Chemical Science Blog

Scientists in France have combined homogeneous catalysis and atomic force microscopy to create intricate surface patterns.

Atomic Force Microscopy (AFM) works by dragging a sharp tip across a material’s surface to map nanoscale surface topologies or measure surface interactions. Innovations in the design of AFM tips have allowed AFM to become a tool, not only for reading, but also for writing onto surfaces, analogous to creating tattoos on a molecular scale.

To date, AFM tips have only been able to use a narrow range of chemical transformations, including heterogeneous catalysis, to create patterns on a surface.

Now, Jean-Luc Parrain, Sylvain Clair, Olivier Chuzel and colleagues from Aix Marseille University and the National Centre for Scientific Research (CNRS), have attached a homogeneous catalyst to a commercially available AFM probe and used it to carry out…

Continue reading the full article in Chemistry World »

Read the original journal article in Chemical Science:
Grafting a homogeneous transition metal catalyst onto a silicon AFM probe: a promising strategy for chemically constructive nanolithography
Dmitry A. Valyaev, Sylvain Clair, Lionel Patrone, Mathieu Abel, Louis Porte, Olivier Chuzel and Jean-Luc Parrain  
Chem. Sci., 2013, 4, 2815-2821
DOI: 10.1039/C3SC50979F

© Shutterstock

Scientists in Australia are closer to harvesting hydrogen from two of the most abundant and naturally occurring resources in our environment – seawater and sunlight.

Water oxidation, the first part of the water splitting reaction that can produce hydrogen, is difficult as it is so kinetically unfavourable. Using photocatalysts to overcome this energy barrier is appealing as sunlight can supply the required energy rather than needing electrical or thermal energy.

Unlike some photocatalytic water oxidation methods that use catalysts mounted on a semiconductor to form an electrode, a team, led by Jun Chen and Gerhard Swiegers, from the University of Wollongong, Australia, have shown that…

Continue reading the full article in Chemistry World »

Read the original journal article in Chemical Science:
A light-assisted, polymeric water oxidation catalyst that selectively oxidizes seawater with a low onset potential
Jun Chen, Pawel Wagner, Lei Tong, Danijel Boskovic, Weimin Zhang, David Officer, Gordon G. Wallace and Gerhard F. Swiegers  
Chem. Sci., 2013, 4, 2797-2803
DOI: 10.1039/C3SC50812A

Research published in Chemical Science describes the design of a new fluorescent probe that can sense ‘mobile’ zinc outside cells by using a targeting peptide that delivers the probe to the extracellular side of the plasma membrane.

Understanding zinc signalling is a significant area of interest in biological studies. Readily-exchangeable or ‘mobile’ zinc is important in human health and has been shown to have a role in the function of the pancreas, prostate and central nervous system. Current fluorescent zinc sensors tend to be based on small molecules that readily diffuse across cell membranes to give information on zinc in the intracellular environment, but it is difficult to predict how these sensors are distributed beyond the cell membrane where it would be useful to monitor zinc ions released by cells.

Scientists in the United States have developed a design for a zinc sensor that is directed the extracellular plasma membrane by attaching the zinc-signalling fluorophore to a membrane-targeting peptide scaffold. The probes can be readily prepared by solid-phase synthesis to insert the targeting peptide between the fluorophore and a fatty acid that anchors the probe to the cell membrane. The scientists conducted live cell imaging experiments that gave a positive signal for zinc in the plasma membranes of the cells.

Read the ‘HOT’ article for free today:

Peptide-based targeting of fluorescent zinc sensors to the plasma membrane of live cells
Robert J. Radford,a Wen Chyana and Stephen J. Lippard*a
Chem. Sci., 2013, Advance Article, DOI: 10.1039/C3SC50974E

An essential feature of cell function and development is the transportation of molecules across the cell wall.

The maxim of ‘like dissolves like’ is well known by every high school chemist and is the reason why the cell itself does not dissolve; the cell wall and the water outside it naturally repel each other.

Whilst this is excellent news for the stability of the cell, it presents a problem for the water-soluble molecules trying to get into the cell.  If such a molecule is dissolved in water outside of the cell then it follows that it will be unhappy passing through the greasy cell wall.

Nature as always has a solution and solves this problem by effectively wrapping up these molecules in an oily layer making transport across the cell wall more efficient.  A similar concept is responsible for the cleaning action of detergent in a dirty cooking pan.

This transportation is of particular interest to the pharmaceutical industry where transport of small drug molecules into cells is of paramount importance.  Drugs can have remarkable activity in a laboratory experiment but if it cannot find its way into the cell then it will be unable to achieve this in a person.  Understanding the factors which control this process is therefore crucial.

Prof. Philip Gale’s research group at the University of Southampton along with co-workers at the Universidade de Aveiro have published a detailed and systematic study which highlights some critical features of molecules which are capable of fulfilling this role.

Interested in more?  Read this HOT Chem Sci Edge article now!

Towards predictable transmembrane transport: QSAR analysis of anion binding and transport
Nathalie Busschaert, Samuel J. Bradberry, Marco Wenzel, Cally J. E. Haynes, Jennifer R. Hiscock, Isabelle L. Kirby, Louise E. Karagiannidis, Stephen J. Moore, Neil J. Wells, Julie Herniman, G. John Langley, Peter N. Horton, Mark E. Light, Igor Marques, Paulo J. Costa, Vítor Félix, Jeremy G. Frey and Philip A. Gale
Chem. Sci., 2013, Advance Article
DOI: 10.1039/C3SC51023A

Ruaraidh McIntosh is a guest web-writer for Chemical Science.  His research interests include supramolecular chemistry and catalysis.  When not working as a Research Fellow at Heriot-Watt University, Ruaraidh can usually be found in the kitchen where he has found a secondary application for his redoubtable skills of burning and profanity.