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Top 25 Chemical Science articles July–September 2015

29 Oct 2015

The 25 most-downloaded Chemical Science articles in the third quarter of 2015 were as follows:

Sulfonyl fluorides as privileged warheads in chemical biology
Arjun Narayanan and Lyn H. Jones
DOI: 10.1039/C5SC00408J Perspective

A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy
Victor Sans, Luzian Porwol, Vincenza Dragonea and Leroy Cronin
DOI: 10.1039/C4SC03075C Edge Article

Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp³)–H bonds
José A. Fernández-Salas, Enrico Marelli and Steven P. Nolan
DOI: 10.1039/C5SC01589H, Edge Article

Evaluating metal–organic frameworks for natural gas storage
Jarad A. Mason, Mike Veenstra and Jeffrey R. Long
DOI: 10.1039/C3SC52633J, Perspective

Macrocycles: lessons from the distant past, recent developments, and future directions
Andrei K. Yudin
DOI: 10.1039/C4SC03089C, Perspective

Reversible photo-induced trap formation in mixed-halide hybrid perovskites for photovoltaics
Eric T. Hoke, Daniel J. Slotcavage, Emma R. Dohner, Andrea R. Bowring, Hemamala I. Karunadasa and Michael D. McGehee
DOI: 10.1039/C4SC03141E, Edge Article

Impacts of gold nanoparticle charge and ligand type on surface binding and toxicity to Gram-negative and Gram-positive bacteria
Vivian Feng, Ian L. Gunsolus, Tian A. Qiu, Katie R. Hurley, Lyle H. Nyberg, Hilena Frew, Kyle P. Johnson, Ariane M. Vartanian, Lisa M. Jacob, Samuel E. Lohse, Marco D. Torelli, Robert J. Hamers, Catherine J. Murphy and Christy L. Haynes
DOI: 10.1039/C5SC00792E, Edge Article

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user’s guide
David S. Surry and Stephen L. Buchwald
DOI: 10.1039/C0SC00331J, Perspective

Rethinking the term “pi-stacking”
Chelsea R. Martinez and Brent L. Iverson
DOI: 10.1039/C2SC20045G, Perspective

Computational discovery and experimental verification of tyrosine kinase inhibitor pazopanib for the reversal of memory and cognitive deficits in rat model neurodegeneration
Yongliang Yang, Guohui Li, Dongyu Zhao, Haoyang Yu, Xiliang Zheng, Xiangda Peng, Xiaoe Zhang, Ting Fu, Xiaoqing Hu, Mingshan Niu, Xuefei Ji, Libo Zou and Jin Wang
DOI: 10.1039/C4SC03416C, Edge Article

Unified approach to prenylated indole alkaloids: total syntheses of (−)-17-hydroxy-citrinalin B, (+)-stephacidin A, and (+)-notoamide I
Eduardo V. Mercado-Marin and Richmond Sarpong
DOI: 10.1039/C5SC01977J, Edge Article

Computational design of molecules for an all-quinone redox flow battery
Süleyman Er, Changwon Suh, Michael P. Marshak and Alán Aspuru-Guzik
DOI: 10.1039/C4SC03030C, Edge Article

Molecular understandings on the activation of light hydrocarbons over heterogeneous catalysts
Zhi-Jian Zhao, Cheng-chau Chiu and Jinlong Gong
DOI: 10.1039/C5SC01227A, Perspective

Rh-catalyzed desymmetrization of α-quaternary centers by isomerization-hydroacylation
Jung-Woo Park, Kevin G. M. Kou, Daniel K. Kim and Vy M. Dong
DOI: 10.1039/C5SC01553G, Edge Article

A single crystalline porphyrinic titanium metal–organic framework
Shuai Yuan,Tian-Fu Liu,Dawei Feng,Jian Tian,Kecheng Wang,Junsheng Qin,Qiang Zhang, Ying-Pin Chen,Mathieu Bosch,Lanfang Zou,Simon J. Teat,Scott J. Dalgarno and Hong-Cai Zhou
DOI: 10.1039/C5SC00916B, Edge Article

Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery
Dali Wang, Chunlai Tu, Yue Su, Chuan Zhang, Udo Greiser, Xinyuan Zhu, Deyue Yan and Wenxin Wang
DOI: 10.1039/C5SC01188D, Edge Article

