Chemical Science Blog

I am delighted to announce that Professor Jihong Yu (Jilin University, China) has joined the Chemical Science Editorial Board as the Associate Editor for Inorganic Materials.

Professor Yu’s research focuses on the designed synthesis of zeolitic porous functional materials. She obtained the National Outstanding Youth Fund of China in 2001, and was awarded National Prize for Natural Science in 2006, the 6th Chinese Youth Woman Scientist Award in 2009, and the Bau Family Award in 2010 for World Chinese Inorganic Chemists. She is now the Chief Scientist of the National Basic Research Project of China. 

Professor Yu’s Editorial Office will open for submissions imminently.

To submit your exceptional research to Professor Yu or any of our other outstanding Associate Editors, please use our online submission site.

Scientists in Germany and Canada have developed a new way to capture sulfur dioxide gas. It could minimise the environmental impact of the gas, which causes acid rain.

The team made a series of frustrated Lewis pairs (FLPs) consisting of a bulky phosphane Lewis base component and a boron Lewis acid component. The FLPs rapidly and efficiently trap sulfur dioxide by adding the phosphane component to sulfur and the boron to oxygen.

Link to journal article
Reactions of Phosphorus/Boron Frustrated Lewis Pairs with SO₂
M Sajid et al
Chem. Sci., 2012, DOI: 10.1039/c2sc21161k

The surface chemistry of proteins makes them stable in complex biological environments. Scientists in the US have investigated why to enable peptide-based materials that resist non-specific interactions (stealth compounds) to be designed.

The cytoplasm is a crowded environment containing lots of different molecules but proteins resist non-specific interactions with these molecules. Understanding and mimicking nature’s resistance to non-specific interactions is key to addressing emerging challenges in chemistry, especially in practical applications where complex environments can degrade materials and surface coatings.

Here, the team has used structural bioinformatics to study proteins and molecular chaperones, which guide proteins from a misfolded or unfolded conformation back into a native conformation. They found that nature uses sequence design to modulate non-specific interactions so that the proteins function properly. Specifically, lysine and glutamic acid are the most abundant amino acids on the surface of proteins.

Link to journal article
Decoding nonspecific interactions from nature
A D White et al
Chem. Sci., DOI: 10.1039/c2sc21135a

Scientists in the UK have demonstrated that bottromycin (an antibiotic that works against MRSA) is biosynthesised from a larger precursor ribosomal peptide. This was proposed following a genome mining analysis of Streptomyces scabies and confirmed by a series of gene deletion experiments. The work also identifies S. scabies as a previously unknown producer of bottromycin. An almost identical gene cluster was also identified in S. bottropensis, an established bottromycin producer. Bottromycin is the first ribosomal peptide natural product that derives from the N-terminus of a larger prepeptide and the first terrestrial peptide to be directly ethylated at beta-positions.

Bottromycin is active in vitro but unstable in vivo so if scientists can engineer its biosynthesis to make unnatural analogues they might be able to make good new antibiotics. By identifying this pathway the team should facilitate the generation of a library of bottromycin-like antibiotics.

Link to journal article
Identification and characterisation of the gene cluster for the anti-MRSA antibiotic bottromycin: Expanding the biosynthetic diversity of ribosomal peptides
W J K Crone, F J Leeper and A W Truman
Chem. Sci., 2012, DOI: 10.1039/c2sc21190d

Physical organic chemistry, the study of the underlying principles and rationale of organic reactions which looks at the interrelationships between the structure and reactivity of organic molecules, now encompasses a wider range of contexts than ever before

Making use of tools such as chemical kinetics, quantum chemistry, thermochemistry, chemical equilibrium and computational chemistry, to name but a few, researchers are investigating topics such as:

• Supramolecular interactions, aggregation and reactivity
• The computation of transition states and mechanisms
• Molecular recognition, reactions and catalysis in biology
• Materials where molecular structure controls function
• Structure activity correlations
• Mechanisms in synthesis and catalysis

To highlight some of the cutting edge research that ChemComm, Chemical Science and Organic & Biomolecular Chemistry publish we have collected a selection of articles for you to enjoy. These will be free to access until 25^th September!

Click here for the full list of free articles

Boronic esters have been used by US scientists to transform the triphenylene core in discotic liquid crystals (DLCs) from electron-rich to electron-deficient.

DLCs are used in electronic devices such as light emitting diodes. They need an electron-rich donor and an electron-poor acceptor. Current electron-poor acceptors have shortcomings including the fact that they can’t form columnar mesophases.

The team incorporated a boronic ester into the triphenylene core, which makes it an electron-poor acceptor and they were able to achieve broad mesophase temperature ranges.

Boronic Esters: A Simple Route to Discotic Liquid Crystals that Are Electron Deficient
Benjamin King and Luke Andrew Tatum
DOI: 10.1039/C2SC20128C

Scientists in Canada have studied the synthetic scope of a new system of [2]rotaxane molecular shuttles based on a templating motif involving a benzimidazolium–crown ether recognition pair.

The template allows an array of molecular shuttles containing macrocyclic crown ethers of varying size and shape to be prepared.

The study also provides the beginnings of a property–structure relationship for molecular shuttling in this rigid, compact [2]rotaxane system. This could aid in the future design of [2]rotaxane molecular shuttles for incorporation into materials such as metal–organic frameworks.

Bis(benzimidazolium) axles and crown ether wheels: a versatile templating pair for the formation of [2]rotaxane molecular shuttles
Stephen J. Loeb, Kelong Zhu, V. Nicholas Vukotic and Nadim Noujeim
DOI: 10.1039/C2SC20986A