Archive for the ‘Article collection’ Category

September 2020 Reviews

Every month we update our Recent Reviews collection. This rolling collection showcases all of the review articles published in RSC Advances in the last 6 months. Don’t forget to come back next month to check out our latest reviews.

We hope you enjoy reading and as always, all of our articles are open access so you can easily share your favourites online and with your colleagues.

Check out the full collection!

Browse a selection of our September reviews below:

Regio- and stereoselective intermolecular carbolithiation reactions
G. Marsico, P. Scafato, S. Belviso and S. Superchi
RSC Adv., 2020, 10, 32581-32601
DOI: 10.1039/D0RA06101H

One-pot construction of carbohydrate scaffolds mediated by metal catalysts
Mana Mohan Mukherjee, Sajal Kumar Maity and Rina Ghosh
RSC Adv., 2020, 10, 32450-32475
DOI: 10.1039/D0RA05355D

Recent progress to construct calixarene-based polymers using covalent bonds: synthesis and applications
Reza Zadmard, Fahimeh Hokmabadi, Mohammad Reza Jalali and Ali Akbarzadeh
RSC Adv., 2020, 10, 32690-32722
DOI: 10.1039/D0RA05707J

Recent progress in porphyrin- and phthalocyanine-containing perovskite solar cells
Yutaka Matsuo, Keisuke Ogumi, Il Jeon, Huan Wang and Takafumi Nakagawa
RSC Adv., 2020, 10, 32678-32689
DOI: 10.1039/D0RA03234D

Furo[3,2-c]coumarins carrying carbon substituents at C-2 and/or C-3. Isolation, biological activity, synthesis and reaction mechanisms
Iván Cortés, L. Javier Cala, Andrea B. J. Bracca and Teodoro S. Kaufman
RSC Adv., 2020, 10, 33344-33377
DOI: 10.1039/D0RA06930B

Graphitic carbon nitride nanotubes: a new material for emerging applications
Oleksandr Stroyuk, Oleksandra Raievska and Dietrich R. T. Zahn
RSC Adv., 2020, 10, 34059-34087
DOI: 10.1039/D0RA05580H

In vivo and in vitro studies of antisense oligonucleotides – a review
Anna Kilanowska and Sylwia Studzińska
RSC Adv., 2020, 10, 34501-34516
DOI: 10.1039/D0RA04978F

 

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest HOT articles, Reviews, Collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

 

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Call for Papers: Emerging Investigators series

We are delighted to announce the start of an Emerging Investigators series in RSC Advances!  This series will showcase some of the best research from scientists in the early stages of their independent careers. The series will be Guest Edited by Professor James Batteas (Texas A&M University), and articles in the series will be accepted and published throughout the year. In addition, an Editorial article featuring recent researchers in the issue will be published annually.

Scope

Papers should provide an insight that advances the chemistry field. Papers that contain little or no chemistry and are not considered to be of interest or relevance to the chemistry community are not within the scope of the journal. The criteria for publication are that the work must be high quality, well conducted and advance the development of the field. Articles submitted to the journal are evaluated by our international team of associate editors and reviewers for the overall quality and accuracy of the science presented.

To be eligible researchers should be roughly within 7 years of starting their first independent research position. Career breaks will be taken into consideration (for example, parental or medical leave).

How to submit

Both Papers and Review articles will be considered for this issue. All submissions will be subject to an initial assessment by Associate Editors and, if suitable for the journal, they will be subject to rigorous peer review to meet the usual high standards of RSC Advances.

Our APC is among the lowest in the industry; £750 for articles as well as reviews (corresponding to approximately $985 or €830 or CNY 6800) and there are no submission charges. Discounts and waivers are offered to authors from developing countries.

If you would like to submit to this issue please notify the Editorial Office at advances-rsc@rsc.org. The manuscript should be prepared according to our article guidelines and submitted via our online system anytime.

 

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Editors’ Collection: Environmental chemistry: Pollution control by Associate Editor Feng Zhao

We are delighted to share with you our latest collection of recently published articles focusing on Environmental chemistry: Pollution control, handpicked by Associate Editor Feng Zhao.