Near-infrared fluorescence activation probes based on disassembly-induced emission cyanine dye
Tai-Cheng Hou, Ying-Yi Wu, Po-Yi Chiang and Kui-Thong Tan
DOI: 10.1039/C5SC01330E, Edge Article

Thin metal nanostructures: synthesis, properties and applications
Zhanxi Fan, Xiao Huang, Chaoliang Tana and Hua Zhang
DOI: 10.1039/C4SC02571G, Minireview

Supramolecular hydrogel microcapsules via cucurbit[8]uril host–guest interactions with triggered and UV-controlled molecular permeability
Ziyi Yu, Jing Zhang, Roger J. Coulston, Richard M. Parker, Frank Biedermann, Xin Liu, Oren A. Scherman and Chris Abell
DOI: 10.1039/C5SC01440A, Edge Article

Bioinspired design of redox-active ligands for multielectron catalysis: effects of positioning pyrazine reservoirs on cobalt for electro- and photocatalytic generation of hydrogen from water
Jonah W. Jurss, Rony S. Khnayzer, Julien A. Panetier, Karim A. El Roz, Eva M. Nichols, Martin Head-Gordon, Jeffrey R. Long, Felix N. Castellano and Christopher J. Chang
DOI: 10.1039/C5SC01414J, Edge Article

Ligand-enabled Ir-catalyzed intermolecular diastereoselective and enantioselective allylic alkylation of 3-substituted indoles
Xiao Zhang, Wen-Bo Liu, Hang-Fei Tu and Shu-Li You
DOI: 10.1039/C5SC01772F, Edge Article

Boron chemistry in a new light
Guillaume Duret, Robert Quinlan, Philippe Bisseret and Nicolas Blanchard
DOI: 10.1039/C5SC02207J, Minireview

Porous ionic liquids: synthesis and application
Shiguo Zhang, Kaoru Dokko and Masayoshi Watanabe
DOI: 10.1039/C5SC01374G, Minireview

Chemical sensing in two dimensional porous covalent organic nanosheets
Gobinda Das, Bishnu P. Biswal, Sharath Kandambeth, V. Venkatesh, Gagandeep Kaur, Matthew Addicoat, Thomas Heine, Sandeep Verma and Rahul Banerjee
DOI: 10.1039/C5SC00512D, Edge Article

Carbon–hydrogen (C–H) bond activation at Pd^IV: a Frontier in C–H functionalization catalysis
Joseph J. Topczewski and Melanie S. Sanford
DOI: 10.1039/C4SC02591A, Minireview

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Hot Chemical Science articles for October

22 Oct 2015

Take a look at this selection of recently published referee-recommended articles – all are open access and free to download.

Connecting electrodes with light: one wire, many electrodes
Moinul H. Choudhury, Simone Ciampi, Ying Yang, Roya Tavallaie, Ying Zhu, Leila Zarei, Vinicius R. Gonçales and J. Justin Gooding
DOI: 10.1039/C5SC03011K, Edge Article

C5SC03011K GA

Linear scaling relationships and volcano plots in homogeneous catalysis – revisiting the Suzuki reaction
Michael Busch, Matthew D. Wodrich and Clémence Corminboeuf
DOI: 10.1039/C5SC02910D, Edge Article

C5SC02910D GA

IspH–RPS1 and IspH–UbiA: “Rosetta stone” proteins
Guodong Rao, Bing O’Dowd, Jikun Li, Ke Wang and Eric Oldfield
DOI: 10.1039/C5SC02600H, Edge Article

C5SC02600H GA

An optoelectronic nose for identification of explosives
Jon R. Askim, Zheng Li, Maria K. LaGasse, Jaqueline M. Rankin and Kenneth S. Suslick
DOI: 10.1039/C5SC02632F, Edge Article

C5SC02632F GA

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Subtle forces yield profound effects on heavy element bonding

08 Sep 2015

Using theoretical calculations, researchers in the US and Japan, have cast a spotlight on the vital role that subtle, and previously overlooked, dispersion forces play in stabilising p-block heavy element bonding.

