Archive for the ‘News’ Category

The 5th ChemComm International Symposium gets underway….

The 5th International ChemComm Symposium got off to an excellent start in Kyoto, Japan, on Monday (16th May) under the Chairmanship of ChemComm Editorial Board member and distinguished Professor Keiji Maruoka (Kyoto University).

World leading authorities from the USA, UK, the Netherlands, China and Japan arrived on Sunday in time to be treated to a ten course western-style dinner. The dinner was a perfect start to proceedings but even the ten courses could not over-shadow the science that was to follow.

With an audience in excess of 100, I opened the symposium and thanked the local organisers, speakers and poster presenters. Special thanks were also given to Professor Maruoka for all his support in organising the event. As the first session Chair, Professor Maruoka then got things underway.

Professor Tsutomu Katsuki (Kyushu University) was up first, speaking initially about oxidation chemistry using ruthenium but then moving, like nature, to iron, for example. He was followed by Professor Kuiling Ding (Shanghai Institute of Organic Chemistry) who gave a talk of two halves, covering his group’s ongoing efforts to overcome the challenging issues in both homogenous and heterogeneous asymmetric catalysis.

A quick stop for refreshments was followed by Professor Véronique Gouverneur (University of Oxford) who spoke about her ongoing efforts to develop transition metal-catalysed reactions to generate C–F bonds. Not easy, but made even more challenging by the fact that the methods need to be incredibly quick so they can be used to incorporate hot [18F], which has a very short half-life. Such [18F] labelled compounds are used in positron emission tomography.

Ben Feringa discussed a posterOver lunch, the seven speakers interacted with the 35 poster presenters, putting them through their paces, with the five lucky winners scheduled to be announced at the end of the day.

The pace of the event did not slow after lunch. Professor Viresh Rawal (University of Chicago) wowed a packed auditorium with some of his latest results using H-bonded systems for asymmetric catalysis. Before the break, Professor Zhengfeng Xi (Peking University) spoke about the synthesis, unique reactivity, cooperative effect and applications of organo-di-lithio reagents.

The symposium was closed first by Professor Atsuhiro Osuka (Kyoto University), who spoke about some of his beautiful results in the area of Möbius porphrin chemistry, and then by Professor Ben Feringa (University of Groningen). Professor Feringa gave a wonderful overview of some of the ongoing research in his lab exploring chiral space in asymmetric catalysis. Some highlights included the latest examples of C–H and C–C bond formation using monodentate phosphoramidite ligands and also new results in the field of asymmetric catalysis using DNA with his colleague Professor Gerard Roelfes. The later certainly generated a number of interesting questions about the length and sequence requirements of the DNA involved in the reactions.

symposium speakers, poster prize winners and chairmanAfter the formal poster prize presentations, the speakers and organising committee were treated to a traditional Japanese meal. Before dinner, the historic nature of the Japanese tea ceremony was explained in detail and served to the group by a Maiko (a young training Geiko). Through dinner, the speakers were also treated to some traditional Japanese singing and dancing performed by the Maiko. The music and dance showcased the four seasons of Kyoto.

The dinner finished with the speakers retiring to bed in preparation for their early flight first to Beijing and then Lanzhou, the next venue for the second of three ChemComm symposia.

Robert Eagling

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Call for communications: Artificial Photosynthesis

We are delighted to announce a forthcoming web themed issue:

Artificial Photosynthesis

Guest editor: Andrew Benniston (Newcastle University)

Submission deadline: 15th August 2011 EXTENDED TO 30TH SEPTEMBER!!

We are now welcoming submissions for this web theme, which will be a celebration of current achievements and future perspectives in this exciting field of research. Communications covering all aspects of the following areas are encouraged:

  • new materials and photocatalysts for solar photochemistry
  • hydrogen production and water splitting
  • nitrogen and carbon dioxide functionalisation
  • light harvesting and energy transfer
  • electron transfer (tunnelling vs hopping)
  • coupled proton/electron transfer
  • long-range electron transport
  • multi-electron redox processes
  • bioinspired molecular systems
  • nanostructures for solar energy usage

All manuscripts will undergo strict peer review and should be very important and conceptually significant in accord with the ChemComm mandate.

Publication of the peer-reviewed articles will occur without delay to ensure the timely dissemination of the work. The articles will then be assembled on the ChemComm website as a web-based thematic issue, to permit readers to consult and download individual contributions from the entire series.

Communications for this web theme can be submitted anytime from now until 30th September using our web submission system. Please add the phrase ‘artifical photosynthesis’ in the comments to the editor field.

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Anticancer drug found to cause zinc deficiency

Cisplatin is responsible for abnormally low zinc levels in patients undergoing chemotherapy, say scientists in China and the UK.