The collection features articles on the theme ‘pollution control’, illustrating the notability, quality and variety of publications in RSC Advances. These articles are already among the most highly cited research articles in the journal, illustrating their impact. Subject areas include absorptive materials, photocatalytic materials, bio-magnetic membranes and method development.

As the world’s largest gold open access chemistry journal, all publications in RSC Advances are free to access. We hope you enjoy reading these articles.

We invite you to submit your research to this collection and give your work the global visibility it deserves.

Submit your research now

Featured articles:

Development and application of novel bio-magnetic membrane capsules for the removal of the cationic dye malachite green in wastewater treatment
Imran Ali, Changsheng Peng, Iffat Naz, Dichu Lin, Devendra P. Saroj and Mohsin Ali
RSC Adv., 2019,9, 3625-3646. DOI: 10.1039/C8RA09275C

Functionalized biochar-supported magnetic MnFe2O4 nanocomposite for the removal of Pb(ii) and Cd(ii)
Lianke Zhang, Jinyue Guo, Xuemin Huang, Weida Wang, Peng Sun, Yumei Li and Jianhong Han
RSC Adv., 2019,9, 365-376. DOI: 10.1039/C8RA09061K

Adsorptive environmental applications of MXene nanomaterials: a review
Yujuan Zhang, Lin Wang, Ningning Zhang and Zhangjian Zhou
RSC Adv., 2018,8, 19895-19905. DOI: 10.1039/C8RA03077D

Read the full collection here

Meet the Editor

Feng Zhao received his doctorate degree in chemistry at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences in 2004; then spent two years as a research assistant at the University of Greifswald in Germany working on the development of low-cost microbial fuel cells for wastewater treatment. In 2007, Dr. Zhao came to the University of Surrey in UK as a senior research officer, and there his research focused on the development of bio-electrochemical systems for wastewater treatment and renewable energy generation. In 2010, he moved to Institute of Urban Environment,  Chinese Academy of Sciences, where his scientific interests are in the areas of bio-energy & environmental technology; wastewater/waste treatment using bio-electrochemical systems.

 

 

 

About RSC Advances

As the world’s largest gold open access journal dedicated to the chemical sciences, we are here for everyone who wants to publish quality chemistry research and share it with the world. Published by the Royal Society of Chemistry and led by active researchers, we publish work in all areas of chemistry and our low article processing charges, discounts and waivers make publishing open access achievable and sustainable. Learn more.

 

RSC Advances Royal Society of Chemistry

Submit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest HOT articles, Reviews, Collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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August 2020 Reviews

Every month we update our Recent Reviews collection. This rolling collection showcases all of the review articles published in RSC Advances in the last 6 months. Don’t forget to come back next month to check out our latest reviews.

We hope you enjoy reading and as always, all of our articles are open access so you can easily share your favourites online and with your colleagues.

Check out the full collection!

Browse a selection of our August reviews below:

Heteroatom-doped graphene as sensing materials: a mini review
Sandeep Kaushal, Manpreet Kaur, Navdeep Kaur, Vanita Kumari and Prit Pal Singh
RSC Adv., 2020, 10, 28608-28629
DOI: 10.1039/D0RA04432F, Review

Recent advancements in g-C3N4-based photocatalysts for photocatalytic CO2 reduction: a mini review
Runlu Liu, Zhixin Chen, Yao Yao, Yao Li, Waqas A. Cheema, Dawei Wang and Shenmin Zhu
RSC Adv., 2020, 10, 29408-29418
DOI: 10.1039/D0RA05779G, Review

Rational design of yolk–shell nanostructures for drug delivery
Ghodsi Mohammadi Ziarani, Parisa Mofatehnia, Fatemeh Mohajer and Alireza Badiei
RSC Adv., 2020, 10, 30094-30109
DOI: 10.1039/D0RA03611K, Review

Recent developments in electrochemical sensors for detecting hydrazine with different modified electrodes
Somayeh Tajik, Hadi Beitollahi, Sayed Zia Mohammadi, Mostafa Azimzadeh, Kaiqiang Zhang, Quyet Van Le, Yusuke Yamauchi, Ho Won Jang and Mohammadreza Shokouhimehr
RSC Adv., 2020, 10, 30481-30498
DOI: 10.1039/D0RA03288C, Review

