Chemical Communications Blog

CASH pictures and poster prize winners

10 Feb 2011

New year, new start and it seems that the Catalysis and sensing for Health (CASH) meeting got the ball rolling. Held last week at the University of Bath, many delegates travelled across the globe to be there. It seems much fun was had by all and below you can see a small glimpse into what went on…

Professors Evans, Maruoka and Ishihara enjoying a coffee break in the CASH meeting	Nothing quite like catching up with friends
ChemComm Editor Robert Eagling grabbing a cuppa with conference organiser Tony James and ex-ChemComm Associate Editor Andy Evans	Sir Professor Fraser Stoddart enjoying the Civic Reception at the Roman Baths

Also, many congratulations to the poster prize winners for the RSC Publishing prizes, who each received an RSC book to help them with their studies:-

‘Anion Receptor Chemistry’ was won by Albert Fahrenbach for his poster.
Suying Xu, who is a student from Professor Yun-Bao Jiang’s group in Xiamen, China won the ‘Calixarenes’ book. She was delighted to win the prize and she said ‘the book is very good, it will help me study…I am very happy.’
‘Boronic acids in Saccharide Recognition’ was won by Shaomin Ji for her poster.

: Poster prize winner Shaomin Ji

Poster prize winner Suying Xu

The general chemistry team (Chemical Science, ChemComm and Chem Soc Rev) will be attending many conferences this year, so why not take a look at our conference plans and see if our paths will cross during 2011? Alternatively, feel free to contact us for information or help with any other questions or queries.

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Paper spray ionisation of polar analytes using non-polar solvents

07 Feb 2011

By Will Dennis, Publishing Editor.

US analytical scientists have used non-polar solvents for the paper spray ionisation of polar compounds.

Polar compounds are normally ionised in mass spectrometry using a desorption ionisation method, such as MALDI, or from solution in a polar solvent using electrospray ionisation (ESI). However, ESI does not usually tolerate non-polar solvents and, as many reactions or purifications of compounds occur in non-polar solvents, this can present some difficulties.

Graham Cooks and co-workers from Purdue University have extended the scope of the recently developed paper spray ionisation technique to allow the use of non-polar solvents. When a low voltage is exposed to a triangle of paper wetted with a solvent such as hexane or toluene, droplets of that solvent are produced. Polar compounds that are deposited on the paper are transported by the non-polar solvent compounds despite being sparingly soluble in them.

This technique can be applied to biological compounds, such as nucleotides, phospholipids and peptides, and avoids a typical problem associated with ESI where there capillary may clog when a non-ideal solvent is used. Furthermore, compounds may be analysed simply by ionising spots separated via TLC.

If you want to find out more then download the ChemComm article today. For wider look at analytical chemistry, why not check out these papers in our sister journal Chemical Science?

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Hot article round up for January

07 Feb 2011

By Emma Shiells, Development Editor.

January can seem like an extra long month for many, with post-holiday blues and dark wintery evenings to contend with. However, the winter solstice has past, so the evenings are gradually getting lighter and here at the ChemComm Editorial Office we have published enough hot articles to keep the blues at bay. So why not take a look at the selection of hot articles below, which caught some of our referees attention…

Clostridium botulinum produces the most lethal toxins known to man and, as such, they are high-risk terrorist threats. Alarmingly, there is no approved therapeutic. Why not read Kim Janda‘s communication to find out about a small molecule he’s discovered that inhibits the neurotoxin.

Matthias Beller and Anahit Pews-Davtyan synthesised a variety of substituted imidazoles from commercially available starting materials, via a hydroamination–cyclization sequence. Take a look at the communication to see the excellent yields obtained, helped by the presence of catalytic zinc triflate.

Enhanced white-light emission was achieved by cleverly loading green- and red-light-emitting donor–acceptor pairs in the separate micellar cores, and inserting blue-light-emitting polymers around their periphery. To find out more on how this system works, take a look at Juan Peng‘s communication.

Juyoung Yoon and her colleagues from Ewha Womans University, have developed a unique pyrene-based colourimetric sensor that changes colour, from light yellow to pink, in the presence of lysine. More details can be found in the communication.

An observation reported by Gerhard Erker in ChemComm has opened up a new way of utilising frustrated Lewis pair chemistry. To see what has been uncovered in more detail, download their communication today!

Andreas Herrmann and co-workers have made ultra-high molecular weight DNA/polymer hybrid materials using molecular biology techniques. Take a look at the communication and read more about this fascinating advance.

Molly Stevens and her colleagues have shown that peptide-modified gold nanoparticles can be enzymatically phosphorylated and rapidly aggregated onto a surface or in solution by action of phosphospecific antibodies. The simple and rapid colorimetric response of the assays makes them an attractive approach for drug-screening applications – so why not download the communication to find out more about this exciting research?

