Archive for the ‘News’ Category

Putting chemical biology in the spotlight

Spanning a vast field of chemistry and biology, it is hard not to notice the flurry of activity and excitement surrounding chemical biology research at the moment. We are seeing chemistry being cleverly applied to biology, in an attempt to understand and answer important biological questions, by directly probing living systems at the chemical level. Areas such as proteomics, glycobiology, combinatorial chemistry, RNA/DNA, microarrays, proteins, peptides (and many, many more!) are becoming prominent topics in the general chemistry literature.   

Here at Chemical Science, we have two fantastic Associate Editors, who handle all submissions in the chemical biology and bioorganic fields; Professor Thomas Carell (Ludwig-Maximilians-Universtät München, Germany) and Professor Benjamin F Cravatt (Scripps, USA). We also have the full support from our dynamic team of chemical biology experts on the Chemical Science Advisory Board; Ben Davis, Linda Hsieh-Wilson, Scott Miller, Paul Reider, Oliver Seitz, Weihong Tan and Jason Chin. 

  

Chemical Science Associate Editor, Professor Benjamin Cravatt

Why not submit your own exciting chemical biology research to Chemical Science today? Our Associate Editors, Professors Thomas Carell and Benjamin Cravatt, handle all submissions within the chemical biology field and eagerly await your next exciting, high impact submission!    

 

Chemical Science Associate Editor, Professor Thomas Carell

We’ve already published some excellent articles in the field of chemical biology and below we’ve given you a little taster. As a reminder, all articles published in Chemical Science are free to access until the end of 2011, so go ahead and enjoy the free content!

Comparative bioinformatics analysis of the mammalian and bacterial glycomes
Alexander Adibekian, Pierre Stallforth, Marie-Lyn Hecht, Daniel B. Werz, Pascal Gagneux and Peter H. Seeberger
Chem. Sci., 2011, 2, 337-344
The programming role of trans-acting enoyl reductases during the biosynthesis of highly reduced fungal polyketides
Mary N. Heneghan, Ahmed A. Yakasai, Katherine Williams, Khomaizon A. Kadir, Zahida Wasil, Walid Bakeer, Katja M. Fisch, Andrew M. Bailey, Thomas J. Simpson, Russell J. Cox and Colin M. Lazarus
Chem. Sci., 2011, 2, 972-979
Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells
Henning Stöckmann, André A. Neves, Shaun Stairs, Heather Ireland-Zecchini, Kevin M. Brindle and Finian J. Leeper
Chem. Sci., 2011, 2, 932-936
Fragment screening against the thiamine pyrophosphate riboswitch thiM
Elena Cressina, Liuhong Chen, Chris Abell, Finian J. Leeper and Alison G. Smith
Chem. Sci., 2011, 2, 157-165
DNA-programmed spatial screening of carbohydrate–lectin interactions
Christian Scheibe, Alexander Bujotzek, Jens Dernedde, Marcus Weber and Oliver Seitz
Chem. Sci., 2011, 2, 770-775
Dissecting tunicamycin biosynthesis by genome mining: cloning and heterologous expression of a minimal gene cluster
Filip J. Wyszynski, Andrew R. Hesketh, Mervyn J. Bibb and Benjamin G. Davis
Chem. Sci., 2010, 1, 581-589
End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans
Song-Gil Lee, Joshua M. Brown, Claude J. Rogers, John B. Matson, Chithra Krishnamurthy, Manish Rawat and Linda C. Hsieh-Wilson
Chem. Sci., 2010, 1, 322-325
Discovery of an orexin receptor positive potentiator
Jiyong Lee, M. Muralidhar Reddy and Thomas Kodadek
Chem. Sci., 2010, 1, 48-54

 

One last thing, you may also be interested to know that the following ISACS5 conference is coming up soon too:-

ISACS 4 Manchester

Call for posters – deadline 27 May 2011
Early bird
registration – deadline 27 May 2011
Registration – deadline 24 June 2011

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Hardy MOFs endure extreme conditions

The most chemically and thermally stable metal-organic frameworks (MOFs) yet have been made by a team in the US. The MOFs could surpass zeolites as industrial catalysts.

