Watch out for artifacts in your next multi-colour fluorescence imaging experiment

The discovery of super resolution microscopy, followed by the announcement of 2014 Chemistry Nobel prize, facilitated a great expansion in the use of multi colour fluorescence imaging to study cellular or sub-cellular systems. Super resolution localization microscopy requires highly photostable, sufficiently bright fluorophores to achieve the blinking which is necessary to distinguish individual fluorophores within the diffraction limit. To validate all these criteria, organic dyes are a most obvious choice as fluorophores. However, chemical conversion of organic dyes upon prolonged laser exposure exhibit multicolour image artifacts leading to false-positive colocalization. Researchers from Pohang University, South Korea demonstrate a detailed protocol to understand and avoid such artifacts.

The researchers labelled cell membrane using far-IR dye (A647) which shows a red photoluminescence. But surprisingly, upon photobleaching of the A647 dye, which is blue in colour, it turned to red. This photobleached product also emits at red region, coinciding with the original emission of A647. This phenomenon is called blue-conversion. A range of commonly used organic dyes are evaluated for blue-conversion occurrences which indicates cyanine dyes show multiple blue-converted species. Interestingly, among all the dye groups there is not a single group that exhibit no blue-conversion at all.

Blue-conversion of far-red organic dyes upon photobleaching. A647 dissolved in DMSO before (left) and after (right) photobleaching using direct laser illumination. (a) TIRF images of A647-EGFR on COS7 cells in the far-red (upper panels) channel excited at 642 nm and the red (lower panels) channel excited at 561 nm before (left panels) and after (right panels) photobleaching of A647-EGFR.

The researchers also study multicolour fluorescence imaging by colocalization of two well-known dyes. They have observed that the single-molecule brightness of the blue-converted species contributed to the production of the artifact in the reconstructed images. Finally, they concluded sufficient care must be taken in multicolour imaging applications, including colocalization, and other fluorescence-based multi-well plate format assays, to prevent false positives produced by blue-conversion of organic dyes.

Although they primarily discussed the negative effect of the blue-conversion of organic dyes, they are also hopeful to use this new photoconversion pathway of cyanine dyes for advantages of fluorescence imaging applications. They propose that super-resolution techniques require the photoactivation of organic dyes, which might exert some undesirable effects in live cells. However, the photoactivation of the blue-converted species occurs without any external stimuli and can be inferred as an advantage for super resolution techniques.

For details please read: https://doi.org/10.1039/D1SC00612F

About the blogger:

Dr. Damayanti Bagchi is a postdoctoral researcher in Irene Chen’s lab at University of California, Los Angeles, United States. She has obtained her PhD in Physical Chemistry from Satyendra Nath Bose National Centre for Basic Sciences, India. Her research is focused on spectroscopic studies of nano-biomaterials. She is interested in exploring light enabled therapeutics. She enjoys travelling and experimenting with various cuisines.

You can find her on Twitter at @DamayantiBagchi.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Chemical Science HOT Articles: June 2021

New month, new HOT articles!

We are pleased to share a selection of our referee-recommended HOT articles for June 2021. We hope you enjoy reading these articles, congratulations to all the authors whose articles are featured! As always, Chemical Science is free to read & download.

You can explore our full 2021 Chemical Science HOT Article Collection here!

Browse a selection of our June HOT articles below:

[GaF(H2O)][IO3F]: a promising NLO material obtained by anisotropic polycation substitution
Qian-Ming Huang, Chun-Li Hu, Bing-Ping Yang, Zhi Fang, Yuan Lin, Jin Chen, Bing-Xuan Li and Jiang-Gao Mao
Chem. Sci., 2021, Advance Article

Photocleavable proteins that undergo fast and efficient dissociation
Xiaocen Lu, Yurong Wen, Shuce Zhang, Wei Zhang, Yilun Chen, Yi Shen, M. Joanne Lemieux and Robert E. Campbell
Chem. Sci., 2021, Advance Article

