HOT ChemComm articles for April

Here are this month’s referee-recommended HOT ChemComm articles– and we’ve made them FREE to access for 4 weeks!

Cleavable trifunctional biotin reagents for protein labelling, capture and release
Yinliang Yang and Steven H.L. Verhelst
Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC42076K

Free to access until 26th May 2013


PCR based magnetic assembled sensor for ultrasensitive DNA detection
Chuanlai Xu
Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC41674G

Free to access until 26th May 2013


ATRP synthesis of poly(2-(methacryloyloxy)ethyl choline phosphate): A multivalent universal biomembrane adhesive
Xifei Yu, Xiaoqiang Yang, Sonja Horte, Jayachandran N. Kizhakkedathu and Donald Brooks
Chem. Commun., 2013, Accepted Manuscript
DOI: 10.1039/C3CC41895B

Free to access until 26th May 2013

Click here for more free HOT ChemComm articles for April!

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‘Breathprint’ analysis as a real-time, non-invasive diagnostic tool

Your breath can reveal more about your body than you know.

Scientists, led by Renato Zenobi of the Swiss Federal Institute of Technology (ETH) in Zurich, have been investigating metabolites in exhaled breath, showing that each person’s breath holds a unique, characteristic molecular ‘breathprint,’ as recently featured on the BBC website.  This means that high-precision chemical analysis of a patient’s breath can potentially provide an instant, pain-free and non-invasive medical diagnosis, and may even provide an early warning for healthy persons at risk for certain diseases.  In the future, it may also be used to calculate safe dosages of anaesthesia tailored to each patient’s metabolism and tolerance, or as a fast and convenient doping check for athletes.

Using mass spectrometry, Zenobi and his team regularly measured and analysed the exhaled breath of eleven volunteers for eleven days, finding that each individual’s metabolic ‘breathprint’ showed a unique core pattern and remained stable enough to be useful for medical purposes.  Their mass spectra of exhaled breath have shown peaks or signals representing around a hundred compounds, most of which they are just beginning to identify and assign.

Their findings represent a significant step towards ‘personalised medicine,’ and show great potential for other applications, such as in forensics or metabolomics.

Zenobi and his co-workers first published their early work in chemical breath analysis in a 2011 ChemComm article, in which they used their novel method to identify valproic acid, a medication for epilepsy, in exhaled breath.

C1CC10343A

Read the ChemComm article where it all began!

Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath
Gerardo Gamez, Liang Zhu, Andreas Disko, Huanwen Chen, Vladimir Azov, Konstantin Chingin, Günter Krämer and Renato Zenobi
Chem. Commun., 2011, 47, 4884-4886
DOI: 10.1039/C1CC10343A

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ChemComm HOT articles for early 2013

In case you missed these, check out some of our referee-recommended HOT ChemComm articles for the first quarter of 2013.

Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo
Daniel J. Coles, Barbara E. Rolfe, Nathan R. B. Boase, Rakesh N. Veedu and Kristofer J. Thurecht
Chem. Commun., 2013, Advance Article
DOI: 10.1039/C3CC00127J

C3CC00127J


Shape assisted fabrication of fluorescent cages of squarate based metal–organic coordination frameworks
Kolleboyina Jayaramulu, Katla Sai Krishna, Subi J. George, Muthuswamy Eswaramoorthy and Tapas Kumar Maji
Chem. Commun., 2013, Advance Article
DOI: 10.1039/C3CC39190F

C3CC39190F

Click to read more HOT articles!

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Gold nanoparticles reveal fingerprints

Gold nanoparticles capped with mercaptocarboxylic acids, followed by silver precipitation, have been used to develop latent fingerprints on paper as high quality negative images. Scientists writing in the journal ChemComm say that the effect stems from hydrogen bonding between the carboxylic group and the paper cellulose.

Recovering fingerprints from paper is a common task for forensic scientists, but often the developed marks are faint. A common approach, therefore, is to use a developing agent that sticks to the clean paper substrate, rather than the fingerprint itself, yielding a reversed image.

The technique described in this study is much less affected by sweat composition, and could improve the yield of latent fingerprints.

