Complexes for future nitroxyl (HNO) therapies have been made by scientists in the US, South Africa and Norway. HNO donors have been used as anti-alcoholism agents and are proving to be promising therapeutics for heart failure.
The team made ferric nitric oxide complexes and described the first insight into the electronic structure, reactivity and potential fate of these {FeNO}8 complexes in biology. The researchers say that {FeNO}8 could be used as a nitroxyl donor at ambient temperature and physiological pH.
Reference:
A thermally stable {FeNO}8 complex: properties and biological reactivity of reduced MNO systems
A K Patra, K S Dube, B C Sanders, G C Papaefthymiou, J Conradie, A Ghosh and T C Harrop, Chem. Sci., 2011
DOI: 10.1039/c1sc00582k