Electrochemically switchable polymerization from surface-anchored molecular catalysts
Miao Qi, Haochuan Zhang, Qi Dong, Jingyi Li, Rebecca A. Musgrave, Yanyan Zhao, Nicholas Dulock, Dunwei Wang and Jeffery A. Byers
Chem. Sci., 2021, Advance Article

Flow electrochemistry: a safe tool for fluorine chemistry
Bethan Winterson, Tim Rennigholtz and Thomas Wirth
Chem. Sci., 2021, Advance Article

Biomimetic enterobactin analogue mediates iron-uptake and cargo transport into E. coli and P. aeruginosa
Robert Zscherp, Janetta Coetzee, Johannes Vornweg, Jörg Grunenberg, Jennifer Herrmann, Rolf Müller and Philipp Klahn
Chem. Sci., 2021, Advance Article

Sensitization-initiated electron transfer via upconversion: mechanism and photocatalytic applications
Felix Glaser, Christoph Kerzig and Oliver S. Wenger
Chem. Sci., 2021, Advance Article
Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Reflecting on #RSCPoster 2021

RSCPoster

#RSCPoster is a global Twitter Poster Conference, held entirely online over the course of 24 hours. The event brings together the global chemistry community to network with colleagues across the world and at every career stage, share their research and engage in scientific debate.

The 2021 #RSCPoster Twitter Conference was held on 2 March, and brought together 5,500 attendees with almost 900 presenters from 62 countries sharing their science to a potential audience of over 41 million.

 

Yi-Tao Long, Chemcial ScienceChemical Science Associate Editor Yi-Tao Long was subject chair for #RSCAnalytical – we caught up with him to get his thoughts on the event and some advice for next year.

“This is the first time I joined this #RSCPoster event and found it really impressive. It is a very good opportunity for early career researchers and graduate students to present their work” noted Yi-Tao.

“As an Associate Editor, I think the presentation and storyline are so important for a scientific paper. Of course, science is the most important, but being interesting and appealing to a broad community is also vital” explains Yi-Tao. This advice holds true for #RSCPoster too. Yi-Tao advises, “be clear and readable when presenting the work, this makes it easier for others to be interested, especially researchers in other fields.”

This year’s #RSCAnalytical prize winner, @kellybrown_94, is a great example of this point, as Yi-Tao mentions, “this poster caught my eye at first glance”.

 

Check out the full list of winners – CLICK HERE

This year we also saw the introduction of #RSCPosterPitch – short videos from our poster presenters bringing their research to life in creative ways. The entries in this new category were impressive, check out the winning #RSCPosterPitch from @alanqf22 for inspiration!

https://twitter.com/alanqf22/status/1366721199858933770

 

And why not enter next year?

Look out for more information on the 2022 #RSCPoster Twitter Conference – coming soon!

  • no registration fees
  • participate from anywhere with Twitter access
  • meet researchers from all over the world, at every career stage
  • spend as little or as much time attending as you like
  • cash and community prizes for the best posters as judged by our excellent Committees
  • community prize for the best #RSCPosterPitch as selected by our General Committee

Thank you to all participants and judges and hope to see you next year!

With thanks to our sponsoring RSC Interest Groups & journals:

Separation Science GroupEnvironmental Chemistry Group | Molecular Spectroscopy Group | Porous Materials Group | Analyst | Analytical Methods | Biomaterials Science | Catalysis Science and Technology | ChemComm  | Chemical Science | Chemistry Education Research and Practice | Chem Soc Rev | CrystEngComm | Dalton Transactions | Energy & Environmental Science | Environmental Science: Atmospheres | Environmental Science: Nano | Environmental Science: Processes and Impacts | Environmental Science: Water Research & Technology | Faraday Discussions | Food & Function | Green Chemistry | JAAS | Journal of Materials Chemistry A | Journal of Materials Chemistry B | Journal of Materials Chemistry C | Lab on a Chip | Materials Advances | Materials Horizons | Molecular Omics | MSDE | Nanoscale | Nanoscale Advances | Nanoscale Horizons | Natural Product Reports | NJC | Organic & Biomolecular Chemistry | PCCP | Polymer Chemistry | Reaction Chemistry & Engineering | RSC Advances | RSC Chemical Biology | RSC Medicinal Chemistry |Soft Matter | Sustainable Energy & Fuels

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Associate Editor highlight – interview with Professor Subi George

Professor Subi George joined the Chemical Science Editorial Board in 2020. To celebrate this occasion, we met virtually with Subi to discuss his research highlights and what attracted him to join the Chemical Science team.