Natural zeolites are porous alumina-silicate rocks used as catalysts in industrial processes. However, their pore sizes and surface functionalisations are difficult to alter, which limits their performance. MOFs – made by joining up metal oxide clusters with linking organic molecules – have similar structures to zeolites and are therefore of interest as alternatives. Until now, they have not been robust enough to withstand the conditions that zeolites undergo during industrial processes. Traditionally, MOFs have only been stable in temperatures up to 500 degrees Celsius, have low chemical stability and some even fall apart in water.

Jeffrey Long from the University of California, Berkeley, and colleagues have made MOFs that can withstand temperatures of 510 degrees Celsius and a pH range of 2 to 14. They made the MOFs by reacting a metal salt, such as nickel chloride or nickel nitrate, with trispyrazolylbenzene. The organic molecules were deprotonated and the functional groups were bound to the metal to create a three-dimensional network.

Scheme of formation of MOFs

Find out more by reading the full news story in Chemistry World and downloading Professor Long’s Chemical Science Edge article.

Also of interest:
Modifying MOFs: new chemistry, new materials
Seth M. Cohen, Chem. Sci., 2010, 1, 32-36

Hydrogen storage and carbon dioxide capture in an iron-based sodalite-type metal–organic framework (Fe-BTT) discovered via high-throughput methods
Kenji Sumida, Satoshi Horike, Steven S. Kaye, Zoey R. Herm, Wendy L. Queen, Craig M. Brown, Fernande Grandjean, Gary J. Long, Anne Dailly and Jeffrey R. Long, Chem. Sci., 2010, 1, 184-191

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Top ten most accessed articles in March

This month sees the following articles in Chemical Science that are in the top ten most accessed:-

A synthesis of strychnine by a longest linear sequence of six steps 
David B. C. Martin and Christopher D. Vanderwal 
Chem. Sci., 2011, 2, 649-651, DOI: 10.1039/C1SC00009H, Edge Article 

Hydroxyl-directed C-H carbonylation enabled by mono-N-protected amino acid ligands: An expedient route to 1-isochromanones 
Yi Lu, Dasheng Leow, Xisheng Wang, Keary M. Engle and Jin-Quan Yu 
Chem. Sci., 2011, 2, 967-971, DOI: 10.1039/C0SC00633E, Edge Article 

Benzoquinone-derived sulfinyl imines as versatile intermediates for alkaloid synthesis: Total synthesis of (-)-3-demethoxyerythratidinone 
Kangway V. Chuang, Raul Navarro and Sarah E. Reisman 
Chem. Sci., 2011, Advance Article, DOI: 10.1039/C1SC00095K, Edge Article 

Transition metal-catalyzed cross coupling with N-acyliminium ions derived from quinolines and isoquinolines 
Thomas J. A. Graham, Jason D. Shields and Abigail G. Doyle 
Chem. Sci., 2011, 2, 980-984, DOI: 10.1039/C1SC00026H, Edge Article 

Asymmetric catalytic reactions by NbO-type chiral metal-organic frameworks 
Kyung Seok Jeong, Yong Bok Go, Sung Min Shin, Suk Joong Lee, Jaheon Kim, Omar M. Yaghi and Nakcheol Jeong 
Chem. Sci., 2011, 2, 877-882, DOI: 10.1039/C0SC00582G, Edge Article 

Catalytic, enantioselective synthesis of stilbene cis-diamines: A concise preparation of (-)-Nutlin-3, a potent p53/MDM2 inhibitor 
Tyler A. Davis and Jeffrey N. Johnston 
Chem. Sci., 2011, Advance Article, DOI: 10.1039/C1SC00061F, Edge Article 

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user’s guide 
David S. Surry and Stephen L. Buchwald 
Chem. Sci., 2011, 2, 27-50, DOI: 10.1039/C0SC00331J, Perspective 

Optimization of distyryl-Bodipy chromophores for efficient panchromatic sensitization in dye sensitized solar cells 
Safacan Kolemen, O. Altan Bozdemir, Yusuf Cakmak, Gokhan Barin, Sule Erten-Ela, Magdalena Marszalek, Jun-Ho Yum, Shaik M. Zakeeruddin, Mohammad K. Nazeeruddin, Michael Grätzel and Engin U. Akkaya 
Chem. Sci., 2011, 2, 949-954, DOI: 10.1039/C0SC00649A, Edge Article 

