Archive for the ‘Uncategorized’ Category

Reflecting on Fifteen Years of Progress in Organometallic Copper(III) Chemistry

To celebrate the 15th anniversary of Chemical Science, we invited authors who published with the journal in its early years and contributed seminal papers since then to revisit their original work and reflect on how their field has evolved. In their new Reflection article, Alicia Casitas and Xavi Ribas return to their influential 2013 review on high‑valent copper species to examine a decade of discovery, debate, and conceptual refinement in organometallic copper(III) chemistry.

Read the Reflection, for free, here: https://doi.org/10.1039/D5SC90259B

In 2013 the notion of isolable organocopper(III) complexes was still taking shape. The field was energized by the finding of copper‑catalysed C–H and C–X bond‑forming reactions, yet there remained fundamental questions:

How do these reactive species behave? What governs their selectivity? And what does “Cu(III)” truly mean in systems where ligand effects blur formal oxidation states?

Casitas and Ribas chart how these questions have guided the evolution of the field, highlighting both mechanistic breakthroughs and the nuanced electronic structures that continue to challenge understanding to this day.

Dissecting a Promiscuous Catalyst

Across different ligand environments and substrates, organocopper(III) complexes exhibit dramatically varied mechanistic profiles. These species sometimes follow pathways reminiscent of classical organometallic reductive elimination, other times behaving showcasing radical or redox activity. This mechanistic “promiscuity” has pushed chemists to refine both computational tools and spectroscopic strategies to capture transient structures.

Recent research published in Chemical Science illustrates these complexities. Fan and co‑workers exploited the distinct hydrogen‑atom‑transfer (HAT) and radical‑capture reactivity of two different copper(III) complexes, Cu(III)-OH and Cu(III)-F, to develop a decoupled approach to C(sp³)-H fluorination (https://doi.org/10.1039/D5SC06381G). This strategy sidesteps the longstanding challenge of expecting a single high‑valent metal complex to excel at both HAT and radical capture.

 

Illuminating Radical Pathways

The Reflection also highlights the continuing debate over the nature of formal Cu(III), particularly in CF₃‑bearing complexes. Photochemical activation strategies have provided a powerful platform for interrogating these species. In an elegant demonstration, Motornov, Beier and co‑workers used violet‑light irradiation to sequentially release all four CF₃ groups from a tetrakis(trifluoromethyl)cuprate(III) complex, enabling efficient C-H trifluoromethylation of (hetero)arenes and even biomolecules (https://doi.org/10.1039/D5SC07405C). Their mechanistic studies reinforce how photochemistry can reveal hidden facets of high‑valent copper intermediates while affording practical transformations.

The interplay of radical and organometallic pathways also features in the combined computational and experimental work of Mandal, Stahl and colleagues (https://doi.org/10.1039/D3SC03597B). Their study dissects N-fluorobenzenesulfonimide (NFSI)-based radical-relay reactions, mapping selectivity trends and evaluating competing pathways such as radical–polar crossover and reductive elimination from formal Cu(III) species.

Expanding the Copper Redox Landscape

New insights into copper(I)/copper(III) redox cycles continue to appear in unexpected places. Sneddon, Kerr and collaborators conducted a deep mechanistic study of a copper(I)-catalysed sulfonylative Suzuki–Miyaura reaction (https://doi.org/10.1039/D3SC01337E), revealing not only the expected Cu(I)/Cu(III) pathways but also a competing Cu(II)-mediated route. Their work highlights the interconnectedness of copper’s redox chemistry, which is explored in the Reflection article from Casitas and Ribas.

Following their early contribution to Chemical Science, this Reflection captures not just how far copper(III) chemistry has come, but how vibrant, and mechanistically rich, future research may be.

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Reflecting on Fifteen Years of Bimetallic Catalysis in Epoxide/CO₂ Copolymerisation

To celebrate the 15th anniversary of Chemical Science, we invited authors who published with the journal in its early years and contributed seminal papers since then to revisit their original work and reflect on how their field has evolved. In their Reflection article, Koji Nakano and Kyoko Nozaki look back on their 2010 study of bimetallic cobalt(salen) complexes, which revealed a cooperative bimetallic mechanism for the alternating copolymerisation of epoxides with carbon dioxide.

Read the Reflection, for free, here: https://doi.org/10.1039/D5SC90244D

Their original work showed that placing two cobalt centres in close proximity allows one to activate the epoxide while the other delivers the propagating carbonate species, affording an elegant intramolecular division of labour that enhanced catalytic activity. In their Reflection, Nakano and Nozaki outline how this discovery helped motivate subsequent developments in both homobimetallic and heterobimetallic catalysts for epoxide/CO₂ copolymerisation.

Bimetallic Catalysts Beyond Polymerisation

The mechanistic principles highlighted in the Reflection, that proximity, complementarity and cooperative activation are all essential, now underpin advances across a wide range of bimetallic catalytic systems.