Subi’s research focuses on the synthesis of small molecules and the study of molecular self-assembly processes. His group use supramolecular approaches to develop bioinspired and adaptive materials, including dynamic supramolecular polymers and optoelectronic materials.

What would you say is your biggest motivation?

I would say my interactions with passionate and creative young researchers. This interaction motivates and encourages me. I am also highly motivated when we are able to come up with new discoveries and are able to publish our exciting findings in high impact journals. As scientists, we are lucky – we never stop learning, and we have the academic freedom of trying new things every day. This provides new opportunities to bring about change and explore solutions to a whole range of problems. These are my biggest motivations to push forward with my research.

What has been the most challenging moment of your career so far?

I would say that I have two moments, one in my earlier career and one later. The point when I decided to pursue chemistry as a career was quite a challenging moment. In India, this kind of decision previously attracted a lot of criticism, because it was believed that there were no job opportunities if you decided to pursue science as a career. Medicine and engineering were always seen as being more promising careers. It was therefore difficult at times to convince my family that a career in chemistry was a good decision. Luckily, I did have support from my close family, so that was a real blessing.

Secondly, I feel that it can be quite challenging when you develop your own independent group. It can be quite difficult to establish and differentiate yourself, and to ensure that you create a strong, internationally recognised group.

In your area of research, what do you feel has been the most revolutionary piece of work within the past 5 years?

The particular class of materials that we have been working on are based on supramolecular polymers, which are dynamic systems. This field has been active over the past two decades, from which we have gained a high level of mechanistic understanding. Over the past five years, significant progress has been made and elegant design strategies have been developed, which have allowed a high level of structural control. We have also witnessed a push in the limit of self-assembly from equilibrium to being out of equilibrium, towards the preparation of biomimetic, adaptive materials. We have been working in this particular field. We recognised that synergy between structural and temporal control would be the most suitable way to prepare biomimetic materials, so we came up with a strategy called bioinspired temporal supramolecular polymerisation. Overall, the past 5 years have therefore seen an increase in our understanding of these systems, and in tools and strategies to assist in the preparation of optimised biomimetic supramolecular polymers.

It’s been over a year since the outbreak of the global pandemic. What changes have you witnessed in the local researcher community? Do you think there are any new challenges or opportunities for chemistry researchers from this ongoing pandemic?

The pandemic has hit every sector, and the scientific community has not been spared. We were required to switch to working online for group meetings and teaching, which was quite difficult. The pandemic has also resulted in a lack of exposure for students, who haven’t been able to attend things such as international conferences, and for those in their final years who were hoping to seek research opportunities abroad. Again, this is such an important experience, so it has definitely been challenging for the community and made it even more important to keep up the motivation of my students.

Looking to the brighter side of things, the pandemic has forced us to slow down and take a step back. We have had the time to consult the literature and to carefully plan what we would like to achieve in the future. The pandemic has therefore definitely provided opportunities.

This is also an important time where the public is looking to the scientific community with a lot of expectations. Many researchers in India have worked to contribute towards COVID-related research to combat the disease, including breakthroughs in diagnostic tools, vaccines, or even the development of PPE equipment. It has given us the chance to think about our responsibilities and what our commitment is to society.

Which of your Chemical Science publications are you most proud of and why?

I would have to say that I love them all. We always ensure that we publish unique and high-quality research. However, if I had to pick one piece, it would be a contribution from 2017. This demonstrated chemically-fuelled temporal switching of an amphillic self-assembly system. We introduced the use of redox fuels for the preparation of these materials that are away from equilibrium. This is a concept that people are starting to utilise.

Chemical Science is the flagship journal of the Royal Society of Chemistry. What aspects of the journal do you feel contribute to us being the flagship?