A review of molybdenum disulfide (MoS2) based photodetectors: from ultra-broadband, self-powered to flexible devices
Hari Singh Nalwa
RSC Adv., 2020, 10, 30529-30602
DOI: 10.1039/D0RA03183F, Review

Challenges and opportunities of hydrothermal carbonisation in the UK; case study in Chirnside
Eloise Bevan, Jile Fu and Ying Zheng
RSC Adv., 2020, 10, 31586-31610
DOI: 10.1039/D0RA04607H, Review

Spinel ferrite (AFe2O4)-based heterostructured designs for lithium-ion battery, environmental monitoring, and biomedical applications
Tuyet Nhung Pham, Tran Quang Huy and Anh-Tuan Le
RSC Adv., 2020, 10, 31622-31661
DOI: 10.1039/D0RA05133K, Review
RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest HOT articles, Reviews, Collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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August HOT Articles

Every month we update our RSC Advances HOT Article Collection. This rolling collection features all of the articles selected by our reviewers and handling editors as HOT in the last 6 months. Don’t forget to come back next month to check out our latest HOT articles.

We hope you enjoy reading and as always, all of our articles are open access so you can easily share your favourites online and with your colleagues.

Check out the full collection!

Browse our August HOT articles below:

Recovery of yttrium and europium from spent fluorescent lamps using pure levulinic acid and the deep eutectic solvent levulinic acid–choline chloride
Ioanna M. Pateli, Andrew P. Abbott, Koen Binnemans and Nerea Rodriguez Rodriguez
RSC Adv., 2020, 10, 28879-28890
DOI: 10.1039/D0RA05508E, Paper

Preparation of cationic proteoliposomes using cell-free membrane protein synthesis: the chaperoning effect of cationic liposomes
Mitsuru Ando, Yoshihiro Sasaki and Kazunari Akiyoshi
RSC Adv., 2020, 10, 28741-28745
DOI: 10.1039/D0RA05825D, Paper

Copper-catalyzed synthesis of α-ketoamides using water and dioxygen as the oxygen source
Yuanyuan Xiao, Zijuan Yi, Xianyong Yu and Fang Xiao
RSC Adv., 2020, 10, 29114-29118
DOI: 10.1039/D0RA05921H, Paper

Direct access to multi-functionalized benzenes via [4 + 2] annulation of α-cyano-β-methylenones and α,β-unsaturated aldehydes
Qianfa Jia, Yunfei Lan, Xin Ye, Yinhe Lin and Qiao Ren
RSC Adv., 2020, 10, 29171-29174
DOI: 10.1039/D0RA05251E, Paper

Modular design and self-assembly of multidomain peptides towards cytocompatible supramolecular cell penetrating nanofibers
Su Yang and He Dong
RSC Adv., 2020, 10, 29469-29474
DOI: 10.1039/D0RA04748A, Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Ahmed E. Allam, Hamdy K. Assaf, Heba Ali Hassan, Kuniyoshi Shimizu and Yaseen A. M. M. Elshaier
RSC Adv., 2020, 10, 29983-29998
DOI: 10.1039/D0RA05265E, Paper

Molecular targets and anticancer activity of quinoline–chalcone hybrids: literature review
Mamdouh F. A. Mohamed and Gamal El-Din A. Abuo-Rahma
RSC Adv., 2020, 10, 31139-31155
DOI: 10.1039/D0RA05594H, Review

 

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest HOT articles, Reviews, Collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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RSC Advances HOT articles – a feature interview with Pavel Bobal, Jan Otevrel and David Svestka

We are very pleased to introduce Pavel Bobal, Jan Otevrel and David Svestka, the authors of the paper One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles. Their article has been very well received and handpicked by our reviewers and handling editors as one of our HOT articles.  The team told us more about the work that went into this article and what they hope to achieve in the future. You can find out more about the authors and their article below and find more HOT articles in our online collection.

Meet the Authors

Pavel Bobal studied organic chemistry at Slovak Technical University, Bratislava, Slovakia, where he received his doctoral degree in 1996. He spent 3 years between 1995 and 1998 as a postdoc at the University of Neuchatel, Switzerland (Prof. Neier) and additional 3 years at the University of Nevada, Reno, USA (Prof. Lightner). From 2001 to 2009 he worked in the pharmaceutical industry (R&D). In 2009 he became an assistant professor and then in 2019 an associate professor at Faculty of Pharmacy, UVPS Brno, Czech Republic. Since 2020 this faculty has been reestablished as a part of Masaryk University, Brno, Czech Republic.
 

