Chemical Science HOT Articles: August 2021

New month, new HOT articles!

We are pleased to share a selection of our referee-recommended HOT articles for August 2021. We hope you enjoy reading these articles, congratulations to all the authors whose articles are featured! As always, Chemical Science is free to read & download.

You can explore our full 2021 Chemical Science HOT Article Collection here!

Browse a selection of our August HOT articles below:

Nickel-catalyzed reductive coupling of unactivated alkyl bromides and aliphatic aldehydes
Cole L. Cruz and John Montgomery
Chem. Sci., 2021, Advance Article

Single-crystal-to-single-crystal synthesis of a pseudostarch via topochemical azide–alkyne cycloaddition polymerization
Arthi Ravi, Amina Shijad and Kana M. Sureshan
Chem. Sci., 2021, Advance Article

Catalytic enantioselective synthesis of 1,4-dihydropyridines via the addition of C(1)-ammonium enolates to pyridinium salts
Calum McLaughlin, Jacqueline Bitai, Lydia J. Barber, Alexandra M. Z. Slawin and Andrew D. Smith
Chem. Sci., 2021, Advance Article

Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo
Hemma Schueffl, Sarah Theiner, Gerrit Hermann, Josef Mayr, Philipp Fronik, Diana Groza, Sushilla van Schonhooven, Luis Galvez, Nadine S. Sommerfeld, Arno Schintlmeister, Siegfried Reipert, Michael Wagner, Robert M. Mader, Gunda Koellensperger, Bernhard K. Keppler, Walter Berger, Christian R. Kowol, Anton Legin and Petra Heffeter
Chem. Sci., 2021, Advance Article

Two-step anti-cooperative self-assembly process into defined π-stacked dye oligomers: insights into aggregation-induced enhanced emission
Yvonne Vonhausen, Andreas Lohr, Matthias Stolte and Frank Würthner
Chem. Sci., 2021, Advance Article

β-Trioxopyrrocorphins: pyrrocorphins of graded aromaticity
Nivedita Chaudhri, Matthew J. Guberman-Pfeffer, Ruoshi Li, Matthias Zeller and Christian Brückner
Chem. Sci., 2021, Advance Article

 

Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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Introducing our Chemical Science Reviewer Spotlight!

At Chemical Science, we recognize the many and varied contributions our reviewer community make to the high quality of the research published in the journal. To further thank and recognise the support from our excellent community, we are delighted to introduce our new Reviewer Spotlight feature. Each month we will highlight reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Sangwoon Yoon, Athina Anastasaki, Jeremiah Gassensmith and Yun Chen. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Sangwoon Yoon

 

 

 

 

 

 

 

Sangwoon Yoon, Chung-Ang University, South Korea. Sangwoon’s work involves the controlled assembly of gold and silver nanoparticles and the study of their plasmonic properties.
Athina Anastasaki

 

 

 

 

 

 

 

Athina Anastasaki, ETH Zürich, Switzerland. Athina’s research focuses on controlled radical polymerisation for the synthesis of polymers with enhanced properties and functions.
Jeremiah Gassensmith

 

 

 

 

 

 

 

Jeremiah Gassensmith, The University of Texas at Dallas, USA. Jeremiah studies solid state materials, like MOFs and molecular crystals, and biomaterials, such as viruses, and their interface.
Yun Chen

 

 

 

 

 

 

 

 

Yun Chen, Nanjing Medical University, China. Yun’s research is focused on the development of mass spectrometry-based chemical mapping and quantification assays towards the molecular understanding of disease.

 

 

 

What encouraged you to review for Chemical Science?

Sangwoon Yoon: Reviewing is just a part of my service to the community. It is also a way of communicating with other scientists. I always try to help improve the quality of manuscripts through the review process.

Jeremiah Gassensmith: I usually review papers that I would read anyway and so it’s not very surprising that the papers at Chemical Science would be at the interdisciplinary interface that I enjoy.

What do you enjoy most about reviewing?

Athina Anastasaki: What I enjoy the most when reviewing is the unique feeling that I am the very first person who reads this exciting piece of science. And this is both an honour and a responsibility.

Yun Chen: By reviewing, I can have a chance to get in touch with the advanced level of research in the world.