Chemical Science is a place where you can publish high quality, high impact, multidisciplinary chemistry. It is one of the few high impact science journals that is diamond open access, meaning that content in the journal is free to read and free to publish. This is incredibly important for the whole research community, but especially for researchers in India because it is not always possible to pay the high article processing charges that are charged by other high impact journals. This is very unique, and contributes to Chemical Science being the flagship. In India, unlike places in Europe, we don’t have a dedicated budget or grants that can be used for open access publications. This is going to be a big challenge for India as we move towards an open publishing platform. At this time, if a journal is not diamond open access, or does not have significant waiver policies, researchers in India will struggle to publish in journals with high article-processing charges.

Another highlight of Chemical Science is the Edge Article format that researchers can use when publishing their primary research. This was so unique when it was introduced. Communication-style articles can be too restrictive, so the Edge Article format helps researchers to be able to communicate their research in as much or as little detail as is required, and allows for a much smoother reading process than having lots of information that has to be put in the supplementary information section. The Edge Article format allows science to be discussed in depth.

What attracted you to join the Editorial Board for Chemical Science?

I feel that I can help to popularise Chemical Science in India, and help to promote the journal to our authors there. Being an Associate Editor of a high-impact journal like Chemical Science provides the opportunity to learn about lots of different research areas first-hand, and I am able to learn more about the latest developments in science through this role, which is great. I’m very happy to be on the board, and to help to contribute to the growth of the journal to continue to make it one of the most exciting and high impact chemistry journals.

How do you see your field progressing in the next 10 years?

Research on supramolecular polymers shows a lot of promise I feel. Given the previous work in this field, we are in a position to access a higher level of complex structures and address further challenges that are still faced when preparing these systems. I think we’ll start to be able to produce more complex, self-organised systems. I am confident that we will be able to make much-enhanced adaptive and multicomponent biomimetic systems in this area soon.

In celebration of joining the Chemical Science team, Subi has highlighted a selection of important contributions from the past few years, with a focus on recent trends in supramolecular polymers, dissipative systems and organic materials. The collection can be viewed here.

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Chemical Science HOT Articles: May 2021

New month, new HOT articles!

We are pleased to share a selection of our referee-recommended HOT articles for May 2021. We hope you enjoy reading these articles, congratulations to all the authors whose articles are featured! As always, Chemical Science is free to read & download.

You can explore our full 2021 Chemical Science HOT Article Collection here!

Browse a selection of our May HOT articles below:

Aromatic side-chain flips orchestrate the conformational sampling of functional loops in human histone deacetylase 8
Vaibhav Kumar Shukla, Lucas Siemons, Francesco L. Gervasio and D. Flemming Hansen
Chem. Sci., 2021, Advance Article

Blue-conversion of organic dyes produces artifacts in multicolor fluorescence imaging
Do-Hyeon Kim, Yeonho Chang, Soyeon Park, Min Gyu Jeong, Yonghoon Kwon, Kai Zhou, Jungeun Noh, Yun-Kyu Choi, Triet Minh Hong, Young-Tae Chang and Sung Ho Ryu
Chem. Sci., 2021, Advance Article

Controllable DNA strand displacement by independent metal–ligand complexation
Liang-Liang Wang, Qiu-Long Zhang, Yang Wang, Yan Liu, Jiao Lin, Fan Xie and Liang Xu
Chem. Sci., 2021, Advance Article

Spatial-confinement induced electroreduction of CO and CO2 to diols on densely-arrayed Cu nanopyramids
Ling Chen, Cheng Tang, Kenneth Davey, Yao Zheng, Yan Jiao and Shi-Zhang Qiao
Chem. Sci., 2021, Advance Article

Manipulating valence and core electronic excitations of a transition-metal complex using UV/Vis and X-ray cavities
Bing Gu, Stefano M. Cavaletto, Daniel R. Nascimento, Munira Khalil, Niranjan Govind and Shaul Mukamel
Chem. Sci., 2021, Advance Article

Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Chemical domain image recognition using autocatalysis

A reaction in which one of the products speeds up further product formation is called an autocatalytic reaction. Autocatalysis plays an important role in living systems including DNA replication, apoptosis, and even in the origin of life, due to self-sustaining growth and oscillation. Researchers from Brown University employ this nature of autocatalytic click chemistry to generate an artificial neural network that can be used for image classification.