Jan Otevrel was a former Ph.D. student of Pavel Bobal, he received his doctoral degree in 2017 and then became an assistant professor at the same university. During his Ph.D. he spent 3 months at Justus Liebig University, Giessen, Germany (Prof. Hrdina) and he will soon (this year) start a postdoc position at Johannes Kepler University, Linz, Austria (Prof. Waser). He has discovered and co-developed the process published in the current study.

David Svestka received his master’s degree in 2019 at UVPS Brno, Czech Republic. He is currently a Ph.D. student in the Pavel Bobal’s laboratory and participated in the development of the present method.

 

Could you briefly explain the focus of your article to the non-specialist (in one or two sentences only) and why it is of current interest?
Our paper describes a new method for synthesis of vicinal amino alcohols from the respective amides or nitriles by a simple set of reaction conditions. Amino alcohols are compounds of high interest in many branches of chemistry.

How big an impact could your results potentially have?
It is always hard to predict feedback of the scientific article. However, from our perspective, we would be glad if the developed process will find place in syntheses of vicinal amino alcohols conducted at research laboratories and if the readers of RSC Advances will appreciate efforts which we have invested in this paper.

Could you explain the motivation behind this study?
Due to our continuous interest in the organocatalyzed aldol-type reactions, we have been exploring syntheses of numerous chiral auxiliaries for the catalyst design and screening. These long-term endeavor paved a way for our current unexpected discovery.

In your opinion, what are the key design considerations for your study?
The key consideration in this study is to use an old and well-known reagent in a new context to reveal the novel and yet unexplored reactivity.

Which part of the work towards this paper proved to be most challenging?
The methodological articles in organic synthesis usually share the common structure such as the optimization section, determination of the substrate scope, and a relevant synthetic application of the method. Thus from the initial interesting observation, it is often quite a long journey towards the good scientific paper. Honestly, one of the most challenging parts of the above article was to establish a plausible mechanism of the reaction and to support it with enough evidence.

What aspect of your work are you most excited about at the moment?
One of the most exciting moments of this discovery was to figure out that benzylic oxidation can occur even under reduction conditions, which is somewhat counter-intuitive. Indeed, sodium bis(methoxyethoxy)aluminum hydride gave us a great lecture that more than 50 years old and almost comprehensively explored reagent is still able to surprise.

What is the next step? What work is planned?
We will continue with our work in organic synthesis and medicinal chemistry and we will look forward to the new and especially the unexpected chemical discoveries.

 

One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles
Jan Otevrel, David Svestka and Pavel Bobal
RSC Adv., 2020,10, 25029-25045
DOI: 10.1039/D0RA04359A, Paper

 

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest HOT articles, Reviews, Collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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July 2020 Reviews

Every month we update our Recent Reviews collection. This rolling collection showcases all of the review articles published in RSC Advances in the last 6 months. Don’t forget to come back next month to check out our latest reviews.

We hope you enjoy reading and as always, all of our articles are open access so you can easily share your favourites online and with your colleagues.

Check out the full collection!

Browse a selection of our July reviews below:

Applications of Cu(0) encapsulated nanocatalysts as superior catalytic systems in Cu-catalyzed organic transformations
Majid M. Heravi, Bahareh Heidari, Vahideh Zadsirjan and Leila Mohammadi
RSC Adv., 2020, 10, 24893-24940
DOI: 10.1039/D0RA02341H, Review

Two decades of the synthesis of mono- and bis-aminomercapto[1,2,4]triazoles
Sayed M. Riyadh and Sobhi M. Gomha
RSC Adv., 2020, 10, 24994-25012
DOI: 10.1039/D0RA04208K, Review

Prospects of kefiran as a food-derived biopolymer for agri-food and biomedical applications
Kei-Xian Tan, Vidya N. Chamundeswari and Say Chye Joachim Loo
RSC Adv., 2020, 10, 25339-25351
DOI: 10.1039/D0RA02810J, Review