Platinum-based compounds, like cisplatin, are the most widely used anticancer drugs in medicine. Research shows that up to 98 per cent of cisplatin binds to blood plasma proteins, particularly albumin. Until now, little has been known about the specific binding sites for platinum on albumin. ‘Since albumin plays a major role in cisplatin metabolism, a better understanding of its interactions with albumin should lead to more effective use of the drug and avoidance or control of side effects,’ says Peter Sadler from the University of Warwick, in the UK.

Cisplatin (structure in the middle) reacts with recombinant human albumin (rHA) (blue and green structures) to create a cisplatin-rHA adduct, which displaces zinc, causing a deficiency

Together with Fuyi Wang’s team from the Chinese Academy of Sciences in Beijing, Sadler used mass spectroscopy techniques to reveal that cisplatin reacts with recombinant human albumin (rHA) to create a cisplatin-rHA adduct. The platinum occupies zinc binding sites on the albumin, displacing the zinc, which causes hypozincemia (lack of zinc for metabolic processes) and hyperzincuria (increased zinc in urine). 

 

 Would you like to know more? Then read the full story on the Chemistry World website and download the ChemComm communication.

 

 

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Titanate cigarette filter

Cigarette in a handChinese researchers have shown for the first time that nanomaterials made from titanium dioxide (TiO2) can be used in cigarette filters to significantly reduce the amount of harmful chemicals inhaled by smokers. They say it offers a cheaper and safer alternative than using carbon-based nanomaterials and show potential for use in other filtering devices including gas masks and air purification systems. 

Current cigarette filters are made from cellulose acetate, which absorbs some of the toxic and carcinogenic compounds present in tobacco smoke, including tar, nicotine, polycyclic aromatic hydrocarbons and tobacco-specific nitrosamines. In recent years, scientists have attempted to improve standard filters by adding nanomaterials, including carbon nanotubes or mesoporous silica, to capture more of these chemicals. But these experimental methods remain expensive and could pose unknown health risks. 

Now, Mingdeng Wei’s lab at Fuzhou University in Fujian province, together with colleagues at the Fujian Tobacco Industrial Corporation, Xiamen, have found that titanate nanosheets and nanotubes can filter tobacco smoke. ‘A great range of harmful compounds including tar, nicotine, ammonia, hydrogen cyanide, selected carbonyls and phenolic compounds can be reduced efficiently,’ says Wei. 
Intrigued? Read the full news story in Chemistry World and download the ChemComm communication.
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ChemComm Emerging Investigator Lectureship – winner announced

On behalf of the ChemComm Editorial Board, I am delighted to announce that Dr Scott Dalgarno (Heriot Watt University, Edinburgh, UK) has won the inaugural ChemComm Emerging Investigator Lectureship.

This annual award recognises an emerging scientist in the early stages of their independent academic career. The Editorial Board commended Dr Dalgarno’s contributions to the field of supramolecular chemistry, in particular the assembly and properties of calixarenes.  

Dr Dalgarno will present his award lecture, entitled ‘Metal-Organic Calixarene Assemblies’, at the following locations:

For more details about these lectures, please contact ChemComm Editor, Robert Eagling.

To find out more about Dr Dalgarno’s research, read these recent ChemComm articles:
Calix[4]arene supported clusters: a dimer of [MnIIIMnII] dimers
Stephanie M. Taylor, Ruaraidh D. McIntosh, Christine M. Beavers, Simon J. Teat, Stergios Piligkos, Scott J. Dalgarno and Euan K. Brechin, Chem. Commun., 2011, 47, 1440-1442

Calixarene supported enneanuclear Cu(II) clusters
Georgios Karotsis, Stuart Kennedy, Scott J. Dalgarno and Euan K. Brechin, Chem. Commun., 2010, 46, 3884-3886

Magnetism in metal–organic capsules
Jerry L. Atwood, Euan K. Brechin, Scott J. Dalgarno, Ross Inglis, Leigh F. Jones, Andrew Mossine, Martin J. Paterson, Nicholas P. Power and Simon J. Teat, Chem. Commun., 2010, 46, 3484-3486

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Antonio Echavarren joins the ChemComm Editorial Board

Antonio EchavarrenOn behalf of the ChemComm Editorial Board, I am delighted to welcome Professor Antonio Echavarren as the new ChemComm Associate Editor for organic chemistry and catalysis.

Professor Echavarren is Group Leader at the Institute of Chemical Research of Catalonia (ICIQ) in Tarragona, Spain. His research focuses on developing new catalytic methods based on the organometallic chemistry of transition metals as well as synthesing natural products and polyarenes.

Professor Echavarren’s editorial office is now open for submissions, welcoming urgent communications highlighting the latest advances in organic chemistry and catalysis.