What are you looking for in a paper that you can recommend for acceptance in Chemical Science?

Sangwoon Yoon: I look at all aspects – whether conclusions are supported by data, whether data are properly interpreted, whether data were acquired using the right methods, whether citations are impartially given, etc.

What makes a paper truly stand out for you when reviewing a paper?

Athina Anastasaki: Cool science is always the most important thing that stands out and this can be better illustrated through good quality and self-explanatory figures.

Do you have any advice to our readers seeking publication in Chemical Science on what makes a good paper?

Jeremiah Gassensmith: Writing papers and cooking food share an open secret—people eat first with their eyes. The figures must tell the story and it is worth every second of your time to get them polished to high art. Good scientists turn good science into art with Adobe Illustrator…the bad ones turn nonsense into science with Photoshop. Learn the difference!

What single piece of advice would you give to someone about to write their first review?

Athina Anastasaki: Treat the authors the way you would like to be treated. As reviewers our job is not to reject papers; this is the editor’s job. Even if the paper will be eventually rejected, our job is to improve it by being respectful and providing constructive feedback.

Did reviewing for Chemical Science affect how you approached preparation of your recent publication with us?

Yun Chen: Yes, absolutely. Reviewing other papers reminds me not to make similar mistakes.

How do you balance reviewing with your other activities?

Jeremiah Gassensmith: Precariously…

 

Tune in next month to meet our next group of #ChemSciReviewers!

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Send us your CV and a completed Reviewer Application Form to becomeareviewer@rsc.org.

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Chemical Science welcomes new Associate Editor Tanja Junkers

We wish a very warm welcome to our new Chemical Science Associate Editor Tanja Junkers!

Tanja Junkers Chemcial Science Associate Editor

 

We are pleased to welcome Professor Tanja Junkers to the Chemical Science Editorial Board this month as a new Associate Editor for the journal. She has joined us from Polymer Chemistry where she remains as an Editorial Board member and will continue to serve as an Associate Editor and handle papers until the end of the year.

Tanja studied chemistry and graduated with a PhD in physical chemistry from Göttingen University, Germany, in 2006 and subsequently worked at the University of New South Wales, Sydney, at the Centre for Advanced Macromolecular Design as research associate. In 2008 she moved to the Karlsruhe Institute of Technology in Germany. In early 2010 she was appointed professor at Hasselt University, Belgium, where she founded the Polymer Reaction Design research group within the Institute for Materials Research. In January 2018 she moved back to Australia where she became full professor at Monash University in Melbourne, and since then continues activities there. She remains guest professor at Hasselt University and her group is currently active at both locations. Her main research interests are precision polymer synthesis, use of continuous flow chemistry approaches, light-induced chemistries, polymer surface modification and investigations on kinetics and mechanisms of radical reactions.

Tanja is currently a Guest Editor for a themed collection on Sustainable Polymers which you can explore here.

Browse a selection of Tanja’s work below:

A machine-readable online database for rate coefficients in radical polymerization
Joren Van Herck, Simon Harrisson, Robin A. Hutchinson, Gregory T. Russell and Tanja Junkers
Polym. Chem., 2021, 12, 3688-3692

Muconic acid isomers as platform chemicals and monomers in the biobased economy
Ibrahim Khalil, Greg Quintens, Tanja Junkers and Michiel Dusselier
Green Chem., 2020, 22, 1517-1541

Simple and secure data encryption via molecular weight distribution fingerprints
Jeroen H. Vrijsen, Maarten Rubens and Tanja Junkers
Polym. Chem., 2020, 11, 6463-6470

Direct synthesis of acrylate monomers in heterogeneous continuous flow processes
Jatuporn Salaklang, Veronique Maes, Matthias Conradi, Rudy Dams and Tanja Junkers
React. Chem. Eng., 2018, 3, 41-47

 

Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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Chemical Science HOT Articles: July 2021

New month, new HOT articles!

We are pleased to share a selection of our referee-recommended HOT articles for July 2021. We hope you enjoy reading these articles, congratulations to all the authors whose articles are featured! As always, Chemical Science is free to read & download.

You can explore our full 2021 Chemical Science HOT Article Collection here!