Autocatalytic reaction rate depends on the concentration of product and shows a non-linear dependency of product formation with progress in reaction time. In this view, a network of autocatalytic reactions is analogous to an artificial neural network. An artificial neuron is a basic learning unit, inspired by biological neurons, which multiplies it’s inputs by a set of weights and transforms their sum through a nonlinear operator. Researchers used this resemblance to formulate a winner-take-all neural network.

Fig 1: Kinetics of autocatalysis. (a) Reagent and autocatalytic product evolution over time (b) Rate of product concentration change over time for the reaction simulated in a, showing the accelerated production typical of an autocatalytic process.

Copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction was chosen for autocatalysis as it is fast, can occur under mild conditions and produce high yield. Also, CuAAC reaction involves colored copper–ligand complexes and can be quantitatively monitored using UV-vis spectroscopy.

In a winner-take-all neural network, winner is determined by it’s achievement to reach to a particular condition. Here, they have used the reaction half-way point (t1/2) as the condition of image classification. Experiment wise, they have used automated liquid handling equipment to remove a certain volume and then added it together into individual pools for potential image class. The pool that reaches the transition time first is determined as the winner.

Fig 2: An overview of the copper (C) catalyzed azide–alkyne cycloaddition reaction, showing the buildup of triazole branches on the amine backbone of (A) after each azide (B) incorporation. The threebranched product (D) catalyzes its own generation by promoting the reduction of Cu(II). Experimental setup for evaluating a chemical WTA network (Right: upper panel). (Right lower panel) Network training and in silico simulation. (a) Example images from each of the considered classes. (b) Trained weights for each class.  

This study shows an interesting adaptation of autocatalysis as a platform for non-linear activation function necessary for artificial neural network classification. The findings are expected to improve future development of chemical-domain computing systems.

 

For further details, please go through:

Leveraging autocatalytic reactions for chemical domain image classification

Christopher E. Arcadia, Amanda Dombroski, Kady Oakley, Shui Ling Chen, Hokchhay Tann, Christopher Rose, Eunsuk Kim, Sherief Reda, Brenda M. Rubensteinb and Jacob K. Rosenstein*

Chem. Sci., 2021, 12, 5464

 

About the blogger

Dr Damayanti Bagchi is a postdoctoral researcher in Irene Chen’s lab at University of California, Los Angeles, United States. She has obtained her PhD in Physical Chemistry from Satyendra Nath Bose National Centre for Basic Sciences, India. Her research is focused on spectroscopic studies of nano-biomaterials. She is interested in exploring light enabled therapeutics. She enjoys travelling and experimenting with various cuisines, which she found resembles with products/ side products of chemical reactions!

You can find her on Twitter at @DamayantiBagchi.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Chemical Science welcomes new Associate Editor Graeme Day

We wish a very warm welcome to our new Chemical Science Associate Editor Graeme Day!

 

Chemcial Science Associate Editor Graeme Day

 

Graeme Day was born in Canada and studied chemistry, mathematics and computing science at Saint Mary’s University in Halifax before moving to the University of Oxford for a Masters in theoretical chemistry and a PhD in computational chemistry at University College London. After postdoctoral work in the Pfizer Institute for Pharmaceutical Materials at the University of Cambridge, Graeme began his independent research as a Royal Society University Research Fellow, also in Cambridge, spending most of his time working on modelling pharmaceutical materials and computational methods for interpreting terahertz spectra of molecular crystals. He moved to the University of Southampton in 2012, where he is now Professor of Chemical Modelling, and was awarded a European Research Council Starting Grant for the ‘Accelerated design and discovery of novel molecular materials via global lattice energy minimisation’ (ANGLE). This grant shifted the focus of his research to functional materials, including porous crystals and organic electronics.

