proteins could be closer to participating in natural biochemical pathways after UK and US researchers show that bacteria will process amino acid sequences entirely unrelated to any natural protein to produce a fully functioning cytochrome.

Scientists trick E. coli into producing their artificial proteins © Shutterstock

The burgeoning field of synthetic biology demands that functional artificial proteins and enzymes seamlessly integrate with natural proteins and substrates. ‘We’re trying to build artificial proteins that exhibit some of the properties and chemistries of natural proteins,’ explains team member Ross Anderson from the University of Bristol.

Anderson and colleagues have used a relatively new methodology called the maquette approach that lets them escape some of the complexities of natural systems to construct their artificial cytochrome. They begin with a generic protein sequence designed only to fold into a 4-helix bundle. Engineered elements are added onto the stripped-down protein chassis; the role of every residue in the amino acid sequence is defined and adjusted by altering critical residues.


Read the full article in Chemistry World»

Read the original journal article online:
Constructing a man-made c-type cytochrome maquette in vivo: electron transfer, oxygen transport and conversion to a photoactive light harvesting maquette
J. L. Ross Anderson, Craig T. Armstrong, Goutham Kodali, Bruce R. Lichtenstein, Daniel W. Watkins, Joshua A. Mancini, Aimee L. Boyle, Tammer A. Farid, Matthew P Crump, Christopher C. Moser and P. Leslie Dutton  
Chem. Sci., 2014, Advance Article, DOI: 10.1039/C3SC52019F

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ISACS13 call for abstracts – Inorganic & Materials Chemistry

RSC_Events_ISACS13

Abstract submission now open – submit today

We are delighted to announce that abstract submission for Challenges in Inorganic and Materials Chemistry (ISACS13), the 13th conference in the highly successful International Symposia on Advancing the Chemical Sciences (ISACS) series, is now open.

Take advantage of this excellent opportunity to showcase your latest research alongside the following leading scientists from across the globe.
 
Confirmed speakers

Louise Berben
 
Kim Dunbar
 
David Parker
 
Guy Bertrand
 
William Evans
 
Matt Rosseinsky
 
Chi-Meng Che
 
Susumu Kitagawa
 
Doug Stephan
 
Luisa De Cola
 
Stephen Mann
 
Andy Weller
 
Liang Deng
 
Chris Orvig
 
Mike Zaworotko
 

Don’t miss your chance to be a part of this significant event – submit today.

We look forward to welcoming you to Dublin in July 2014.

Professor Thorri Gunnlaugsson Dr Robert D. Eagling
Conference Chair Editor, Chemical Science
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HOT Chemical Science articles for November

Here are this month’s referee-recommended HOT Chemical Science articles – download them for FREE for a limited time! Keep checking this post for more HOT articles throughout the month!

Targeting the endoplasmic reticulum with a membrane-interactive luminescent ruthenium(II) polypyridyl complex
Martin R. Gill, Denis Cecchin, Michael G. Walker, Raminder S. Mulla, Giuseppe Battaglia, Carl Smythe and Jim A. Thomas
Chem. Sci., 2013,4, 4512-4519
DOI: 10.1039/C3SC51725J, Edge Article

Free to access until 15th December 2013


Benz[c]indeno[2,1-a]fluorene: a 2,3-naphthoquinodimethane incorporated into an indenofluorene frame
Hirokazu Miyoshi, Shunpei Nobusue, Akihiro Shimizu, Ichiro Hisaki, Mikiji Miyata and Yoshito Tobe
Chem. Sci., 2014, Advance Article
DOI: 10.1039/C3SC52622D, Edge Article

C3SC52622D ga

Free to access until 15th December 2013


Sodium hydroxide-assisted growth of uniform Pd nanoparticles on nanoporous carbon MSC-30 for efficient and complete dehydrogenation of formic acid under ambient conditions
Qi-Long Zhu, Nobuko Tsumori and Qiang Xu
Chem. Sci., 2014, Advance Article
DOI: 10.1039/C3SC52448E, Edge Article

C3SC52448E ga

Free to access until 15th December 2013


Direct Observation of a Lithiated Oxirane: A Synergistic Study Using Spectroscopic, Crystallographic, and Theoretical Methods on the Structure and Stereodynamics of Lithiated ortho-Trifluoromethyl Styrene Oxide
Vito Capriati, Antonio Salomone, Filippo Maria Perna, Saverio Florio, Aurelia Falcicchio, Anna Moliterni, Sten O. Nilsson Lill, Dietmar Stalke and Reent G. Michel
Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC52099D, Edge Article

C3SC52099D ga

Free to access until 15th December 2013

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Exotic interactions uncovered in actinide systems

Jennifer Newton writes about a HOT Chemical Science article for Chemistry World

The six orbital phase changes around the internuclear axis are unique to phi interactions

Theory had predicted the presence of Φ interactions in actinide systems but it had never been observed experimentally, until now. Scientists in the US using high-energy x-ray spectroscopy to study the involvement of the f-orbitals in actinide sandwich complexes have experimental evidence for this unusual interaction in thorocene.