QM/MM mechanistic modelling has been used to help understand the role of carbamate reactivity in fatty acid amide hydrolase inhibition, as reported in Adrian Mulholland‘s latest communication in ChemComm.

Paul O’Brien reports slow temperature growth of crystalline PbS films on plastic substrates by Chemical Vapour Deposition using xanthate. Why not read the communication for further details on the method, as well as looking at the mechanism proposed by the team, with the help of density functional theory calculations.

Jeremy Sanders and Ulrich Lüning present the efficient synthesis of a new type of a multi-hydrazone based macrocyclic receptor and investigates its complexation properties with alkali and alkaline earth metal ions using a dynamic combinatorial approach. Read more by downloading the communication today!

All communications have been made freely available until the 7th March 2011, so why not download the ones that interest you today and let us know what you think in our blog below.

If you have some of your own exciting, high impact research to publish then consider submitting your communication to ChemComm, via our online submission system.

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Negishi cross-coupling using a bulky Pd-NHC catalyst

07 Feb 2011

By Andrea McGhee.

The hugely important field of transition metal catalysed C–C cross-coupling has come a long way over the years, but efficient coupling between Csp² and secondary Csp³ centres remains a challenge. To achieve just that, Michael Organ and his colleague Selcuk Calimsiz (York University, Toronto) have developed and used a bulky Pd-NHC (N-heterocyclic carbene) catalyst called Pd-PEPPSI-IPent.

In the reactions of secondary alkylzincs with a variety aryl or heteroaryl halides, this catalyst provided excellent regioselectivity for the branched product over the isomerised unbranched product, far outperforming the less bulky Pd-PEPPSI-IPr analogue.

To see the impressive scope of the reaction download the ChemComm communication for free up until 7th March 2011 and leave your comments below.

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MOF magnets deliver drugs

07 Feb 2011

By Emma Shiells, Development Editor.

German scientists have encapsulated nanomagnets inside metal organic frameworks (MOFs). The MOF magnets can be filled with a drug, which is released when a magnetic field is applied.

Stefan Kaskel from the Technical University of Dresden and colleagues made the MOF magnets by integrating superparamagnetic iron oxide particles into carboxylate MOFs. ‘Carboxylate molecules stabilise and activate the nanoparticles,’ explains team member Martin Lohe.

The group then loaded their MOF with ibuprofen and found that they were able to trigger and control its release by simply applying an external magnetic field. The magnetic field heats the magnets in the MOF, which causes the load to burst from the framework.

Superparamagnetic functionalisation of MOFs enables magnetic heating to trigger drug delivery

MOFs in which the frameworks themselves are magnetic have been made before, but they are not easy to manipulate. Kaskel’s embedded MOF magnets, however, can easily be manipulated from the outside. Magnetic fields can penetrate human skin, and magnetic triggers that could be used to release the drugs are already available on the market. However, before the MOF magnets can be used in the human body, toxicity tests will need to be done.

‘An enhanced sustainability of industrial and medical processes is crucial for our future,’ says Lohe. ‘Magnetically functionalised MOFs could be a small building block on this path.’

‘The particles will certainly increase the possibility of using nanoMOFs for drug delivery applications in the near future,’ agrees Christian Serre, an expert in porous solids from the University of Versailles in France, ‘and they’ll add a new tool to the emerging domain of MOFs in biomedicine.’

Ruth Doherty

Link to ChemComm article

Heating and separation using nanomagnet-functionalized metal–organic frameworks
Martin R. Lohe, Kristina Gedrich, Thomas Freudenberg, Emanuel Kockrick, Til Dellmann and Stefan Kaskel,

Chem. Commun., 2011, DOI: 10.1039/c0cc05278g

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Palladium impurites are not essential for gold catalysis

02 Feb 2011

By Joanne Thomson.

Spanish scientists have proved that gold alone can catalyse cross-coupling reactions, following a claim made last year that palladium impurities in the gold are essential for the catalysis.

Avelino Corma from the Polytechnic University of Valencia and colleagues used kinetic and theoretical studies to prove that gold can catalyse the Sonogashira coupling reaction between phenylacetylene and iodobenzene. ‘Gold nanoparticles are active enough to promote the reaction, regardless of the presence or absence of palladium,’ says Corma.

Graphical abstract: Gold catalyzes the Sonogashira coupling reaction without the requirement of palladium impurities

Read the full news story in Chemistry World and download Corma’s ChemComm communication

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Novel chemical tag illuminates protein cholesterylation in cells

28 Jan 2011

By Will Dennis, Publishing Editor.

UK chemists have for the first time used a chemical probe to study the post- translational cholesterylation of proteins in living cells.