Read the ‘HOT’ ChemComm article today for free:

A novel approach to fingerprint visualization on paper using nanotechnology: reversing the appearance by tailoring the gold nanoparticles’ capping ligands
Sanaa Shenawi , Nimer Jaber , Joseph Almog and Daniel Mandler
Chem. Commun., 2013, DOI: 10.1039/C3CC41610K

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Tomoki Ogoshi wins Cram Lehn Pedersen Prize 2013

Congratulations to Professor Tomoki Ogoshi (Kanazawa University, Japan), the winner of the 2013 Cram Lehn Pedersen Prize.

The annual prize, sponsored by ChemComm and named in honour of the winners of the 1987 Nobel Prize in Chemistry, recognises significant, original and independent work by emerging investigators in supramolecular chemistry.

This year the prize is awarded to Professor Ogoshi for his pioneering work in macrocyclic and supramolecular chemistry and, in particular, for his groundbreaking research on pillar[5]arenes, a new class of macrocyclic compounds.  “I’m really honoured to receive the 2013 Cram Lehn Pedersen Prize,” says Professor Ogoshi.  “Cram, Lehn and Pedersen were great pioneers in the synthesis of macrocyclic hosts, and thus receiving this prize is also a great honour for pillararene chemistry.  I hope this will someday place pillararenes alongside other well-known macrocyclic hosts.”

Professor Ogoshi will receive £2,000 and will present his award lecture at the 8th International Symposium on Macrocyclic and Supramolecular Chemistry (8-ISMSC) in Crystal City, Virginia, USA from 7-11 July 2013.  He will also speak at other events during the year– keep an eye on this blog for more details.

“With the introduction of a new class of macrocycles, the pillararenes, Professor Ogoshi has started another area of host-guest molecules,” says Professor Roger Harrison, Associate Professor at Brigham Young University and Secretary of the ISMSC International Scientific Committee.  He adds, “The over 90 publications on these molecules since they were introduced in 2008, show the fascination and possibilities these molecules afford.  Professor Ogoshi’s introduction of these new molecules, along with his insights, creativity, and persistence make him one of the most exciting and up-and-coming supramolecular chemists to follow.  I congratulate Prof. Ogoshi on receiving this award and look forward to seeing more of his discoveries.”

Pillar[5]arene structure

Pillararene structure

“Ogoshi has created a new class of easy-to-make macrocycles, pillar[5]arenes, with a novel cross section of properties,” says Professor Amar Flood (Indiana University), a member of the ISMSC International Committee and 2011 Cram Lehn Pedersen Prize winner.  “Ogoshi has highlighted the properties and features of pillararenes in a series of papers and we are now seeing many others in the field of supramolecular chemistry moving forwards with these compounds in their own research endeavors.”

Last year’s prize was awarded to Dr Jonathan Nitschke (University of Cambridge).

Early bird registration for 8-ISMSC closes on 15 April 2013, so do hurry and register online.  You can listen to Professor Ogoshi’s lecture, get to meet a mix of established and younger researchers in supramolecular and macrocyclic chemistry, and you may even submit an abstract to present a short talk or a poster to showcase your work.  ChemComm‘s own brilliant and dynamic Deputy Editor Jane Hordern will be at the symposium – let us know if you’ll be there, too.

Find out more about Professor Ogoshi’s innovative research by reading his recent articles in Chemical Science and in ChemComm:

Supramolecular polymers with alternating pillar[5]arene and pillar[6]arene units from a highly selective multiple host–guest complexation system and monofunctionalized pillar[6]arene
Tomoki Ogoshi, Hitoshi Kayama, Daiki Yamafuji, Takamichi Aoki and Tada-aki Yamagishi
Chem. Sci., 2012, 3, 3221-3226

Thermally responsive shuttling behavior of a pillar[6]arene-based [2]rotaxane
Tomoki Ogoshi, Daiki Yamafuji, Takamichi Aoki and Tada-aki Yamagishi
Chem. Commun., 2012, 48, 6842-6844

Ionic liquid pillar[5]arene: its ionic conductivity and solvent-free complexation with a guest
Tomoki Ogoshi, Naosuke Ueshima, Tada-aki Yamagishi, Yoshiyuki Toyota and Noriyoshi Matsumi
Chem. Commun., 2012, 48, 3536-3538

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Porous organic polymers filter toxins from the air

In a search for the next generation of filtration materials, for use in devices such as gas masks, a group of US scientists has synthesised a series of porous organic polymers (POPs) bearing metal-catecholate groups. By changing the molecular building blocks the researchers were able to tailor the materials to hydrogen bond to, and consequently remove, different toxins, such as ammonia.