Browse a selection of our July HOT articles below:

Physically inspired deep learning of molecular excitations and photoemission spectra
Julia Westermayr and Reinhard J. Maurer
Chem. Sci., 2021, Advance Article

Synthesis and enantioseparation of chiral Au13 nanoclusters protected by bis-N-heterocyclic carbene ligands
Hong Yi, Kimberly M. Osten, Tetyana I. Levchenko, Alex J. Veinot, Yoshitaka Aramaki, Takashi Ooi, Masakazu Nambo and Cathleen M. Crudden
Chem. Sci., 2021, Advance Article

A copper-free and enzyme-free click chemistry-mediated single quantum dot nanosensor for accurate detection of microRNAs in cancer cells and tissues
Zi-yue Wang, Dong-ling Li, Xiaorui Tian and Chun-yang Zhang
Chem. Sci., 2021, Advance Article

Azanone (HNO): generation, stabilization and detection
Cecilia Mariel Gallego, Agostina Mazzeo, Paola Vargas, Sebastián Suárez, Juan Pellegrino and Fabio Doctorovich
Chem. Sci., 2021, Advance Article

Coumarin luciferins and mutant luciferases for robust multi-component bioluminescence imaging
Zi Yao, Donald R. Caldwell, Anna C. Love, Bethany Kolbaba-Kartchner, Jeremy H. Mills, Martin J. Schnermann and Jennifer A. Prescher
Chem. Sci., 2021, Advance Article

Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles
Sebastian Dengler, Pradeep K. Mandal, Lars Allmendinger, Céline Douat and Ivan Huc
Chem. Sci., 2021, Advance Article

Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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Watch out for artifacts in your next multi-colour fluorescence imaging experiment

The discovery of super resolution microscopy, followed by the announcement of 2014 Chemistry Nobel prize, facilitated a great expansion in the use of multi colour fluorescence imaging to study cellular or sub-cellular systems. Super resolution localization microscopy requires highly photostable, sufficiently bright fluorophores to achieve the blinking which is necessary to distinguish individual fluorophores within the diffraction limit. To validate all these criteria, organic dyes are a most obvious choice as fluorophores. However, chemical conversion of organic dyes upon prolonged laser exposure exhibit multicolour image artifacts leading to false-positive colocalization. Researchers from Pohang University, South Korea demonstrate a detailed protocol to understand and avoid such artifacts.

The researchers labelled cell membrane using far-IR dye (A647) which shows a red photoluminescence. But surprisingly, upon photobleaching of the A647 dye, which is blue in colour, it turned to red. This photobleached product also emits at red region, coinciding with the original emission of A647. This phenomenon is called blue-conversion. A range of commonly used organic dyes are evaluated for blue-conversion occurrences which indicates cyanine dyes show multiple blue-converted species. Interestingly, among all the dye groups there is not a single group that exhibit no blue-conversion at all.

Blue-conversion of far-red organic dyes upon photobleaching. A647 dissolved in DMSO before (left) and after (right) photobleaching using direct laser illumination. (a) TIRF images of A647-EGFR on COS7 cells in the far-red (upper panels) channel excited at 642 nm and the red (lower panels) channel excited at 561 nm before (left panels) and after (right panels) photobleaching of A647-EGFR.

The researchers also study multicolour fluorescence imaging by colocalization of two well-known dyes. They have observed that the single-molecule brightness of the blue-converted species contributed to the production of the artifact in the reconstructed images. Finally, they concluded sufficient care must be taken in multicolour imaging applications, including colocalization, and other fluorescence-based multi-well plate format assays, to prevent false positives produced by blue-conversion of organic dyes.

Although they primarily discussed the negative effect of the blue-conversion of organic dyes, they are also hopeful to use this new photoconversion pathway of cyanine dyes for advantages of fluorescence imaging applications. They propose that super-resolution techniques require the photoactivation of organic dyes, which might exert some undesirable effects in live cells. However, the photoactivation of the blue-converted species occurs without any external stimuli and can be inferred as an advantage for super resolution techniques.