Yue, Yang, Tang et al. recently achieved atomic‑level spatial precision of cobalt and nickel sites within a covalent organic framework, creating a highly active bimetallic catalyst for CO₂ photoreduction in which the two metals influence each other electronically (https://doi.org/10.1039/D5SC08435K).

Römelt, Apfel et al. show that a CuICoII cryptate complex exhibits strong synergistic behaviour in visible‑light CO₂ reduction, outperforming its mononuclear analogues (https://doi.org/10.1039/D3SC02679E). These examples underscore how strategically combining metals can unlock reactivity that neither metal achieves alone.

Broader Advances in Polymerisation Chemistry

Other recent studies in Chemical Science reflect that the same emphasis on mechanistic clarity and controlled monomer insertion noted in the Reflection article is essential beyond bimetallic systems.

Seidel and Sumerlin et al. present a practical strategy for accessing alternating styrene–propylene and styrene–ethylene copolymers by coupling RAFT polymerisation with mild photocatalytic decarboxylation, sidestepping long‑standing reactivity‑ratio limitations (https://doi.org/10.1039/D3SC03827K).

Meanwhile, Plajer et al. offer monomer‑centred guidelines for selectivity in sulfurated ring‑opening copolymerisation, showing how an understanding of backbiting, chain‑end stability and ring strain can deliver perfectly alternating poly(esters‑alt‑thioesters) (https://doi.org/10.1039/D4SC05858E).

Though distinct from bimetallic approaches, both studies reinforce that precise control of fundamental steps in chain growth, as showcased in the Reflection and original Chemical Science paper, enables new polymer structures and reactivities.

Looking Ahead

Nakano and Nozaki’s Reflection highlights how the principles of cooperative catalysis have shaped fifteen years of progress in epoxide/CO₂ copolymerisation. Recent advances in both bimetallic activation strategies and mechanistically informed polymerisation methods show that these ideas continue to influence catalyst and polymer design across the field.

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2026 Chemical Science Lectureship awarded to Alán Aspuru-Guzik

Awarded for contributions to the field of digital chemistry and the chemical applications of artificial intelligence, machine learning and automation.

Chemical Science is delighted to announce the winner of our 2026 Lectureship, Professor Alán Aspuru-Guzik!

The Chemical Science Lectureship celebrates leading, independent researchers at all career stages who have made exceptional discoveries and innovations in their field within the last five years. This annual lectureship focuses on a specific subject area that aligns with the Chemical Science symposium each year, rotating to cover the breadth of the journal and all areas of the chemical sciences.

This year, the Lectureship focused on digital chemistry and Professor Alán Aspuru-Guzik was selected as the winner for his recent research on machine learning and automation. Alán will deliver the Lectureship at the 2026 Chemical Science Symposium on the same theme on 29–30 October in London, UK.

 

About our 2026 winner:

Photo credit: Carlos Osorio

Alán Aspuru-Guzik, University of Toronto

Alán Aspuru-Guzik is a professor of Chemistry and Computer Science at the University of Toronto, the Canada 150 Laureate in Theoretical Chemistry, and a Canada CIFAR AI Chair at the Vector Institute for Artificial Intelligence. He is also a CIFAR Fellow and co-directs CIFAR’s Accelerated Decarbonization program.

Alán directs the Acceleration Consortium, a University of Toronto strategic initiative that brings together researchers from industry, government, and academia to advance pre-competitive research related to the lab of the future. Before joining the University of Toronto, Alán began his independent career at Harvard University in 2006, where he was a full professor from 2013 to 2018. He received his B.Sc. from the National Autonomous University of Mexico (UNAM) in 1999 and his PhD from the University of California, Berkeley in 2004, where he was a postdoctoral fellow from 2005 to 2006.

Alán’s research spans quantum information, machine learning, and chemistry. He pioneered the development of algorithms and experimental implementations of quantum computers and quantum simulators for chemical systems. His work has also examined the role of quantum coherence in excitonic energy transfer in photosynthetic complexes and accelerated discovery through calculations on organic semiconductors, organic photovoltaic materials, organic batteries, and organic light-emitting diodes.

He has worked extensively on molecular representations and generative models for learning molecular properties. His current interests include automation and autonomous chemical laboratories for accelerating scientific discovery as well as AI Scientists, in particular the El Agente project.

Alán has also made significant contributions to scientific publishing and editorial leadership. He served as the first Chemical Science Associate Editor for theoretical and computational chemistry. He is editor-in-chief of Digital Discovery, the Royal Society of Chemistry journal focused on data-driven approaches to scientific discoveries.

Among other recognitions, Alán has received the Google Focused Award for Quantum Computing, the Sloan Research Fellowship, and the Camille and Henry Dreyfus Teacher-Scholar Award. He won the Heinrich Emanuel Merck Award for Computational Sciences in 2025 and was named a Fellow of the Royal Society of Canada in 2025. He was selected by MIT Technology Review as one of the top innovators under 35 and received the Early Career Award in Theoretical Chemistry from the American Chemical Society. He is also an elected fellow of the American Physical Society and the American Association for the Advancement of Science.