In 2020, Graeme was awarded an ERC Synergy grant ‘Autonomous Discovery of Advanced Materials’ (ADAM) with Professors Andrew Cooper (Liverpool) and Kerstin Thurow (Rostock) to integrate computational predictions, chemical space exploration with automation and robotics in the materials discovery lab. He continues to work in the area of pharmaceutical solid form modelling, has worked on methods for NMR crystallography and has a developing interest in applying machine learning methods for accelerating simulations, analysing energy landscapes and generating ideas.

Browse a selection of Graeme’s work below:

Evolutionary chemical space exploration for functional materials: computational organic semiconductor discovery
Chi Y. Cheng, Josh E. Campbell and Graeme M. Day
Chem. Sci., 2020, 11, 4922-4933

Crystal structure determination of an elusive methanol solvate – hydrate of catechin using crystal structure prediction and NMR crystallography
Marta K. Dudek, Piotr Paluch, Justyna Śniechowska, Karol P. Nartowski, Graeme M. Day and Marek J. Potrzebowski
CrystEngComm, 2020, 22, 4969-4981

Photocatalytic proton reduction by a computationally identified, molecular hydrogen-bonded framework
Catherine M. Aitchison, Christopher M. Kane, David P. McMahon, Peter R. Spackman, Angeles Pulido, Xiaoyan Wang, Liam Wilbraham, Linjiang Chen, Rob Clowes, Martijn A. Zwijnenburg, Reiner Sebastian Sprick, Marc A. Little, Graeme M. Day and Andrew I. Cooper
J. Mater. Chem. A, 2020, 8, 7158-7170

Mining predicted crystal structure landscapes with high throughput crystallisation: old molecules, new insights
Peng Cui, David P. McMahon, Peter R. Spackman, Ben M. Alston, Marc A. Little, Graeme M. Day and Andrew I. Cooper
Chem. Sci., 2019, 10, 9988-9997

 

Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Associate Editor highlight – interview with Professor Jinlong Gong

In 2021, Chemical Science was delighted to welcome Professor Jinlong Gong as an Associate Editor, handling manuscripts within the area of heterogenous catalysis. To celebrate this occasion, we met virtually with Jinlong to discuss his research and to discuss the kind of manuscripts that he is looking forward to handling for the journal.

Jinlong’s research focuses on understanding the catalytic processes occurring during alkane dehydrogenation and CO2 hydrogenation by developing advanced catalytic materials, as well as optimised industrial processes.

What excites you most about your area of research and what has been the most exciting moment of your career so far?

The major motivation of my research is to provide constructive solutions for a sustainable society, particularly associated with the chemical industry. For example, propane dehydrogenation is a traditional chemical process which has been under development over the past 60-80 years. Our research therefore focuses on trying to develop new catalytic processes to reduce the energy consumption with enhanced catalytic performance. Another example is about the utilisation of CO2 with sustainable energy to produce renewable fuels and help reduce emissions. President Xi Jinping has announced that China’s aim is to achieve a carbon neutral society by 2060. Actually, my work on photocatalytic reduction of CO2 follows such a direction. The big challenge in this area is to improve the efficiency, which is currently still low.

Some of the most exciting moments of my career have been when former students of mine have been recruited into faculty positions at top universities. It is always a pleasure to see young researchers grow up independently and then go on to do amazing things! Another exciting moment for me was when we were able to find new oxide materials that displayed very high efficiency for propane dehydrogenation. We believe that this is going to be the next generation of catalysts for this process.

What has been the most challenging moment of your career so far?

It is always challenging to navigate research into a scientifically critical direction at the right time, rather than staying in a comfortable zone. Transitioning the direction of your research into a new but important area tends be exhausting, especially at the start. On the other hand, the potential reward can be more exciting. Sometimes, it is also challenging to convince funders to support an unrevealed but potentially important research direction, which can be a common issue for most scientists.

You have published over 10 papers with Chemical Science since your first publication with us in 2015. Of these papers, which one do you feel has made the most significant contribution to your area of research and why?