For details please read: https://doi.org/10.1039/D1SC00612F

About the blogger:

Dr. Damayanti Bagchi is a postdoctoral researcher in Irene Chen’s lab at University of California, Los Angeles, United States. She has obtained her PhD in Physical Chemistry from Satyendra Nath Bose National Centre for Basic Sciences, India. Her research is focused on spectroscopic studies of nano-biomaterials. She is interested in exploring light enabled therapeutics. She enjoys travelling and experimenting with various cuisines.

You can find her on Twitter at @DamayantiBagchi.

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Chemical Science HOT Articles: June 2021

New month, new HOT articles!

We are pleased to share a selection of our referee-recommended HOT articles for June 2021. We hope you enjoy reading these articles, congratulations to all the authors whose articles are featured! As always, Chemical Science is free to read & download.

You can explore our full 2021 Chemical Science HOT Article Collection here!

Browse a selection of our June HOT articles below:

[GaF(H2O)][IO3F]: a promising NLO material obtained by anisotropic polycation substitution
Qian-Ming Huang, Chun-Li Hu, Bing-Ping Yang, Zhi Fang, Yuan Lin, Jin Chen, Bing-Xuan Li and Jiang-Gao Mao
Chem. Sci., 2021, Advance Article

Photocleavable proteins that undergo fast and efficient dissociation
Xiaocen Lu, Yurong Wen, Shuce Zhang, Wei Zhang, Yilun Chen, Yi Shen, M. Joanne Lemieux and Robert E. Campbell
Chem. Sci., 2021, Advance Article

Electrochemically switchable polymerization from surface-anchored molecular catalysts
Miao Qi, Haochuan Zhang, Qi Dong, Jingyi Li, Rebecca A. Musgrave, Yanyan Zhao, Nicholas Dulock, Dunwei Wang and Jeffery A. Byers
Chem. Sci., 2021, Advance Article

Flow electrochemistry: a safe tool for fluorine chemistry
Bethan Winterson, Tim Rennigholtz and Thomas Wirth
Chem. Sci., 2021, Advance Article

Biomimetic enterobactin analogue mediates iron-uptake and cargo transport into E. coli and P. aeruginosa
Robert Zscherp, Janetta Coetzee, Johannes Vornweg, Jörg Grunenberg, Jennifer Herrmann, Rolf Müller and Philipp Klahn
Chem. Sci., 2021, Advance Article

Sensitization-initiated electron transfer via upconversion: mechanism and photocatalytic applications
Felix Glaser, Christoph Kerzig and Oliver S. Wenger
Chem. Sci., 2021, Advance Article
Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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Reflecting on #RSCPoster 2021

RSCPoster

#RSCPoster is a global Twitter Poster Conference, held entirely online over the course of 24 hours. The event brings together the global chemistry community to network with colleagues across the world and at every career stage, share their research and engage in scientific debate.

The 2021 #RSCPoster Twitter Conference was held on 2 March, and brought together 5,500 attendees with almost 900 presenters from 62 countries sharing their science to a potential audience of over 41 million.

 

Yi-Tao Long, Chemcial ScienceChemical Science Associate Editor Yi-Tao Long was subject chair for #RSCAnalytical – we caught up with him to get his thoughts on the event and some advice for next year.

“This is the first time I joined this #RSCPoster event and found it really impressive. It is a very good opportunity for early career researchers and graduate students to present their work” noted Yi-Tao.

“As an Associate Editor, I think the presentation and storyline are so important for a scientific paper. Of course, science is the most important, but being interesting and appealing to a broad community is also vital” explains Yi-Tao. This advice holds true for #RSCPoster too. Yi-Tao advises, “be clear and readable when presenting the work, this makes it easier for others to be interested, especially researchers in other fields.”

This year’s #RSCAnalytical prize winner, @kellybrown_94, is a great example of this point, as Yi-Tao mentions, “this poster caught my eye at first glance”.

 

Check out the full list of winners – CLICK HERE

This year we also saw the introduction of #RSCPosterPitch – short videos from our poster presenters bringing their research to life in creative ways. The entries in this new category were impressive, check out the winning #RSCPosterPitch from @alanqf22 for inspiration!

https://twitter.com/alanqf22/status/1366721199858933770

 

And why not enter next year?

Look out for more information on the 2022 #RSCPoster Twitter Conference – coming soon!