In 2024, Alán received the University of Toronto President’s Impact Award and the 2024 PRISM Prize from the Istituto di Struttura della Materia.

Alán was named in Maclean’s 2024 Power List as one of Canada’s 100 most powerful people, in the AI category. In 2026, he was featured as a BetaKit Most Ambitious Canadian.

Alán has served as a co-founder and advisor of several companies.

 

Read Alán’s recent Chemical Science articles:

Photochemical post-functionalization of polystyrene enables accelerated chemical recycling

Stanley Lo, Angela Lin, Cher Tian Ser, Alán Aspuru-Guzik* and  Helen Tran* 

Chem. Sci., 2026, 17, DOI: 10.1039/D6SC03696A

Grammar-driven SMILES standardization with TokenSMILES

 Luis Armando Gonzalez-Ortiz,* Lisset Noriega, Filiberto Ortiz-Chi, Gabriela Vidales-Ayala, Emmanuel Soberanis-Cáceres, Amilcar Meneses-Viveros,*  Alan Aspuru-Guzik* and Gabriel Merino*

Chem. Sci., 2026,17, 1666-1675

Automated electrosynthesis reaction mining with multimodal large language models (MLLMs)

 Shi Xuan Leong, Sergio Pablo-García, Zijian Zhang and Alán Aspuru-Guzik*

Chem. Sci., 2024,15, 17881-17891

 

Find out more about the 2026 Chemical Science Symposium on digital chemistry in the age of AI and machine learning where Alán will deliver the 2026 Lectureship on our event webpage.

 

 

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Chemical Science Reviewer Spotlight – September 2025

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Professor Mercedes Taylor, Professor Renana Gershoni-Poranne, Professor Dan Li and Professor Nick Le Brun. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Professor Mercedes Taylor, University of Maryland. Mercedes Taylor’s lab uses supramolecular assembly and reticular chemistry to design robust organic materials for challenging ion separations.

Professor Renana Gershoni-Poranne, Technion-Israel Institute of Technology. My group uses computational chemistry and data-driven approaches to understand and predict the chemical properties and reactivity of polycyclic aromatic systems. We then try to encapsulate these insights into conceptual frameworks to enable the design of molecules with tailored properties that can be used in various areas, such as organic semiconductors or ligands for catalysts. We’ve recently also started to employ machine- and deep-learning techniques for generative design of these molecules.

Professor Dan Li, Jinan University. My research focuses on designing and building complex molecules, combining different types of chemical bonds/weak interactions to create visually appealing shapes with exciting properties, aiming to develop sustainable materials.

Professor Nick Le Brun, University of East Anglia. My research is focused on understanding the roles of metals in life, how organisms minimise the toxicity of essential metals, and how they assemble complex metallocofactors.

 

What encouraged you to review for Chemical Science?

Professor Renana Gershoni-Poranne: Chemical Science is a leading journal that publishes innovative, high-quality work across all areas of chemistry. I was motivated to contribute to maintaining these standards and to support a journal that fosters scientific excellence and broad accessibility. I am particularly grateful that Chemical Science provides an important platform for aromaticity-related work, allowing the work of our community to reach broad audiences and have an impact.

Professor Dan Li: Chemical Science serves as an interdisciplinary platform for researchers across a wide range of fields. Reviewing for it offers a unique opportunity to engage with chemists from diverse backgrounds.

Professor Mercedes Taylor: I enjoy reading articles in Chemical Science because of their fundamental approach to broadly-relevant questions, so this enjoyment encouraged me to contribute as a reviewer.

 

What advice would you give a first-time author looking to maximise their chances of successful peer review?

Professor Nick Le Brun: Aside from the obvious things such as making sure that the main messages of the manuscript are well supported by the data (including the right controls), and that it’s been carefully proof read before submission, it’s important to capture the interest of the reader from the beginning – weave your findings into an engaging story that emphasises why the science is important.

 

What makes a paper truly stand out for you when reviewing a paper?

Professor Mercedes Taylor: I appreciate papers with thoughtful, unusual introductions. Occasionally authors will depart from the standard format of an introduction to offer more original musings on the state of the field, which sets the paper apart from the beginning.

 

What do you enjoy most about reviewing

Professor Renana Gershoni-Poranne: Getting to read manuscripts before they are published feels like getting a ‘sneak peek’ – which is always fun! I also enjoy the opportunity to contribute constructive feedback that strengthens the work, if I think I can. Reviewing also broadens my own perspective by exposing me to ideas and methods outside my immediate field. I always include something complimentary in each review, because I know that the students and postdocs who worked on the manuscript deserve encouragement, even if there are still some areas that can be improved. I like to think that this makes the reviewing process less stressful for them.

Professor Nick Le Brun: Reviewing a manuscript properly takes significant time, but can be very rewarding. Helping to get fascinating new science published is enjoyable, as is the opportunity to suggest ways to improve a manuscript.