One of the pieces that I like the most is a paper that we published in 2019 – hydroxyl-mediated ethanol selectivity of CO2 hydrogenation. In this paper, we developed a catalyst based on Rh, where we simply added some Fe and Li metals as promoters. One interesting thing we found was that, with various oxide supports, we can tune the surface coverage of hydroxyl groups bound on Rh-based catalysts, which has a very important correlation with ethanol selectivity for CO2 hydrogenation. I believe that this story will provide researchers with a deeper understanding of the formation mechanism of ethanol on this kind of catalyst, particularly in understanding the C-C coupling mechanism for this reaction, which is very important if we want to have a high C2 selectivity.

It’s been over a year after China’s first lockdown started. What changes have you witnessed in the Chinese researcher community? Do you think there are any new challenges or opportunities for chemistry researchers from this ongoing global pandemic?

This is a very good question! Last spring, early in the pandemic, many online seminars were arranged by researchers from all over the world and involved various publishers, which was great for scientific communication. In terms of academic activities, I noticed that there weren’t any big delays in the publication process, which again was great. Since last fall, the situation in China has become much better, with most academic meetings now being able to take place on-site.

One noticeable opportunity from the overall research strategy in China is the focus on health. Funding agencies will now put even more emphasis on bio-relevant research. I think there will be a big boom in this area in China in the next few decades. Globally, I believe we will see lots of joint projects taking place between research groups that work in chemical engineering, chemistry, materials and medicine, which will promote multidisciplinary collaboration.

Why do you feel that researchers should choose to publish their work in Chemical Science

Chemical Science, as flagship journal of the Royal Society of Chemistry, has a prestigious reputation in the chemistry and physical science community. Chemical Science publishes cutting-edge papers that provide deep and novel understanding of the chemistry of important reactions. Multidisciplinary research, including radical physical chemistry, is also welcome. For example, AI methods used to screen candidate materials or analyse chemical reactions can be attractive. This kind of research, in turn, will reward the scientific community. Chemical Science, as an open-access journal, provides a highly fair publishing platform, and the Editorial Office is also very efficient – manuscripts are turned around in a very timely manner. It is one of best journals publishing chemical research.

What attracted you to join the Editorial Board of Chemical Science?

I have served on the Advisory Board for Chemical Science since 2013, and I am also a regular referee for the journal. Now, I feel that I am very fortunate to have the opportunity to handle submissions to Chemical Science, particularly in the area of heterogeneous catalysis. Chemical Science has a high-profile impact on the scientific community, which provides me with the opportunity to handle exciting scientific research, communicate with diverse groups of scientists, and most importantly, serve the research community. Together with the warm editorial team, we can provide authors with a professional publication experience.

It is important for Chemical Science to have an open and inclusive Editorial Board. Do you feel that we are achieving this goal?

I received a lot of warm greetings when May introduced me to the other members of the Editorial Board. Looking at the profiles of our members in the editorial team, we have great diversity among the board, including Associate Editors from all over the world, with expertise spanning across the chemical sciences. So far, I think we are achieving the goal. They are all renowned scientists.

What impact do you feel that your area of research can make over the next 10 years?

First of all, I would like to highlight the impact that I feel light alkane dehydrogenation can make in the next 10 years. This is a major industrial process to produce ethylene/propylene, which are building blocks for preparing polymers. The development of new technology as well as catalytic materials will further decrease the energy consumption during this process, and also increase the catalytic efficiency overall. This can help to ensure a better and greener industrial process in the future.

My second area of research focuses on the photocatalytic reduction of CO2. It’s very important for us to transform from a fossil fuel society into a renewable energy society. Energy conversion and storage technologies will play critical roles in this area. In the next 10-20 years, I think this type of research will definitely have more impact. There has already been a lot of investment into the research as well as infrastructure to support this initiative, so I hope that this goal will be able to be realised.

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Chemical Science HOT Articles: April 2021

New month, new HOT articles!

We are pleased to share a selection of our referee-recommended HOT articles for April 2021. We hope you enjoy reading these articles, congratulations to all the authors whose articles are featured! As always, Chemical Science is free to read & download.

You can explore our full 2021 Chemical Science HOT Article Collection here!