  • no registration fees
  • participate from anywhere with Twitter access
  • meet researchers from all over the world, at every career stage
  • spend as little or as much time attending as you like
  • cash and community prizes for the best posters as judged by our excellent Committees
  • community prize for the best #RSCPosterPitch as selected by our General Committee

Thank you to all participants and judges and hope to see you next year!

With thanks to our sponsoring RSC Interest Groups & journals:

Separation Science GroupEnvironmental Chemistry Group | Molecular Spectroscopy Group | Porous Materials Group | Analyst | Analytical Methods | Biomaterials Science | Catalysis Science and Technology | ChemComm  | Chemical Science | Chemistry Education Research and Practice | Chem Soc Rev | CrystEngComm | Dalton Transactions | Energy & Environmental Science | Environmental Science: Atmospheres | Environmental Science: Nano | Environmental Science: Processes and Impacts | Environmental Science: Water Research & Technology | Faraday Discussions | Food & Function | Green Chemistry | JAAS | Journal of Materials Chemistry A | Journal of Materials Chemistry B | Journal of Materials Chemistry C | Lab on a Chip | Materials Advances | Materials Horizons | Molecular Omics | MSDE | Nanoscale | Nanoscale Advances | Nanoscale Horizons | Natural Product Reports | NJC | Organic & Biomolecular Chemistry | PCCP | Polymer Chemistry | Reaction Chemistry & Engineering | RSC Advances | RSC Chemical Biology | RSC Medicinal Chemistry |Soft Matter | Sustainable Energy & Fuels

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Associate Editor highlight – interview with Professor Subi George

Professor Subi George joined the Chemical Science Editorial Board in 2020. To celebrate this occasion, we met virtually with Subi to discuss his research highlights and what attracted him to join the Chemical Science team.

Subi’s research focuses on the synthesis of small molecules and the study of molecular self-assembly processes. His group use supramolecular approaches to develop bioinspired and adaptive materials, including dynamic supramolecular polymers and optoelectronic materials.

What would you say is your biggest motivation?

I would say my interactions with passionate and creative young researchers. This interaction motivates and encourages me. I am also highly motivated when we are able to come up with new discoveries and are able to publish our exciting findings in high impact journals. As scientists, we are lucky – we never stop learning, and we have the academic freedom of trying new things every day. This provides new opportunities to bring about change and explore solutions to a whole range of problems. These are my biggest motivations to push forward with my research.

What has been the most challenging moment of your career so far?

I would say that I have two moments, one in my earlier career and one later. The point when I decided to pursue chemistry as a career was quite a challenging moment. In India, this kind of decision previously attracted a lot of criticism, because it was believed that there were no job opportunities if you decided to pursue science as a career. Medicine and engineering were always seen as being more promising careers. It was therefore difficult at times to convince my family that a career in chemistry was a good decision. Luckily, I did have support from my close family, so that was a real blessing.

Secondly, I feel that it can be quite challenging when you develop your own independent group. It can be quite difficult to establish and differentiate yourself, and to ensure that you create a strong, internationally recognised group.

In your area of research, what do you feel has been the most revolutionary piece of work within the past 5 years?

The particular class of materials that we have been working on are based on supramolecular polymers, which are dynamic systems. This field has been active over the past two decades, from which we have gained a high level of mechanistic understanding. Over the past five years, significant progress has been made and elegant design strategies have been developed, which have allowed a high level of structural control. We have also witnessed a push in the limit of self-assembly from equilibrium to being out of equilibrium, towards the preparation of biomimetic, adaptive materials. We have been working in this particular field. We recognised that synergy between structural and temporal control would be the most suitable way to prepare biomimetic materials, so we came up with a strategy called bioinspired temporal supramolecular polymerisation. Overall, the past 5 years have therefore seen an increase in our understanding of these systems, and in tools and strategies to assist in the preparation of optimised biomimetic supramolecular polymers.

It’s been over a year since the outbreak of the global pandemic. What changes have you witnessed in the local researcher community? Do you think there are any new challenges or opportunities for chemistry researchers from this ongoing pandemic?