It was once thought that heavy elements could not form multiple bonds, but landmark work by inorganic chemists such as Mike Lappert in the 1970s blew the doors off this notion and opened up a whole new world for main group chemistry. Since then, the study of heavier p-block elements with multiple bonds has remained a topic of broad interest and exciting discoveries. One key development was that sterically large ligands block decomposition and stabilise bonds. However, questions over how and why these compounds remain stable continue to be debated. Read the full article in Chemistry World»

Read the original journal article in Chemical Science – it’s open access:
The multiple bonding in heavier group 14 element alkene analogues is stabilized mainly by dispersion force effects
Jing-Dong Guo, David J. Liptrot, Shigeru Nagase and Philip P. Power
DOI: 10.1039/C5SC02707A, Edge Article

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Hypervalent bonding controversy out for the electron count?

07 Sep 2015

Durrant has proposed a simple but quantitative measure of hypervalency

A researcher in the UK has presented a controversial new definition for hypervalency that may ignite debates over atomic charge and allow students to draw nitrogen atoms with five covalent bonds.

Marcus Durrant from the University of Northumbria describes his account of hypervalency as going back to the drawing board. By bringing together electron counts on atoms in different resonance structures, he presents a valence electron equivalent parameter to indicate an overall number of electrons associated with each atom. A count greater than eight defines hypervalency. Read the full article in Chemistry World»

Read the original journal article in Chemical Science – it’s open access:
A quantitative definition of hypervalency
Marcus C. Durrant
DOI: 10.1039/C5SC02076J, Edge Article

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Hot Chemical Science articles for September

04 Sep 2015

Here are some of the latest referee-recommended articles published in Chemical Science – all are open access and free to read:

Design rationale of thermally responsive microgel particle films that reversibly absorb large amounts of CO2: fine tuning the pKa of ammonium ions in the particles
Mengchen Yue, Yu Hoshino and Yoshiko Miura
DOI: 10.1039/C5SC01978H, Edge Article

C5SC01978H GA

Singly and doubly ß-to-ß platinum-bridged porphyrin dimers and their reductive eliminations
Hua-Wei Jiang, Takayuki Tanaka and Atsuhiro Osuka
DOI: 10.1039/C5SC02553B, Edge Article

C5SC02553B GA

Fluorescent carbon dot–molecular salt hydrogels
Angelina Cayuela, Stuart R. Kennedy, M. Laura Soriano, Christopher D. Jones, Miguel Valcárcel and Jonathan W. Steed
DOI: 10.1039/C5SC01859E, Edge Article

C5SC01859E GA

Molecular computing: paths to chemical Turing machines
Shaji Varghese, Johannes A. A. W. Elemans, Alan E. Rowan and Roeland J. M. Nolte
DOI: 10.1039/C5SC02317C, Perspective

C5SC02317C GA

Lab on a single microbead: an ultrasensitive detection strategy enabling microRNA analysis at the single-molecule level
Xiaobo Zhang, Chenghui Liu, Lingbo Sun, Xinrui Duan and Zhengping Li
DOI: 10.1039/C5SC02641E, Edge Article

C5SC02641E GA

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Individual microRNA molecules detected with a single microbead

02 Sep 2015

An elegant strategy for detecting minuscule quantities of microRNA using just a single functionalised microbead could be an important innovation for biomedical research and molecular diagnostics.

Identifying biomolecules with vanishingly small copy numbers in cells is vital in deciphering the chemical blueprint for life. Homogeneous exponential amplification methods (such as the polymerase chain reaction), northern blotting, microarray detection and the isothermal exponential amplification reaction (EXPAR) are just some of the techniques that have undergone extensive tailoring to detect all manner of genetic material in cells as sensitively as possible. However, few approaches have even come close to reliably detecting nucleic acids at the single molecule level. Read the full article in Chemistry World»

Read the original journal article in Chemical Science – it’s open access:
Lab on a single microbead: an ultrasensitive detection strategy enabling microRNA analysis at the single-molecule level
Xiaobo Zhang, Chenghui Liu, Lingbo Sun, Xinrui Duan and Zhengping Li
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C5SC02641E, Edge Article

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Antioxidant assumptions flipped for garlic thiosulfinates

18 Aug 2015

Garlic is often called the world's oldest know medicine © Shutterstock

New mechanistic investigations at the interface of chemistry and biology reveal thiosulfinates of garlic and petiveria are not the superstars of the antioxidant world they were once thought to be.