At its most basic level, bonding in actinide molecules is typically comprised of a small amount of covalent orbital mixing in the presence of overwhelming ionic attractions. However, in many cases it is proposed that these small changes in f-element covalency are responsible for profound changes in chemical reactivity and actinide properties.

Covalency is a fundamental concept used to describe how elements share electrons in chemical bonds. For the d-block transition metal series, 3d, 4d, and 5d orbitals extend well into the periphery of the atom and can interact with valence orbitals of ligand atoms to form covalent chemical bonds. In contrast, the 4f orbitals of lanthanides are very core-like and their interactions with ligands are – in general – assumed to be of comparatively little chemical consequence. The actinide elements lie between these two extremes, and the extent to which valence f and d orbitals participate in chemical bonding is a subject of debate in the community.


You can also read this article in Chemistry World

Read the original journal article in Chemical Science:

New evidence for 5f covalency in actinocenes determined from carbon K-edge XAS and electronic structure theory
Stefan G. Minasian, Jason M. Keith, Enrique R. Batista, Kevin S. Boland, David L. Clark, Stosh A. Kozimor, Richard L. Martin, David K. Shuh and Tolek Tyliszczak
Chem. Sci., 2014, Advance Article
DOI: 10.1039/C3SC52030G, Edge Article

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Hole hopping in solar cells

Jason Woolford writes about a HOT Chemical Science article for Chemistry World

The technique estimates the energetic cost of a dye molecule changing conformation

Researchers in the UK, Spain and Switzerland say a method they have developed for probing electron transfer reactions could help them design more efficient solar cells.

Monitoring the behaviour of charges in photovoltaic devices is important for improving charge collection, especially in dye sensitised solar cells (DSSCs) that convert sunlight to electricity. Creating efficient solar cells is pivotal for meeting increasing energy demands especially as the world looks to move away from fossil fuels. DSSCs have many attractive features being simple to make, flexible and transparent, but they still have a way to go in terms of efficiency.

A research team led by Piers Barnes of Imperial College London has pioneered a technique that measures the diffusion coefficient of a less well reported phenomenon known as hole hopping, which occurs between sensitised dye molecules anchored to surfaces (in this case TiO2).


You can also read this article in Chemistry World

Read the original journal article in Chemical Science:

The reorganization energy of intermolecular hole hopping between dyes anchored to surfaces
Davide Moia, Valérie Vaissier, Ismael López-Duarte, Tomás Torres, Mohammad K. Nazeeruddin, Brian C. O’Regan, Jenny Nelson and Piers R. F. Barnes
Chem. Sci., 2014, Advance Article
DOI: 10.1039/C3SC52359D

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Chemical Science chemical biology symposium – the highlights

Matthew Gibson, University of Warwick, gives us the highlights from the recent Chemical Science–RSC Prizes and Awards Symposium

On 6th November 2013, the Department of Chemistry at the University of Warwick hosted a Chemical-Science sponsored symposium on Chemical Biology. The symposium was convened to celebrate several prizes and awards from the RSC Chemistry Biology Interface Division. There were over 130 attendees from industry and many different UK Universities, including a healthy number of local attendees from Warwick.

The first talk of the day was from Prof. Richard Silverman, winner of the RSC Centenary Prize medal, who got things off to a great start and some excellent discussion/questions from the audience. Prof Thomas Carell (Chemical Science invited speaker) and Prof Gregory Challis (from the home team) completed an excellent first session. After a quick break, we had talks from Prof Benjamin Davis (President of RSC Chemistry Biology Interface Division and Chemical Science Associate Editor) and last but not least, Prof Rein Ulijn gave his Norman Heatley Award lecture.

It is also important to thank the Warwick Centre for Analytical Science for sponsoring lunch and the student helpers who helped make this a great event. It goes without saying that the speakers enjoyed a well-earned dinner in the evening to celebrate the awards!

Dr. Matthew I. Gibson
University of Warwick and Conference Chair
@LabGibson on Twitter

Warwick speakers

Speakers at the Chemical Science-RSC Awards Symposium

Click here for more photos!