The pandemic has hit every sector, and the scientific community has not been spared. We were required to switch to working online for group meetings and teaching, which was quite difficult. The pandemic has also resulted in a lack of exposure for students, who haven’t been able to attend things such as international conferences, and for those in their final years who were hoping to seek research opportunities abroad. Again, this is such an important experience, so it has definitely been challenging for the community and made it even more important to keep up the motivation of my students.

Looking to the brighter side of things, the pandemic has forced us to slow down and take a step back. We have had the time to consult the literature and to carefully plan what we would like to achieve in the future. The pandemic has therefore definitely provided opportunities.

This is also an important time where the public is looking to the scientific community with a lot of expectations. Many researchers in India have worked to contribute towards COVID-related research to combat the disease, including breakthroughs in diagnostic tools, vaccines, or even the development of PPE equipment. It has given us the chance to think about our responsibilities and what our commitment is to society.

Which of your Chemical Science publications are you most proud of and why?

I would have to say that I love them all. We always ensure that we publish unique and high-quality research. However, if I had to pick one piece, it would be a contribution from 2017. This demonstrated chemically-fuelled temporal switching of an amphillic self-assembly system. We introduced the use of redox fuels for the preparation of these materials that are away from equilibrium. This is a concept that people are starting to utilise.

Chemical Science is the flagship journal of the Royal Society of Chemistry. What aspects of the journal do you feel contribute to us being the flagship?

Chemical Science is a place where you can publish high quality, high impact, multidisciplinary chemistry. It is one of the few high impact science journals that is diamond open access, meaning that content in the journal is free to read and free to publish. This is incredibly important for the whole research community, but especially for researchers in India because it is not always possible to pay the high article processing charges that are charged by other high impact journals. This is very unique, and contributes to Chemical Science being the flagship. In India, unlike places in Europe, we don’t have a dedicated budget or grants that can be used for open access publications. This is going to be a big challenge for India as we move towards an open publishing platform. At this time, if a journal is not diamond open access, or does not have significant waiver policies, researchers in India will struggle to publish in journals with high article-processing charges.

Another highlight of Chemical Science is the Edge Article format that researchers can use when publishing their primary research. This was so unique when it was introduced. Communication-style articles can be too restrictive, so the Edge Article format helps researchers to be able to communicate their research in as much or as little detail as is required, and allows for a much smoother reading process than having lots of information that has to be put in the supplementary information section. The Edge Article format allows science to be discussed in depth.

What attracted you to join the Editorial Board for Chemical Science?

I feel that I can help to popularise Chemical Science in India, and help to promote the journal to our authors there. Being an Associate Editor of a high-impact journal like Chemical Science provides the opportunity to learn about lots of different research areas first-hand, and I am able to learn more about the latest developments in science through this role, which is great. I’m very happy to be on the board, and to help to contribute to the growth of the journal to continue to make it one of the most exciting and high impact chemistry journals.

How do you see your field progressing in the next 10 years?

Research on supramolecular polymers shows a lot of promise I feel. Given the previous work in this field, we are in a position to access a higher level of complex structures and address further challenges that are still faced when preparing these systems. I think we’ll start to be able to produce more complex, self-organised systems. I am confident that we will be able to make much-enhanced adaptive and multicomponent biomimetic systems in this area soon.

In celebration of joining the Chemical Science team, Subi has highlighted a selection of important contributions from the past few years, with a focus on recent trends in supramolecular polymers, dissipative systems and organic materials. The collection can be viewed here.

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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Chemical Science HOT Articles: May 2021

New month, new HOT articles!

We are pleased to share a selection of our referee-recommended HOT articles for May 2021. We hope you enjoy reading these articles, congratulations to all the authors whose articles are featured! As always, Chemical Science is free to read & download.

You can explore our full 2021 Chemical Science HOT Article Collection here!