Find out more about Professor Echavarren’s research on gold catalysis by reading these exciting articles:

A multipurpose gold(I) precatalyst
Mihai Raducan, Carles Rodríguez-Escrich, Xacobe C. Cambeiro, Eduardo C. Escudero-Adán, Miquel A. Pericàs and Antonio M. Echavarren, Chem. Commun., 2011, 47, 4893-4895

Mechanism of the gold-catalyzed cyclopropanation of alkenes with 1,6-enynes
Patricia Pérez-Galán, Elena Herrero-Gómez, Daniel T. Hog, Nolwenn J. A. Martin, Feliu Maseras and Antonio M. Echavarren, Chem. Sci., 2011, 2, 141-149

Are you an organic chemist based in North America? Submit your research to Michael Krische, ChemComm North American Associate Editor for organic chemistry.

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Antibody acts as rudder to steer DNA into a pore

Scientists from China and Canada have studied the effect of a DNA-binding antigen-binding fragment (Fab) of an antibody on the translocation of a DNA polymer. Both poly(dT)45:Fab HED10 and poly(dT)45 produce unique double step current traces, which were analysed in detail to get information about the translocation events.

Representation of an α-HL pore and the mechanism for the poly(dT)45 specific binding with Fab HED10. A biological α-HL nanopore is embedded in a lipid bilayer. The narrowest section of α-HL is 1.4 nm. The potential across the bilayer membrane is applied through Ag/AgCl electrodes. In 10 mM Tris-HCl (pH = 7.8) buffer, the antibody recognizes four consecutive thymine residues of poly(dT)45.

The results have important implications for understanding the translocation behaviour of polymers, which could help to develop nanopore biosensors with high sensitivity and specificity, says Yitao Long, from East China University of Science and Technology. In particular, the addition of polymer-binding antibodies may facilitate the use of nanopores in sequencing technologies.

The presence of the FAB HED10 decreases the time of the first level of the step but not the second. The Fab appears to behave as a rudder, which significantly decreases the energy barrier for poly(dT)45 translocation. A more rigid or extended conformation of poly(dT)45 would decrease the time required to find the entrance to the narrow constriction in the pore. The entropic barrier required to linearise the DNA strand may be the dominant contribution to the entire energy barrier.

Find out more by downloading the communication, recently published in ChemComm.

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Call for communications: catalytic C–C bond formation via late transition metals

Michael KrischeChemComm Associate Editor Michael Krische is delighted to announce a forthcoming web themed issue:

New advances in catalytic C–C bond formation via late transition metals

Guest editor: Michael Krische (University of Texas at Austin)

Submission deadline: 30th September 2011

We are now welcoming submissions for this web theme, which will be a celebration of current achievements and future perspectives in this exciting field of research.

All manuscripts will undergo strict peer review and should be very important and conceptually significant in accord with the ChemComm mandate.

Publication of the peer-reviewed articles will occur without delay to ensure the timely dissemination of the work. The articles will then be assembled on the ChemComm website as a web-based thematic issue, to permit readers to consult and download individual contributions from the entire series.

Communications for this web theme can be submitted anytime from now until 30th September using our web submission system. Please add the phrase ‘catalytic C–C bond formation’ in the comments to the editor field.

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Nanoparticles help reveal hidden fingerprints

Criminal investigations may benefit from new forensic methods based on nanoparticles. A technique using gold nanoparticles in combination with antibodies has shown promising results for enhancing fingerprints that are over a week old.

Fingerprinting, first reported in the 19th century, is still the primary source of evidence used in crime scene investigation and new methods for improving fingerprint visualisation remain in demand. Unseen (latent) fingerprints can be revealed using chemical treatments that target molecules likely to be deposited in fingerprints, such as those in hair follicle secretions.

Xanthe Spindler at the University of Technology Sydney in Australia and colleagues now report a technique that targets amino acids – present ubiquitously in sweat and thus in most fingerprints. They linked amino acid-binding antibodies to gold nanoparticles and applied them to fingerprints. To develop and image the prints, they used red fluorescent secondary antibodies that would stick to the nanoparticle-bound antibodies.

Antibody structures
Antibodies bound to nanoparticles can bind to amino acids in fingerprints that are over 12 months old

 Read the full news story in Chemistry World and Spindler’s ChemComm communication to find out more.

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A Sustainable Global Society: How Can Materials Chemistry Help?

A high profile white paper A Sustainable Global Society: How Can Materials Chemistry Help? was launched internationally on 27 March.

The output of the Chemical Sciences and Society Summit (CS3) 2010, which took place in London, September 2010, outlines five key areas in which materials chemists, through collaboration with other scientists, industry and policy makers, can seize exciting opportunities to address global challenges. This project was driven by the RSC and is a collaboration between the chemical societies of China, Germany, Japan, the US, the UK and national funding bodies. Around 30 leading materials chemists from the participating nations participated in CS3 2010 and the white paper is a reflection of the outcome of the summit, in particular their view of the future direction for materials chemistry.

View the official website of the white paper.

Read the 27 March press release.

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