Simultaneous wastewater treatment and energy harvesting in microbial fuel cells: an update on the biocatalysts
Yajing Guo, Jiao Wang, Shrameeta Shinde, Xin Wang, Yang Li, Yexin Dai, Jun Ren, Pingping Zhang and Xianhua Liu
RSC Adv., 2020, 10, 25874-25887
DOI: 10.1039/D0RA05234E, Review

Phosphonopeptides containing free phosphonic groups: recent advances
Paweł Kafarski
RSC Adv., 2020, 10, 25898-25910
DOI: 10.1039/D0RA04655H, Review

A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Yongtao Duan, Abhishek Dhar, Chetan Patel, Mehul Khimani, Swarnali Neogi, Prolay Sharma, Nadavala Siva Kumar and Rohit L. Vekariya
RSC Adv., 2020, 10, 26777-26791
DOI: 10.1039/D0RA03491F, Review

Understanding the relevance of protein corona in nanoparticle-based therapeutics and diagnostics
Debolina Chakraborty, K. R. Ethiraj and Amitava Mukherjee
RSC Adv., 2020, 10, 27161-27172
DOI: 10.1039/D0RA05241H, Review

Systematic overview of soft materials as a novel frontier for MRI contrast agents
Enrico Gallo, Elisabetta Rosa, Carlo Diaferia, Filomena Rossi, Diego Tesauro and Antonella Accardo
RSC Adv., 2020, 10, 27064-27080
DOI: 10.1039/D0RA03194A, Review

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Maryam S. Hosseini-Zare, Ramasamy Thilagavathi and Chelliah Selvam
RSC Adv., 2020, 10, 28287-28299
DOI: 10.1039/D0RA04395H, Review

 

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest HOT articles, Reviews, Collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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July HOT Articles

Every month we update our RSC Advances HOT Article Collection. This rolling collection features all of the articles selected by our reviewers and handling editors as HOT in the last 6 months. Don’t forget to come back next month to check out our latest HOT articles.

We hope you enjoy reading and as always, all of our articles are open access so you can easily share your favourites online and with your colleagues.

Check out the full collection!

Browse our July HOT articles below:

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Marisa G. Santibáñez-Morán, Edgar López-López, Fernando D. Prieto-Martínez, Norberto Sánchez-Cruz and José L. Medina-Franco
RSC Adv., 2020, 10, 25089-25099
DOI: 10.1039/D0RA04922K, Paper

Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions
Weihang Miao, Pingting Ye, Mengjiao Bai, Zhixin Yang, Suyue Duan, Hengpan Duan and Xuequan Wang
RSC Adv., 2020, 10, 25165-25169
DOI: 10.1039/D0RA05217E, Paper

Near-infrared and metal-free tetra(butylamino)phthalocyanine nanoparticles for dual modal cancer phototherapy
Ying-Jie Wu, Fan-Hong Lv, Jing-Lan Kan, Qun Guan, Anqi Xue, Quanbo Wang, Yan-An Li and Yu-Bin Dong
RSC Adv., 2020, 10, 25958-25965
DOI: 10.1039/D0RA03898A, Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Shruti Koulgi, Vinod Jani, Mallikarjunachari V. N. Uppuladinne, Uddhavesh Sonavane and Rajendra Joshi
RSC Adv., 2020, 10, 26792-26803
DOI: 10.1039/D0RA04743K, Paper

Label-free single-molecule identification of telomere G-quadruplexes with a solid-state nanopore sensor
Sen Wang, Liyuan Liang, Jing Tang, Yao Cai, Chuanqi Zhao, Shaoxi Fang, Huabin Wang, Ting Weng, Liang Wang and Deqiang Wang
RSC Adv., 2020, 10, 27215-27224
DOI: 10.1039/D0RA05083K, Paper

Co-cultured Lepista sordida and Pholiota nameko polysaccharide-iron(iii) chelates exhibit good antioxidant activity
Shuping Yu, Jikang Jiang and Wenxiang Li
RSC Adv., 2020, 10, 27259-27265
DOI: 10.1039/D0RA03258A, Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Eman Shawky, Ahmed A. Nada and Reham S. Ibrahim
RSC Adv., 2020, 10, 27961-27983
DOI: 10.1039/D0RA05126H, Paper

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest HOT articles, Reviews, Collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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RSC Advances HOT articles – a feature interview with Saurabh Das

We are very pleased to introduce Saurabh Das, the corresponding author of the paper A ZnII complex of ornidazole with decreased nitro radical anions that is still highly active on Entamoeba histolytica. His article has been very well received and handpicked by our reviewers and handling editors as one of our June HOT articles.  Saurabh was kind enough to tell us more about the work that went into this article and what he hopes to achieve in the future. You can find out more about the author and their article below and find more HOT articles in our online collection.