Browse a selection of our May HOT articles below:

Aromatic side-chain flips orchestrate the conformational sampling of functional loops in human histone deacetylase 8
Vaibhav Kumar Shukla, Lucas Siemons, Francesco L. Gervasio and D. Flemming Hansen
Chem. Sci., 2021, Advance Article

Blue-conversion of organic dyes produces artifacts in multicolor fluorescence imaging
Do-Hyeon Kim, Yeonho Chang, Soyeon Park, Min Gyu Jeong, Yonghoon Kwon, Kai Zhou, Jungeun Noh, Yun-Kyu Choi, Triet Minh Hong, Young-Tae Chang and Sung Ho Ryu
Chem. Sci., 2021, Advance Article

Controllable DNA strand displacement by independent metal–ligand complexation
Liang-Liang Wang, Qiu-Long Zhang, Yang Wang, Yan Liu, Jiao Lin, Fan Xie and Liang Xu
Chem. Sci., 2021, Advance Article

Spatial-confinement induced electroreduction of CO and CO2 to diols on densely-arrayed Cu nanopyramids
Ling Chen, Cheng Tang, Kenneth Davey, Yao Zheng, Yan Jiao and Shi-Zhang Qiao
Chem. Sci., 2021, Advance Article

Manipulating valence and core electronic excitations of a transition-metal complex using UV/Vis and X-ray cavities
Bing Gu, Stefano M. Cavaletto, Daniel R. Nascimento, Munira Khalil, Niranjan Govind and Shaul Mukamel
Chem. Sci., 2021, Advance Article

Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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Chemical domain image recognition using autocatalysis

A reaction in which one of the products speeds up further product formation is called an autocatalytic reaction. Autocatalysis plays an important role in living systems including DNA replication, apoptosis, and even in the origin of life, due to self-sustaining growth and oscillation. Researchers from Brown University employ this nature of autocatalytic click chemistry to generate an artificial neural network that can be used for image classification.

Autocatalytic reaction rate depends on the concentration of product and shows a non-linear dependency of product formation with progress in reaction time. In this view, a network of autocatalytic reactions is analogous to an artificial neural network. An artificial neuron is a basic learning unit, inspired by biological neurons, which multiplies it’s inputs by a set of weights and transforms their sum through a nonlinear operator. Researchers used this resemblance to formulate a winner-take-all neural network.

Fig 1: Kinetics of autocatalysis. (a) Reagent and autocatalytic product evolution over time (b) Rate of product concentration change over time for the reaction simulated in a, showing the accelerated production typical of an autocatalytic process.

Copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction was chosen for autocatalysis as it is fast, can occur under mild conditions and produce high yield. Also, CuAAC reaction involves colored copper–ligand complexes and can be quantitatively monitored using UV-vis spectroscopy.

In a winner-take-all neural network, winner is determined by it’s achievement to reach to a particular condition. Here, they have used the reaction half-way point (t1/2) as the condition of image classification. Experiment wise, they have used automated liquid handling equipment to remove a certain volume and then added it together into individual pools for potential image class. The pool that reaches the transition time first is determined as the winner.

Fig 2: An overview of the copper (C) catalyzed azide–alkyne cycloaddition reaction, showing the buildup of triazole branches on the amine backbone of (A) after each azide (B) incorporation. The threebranched product (D) catalyzes its own generation by promoting the reduction of Cu(II). Experimental setup for evaluating a chemical WTA network (Right: upper panel). (Right lower panel) Network training and in silico simulation. (a) Example images from each of the considered classes. (b) Trained weights for each class.  

This study shows an interesting adaptation of autocatalysis as a platform for non-linear activation function necessary for artificial neural network classification. The findings are expected to improve future development of chemical-domain computing systems.

 

For further details, please go through:

Leveraging autocatalytic reactions for chemical domain image classification

Christopher E. Arcadia, Amanda Dombroski, Kady Oakley, Shui Ling Chen, Hokchhay Tann, Christopher Rose, Eunsuk Kim, Sherief Reda, Brenda M. Rubensteinb and Jacob K. Rosenstein*

Chem. Sci., 2021, 12, 5464

 

About the blogger

Dr Damayanti Bagchi is a postdoctoral researcher in Irene Chen’s lab at University of California, Los Angeles, United States. She has obtained her PhD in Physical Chemistry from Satyendra Nath Bose National Centre for Basic Sciences, India. Her research is focused on spectroscopic studies of nano-biomaterials. She is interested in exploring light enabled therapeutics. She enjoys travelling and experimenting with various cuisines, which she found resembles with products/ side products of chemical reactions!

You can find her on Twitter at @DamayantiBagchi.

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