Scientists in China have developed an intelligent nanoparticle system that delivers a chemotherapeutic and radiosensitiser drug directly to the nucleus of cancer cells. Tests suggest this intranuclear radiosensitisation technique could intensify the effects of radiotherapy.
Along with radiotherapy, chemotherapy assumes a frontline position in the battle against cancer. However, many drugs fail to enter cancer cell nuclei when they should. This often leads to multidrug resistance in tumours and a diminished response to radiotherapy.
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Read the original journal article for free in Chemical Science:
Design of An Intelligent Sub-50 nm Nuclear-targeting Nanotheranostic System for Imaging Guided Intranuclear Radiosensitization
Wenpei Fan, Bo Shen, Wenbo Bu, Xiangpeng Zheng, Qianjun He, Zhaowen Cui, Kuaile Zhao, Shengjian Zhang and Jianlin Shi
Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC03080J, Edge Article