Allicin, a thiosulfinate from garlic, well-known for its potent antimicrobial activity, is a popular molecule under investigation for its medicinal potential to treat diseases such as cardiovascular and neurodegenerative diseases. It has long been hoped that its biocidal properties would translate into therapeutic effects in human cells. Previous studies carried out in organic solution indicated that allicin and petivericin, an analogous thiosulfinate derived from the South American plant Petiveria alliacea, were potent radical-trapping antioxidants because they decompose to give sulfenic acids that reduced free radicals and inhibited the undesirable oxidation of important biomolecules. Read the full article in Chemistry World»

Read the original journal article in Chemical Science:
The medicinal thiosulfinates from garlic and Petiveria are not radical-trapping antioxidants in liposomes and cells, but lipophilic analogs are
Bo Li, Feng Zheng, Jean-Philippe R. Chauvin and Derek A. Pratt
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C5SC02270C, Edge Article

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Streamlined synthesis yields longer sugar chains

12 Aug 2015

By using bigger building blocks, scientists in the UK have shown they can make much longer oligosaccharide sequences than previously possible.

The traditional synthetic route to long chain oligosaccharides is drawn out and complicated; they require numerous steps to produce the precursor tetrasaccharides, then further steps to connect these precursors into long chains. Normally they’re made by an iterative two block process, generating chains up to 12 units long. Now, a four block approach, developed by John Gardiner and colleagues at the University of Manchester, significantly reduces the number of steps enabling longer sugar lengths from 16 up to 40 units. Read the full article in Chemistry World»

Read the original journal article in Chemical Science – it’s open access:
Making the longest sugars: a chemical synthesis of heparin-related [4]n oligosaccharides from 16-mer to 40-mer
Steen U. Hansen, Gavin J. Miller, Matthew J. Cliff, Gordon C. Jayson and John M. Gardiner
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C5SC02091C, Edge Article

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Top 25 Chemical Science articles April–June 2015

04 Aug 2015

The 25 most-downloaded Chemical Science articles in the second quarter of 2015 were as follows:

Copper-catalyzed intermolecular C(sp³)–H bond functionalization towards the synthesis of tertiary carbamates
Prasanna Kumara Chikkade, Yoichiro Kuninobu and Motomu Kanai
DOI: 10.1039/C5SC00238A, Edge Article

Palladium(0) NHC complexes: a new avenue to highly efficient phosphorescence
Adam F. Henwood, Mathieu Lesieur, Ashu K. Bansal, Vincent Lemaur, David Beljonne, David G. Thompson, Duncan Graham, Alexandra M. Z. Slawin, Ifor D. W. Samuel, Catherine S. J. Cazin and Eli Zysman-Colman
DOI: 10.1039/C4SC03914A, Edge Article

Rh-catalyzed decarbonylation of conjugated ynones via carbon–alkyne bond activation: reaction scope and mechanistic exploration via DFT calculations
Alpay Dermenci, Rachel E. Whittaker, Yang Gao, Faben A. Cruz, Zhi-Xiang Yu and Guangbin Dong
DOI: 10.1039/C5SC00584A, Edge Article

Sulfonyl fluorides as privileged warheads in chemical biology
Arjun Narayanan and Lyn H. Jones
DOI: 10.1039/C5SC00408J, Perspective

A divergent route to core- and peripherally functionalized diazacoronenes that act as colorimetric and fluorescence proton sensors
Bo He, Jing Dai, Danylo Zherebetskyy, Teresa L. Chen, Benjamin A. Zhang, Simon J. Teat, Qichun Zhang, Linwang Wang and Yi Liu
DOI: 10.1039/C5SC00304K, Edge Article

Spatial imaging of carbon reactivity centers in Pd/C catalytic systems
E. O. Pentsak, A. S. Kashin, M. V. Polynski, K. O. Kvashnina, P. Glatzel and V. P. Ananikov
DOI: 10.1039/C5SC00802F, Edge Article

Chemical assay-guided natural product isolation via solid-supported chemodosimetric fluorescent probe
Hongjun Jeon, Chaemin Lim, Ji Min Lee and Sanghee Kim
DOI: 10.1039/C5SC00360A, Edge Article

Very bright mechanoluminescence and remarkable mechanochromism using a tetraphenylethene derivative with aggregation-induced emission
Bingjia Xu, Jiajun He, Yingxiao Mu, Qiangzhong Zhu, Sikai Wu, Yifan Wang, Yi Zhang, Chongjun Jin, Changcheng Lo, Zhenguo Chi, Alan Lien, Siwei Liu and Jiarui Xu
DOI: 10.1039/C5SC00466G, Edge Article