Meet the Author

Saurabh Das completed his bachelor’s degree with honours in Chemistry from Presidency College in 1990, then affiliated to University of Calcutta. His Master’s with specialization in Inorganic Chemistry was done at the University College of Science, University of Calcutta in 1992. He received his PhD from University of Calcutta in 2000 having worked at the Chemical Sciences Division of Saha Institute of Nuclear Physics (Ph D Supervisor: Prof. Parikshit C Mandal). After two years of teaching at the Calcutta International School, Kolkata (1998-2000), five and a half years of teaching at the Department of Chemistry, Bejoy Narayan Mahavidyalaya, Hooghly (under University of Burdwan) (2000-2006) he joined the Department of Chemistry, Jadavpur University in January, 2006.

He is now a Professor with research interests in modulating the generation of reactive intermediates of different drugs forming inorganic complexes to strike a balance between efficacy and adverse effects; and offshoots of that general theme. He has 66 publications in peer reviewed international journals.

 

The research team:

Ms Neha Banyal (left photo) and Professor Kasturi Mukhopadhyay (right photo)

Professor Saurabh Das and Ms Promita Nandy (left photo) and Professor Sanjay Kumar and Mr Soumen Singha (right photo)

Could you briefly explain the focus of your article to the non-specialist (in one or two sentences only) and why it is of current interest?
The molecule (Ornidazole) is a drug belonging to the 5-nitroimidazole family that is used to treat bacterial and/or parasitic infections. The performance of the drug depends on the generation of an intermediate (the nitro radical-anion) that kills disease causing microbes. The same intermediate is neurotoxic to the host (i.e. the system affected by disease causing microbes) upon prolonged use. Hence, controlling the generation of the nitro-radical anion is essential to strike a balance between efficacy and neurotoxic side effects.

How big an impact could your results potentially have?
The results should have a good impact since we worked with a compound that is already established as a drug and is part of a number of pharmaceutical formulations. The modified compound, i. e. the zinc complex needs to be tried in vivo, in living systems in order to identify the extent of difference between the work performed by in the laboratory (on model systems) and what the results would be on living systems. Experts would understand and realize here that a certain difference would exist which needs to be identified.

Could you explain the motivation behind this study?
The motivation of the study was to strike a balance between efficacy and neurotoxic side effects for this family of drugs. For most drugs, intermediates involved with the drug’s efficacy are its problems as well. If they can be separated, then one can either increase cure for an accepted level of complication or decrease complications for an accepted level of cure.

In your opinion, what are the key design considerations for your study?
Modification of Ornidazole (the drug) in a manner that generation of nitro-radical anion is controlled, i.e, modulated. For our study, this was achieved through complex formation with Zn(II).

Which part of the work towards this paper proved to be most challenging?
There were three aspects to the study i) preparation of the complex and its characterization,, ii) showing that generation of nitro-radical anion is less for the complex which we followed by an enzyme assay and iii) inspite of decrease in nitro-radical anion formation, the complex showed the same efficacy on amoeba, as that observed for Ornidazole. A combination of these three aspects performed through suitable experiments suggest decrease in the formation of the nitro radical-anion should decrease neurotoxicity on the host (although we did not verify this in our study) but it should happen since studies earlier to ours have linked neurotoxicity to nitro radical-anion formation. Simultaneously, bacteria or parasite killing should also be affected which in our case did not happen. The complex maintained its killing efficacy of amoeba even with decreased nitro radical-anion; being as good as Ornidazole. This we attributed to aspects related to complex formation. We showed one such attribute of the complex in our study, that of it being able to bind DNA better than Ornidazole. So it’s really a culmination of different experiments we performed.