A quantum-chemical perspective into low optical-gap polymers for highly-efficient organic solar cells 
Chad Risko, Michael D. McGehee and Jean-Luc Brédas 
Chem. Sci., 2011, Advance Article, DOI: 10.1039/C0SC00642D, Perspective 

Cation-induced molecular motion of spring-like [2]catenanes 
Alexandre V. Leontiev, Christopher J. Serpell, Nicholas G. White and Paul D. Beer 
Chem. Sci., 2011, 2, 922-927, DOI: 10.1039/C1SC00034A, Edge Article 

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Chemical Science? Then why not contact us today with your suggestions.

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Register now for ISACS meetings to receive early bird discount

challenges in renewable energy (ISACS 4)

Call for posters – deadline 6 May 2011
Early bird registration – deadline 6 May 2011
 – Registration – deadline 3 June 2011
www.rsc.org/isacs4

ISACS 4 Manchester

Call for posters – deadline 27 May 2011
Early bird registration – deadline 27 May 2011
Registration – deadline 24 June 2011
www.rsc.org/isacs5

 
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Molybdenum sulfide hydrogen evolution catalysts

Amorphous molybdenum sulfide films are highly active hydrogen evolution catalysts, say researchers from Switzerland.

Xile Hu and colleagues made the catalysts from relatively cheap and abundant elements. The catalysts offer significant advantages over noble metal catalysts, they say. The catalysts can be easily prepared in a procedure that is amenable to large scale manufacture, they work in water and are compatible with a wide range of pHs.

‘Our results provide new opportunities for the development of renewable and economic hydrogen production technologies,’ says the team.

Read more for free in Chemical Science or check out the news story on the EPFL website.

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Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis

US scientists have made new pleuromutilin-like compounds that show promise as leads for the development of new antibiotics. Erik Sorensen and colleagues made the compounds in approximately 11 steps from 3-allylcyclopent-2-enone by a strategy featuring sequential carbonyl addition reactions.

They found that the compounds displayed activity against Mycobacterium tuberculosis.

Graphical abstract: Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis

‘As we move forward in our effort to expand the structural and stereochemical diversity of the pleuromutilin class of antibiotics, there is a high likelihood that we will discover additional, new compounds with promising activity against M. tuberculosis and possibly resistant strains of TB as well as other bacteria,’ say the team.

Download the article, which is free to access in Chemical Science.

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Molecular fridge can reach millikelvin

Molecular coolerScientists have laid the foundations for a high-performance ‘molecular fridge’ capable of reaching temperatures within a few thousandths of a degree of absolute zero (0K) with a high degree of efficiency. Such ultracoolers could have applications in areas such as ultra-low temperature physics, where alternative technologies such as those that rely on expensive and rare helium-3 could be unsuitable or too costly.

The system relies on a phenomenon called the magneto-caloric effect, where the removal of a magnetic field from a ferromagnetic material causes a drop in temperature. The key to achieving a high magneto-caloric effect is to have a material with many unpaired electrons, all of whose spin states are aligned.

Euan Brechin from the University of Edinburgh in the UK, Keith Murray from Monash University in Australia and Marco Evangelisti from the University of Zaragoza in Spain and their colleagues designed a molecule based on gadolinium and copper, which can be cooled to a few millikelvin.

Read the rest of the news story on the Chemistry World website and download the group’s Chemical Science Edge article for free.

Think this is cool? Let us know by leaving your comments below.

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Hydrogenation in flow – scalable, economical and safer

Hydrogen is explosive – it’s one of the first things children learn in their chemistry classes.

This is a serious drawback for the catalytic hydrogenation of multiple bonds, one of the most widely used reactions in organic synthesis. But now Steven Ley and colleagues at the University of Cambridge, UK, have improved the safety profile of both homogeneous and heterogeneous catalytic hydrogenations using flow chemistry.

In their Chemical Science Edge article, the group describe their ‘Tube-in-Tube’ reactor/injector and a novel computer-assisted bubble counting technique to measure the levels of hydrogen uptake.