Stereocontrolled 1,2-cis glycosylation as the driving force of progress in synthetic carbohydrate chemistry
Swati S. Nigudkar and Alexei V. Demchenko
DOI: 10.1039/C5SC00280J, Perspective

Combination of Ru(II) complexes and light: new frontiers in cancer therapy
Cristina Mari, Vanessa Pierroz, Stefano Ferrari and Gilles Gasser
DOI: 10.1039/C4SC03759F, Perspective

Enantioselective synthesis of bicyclo[3.n.1]alkanes by chiral phosphoric acid-catalyzed desymmetrizing Michael cyclizations
Alan R. Burns, Amaël G. E. Madec, Darryl W. Low, Iain D. Roy and Hon Wai Lam
DOI: 10.1039/C5SC00753D, Edge Article

Ratiometric detection of pH fluctuation in mitochondria with a new fluorescein/cyanine hybrid sensor
Yuncong Chen, Chengcheng Zhu, Jiajie Cen, Yang Bai, Weijiang He and Zijian Guo
DOI: 10.1039/C4SC04021J, Edge Article

Enantioselective and diastereoselective azo-coupling/iminium-cyclizations: a unified strategy for the total syntheses of (−)-psychotriasine and (+)-pestalazine B
Qi Li, Tingting Xia, Licheng Yao, Haiteng Deng and Xuebin Liao
DOI: 10.1039/C5SC00338E, Edge Article

Iron(II)-catalyzed asymmetric intramolecular olefin aminochlorination using chloride ion
Cheng-Liang Zhu, Jun-Shan Tian, Zhen-Yuan Gu, Guo-Wen Xing and Hao Xu
DOI: 10.1039/C5SC00221D, Edge Article

Evaluating metal–organic frameworks for natural gas storage
Jarad A. Mason, Mike Veenstra and Jeffrey R. Long
DOI: 10.1039/C3SC52633J, Perspective

Enhancing H₂ evolution performance of an immobilised cobalt catalyst by rational ligand design
Janina Willkomm, Nicoleta M. Muresan and Erwin Reisner
DOI: 10.1039/C4SC03946G, Edge Article

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user’s guide
David S. Surry and Stephen L. Buchwald
DOI: 10.1039/C0SC00331J, Perspective

Diverse reactivity of a tricoordinate organoboron L₂PhB: (L = oxazol-2-ylidene) towards alkali metal, group 9 metal, and coinage metal precursors
Lingbing Kong, Rakesh Ganguly, Yongxin Li and Rei Kinjo
DOI: 10.1039/C5SC00404G, Edge Article

Is a polymer semiconductor having a “perfect” regular structure desirable for organic thin film transistors?
Wei Hong, Shaoyun Chen, Bin Sun, Mark A. Arnould, Yuezhong Meng and Yuning Li
DOI: 10.1039/C5SC00843C, Edge Article

Palladium-catalyzed cross-coupling of α-bromocarbonyls and allylic alcohols for the synthesis of α-aryl dicarbonyl compounds
Yang Yu and Uttam K. Tambar
DOI: 10.1039/C5SC00505A, Edge Article

Charging and discharging at the nanoscale: Fermi level equilibration of metallic nanoparticles
Micheál D. Scanlon, Pekka Peljo, Manuel A. Méndez, Evgeny Smirnov and Hubert H. Girault
DOI: 10.1039/C5SC00461F, Perspective

A highly selective ratiometric near-infrared fluorescent cyanine sensor for cysteine with remarkable shift and its application in bioimaging
Zhiqian Guo, SeongWon Nam, Sungsu Park and Juyoung Yoon
DOI: 10.1039/C2SC20540H, Edge Article

Virtual screening for high affinity guests for synthetic supramolecular receptors
William Cullen, Simon Turega, Christopher A. Hunter and Michael D. Ward
DOI: 10.1039/C5SC00534E, Edge Article

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Chemical Science Blog

Author Archive

Top 25 Chemical Science articles July–September 2015

Hot Chemical Science articles for October

Subtle forces yield profound effects on heavy element bonding

Hypervalent bonding controversy out for the electron count?

Hot Chemical Science articles for September

Individual microRNA molecules detected with a single microbead

Antioxidant assumptions flipped for garlic thiosulfinates

Streamlined synthesis yields longer sugar chains

More hot Chemical Science articles for July

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