POPs are very similar in nature to metal-organic frameworks (MOFs) but do not suffer from such instability, particularly towards water, making them ideal for use as filters in real-word environments.

Read this ‘HOT’ Communication now:

Removal of airborne toxic chemicals by porous organic polymers containing metal–catecholates
Mitchell H. Weston , Gregory W. Peterson , Matthew A. Browe , Paulette Jones , Omar K. Farha , Joseph T. Hupp and SonBinh T. Nguyen
Chem. Commun., 2013,49, 2995-2997

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Making Bispirin: A new drug to fight both indigestion and pain

Until now, drugs which fight gastrointestinal infections and those which treat acute inflammation have been found to interfere with each other.  For instance, people infected with the Helicobacter pylori bacterium have needed to deal with the additional risk of gastrointestinal bleeding associated with the use of aspirin and other inflammatory drugs.

Australian research chemists, led by Philip C. Andrews of Monash University, have designed a new drug which treats gastrointestinal infections and acute inflammation at the same time.  They have successfully synthesized bispirin, a bismuth acetylsalicylate complex which combines the effectiveness of bismuth carboxylate compounds as anti-infection agents with that of acetyl­salicylic acid (aspirin) as an anti-inflammatory drug.  Their initial tests have shown that bispirin’s antibacterial effects are comparable or better than those of current bismuth drugs, and investigations of bispirin’s anti-inflammatory activity are currently in progress.

Making Bispirin_graphical abstract

This journal article has also been recently featured on C&ENread it here.

Read this ‘HOT’ ChemComm article in full:

Philip C. Andrews, Victoria L. Blair, Richard L. Ferrero, Peter C. Junk and Ish Kumar
Chem. Commun., 2013, 49, 2870-2872
DOI: 10.1039/C3CC40645H

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Ready to order? Yes, I’ll have the extra cold superconducting penne, please…

Written by guest web-writer Kevin Murnaghan.

In this highly original work, researchers from the Complex Functional Materials Group at the University of Bristol and the Superconductivity and Magnetism Group at the University of Warwick have used off-the-shelf, supermarket pasta as a sacrificial template for the production of a variety of superconducting wires, tubes and spirals.  They have even made a superconducting ‘jolly roger’ skull and crossbones.

Here’s how: The pasta was pre-washed to remove impurities and then rehydrated in a solution containing a mixture of nitrates of yttrium, barium and copper. A slight excess of barium nitrate was used to make sure the desired superconducting material YBa2Cu2O7-x phase (Y123) was attained. Via a calcination process the superconducting pasta shapes were produced, removing the organic material of the sacrificial template and neatly retaining the macroscopic shape of the template.

C3CC38271K_graphical abstract

‘Chemical black pepper and parmesan’ were provided by the use of silver nitrate in the process, which boosts electrical and structural properties. Without using this salt, structures formed are brittle, but with it, compressive strength of the shapes doubled in strength from 0.76 to 1.56 MPa.  This helped counteract the effect of porosity formed from the outgassing of the sacrificial pasta during the calcination process.

Interestingly, the pasta had its own influence on the properties of the material.  Starch-mediated reduction of Ag(I) to Ag(0) is the reason for the dark colour of the materials formed, and trace transition metals in the foodstuff were found to have an effect on electrical and superconducting properties.