Graphical abstract: Hydrogenation in flow: Homogeneous and heterogeneous catalysis using Teflon AF-2400 to effect gas–liquid contact at elevated pressure

Read the article for free and leave your comments below. If you’d like to be seen with the best, submit to Chemical Science today.

Also of interest:
Ten key issues in modern flow chemistry – a ChemComm Highlight in Chemistry article by Andreas Kirschning and colleagues

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A Sustainable Global Society: How Can Materials Chemistry Help?

A high profile white paper A Sustainable Global Society: How Can Materials Chemistry Help? was launched internationally on 27 March.

The output of the Chemical Sciences and Society Summit (CS3) 2010, which took place in London, September 2010, outlines five key areas in which materials chemists, through collaboration with other scientists, industry and policy makers, can seize exciting opportunities to address global challenges.  This project was driven by the RSC and is a collaboration between the chemical societies of China, Germany, Japan, the US, the UK and national funding bodies.  Around 30 leading materials chemists from the participating nations participated in CS3 2010 and the white paper is a reflection of the outcome of the summit, in particular their view of the future direction for materials chemistry.

View the official website of the white paper.

Read the 27 March press release.

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Top ten most accessed articles in February

This month sees the following articles in Chemical Science that are in the top ten most accessed:-

Why not take a look at the articles today and blog your thoughts and comments below.

A synthesis of strychnine by a longest linear sequence of six steps 
David B. C. Martin and Christopher D. Vanderwal 
Chem. Sci., 2011, 2, 649-651, DOI: 10.1039/C1SC00009H, Edge Article 

Transition metal-catalyzed cross coupling with N-acyliminium ions derived from quinolines and isoquinolines 
Thomas J. A. Graham, Jason D. Shields and Abigail G. Doyle 
Chem. Sci., 2011, Advance Article, DOI: 10.1039/C1SC00026H, Edge Article 

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user’s guide 
David S. Surry and Stephen L. Buchwald 
Chem. Sci., 2011, 2, 27-50, DOI: 10.1039/C0SC00331J, Perspective 

Enantioselective silver-catalyzed propargylation of imines 
Hanna M. Wisniewska and Elizabeth R. Jarvo 
Chem. Sci., 2011, 2, 807-810, DOI: 10.1039/C0SC00613K, Edge Article 

Chemoselective enrichment for natural products discovery 
Antoinette Y. Odendaal, Darci J. Trader and Erin E. Carlson 
Chem. Sci., 2011, 2, 760-764, DOI: 10.1039/C0SC00620C, Edge Article 

Gold(i)-catalyzed intermolecular (4 + 2) cycloaddition of allenamides and acyclic dienes 
Hélio Faustino, Fernando López, Luis Castedo and José L. Mascareñas 
Chem. Sci., 2011, 2, 633-637, DOI: 10.1039/C0SC00630K, Edge Article 

Palladium-catalyzed coupling of functionalized primary and secondary amines with aryl and heteroaryl halides: two ligands suffice in most cases 
Debabrata Maiti, Brett P. Fors, Jaclyn L. Henderson, Yoshinori Nakamura and Stephen L. Buchwald 
Chem. Sci., 2011, 2, 57-68, DOI: 10.1039/C0SC00330A, Edge Article 

Total synthesis of diazonamide A 
Robert R. Knowles, Joseph Carpenter, Simon B. Blakey, Akio Kayano, Ian K. Mangion, Christopher J. Sinz and David W. C. MacMillan 
Chem. Sci., 2011, 2, 308-311, DOI: 10.1039/C0SC00577K, Edge Article 

Coordination chemistry of group 13 monohalides 
Dragoslav Vidovic and Simon Aldridge 
Chem. Sci., 2011, 2, 601-608, DOI: 10.1039/C0SC00508H, Minireview 

Stable singlet carbenes as mimics for transition metal centers 
David Martin, Michele Soleilhavoup and Guy Bertrand 
Chem. Sci., 2011, 2, 389-399, DOI: 10.1039/C0SC00388C, Perspective 

Fancy submitting an article to Chemical Science ? Then why not
submit to us today or alternatively email us your suggestions.

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