First efficient catalyst to synthesise hindered heterobiaryls by direct C–H coupling

Scientists in Japan and Germany have made the first efficient catalyst to enable the synthesis of hindered heterobiaryls by direct C–H coupling.  Hindered biaryls have numerous applications such as catalysts/ligands for asymmetric synthesis and chiral materials, and are often found in biologically active natural products.

Link to journal article
Hindered Biaryls by C-H Coupling: Bisoxazoline-Pd Catalysis Leading to Enantioselective C-H Coupling
K Yamaguchi et al
Chem. Sci., 2012, DOI: 10.1039/c2sc20277h

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