What aspect of your work are you most excited about at the moment?
The fact modification of Ornidazole through complex formation with Zn(II) could increase its therapeutic index (T I) where T I = TD50/ED50; TD50 implies toxic dose in 50% of subjects and ED50 implies effective dose for 50% of population. The larger the T I, safer the drug. Besides, Zn being relatively non-toxic unlike other metal ions and since there is use for it in the bio-system, it should not be harmful if it goes into our bodies

What is the next step? What work is planned?
I have not really thought about it. Since the manuscript has been well received I will have to speak to one of my collaborators (Prof. Kasturi Mukhopadhyay of School of Environmental Sciences at the Jawaharlal Nehru University, New Delhi) in whose laboratory the biological experiments were performed, if she could take the Zn(II) complex forward and do few more studies with it that reveal its mechanism of action on bacteria and amoeba strains; may be try on different bacterial strains, while we perform more model studies to search for other attributes of complex formation. After these are done a sharing of data on biological experiments for mechanism of action and model studies performed (by us) could be useful to see for ourselves whether they correct to each other or establish a difference of opinion.

 

A ZnII complex of ornidazole with decreased nitro radical anions that is still highly active on Entamoeba histolytica
Promita Nandy, Soumen Singha, Neha Banyal, Sanjay Kumar, Kasturi Mukhopadhyay and Saurabh Das
RSC Adv., 2020,10, 23286-23296
DOI: 10.1039/D0RA02597F, Paper

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Editors’ Collection: Ferroelectric and Multiferroelectric Materials by Associate Editor Donna Arnold

We are delighted to share with you our latest collection of recently published articles focusing on Ferroelectric and Multiferroic Materials, handpicked by Associate Editor Donna Arnold.

Ferroelectric and multiferroic materials continue to attract extensive attention within the literature due to the potential of these materials to have an increased impact in our everyday lives. Research covers a whole plethora of chemistry and physics from the search for Pb-free ferroelectrics and new energy storage materials to demonstration of real-world device applications based on inorganic and/or organic materials including experimental and computational studies.

The collection features articles focussing on experimental studies of inorganic solid-state ceramics and thin films (including heterostructures and devices). The collection showcases the significance of not only the search for new materials with enhanced properties but also the importance of understanding the structure-property correlations in both powders and films as well as demonstrating their application in environments closer to commercial use. These articles demonstrate the continued growth of these areas as we strive towards next generation devices based on ferroelectric and multiferroic materials.

As the world’s largest gold open access chemistry journal, all publications in RSC Advances are free to access. We hope you enjoy reading these articles.

We invite you to submit your research to this collection and give your work the global visibility it deserves.

 

Submit your research now

 

Featured articles:

Effect of Bi-substitution into the A-site of multiferroic La0.8Ca0.2FeO3 on structural, electrical and dielectric properties
H. Issaoui, A. Benali, M. Bejar, E. Dhahri, B. F. O. Costa, M. P. F. Graca and M. A. Valente
RSC Adv., 2020,10, 16132-16146. DOI: 10.1039/D0RA02995E

Formation of polarization needle-like domain and its unusual switching in compositionally graded ferroelectric thin films: an improved phase field model
Le Van Lich and Van-Hai Dinh
RSC Adv., 2019,9, 7575-7586. DOI: 10.1039/C8RA10614B

Mechanical switching in ferroelectrics by shear stress and its implications on charged domain wall generation and vortex memory devices
W. J. Chen, Shuai Yuan, L. L. Ma, Ye Ji, Biao Wang and Yue Zheng
RSC Adv., 2018,8, 4434-4444. DOI: 10.1039/C7RA12233K

 

 Read the full collection here

 

Meet the Editor

Donna was awarded her PhD in 2004 from the University of London having studied structure -property correlations in porous manganese oxides. Postdoctoral positions at the Foundation of Research and Technology – Hellas (FORTH), Crete, University College Cork, Ireland and University of St Andrews, UK followed where she continued to investigate the behaviour in complex materials. In 2010 she took an academic position at the University of Kent.

Her current research interests lie in the area of correlating structure-property relationships in oxide materials with a particular emphasis on magnetic, ferroelectric and multiferroic materials.

 

 

 

RSC Advances Royal Society of Chemistry

Submit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

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