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Moving the goalposts for MRI

Jennifer Newton writes about a HOT Chemical Science article for Chemistry World

A new class of MRI (magnetic resonance imaging) contrast agents developed by scientists in the UK is promising to deliver clearer images in less time. ‘In any NMR experiment you are chasing sensitivity. We have enhanced the intrinsic ability to observe an MRI probe signal by a factor of 20,’ explains David Parker of Durham University who led the study. 

MRI is used in clinical settings to image the inside of the body. It uses strong magnetic fields and radio waves to probe the behaviour of nuclei that possess nuclear spin. Chemical shifts from proton NMR normally fall between 0–12ppm but water and fat resonate at 4.7 and 1.3ppm, respectively, and can overlap with MRI probe signals. Parker’s new probes shunt the spectral window of MRI scans well away from these interfering signals, a concept he describes as ‘moving the goalposts’. The probes consist of lanthanide complexes with a t-butyl group and the distance between the lanthanide and t-butyl group was fixed to optimise the rate of decay of the t-butyl signal as well as move its chemical shift. Data acquisition was possible just a few minutes after administering the probe and the signal from the lanthanide induced relaxation of the nine protons in the t-butyl groups has been shifted by up to 80ppm. 

Proton NMR spectra showing the shifted t-butyl resonances in some of the new dysprosium and thulium complexes

 


 

  Read the full article in Chemistry World»

Read the original journal article in Chemical Science:
Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy
Peter Harvey, Andrew M. Blamire, J. Ian Wilson, Katie-Louise N. A. Finney, Alexander M. Funk, P. Kanthi Senanayake and David Parker  
Chem. Sci., 2013,4, 4251-4258, DOI: 10.1039/C3SC51526E

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Light harvesting with many man-made leaves

Jeanne Andres writes about a HOT Chemical Science article for Chemistry World

Scientists from Japan have harvested light energy using an exceptionally large number of light absorbers to relay photons via antennas into one final energy acceptor. This two-step sequence closely mimics natural photosynthesis, resulting in greater and more efficient energy transfer.

Previously, researchers had only used one-step light harvesting systems, greatly limiting the number of absorbers able to feed light into a single reaction centre. Now, by imitating photosynthetic systems, Osamu Ishitani at the Tokyo Institute of Technology, Shinji Inagaki at the Toyota Central R&D labs and their co-workers have efficiently harvested light using the highest number of artificial leaves to date.


Read the full article in Chemistry World»

Read the original journal article in Chemical Science:
Efficient Light Harvesting via Sequential Two-Step Energy Accumulation Using a Ru–Re5 Multinuclear Complex Incorporated into Periodic Mesoporous Organosilica
Yohei Yamamoto, Hiroyuki Takeda, Tatsuto Yui, Kotaro Ueda, Kazuhide Koike, Shinji Inagaki and Osamu Ishitani 
Chem. Sci., 2013, Accepted Manuscript, DOI: 10.1039/C3SC51959G

 

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HOT Chemical Science articles for October

Here are our referee-recommended HOT Chem Sci articles – download them for FREE for a limited time!

Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy
Michael R Reithofer, Kiat-Hwa Chan, Anupama Lakshmanan, Dang Hoang Lam, Archana Mishra, Began Gopalan, Mangesh Joshi, Shu Wang and Charlotte A. E. Hauser
Chem. Sci., 2013, Accepted Manuscript
DOI: 10.1039/C3SC51930A, Edge Article

Free to access until 1st December 2013


Inaccessibility of the μ-hydride species in [FeFe] hydrogenases
Arndt R. Finkelmann, Martin T. Stiebritz and Markus Reiher
Chem. Sci., 2014, Advance Article
DOI: 10.1039/C3SC51700D, Edge Article

Free to access until 1st December 2013


Development of cell-impermeable coelenterazine derivatives
Eric Lindberg, Shin Mizukami, Keiji Ibata, Takashi Fukano, Atsushi Miyawaki and Kazuya Kikuchi
Chem. Sci., 2013,4, 4395-4400
DOI: 10.1039/C3SC51985F, Edge Article

Free to access until 1st December 2013


Mechanism of electrophilic fluorination with Pd(IV): fluoride capture and subsequent oxidative fluoride transfer
Jochen R. Brandt, Eunsung Lee, Gregory B. Boursalian and Tobias Ritter
Chem. Sci., 2014, Advance Article
DOI: 10.1039/C3SC52367E, Edge Article

Free to access until 1st December 2013

Click here for more free HOT Chemical Science articles for October!

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