Post-translational modification (PTM) in cells plays an important role in the function of proteins in vivo. One example is the mammalian Hedgehog (Hh) protein family: the post-translational cholesterylation of Sonic hedgehog (shh) protein regulates its secretion. However, mis-regulation of this protein can promote different types of cancers. Therefore a simple way of studying this type of modification is important.

Graphical abstract: Bioorthogonal chemical tagging of protein cholesterylation in living cells

Edward Tate and colleagues at Imperial College, London have done just this. They first modified cholesterol molecules to bear an azide group and then gave this to their target cells, where it was used in PTM. They next managed to attach, via ‘click’ chemistry, a dye molecule called TAMRA to the modified proteins that carried the synthetic cholesterol. The team used this dye for ‘fluorescence visualisation’ of the target protein.

When compared to traditional techniques for studying cholesterylated proteins, this new method stacks up well. It makes significant savings in both time and expense, as well as avoiding the use of potentially harmful radiation. Furthermore, Tate suspects that in the future an optimised version of this process might be used to search for new cholesterylated proteins.

Want to find out more? Then download the ChemComm article for free today. You can also check out coverage of this article in C&EN.

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Proof-of-principle concept for label-free detection of glucose and alpha-glucosidase activity

28 Jan 2011

By Andrea McGhee.

Research offers hope of better diagnosis and treatment for Pompe disease patients

Glycogen storage disease type II (GSD II), also known as Pompe disease, is a genetic disorder that results in muscle and nerve cell damage caused by deficiency of the lysosomal acid a-glucosidase enzyme. In an effort to achieve a better technique for screening enzyme activity in patients suffering from Pompe disease, Prof. Vivian Yam and colleagues at the Institute of Molecular Functional Materials, University of Hong Kong, have synthesised a two-component platinum (II) complex-polymer ensemble for glucose sensing and a-glucosidase assay.

The system works by strongly binding glucose, resulting in a 46-fold increase in the low energy emission band (800 nm) of the electronic emission spectrum. Additionally, in the presence of a-glucosidase and maltose (which is broken down to glucose by a-glucosidase), the intensity of the 800 nm emission band was found to increase with time. These results provide a “proof-of-principle” concept for label-free detection of glucose and open the way for rapid and sensitive detection of a-glucosidase.

To find out more download the ChemComm communication for free until 25th February 2011.

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Cram Lehn Pedersen Prize – winner announced

26 Jan 2011

By Joanne Thomson.

Congratulations to Professor Amar Flood (Indiana University) who is the winner of the Cram Lehn Pedersen prize 2011.

The prize, sponsored by ChemComm and named in honour of the winners of the 1987 Nobel Prize in Chemistry, recognises significant, original and independent work in supramolecular chemistry by emerging investigators.

The prize is awarded to Professor Flood for his pioneering work in macrocyclic and supramolecular chemistry and, in particular, for his development of receptors that employ pure CH hydrogen bonding to bind anionic guest species.

Professor Flood will receive £2,000 and will present his award lecture at the 6th International Symposium on Macrocyclic and Supramolecular Chemistry (6-ISMSC) in Brighton in July. ChemComm Editor Robert Eagling and Deputy Editor Joanne Thomson will be at the symposium – let us know if you’ll be there too.

Prof Phil Gale, Chair of the Scientific Committee for 6-ISMSC said: “I’m really delighted that Amar has been selected by the International Committee to be the first recipient of the Cram Lehn Pedersen Prize. I’m already looking forward to hearing his latest results in Brighton in July.”

Nominations for the 2012 award, which will be presented at 7-ISMSC in New Zealand, will open shortly. Email us to register your interest.

Find out more about Professor Flood’s research by reading his Chem Soc Rev tutorial review:

Click chemistry generates privileged CH hydrogen-bonding triazoles: the latest addition to anion supramolecular chemistry, Yuran Hua and Amar H. Flood, Chem. Soc. Rev., 2010, 39, 1262-1271
(This review is part of the themed issue Click chemistry: Function follows form)

Also of interest:
A tristable [2]pseudo[2]rotaxane, Ali Trabolsi, Albert C. Fahrenbach, Sanjeev K. Dey, Andrew I. Share, Douglas C. Friedman, Subhadeep Basu, Travis B. Gasa, Niveen M. Khashab, Sourav Saha, Ivan Aprahamian, Hussam A. Khatib, Amar H. Flood and J. Fraser Stoddart, Chem. Commun., 2010, 46, 871-873

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Chemical Communications Blog

CASH pictures and poster prize winners

Paper spray ionisation of polar analytes using non-polar solvents

Hot article round up for January

Negishi cross-coupling using a bulky Pd-NHC catalyst

MOF magnets deliver drugs

Palladium impurites are not essential for gold catalysis

Novel chemical tag illuminates protein cholesterylation in cells

Proof-of-principle concept for label-free detection of glucose and alpha-glucosidase activity

Cram Lehn Pedersen Prize – winner announced

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