Critical temperatures, Tc and current densities, Jc, in early samples were found to be low, relative to typical Y123 type superconductors when silver was not included in the synthesis, and were markedly improved when it was.  Further improvements to the superconductivity of the spaghetti-based replicas were achieved via sintering and annealing.  This work represents a highly cost-effective route to a range of superconducting materials with macroscopic architectures, compared with current state of the art processes such as CVD or PLD.  Future work will focus, in part, on further densification of the product, and purity of the sacrificial template.  Further fascinating information is provided in the electronic supplementary information.  Buon appetito!

C3CC38271K_coverRead this ChemComm cover article today:

Designed 3D architectures of high-temperature superconductors

David C. Green, Martin R. Lees and Simon R. Hall
Chem. Commun., 2013,49, 2974-2976
DOI: 10.1039/C3CC38271K

Kevin Murnaghan is a guest web-writer for Chemical Communications. He is currently a Research Chemist in the Adhesive Technologies Business Sector of Henkel AG & Co. KGaA, based in Düsseldorf, Germany. His research interests focus primarily on enabling chemistries and technologies for next generation adhesives and surface treatments. Any views expressed here are his personal ones and not those of Henkel AG & Co. KGaA.

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11th International Conference on Materials Chemistry (MC11)– Registration now open!

We are delighted to announce that registration for the 11th International Conference on Materials Chemistry (MC11) is now open.

Why take part in this conference?

In the 20th year of this international Materials Chemistry conference series, this meeting will bring together researchers from across this exciting field to discuss four key areas of application of materials chemistry:

  • Energy Materials – including all aspects of Materials Chemistry related to energy generation, conversion and storage.
  • Environmental Materials – the design, synthesis and applications of materials that facilitate processes to provide a sustainable environment.
  • Biomaterials – materials for tissue engineering and healthcare, green biomaterials and advanced synthesis methods of biomaterials.
  • Electronic, Magnetic and Optical Materials – encompassing inorganic, organic, hybrid and nano materials, soft matter and interfaces.

Registering early guarantees you an early bird discount of £50 – so register now!  And you can showcase your own work by presenting a poster.

MC11 will appeal to academic and industrial scientists working on the chemistry, physics and materials science of functional materials.  Come and hear the best in the field and take advantage of many opportunities for discussion with other researchers in materials chemistry.

For more information visit: http://rsc.li/mc11

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If you like it, then you should put two rings on it

Microring resonators are pretty amazing things, offering label-free biosensing by coupling with light and then circulating the photons inside the cavity of the ring, enhancing the interaction between the light and the analytes.

However, I like to think of traditional microring resonators as tents: difficult to construct. They require a submicrometer gap between the input waveguide and the resonator ring structure to allow the coupling of light and before you can even get to that stage, you need to make the microring resonator, which requires a series of complex fabrication steps (FIG 1a).  In this Communication, which is part of ChemComm‘s Microfluidics themed web collection, Professor Jonathan Cooper and his colleagues at Glasgow University and at the International Islamic University Malaysia’s CTS Department have made (what I think of as) the double pop-up tent equivalent– or as they call it, the dual disk resonator (DDR). Made from SU8, an epoxy-based polymer used in microfluidics chips, it can be patterned in a single lithographic step. Not only that, but the DDR uses a gapless design and two rings, increasing the sensitivity of the device (FIG 1b).

FIG 1: The hard way or the easy way (a) the traditional microring resonator with submicrometer gap (b) gapless dual disk resonator

Once they had constructed the DDR, the team characterised the optical sensitivity of the device using sucrose solutions to vary the refractive index of the sample above the waveguide. They then went on to show that the sensor could be used to evaluate the dynamics of antibody interactions on surfaces, exploring avidin-biotin-based immobilisations; sharp resonance shifts confirmed the assembly and disassembly of constructs.

The simpler fabrication shows great promise, as the authors suggest that the sensitivity of the device could be greatly improved by coupling more disks to it– in which case Beyoncé might soon be singing ‘if you like it, then you should put a chain on it.’

Read this ‘HOT’ ChemComm article today:

Polymer dual ring resonators for label-free optical biosensing using microfluidics

Muhammad H. M. Salleh, Andrew Glidle, Marc Sorel, Julien Reboud and Jonathan M. Cooper

Chem. Commun., 2013, Advance Article

DOI: 10.1039/C3CC38228A

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