Professor Dan Li: Reviewing embodies both a privilege and a solemn duty.

 

How did you prepare to write a review for Chemical Science?

Professor Mercedes Taylor: I prepare to write a review by reading the article through from start to finish; I try to resist the urge to make notes and form opinions until the second read. 

 

How do you find that Chemical Science has contributed to your research field?

Professor Nick Le Brun: Chemical Science, as the flagship journal of the RSC, is a leading broad remit chemistry journal, and as such publishes some of the best science in bioinorganic chemistry. It’s led the way in terms of making science accessible to all through its highly unusual and long-standing free-to-publish policy.

Professor Renana Gershoni-Poranne: As a computational chemist, I particularly appreciate that Chemical Science serves as an important venue for disseminating high-impact research in computational and theoretical chemistry, fields which have traditionally had a much harder time getting published in broader journals. As mentioned above, in recent years Chemical Science has also provided a platform for research in the area of aromaticity, which has been important for our community. 

 

Tune in soon to meet our next group of #ChemSciReviewers!

 

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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Chemical Science Reviewer Spotlight – November 2024

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Professor Amy Fraley, Professor Knut Asmis, Dr Chidambar Kulkarni and Professor Mark MacLachlan. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Professor Amy Fraley, ETH Zürich. Our group approaches medicinal chemistry from a non-traditional angle, taking inspiration from nature, and tuning natural systems (for example enzymes and even whole organisms) towards challenges impacting human health or the environment.

 

Professor Knut Asmis, Universität Leipzig. Our group characterizes the intrinsic properties of molecules, clusters and nanoparticles in order to gain a deeper understanding on how these can be affected by their environment.

 

Dr Chidambar Kulkarni, IIT Bombay. Our research involves the design, synthesis and understanding the mesoscopic assembly of functional organic molecules/polymers to ultimately gain control over the macroscopic devices made up of these materials. We use a physical-organic chemistry approach to gain insights into soft functional materials.

 

Professor Mark MacLachlan, The University of British Columbia. Our group makes new molecules and materials that have interesting structures and stretch our chemical creativity. We are especially interested in new substances with interesting optical properties that can make them useful for sensing.

 

What encouraged you to review for Chemical Science?

Professor Amy Fraley:  I was motivated to review for Chemical Science due to the breadth of interdisciplinary work that they foster. I enjoy contributing feedback and giving back to the community, especially when these efforts are toward a journal offering to make peer-reviewed articles freely and permanently available online such as the Diamond Open Access program offered by Chemical Science.

Dr Chidambar Kulkarni: Chemical science is one of my frequently read general chemistry journals, contributing to this community at large by reviewing is an honour. 

Professor Knut Asmis: Reviewing is part of my community duty and since Chemical Science is one of the few outstanding and interdisciplinary journals I particularly enjoy to review for them. 

Professor Mark MacLachlan: I have been asked to review several papers for Chemical Science.  As I like the journal and publish there, I feel a responsibility to occasionally review manuscripts for the journal.  I find the papers are generally high quality and of interest to me.

 

What do you enjoy most about reviewing?

Professor Amy Fraley: I like that reviewing provides me with the opportunity to read about the latest discoveries in my field, and contribute my thoughts to constructively shape the work in its final published form.

Dr Chidambar Kulkarni: The fact that I get to view a new piece of science for the first time and help improve it is enjoyable.

Professor Knut Asmis: Learning how others do research, what research topics they work on and how they place their research results in a more general context. 

Professor Mark MacLachlan: I like to review papers as a way to keep up on the literature – even before the work is published.

 

What are you looking for in a paper that you can recommend for acceptance in Chemical Science?

Professor Amy Fraley: I look for innovative work that presents groundbreaking discoveries in the field, but also recognizes the foundational work that came before. The authors should be able to place their discoveries in the context of related research, and describe what makes their work stand out.

Dr Chidambar Kulkarni: I look for either a conceptual advancement or new materials with appealing properties or novel insights into existing systems.

Professor Knut Asmis: Insights into chemistry, based on state-of-the-art research approaches that yield high quality data that is presented in a clear form and from which concise conclusions can be derived, that go beyond the borders of a particular discipline. 

Professor Mark MacLachlan: I am looking for a paper that is easy to read and understand, reports something new, and has results that are either surprising or significant.  My favourite papers to review usually involve an element of serendipity – an unexpected crystal structure, reaction, or effect – or achieving something challenging.

 

What would you recommend to new reviewers to ensure their report is helpful?

Professor Knut Asmis: Think twice, before accepting to review a particular manuscript. Identify weak spots and suggest improvements. Don’t get lost in detail. Treat the authors as you would like to be treated.   

 

Tune in next month to meet our next group of #ChemSciReviewers!

 

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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Chemical Science Reviewer Spotlight October 2024

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Dr Alexa Kuenstler, Dr John Mack, Professor AnnMarie O’Donoghue and Professor Nathalie Steunou. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Dr Alexa Kuenstler, University of Illinois Urbana-Champaign (USA).  My group works at the intersection of polymer chemistry and polymer physics to develop soft materials that address challenges in sustainability, energy, and human health.