 

Browse a selection of our April HOT articles below:

Reaction-based machine learning representations for predicting the enantioselectivity of organocatalysts
Simone Gallarati, Raimon Fabregat, Rubén Laplaza, Sinjini Bhattacharjee, Matthew D. Wodrich and Clemence Corminboeuf
Chem. Sci., 2021, Advance Article

Deaminative meta-C–H alkylation by ruthenium(ii) catalysis
Wen Wei, Hao Yu, Agnese Zangarelli and Lutz Ackermann
Chem. Sci., 2021, Advance Article

Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies
Jiahui Chen, Kaifu Gao, Rui Wang and Guo-Wei Wei
Chem. Sci., 2021, Advance Article

Recent advances in single atom catalysts for the electrochemical carbon dioxide reduction reaction
Jincheng Zhang, Weizheng Cai, Fang Xin Hu, Hongbin Yang and Bin Liu
Chem. Sci., 2021, Advance Article

Wavy graphene sheets from electrochemical sewing of corannulene
Carlo Bruno, Eleonora Ussano, Gianni Barucca, Davide Vanossi, Giovanni Valenti, Edward A. Jackson, Andrea Goldoni, Lucio Litti, Simona Fermani, Luca Pasquali, Moreno Meneghetti, Claudio Fontanesi, Lawrence T. Scott, Francesco Paolucci and Massimo Marcaccio
Chem. Sci., 2021, Advance Article

Oxidative additions of alkynyl/vinyl iodides to gold and gold-catalyzed vinylation reactions triggered by the MeDalphos ligand
Jessica Rodriguez, Alexis Tabey, Sonia Mallet-Ladeira and Didier Bourissou
Chem. Sci., 2021, Advance Article

 

Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Chemical Science welcomes new Associate Editor Hemamala Karunadasa

We wish a very warm welcome to our new Chemical Science Associate Editor Hemamala Karunadasa!

Hemamala Karunadasa Chemical Science Associate Editor

 

Hemamala Karunadasa is an Associate Professor of Chemistry at Stanford University and a Faculty Scientist at the SLAC National Lab. Her group is invested in gaining synthetic control over extended ionic solids, with a focus on halide perovskites. They seek to both improve technologically important materials as well as to design new materials with unprecedented properties.

Hemamala was born in Sri Lanka and attended school in Colombo. She studied solid-state chemistry at Princeton University, receiving her A.B. in 2003. She moved to molecular inorganic chemistry for my Ph.D., which she received from UC Berkeley in 2009, and for her postdoctoral studies at the Lawrence Berkeley National Lab and at the California Institute of Technology.

As an associate editor, Hemamala looks forward to receiving papers that provide fundamental insights into obtaining desirable properties from new materials.

 

Browse a selection of Hemamala’s work below:

Dimensional reduction of the small-bandgap double perovskite Cs2AgTlBr6
Bridget A. Connor, Raisa-Ioana Biega, Linn Leppert and Hemamala I. Karunadasa
Chem. Sci., 2020, 11, 7708-7715
DOI: 10.1039/D0SC01580F, Edge Article

A pencil-and-paper method for elucidating halide double perovskite band structures
Adam H. Slavney, Bridget A. Connor, Linn Leppert and Hemamala I. Karunadasa
Chem. Sci., 2019, 10, 11041-11053
DOI: 10.1039/C9SC03219C, Edge Article

Tuning the bandgap of Cs2AgBiBr6 through dilute tin alloying
Kurt P. Lindquist, Stephanie A. Mack, Adam H. Slavney, Linn Leppert, Aryeh Gold-Parker, Jonathan F. Stebbins, Alberto Salleo, Michael F. Toney, Jeffrey B. Neaton and Hemamala I. Karunadasa
Chem. Sci., 2019, 10, 10620-10628
DOI: 10.1039/C9SC02581B, Edge Article

Structural origins of broadband emission from layered Pb–Br hybrid perovskites
Matthew D. Smith, Adam Jaffe, Emma R. Dohner, Aaron M. Lindenberg and Hemamala I. Karunadasa
Chem. Sci., 2017, 8, 4497-4504
DOI: 10.1039/C7SC01590A, Edge Article

 

Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)