Scientists in Canada have made DNA cubes that are programmed to unzip and reveal molecules locked inside them in response to a carefully chosen trigger. Hanadi Sleiman and colleagues at McGill University and the Jewish General Hospital in Montreal, designed the cubes to release the drug cargo they might be carrying only in diseased cells and not normal cells.
The mRNA trigger binds tothe overhangs and opens the cube by strand displacement and strategically placed nicks on the structure
Read the full article in Chemistry World»
Read the original journal article in Chemical Science – it’s free to download until 7th May:
Sequence-responsive unzipping DNA cubes with tunable cellular uptake profiles
Katherine E. Bujold, Johans Fakhoury, Thomas G. W. Edwardson, Karina M. M. Carneiro, Joel Neves Briard, Antoine G. Godin, Lilian Amrein, Graham D. Hamblin, Lawrence C. Panasci, Paul W. Wiseman and Hanadi F. Sleiman
Chem. Sci., 2014, Advance Article, DOI: 10.1039/C4SC00646A, Edge Article