 

Dr John Mack, Rhodes University (South Africa). I use molecular modelling to guide the rational selection of porphyrins and their analogues for applications, often in the context of their nanoparticle conjugates. The applications include use as photosensitizer dyes in photodynamic therapy against cancer cells and antibiotic-resistant bacterial strains, and as optical limiting materials for attenuating intense incident laser pulses.

 

Professor AnnMarie O’Donoghue, Durham University (United Kingdom). I am a physical organic chemist focused on the detailed understanding of reaction mechanism in organo- and enzymatic catalysis. Following decades of impressive developments and identification of many new catalysts, I strongly believe that further progress will depend on in-depth understanding of mechanism and is particularly important in addressing sustainability goals.

 

Professor Nathalie Steunou, Université de Versailles – Saint-Quentin-en-Yvelines (France). The research of Nathalie Steunou is focused on the design of hybrid inorganic-organic materials including MOFs and composites for energy, health and environment related applications.

 

 

What encouraged you to review for Chemical Science?

Dr Alexa Kuenstler: Chemical Science publishes work at interdisciplinary interfaces – I both value this scientific ethos and appreciate the opportunity to serve the greater scientific community.

Dr John Mack: The very high quality of this journal means that almost all manuscripts sent out for review are likely to be on the cutting edge in terms of the fields I am involved in.

Professor AnnMarie O’Donoghue: Chemical Science is one of the flagship international RSC journals. It is good to support both the journal and the chemistry field more widely through provision of reviews.

Professor Nathalie Steunou: Reviewing articles is one of the scientific activities a researcher must carry out, and it’s always very interesting to read articles covering interdisciplinary topics in chemistry and materials science and to have the opportunity to exchange scientific views with the authors.

 

What do you enjoy most about reviewing?

Dr Alexa Kuenstler: I enjoy the opportunity to engage with cutting-edge work that is cross-disciplinary.

Dr John Mack: Although it can be time-consuming at times, it does provide an opportunity to stay current on how a broader scientific field is developing with regards to what experiments are possible with regards to the characterization of compounds and the analysis of their properties and utility for applications while providing a service to the broader scientific community as part of the basic obligations of being an academic.

Professor AnnMarie O’Donoghue: I enjoy the insights provided of current state-of-the-art developments and concepts in chemistry. I also learn from the different presentation styles of Chemical Science authors. I am always impressed by the creative graphics included by authors!

Professor Nathalie Steunou: It’s very important to read the recent works submitted by my scientific community and to keep abreast of scientific advances. It’s also a time for scientific exchanges and, of course, a time for reflection on one’s own work.

 

What advice would you give a first-time author looking to maximise their chances of successful peer review?

Dr Alexa Kuenstler: Good papers tell good stories – use compelling figures to present interesting data and use the text to place these into the broader context of the work. Above all, make sure the work teaches the community something!

Dr John Mack: It is extremely important to master how to use software such as Excel and Powerpoint to present their data sets as clearly as possible to the reviewer.

What makes a paper truly stand out for you when reviewing a paper?

Professor AnnMarie O’Donoghue: It can be difficult to give the necessary time to providing detailed, constructive, balanced reviews as we are all time-pressed, however, it is one of the most important contributions we can make to the community. Particularly for Early Career Researchers, I think it is very important to maintain a positive, constructive tone and highlight positive aspects of a manuscript in addition to potential areas for improvement.

 

Do you have any advice to our readers seeking publication in Chemical Science on what makes a good paper?

Professor Nathalie Steunou: I don’t have any advice to give, just an opinion. To write a good article is to concisely tell a creative scientific story and, as a result, send a message that is likely to be of interest to the entire chemistry community.

 

Are there any steps that reviewers can undertake to improve the quality of their review?

Dr John Mack: I think it is important to avoid only being harshly negative when it becomes necessary to outright reject a paper. Time should be taken to leave the corresponding author with a clear picture of what you think they will need to do in future to reach the level that they aspire to.

Professor AnnMarie O’Donoghue: It can be difficult to give the necessary time to providing detailed, constructive, balanced reviews as we are all time-pressed, however, it is one of the most important contributions we can make to the community. Particularly for Early Career Researchers, I think it is very important to maintain a positive, constructive tone and highlight positive aspects of a manuscript in addition to potential areas for improvement.

 

Did reviewing for Chemical Science affect how you approached preparation of your recent publication with us?

Professor Nathalie Steunou: Writing a really good article isn’t easy, and you learn a lot about writing by reading and assessing the work of others.

 

Tune in next month to meet our next group of #ChemSciReviewers!

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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Chemical Science Reviewer Spotlight – July 2024

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Professor Arturo Jimenez-Sanchez, Professor Ganna Gryn’ova, Professor Kazuya Kikuchi, and Professor Michael Weiss. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Professor Arturo Jimenez-Sanchez, Institute of Chemistry, UNAM. My research focuses on developing new bioanalytical molecular platforms that integrate aspects of organic synthesis, cellular biology, and optical imaging to create efficient and precise methods for delivering molecules into cells and monitoring cellular processes. https://orcid.org/0000-0002-8757-4589

Professor Ganna Gryn’ova, University of Birmingham.I use theoretical and computational chemistry, physics, and materials science in combination with chemical machine learning to explore and exploit diverse functional organic and hybrid materials and molecules. https://orcid.org/0000-0003-4229-939X

Professor Kazuya Kikuchi, Osaka University. I use chemical technique to make functional molecules in living cells, body, etc. visible. https://orcid.org/0000-0001-7103-1275

Professor Michael Weiss, Indiana University.Our research focuses on the biosynthesis, evolution and function of the insulin molecule with application to (a) monogenic diabetes syndromes in children and (b) molecular engineering of improved insulin analogs for clinical management.

 

What encouraged you to review for Chemical Science?

Professor Arturo Jimenez-Sanchez: I have always valued Chemical Science for its rigorous standards and the high quality of its published research. Reviewing for the journal allows me to contribute to the scientific community by ensuring that these standards are upheld and by helping to disseminate important advancements in the field.

Professor Ganna Gryn’ova: I always receive great papers to review from Chemical Science, fitting my expertise and interests. Reviewing these papers goes beyond service to community as it enriches me scientifically.

Professor Kikuchi: I sometimes am not happy about the comments made by reviewers, so I should write comments with convincing logic, evidence and background.

Professor Weiss: Because our work is grounded in chemical and biophysical principles, the breadth and depth of the studies in Chemical Science broadly inform our experimental design.

 

What do you enjoy most about reviewing?

Professor Arturo Jimenez-Sanchez: I enjoy the opportunity to engage with cutting-edge research and to provide constructive feedback that can help authors improve their work. Reviewing also allows me to stay updated on the latest developments and trends in my field.

Professor Ganna Gryn’ova: I enjoy learning how to write better papers from the manuscripts themselves and from the fellow referees’ comments.

Professor Kikuchi: I can make out points which I may overlook when I read paper without critical thinking.

Professor Weiss: It is a pleasure to review for this journal because in general the manuscripts combine focused insight into a given chemical or biochemical system with a broad awareness of foundational principles in bioorganic chemistry. Reviewing such excellent manuscripts has helped us to improve our own style of presentation.

 

What makes a paper truly stand out for you when reviewing a paper?

Professor Arturo Jimenez-Sanchez: A paper stands out when it presents novel ideas or approaches, is well-structured and clearly written, and includes comprehensive data that supports its conclusions. Innovative methodologies and a strong potential for real-world application also make a significant impact.

Professor Ganna Gryn’ova: A single strong, clear message, which certainly needs to be fully supported by well-executed and well-documented research.

Professor Kikuchi: Original and elegant molecular design.

 

Are there any steps that reviewers can undertake to improve the quality of their review?

Professor Arturo Jimenez-Sanchez: Reviewers can improve the quality of their reviews by being thorough, objective, and constructive. It is important to provide specific feedback that can help authors enhance their manuscripts, including pointing out both strengths and areas for improvement. Additionally, staying current with the latest research and methodologies in the field can provide valuable context and insights during the review process.

 

Tune in next month to meet our next group of #ChemSciReviewers!

 

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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Chemical Science Reviewer Spotlight – March 2024

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Professor Anna Pasternak, Dr Joshua Barham and Professor Abhishek Dey. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Professor Anna Pasternak, Institute of Bioorganic Chemistry, Polish Academy of Sciences. The research of Professor Anna Pasternak’s group is focused on development of novel, nucleic acid based therapeutics, such as ASOs, SSOs, aptamers, triplexes and G-quadruplexes, targeted towards cardiovascular and cancer diseases. The particular interest includes not only their biological activity but also structural aspects which are crucial to understand their action within living cells.

 

Dr Joshua Barham, University of Regensburg. Dr Joshua Barham’s research uses emerging technologies for chemical synthesis that are powered by safe, sustainable energy sources like visible light and electricity. His research group develops catalysts that harness these energy sources to access highly reactive chemical intermediates under very mild conditions. Their vision is to valorize this technology to streamline the synthesis of active pharmaceutical ingredients, utilize biomass feedstocks, and recycle persistent pollutants.

 

Professor Abhishek Dey, Indian Association for the Cultivation of Science. Professor Abhishek Dey is interested in understanding and facilitating chemical reactions involving multiple electron multiple electron reductions of small molecules.

 

What encouraged you to review for Chemical Science?

Dr Joshua Barham: Chem. Sci. is the RSC’s flagship journal and it is diamond open access. It is rare for a Chemistry journal with international visibility and impact as high as Chem. Sci. to be open access, and I strongly support this principle. Therefore, I want to contribute to maintaining the high standards of Chem. Sci. by providing an appropriately high level of scrutiny and thoroughness during the peer-review process.

Professor Abhishek Dey: It’s one of the top journals in chemistry where I enjoy publishing. I feel responsible to ensure that the scientific quality of the article and inclusive nature of this journal is maintained. Hence I review for Chemical Science.

 

What do you enjoy most about reviewing?

Dr Joshua Barham: I particularly enjoy when authors take critical reviewer comments seriously and approach the response in a collaborative rather than combative way. For example, I have reviewed papers where the proposed mechanism was initially surprising or key control reactions were missing, and once authors addressed this it changed the story of the manuscript in a major way. Such experiences show the crucial importance of peer review. It was highly satisfying for me as a reviewer to see the value and impact that my comments had on the final manuscripts.

Professor Anna Pasternak: The possibility to verify quality of the research and improvement of the articles, if necessary, is the most satisfying for me.

Professor Abhishek Dey: Being able to contribute to the scientific thinking of peers across the world.

 

What advice would you give a first-time author looking to maximise their chances of successful peer review?

Professor Anna Pasternak: Do not rush, make a story – write in such way that the reader will be interested in the article, use logical interpretation of the results, never over-interpret the data, support discussion with already published facts, and last but not least – ask a friend to read the draft critically and give you advice before submission – another point of view is invaluable.

 

Tune in next month to meet our next group of #ChemSciReviewers!

 

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Apply here now!

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Themed collection on Emerging Frontiers in Aromaticity

We are delighted to announce our themed collection in Chemical Science on Emerging Frontiers in Aromaticity. Guest edited by Prof. Gabriel Merino, Cinvestav Mérida (Mexico), Prof. Miquel Solà, Universitat de Girona (Spain), and Prof. Israel Fernández, Universidad Complutense de Madrid (Spain), this collection highlights the most recent methodological developments and unique aspects of aromaticity.

Read the guest editor’s insights and summary of the collection in the accompanying editorial.

The collection features a combination of Review, Perspective, Focus and Edge articles covering a variety of topics within the field of aromaticity, including metalla-aromaticity, macrocyclic aromaticity, 3D-aromaticity, Möbius aromaticity, and the aromaticity of polycyclic conjugated hydrocarbons and nanographenes.

 

Browse the collection, including:

Aromaticity: Quo Vadis
Gabriel Merino, Miquel Solà, Israel Fernández, Cina Foroutan-Nejad, Paolo Lazzeretti, Gernot Frenking, Harry L. Anderson, Dage Sundholm, Fernando P. Cossío, Marina A. Petrukhina, Jishan Wu, Judy I. Wu and Albeiro Restrepo
Chem. Sci., 2023, 14, 5569-5576, DOI: 10.1039/D2SC04998H

In this Perspective article, the authors aim to reflect where the aromaticity community is currently, and where it is going.

Synthesis of octagon-containing molecular nanocarbons

Greco González Miera, Satoshi Matsubara, Hideya Kono, Kei Murakami and Kenichiro Itami
Chem. Sci., 2022,13, 1848-1868, DOI: 10.1039/D1SC05586K

This Review describes the synthetic achievements that the scientific community has performed to obtain curved polycyclic nanocarbons with 8-membered rings, building blocks that could potentially give access as templates to larger nanographenes, and eventually to Mackay-Terrones crystals.

A focus on aromaticity: fuzzier than ever before?

Henrik Ottosson

Chem. Sci., 2023,14, 5542-5544, DOI: 10.1039/D3SC90075D

In this Focus article, the author poses the question: Who utilises the aromaticity concept, and who benefits from it? Especially, who benefits from it being overly fuzzy, and who goes the opposite?

The smallest 4f-metalla-aromatic molecule of cyclo-PrB2 with Pr–B multiple bonds

Zhen-Ling Wang, Teng-Teng Chen, Wei-Jia Chen, Wan-Lu Li, Jing Zhao, Xue-Lian Jiang, Jun Li, Lai-Sheng Wang and Han-Shi Hu

Chem. Sci., 2022,13, 10082-10094, DOI: 10.1039/D2SC02852B

The authors report the discovery of a doubly aromatic triatomic lanthanide-boron molecule PrB2based on a joint photoelectron spectroscopy and quantum chemical investigation in this Edge article.

Aromatic heterobicycle-fused porphyrins: impact on aromaticity and excited state electron transfer leading to long-lived charge separation

Austen Moss, Youngwoo Jang, Jacob Arvidson, Vladimir N. Nesterov, Francis D’Souza and Hong Wang

Chem. Sci., 2022,13, 9880-9890, DOI: 10.1039/D2SC03238D

This Edge article reports a new synthetic method to fuse benzo[4,5]imidazo[2,1-a]isoindole to the porphyrin periphery at the β,β-positions, and its impact on the aromaticity and electronic structures is investigated.

Substituent effects on aromatic interactions in water

Gloria Tobajas-Curiel, Qingqing Sun, Jeremy K. M. Sanders, Pablo Ballester and Christopher A. Hunter

Chem. Sci., 2023,14, 6226-6236, DOI: 10.1039/D3SC01027A

In this Edge article, the authors describe a supramolecular system for measuring aromatic interactions in water and show that substituents have a remarkable effect on interaction strength, with an increase of three orders of magnitude in the stability of a complex when a single nitro group is added to one of the aromatic rings.

Mining anion–aromatic interactions in the Protein Data Bank

Emilia Kuzniak-Glanowska, Michał Glanowski, Rafał Kurczab, Andrzej J. Bojarski and Robert Podgajny

Chem. Sci., 2022,13, 3984-3998, DOI: 10.1039/D2SC00763K

The authors of this Edge article introduce the first comprehensive analysis of non-redundant Protein Data Bank (PDB) macromolecular structures investigating anion distributions around all aromatic molecules in available biosystems, including ligands.

We hope you enjoy reading this themed collection in Chemical Science!

 

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How can Chemical Science increase confidence in research?

Publishing practices you can rely on

Open access research benefits everyone around the planet. It makes research more widely accessible, which can lead to positive change in many areas of daily life. As a diamond open access journal, Chemical Science makes this form of publishing an easy option. We cover all publication costs, so our community can read and publish with us for free.

We are real advocates for open access, and in this blog post, we will explain how it can improve research culture and benefit every single one of us. Interested in learning more? Explore our research or submit your article today.

 

Discover what you could achieve with open access

Greater impact for you

As a researcher, you will find that the biggest benefit of publishing open access is increasing the discoverability of your work. The number of potential readers of your publications increases significantly with open access. If anyone can access your research – including other scientists, funders, policymakers and the general public – then it is more likely to be cited and make an impact.

Every article we publish is diamond open access, but we don’t only rely on our publications being available to all to make an impact. We celebrate our community, offering promotional opportunities like #ChemSciVoices where our authors can discuss their research in a video or blog post. When you publish with us, you can trust that your research will find the communities it needs to.

Better research culture for all

The benefits of open access for individual researchers are clear – but how can it improve research culture too? Open access helps make sure that publications are visible, reliable and reproducible. Ensuring research findings are available to everyone, in any part of the world is the key to building a fairer, more equitable society – one where everyone can access and benefit from discoveries. Open access can also encourage greater multi-disciplinary collaboration, as scientists in all disciplines and subjects can access and inspire each other, so driving scientific progress faster. Chemical Science harnesses these benefits of open access for everyone, by publishing leading-edge articles that have undergone rigorous peer review, at no cost to the author.

 

What makes Chemical Science different?

Our diamond open access policy sets us apart from other journals. This policy means that our community can read our articles and publish with us for free. We cover all of the publication costs, so everyone can choose an open access path for their research. And this is only a possibility because we are a society publisher with a mission to disseminate scientific knowledge.

Fair and rigorous peer review

We see open access as part of a larger vision to improve research culture. It’s not enough to increase the accessibility of articles – we need to make sure that our publications are reliable and reproducible too. Providing a robust peer review process is one way we make sure our publications are reliable. In every submission, our peer reviewers are looking for novel ideas, progressive thinking and research that can make a real-world difference. This approach means that Chemical Science is a home to both accessible and impactful work.

The choice of transparent peer review

We are continually looking for ways in which we can increase the quality of our peer-review. For this reason, we now offer our authors the choice of transparent peer review, which aims to cultivate a more open and robust peer-review process. If an author chooses this option, the peer reviewers’ reports, authors’ responses and editors’ decision letters are published alongside the accepted article. Transparent peer review can:

  • encourage fair and rigorous peer review
  • amplify the hard work of our editors and reviewers
  • allow scientists to learn from the published reports
  • promote more constructive reviewer comments

Transparent peer review is compatible with both single- and double-anonymised peer review. And if you are a reviewer, you will stay anonymous during the process by default. As an author, you can opt in for transparent peer review at any stage before publication.

FAIR publications

Reproducibility is a key part of the open access picture for Chemical Science. We encourage our authors to make sure that the data in publications is FAIR (Findable, Accessible, Interoperable and Reusable), and we also ask authors to provide a data availability statement in their article. This can improve research culture by:

  • supporting the validity of data and maintaining research reproducibility
  • increasing transparency and encouraging trust in the scientific process
  • enabling and encouraging the reuse of new findings
  • giving authors credit through the formal citation of data

Author Contributions

We also ask all authors to provide an Author Contribution Statement as part of their article as standard. Author contribution statements are important as they can:

  • provide transparency about who contributed to the research and in what capacity. It allows readers to understand the specific roles of each author in the study, which can be helpful for assessing the validity and reliability of the research findings. 
  • promote inclusion and diversity by acknowledging the different types of contributions made by each author. 
  • ensure that all authors are given credit for their work, and that those who did not contribute significantly are not listed as authors. 

Start your journey

We are ready when you are. Explore some of these resources to get started with confidence and inspire a global audience.

 

Read our how to publish guide Learn more about open access Watch #ChemSciVoices

 

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