Polymer Chemistry Blog

In this article, Endo, Timur, Yagci and co-workers reported on a simple and efficient approach for the electrochemical deposition of polypeptides as bio-based covering materials for surface design. The method involves N-carboxyanhydride (NCA) ring-opening polymerization from its precursor to form a thiophene-functionalized polypeptide macromonomer (T-Pala), followed by electropolymerization. The obtained conducting polymer, namely polythiophene-g-polyalanine (PT-Pala), was characterized and utilized as a matrix for biomolecule attachment. The biosensing applicability of PT-Pala was also investigated by using glucose oxidase (GOx) as a model enzyme to detect glucose. Finally, the antimicrobial activities of newly synthesized T-Pala and PT-Pala were also evaluated. Interestingly, this technique is experimentally facile and can be applied to various types of polypeptides.

Electrochemical deposition of polypeptides: bio-based covering materials for surface design by Huseyin Akbulut, Murat Yavuz, Emine Guler, Dilek Odaci Demirkol, Takeshi Endo, Shuhei Yamada, Suna Timur and Yusuf Yagci, Polym. Chem. 2014, 5, 3929-3936.

Julien Nicolas is a web-writer and advisory board member for Polymer Chemistry. He currently works at Univ. Paris-Sud (FR) as a CNRS researcher.

In this article, Albertsson and co-workers felt inspired to use γ-lactones as inexpensive and straightforward monomers that can bestow the desired functionality on commonly used aliphatic polyester. More specifically, they used α-bromo-γ-butyrolactone (αBrγBL) as a comonomer with ε-caprolactone (εCL) or L-lactide (LLA) to produce copolymers with active and available grafting sites, e.g., for SET-LRP, where the choice of the grafting monomers is limited only by one’s imagination. The authors believe that αBrγBL inherently holds all the prerequisites to act as a platform monomer for the synthesis of functional aliphatic polyesters, i.e., it is inexpensive, available, and able to form isolated grafting sites along the polymer chain. The incorporation of isolated αBrγBL is a feature that makes this class of copolymers unique and is considered to provide a route to the “perfect graft copolymer” with a degradable backbone.

Establishing α-bromo-γ-butyrolactone as a platform for synthesis of functional aliphatic polyesters – bridging the gap between ROP and SET-LRP by Peter Olsén, Jenny Undin, Karin Odeliusa and Ann-Christine Albertsson, Polym. Chem. 2014, 5, 3847-3854.

Julien Nicolas is a web-writer and advisory board member for Polymer Chemistry. He currently works at Univ. Paris-Sud (FR) as a CNRS researcher.

In this paper, Harth and co-workers reported on the synthesis of biodegradable nanoparticles capable of paclitaxel entrapment and demonstrated the ability to control release of paclitaxel by adjusting the single parameter of the particles’ crosslinking density. Additionally, particles with different densities can be mixed to yield various rates of release that can be fast or slow depending on the specific application. The ability of these particles to withstand simulated gastric fluid allows for the possibility of an oral drug delivery route.

An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization by David M. Stevens, Kelly A. Gilmore and Eva Harth Polym. Chem. 2014, 5, 3551-3554.

Julien Nicolas is a web-writer and advisory board member for Polymer Chemistry. He currently works at Univ. Paris-Sud (FR) as a CNRS researcher.

Driven by the interest in developing new efficient methodologies to prepare well-defined grafted poly(1,4-butadiene)s, Fontaine and co-workers used in the present work a consecutive organocatalyzed ring-opening polymerization (ROP)/ROMP route to prepare poly(1,4-butadiene)-g-polyesters from cyclobutenyl macromonomers bearing one or two polyester segment(s) derived from L-lactide (LA) or ε-caprolactone (CL). The products resulting from this strategy represent the first examples of poly(1,4-butadiene)-g-polyesters through the macromonomer route. These results pave the way for more complicated macromolecular architectures, e.g., by modification of the side-chain termini. Moreover, the hydrolytic (bio)degradation potential of the side chains (that can be used as sacrificial domains) of those bottlebrush copolymers makes them attractive candidates to be used for the preparation of complex hollowed nanostructures.

Synthesis and polymerization of cyclobutenyl-functionalized polylactide and polycaprolactone: a consecutive ROP/ROMP route towards poly(1,4-butadiene)-g-polyesters by Flavien Leroux, Véronique Montembault, Sagrario Pascual, William Guerin, Sophie M. Guillaume and Laurent Fontaine Polym. Chem.2014, 5, 3476-3486.

Julien Nicolas is a web-writer and advisory board member for Polymer Chemistry. He currently works at Univ. Paris-Sud (FR) as a CNRS researcher.

In their paper, Gao , Yang and co-workers grafted β-cyclodextrins (β-CDs) onto star-shaped poly(glycidyl methacrylate)s (S5-PGMAs) with a straightforward and efficient ring-opening addition of amine groups to result in PGMA–β-CDs, which not only possess good water-solubility and biocompatibility, but also can serve as polymeric supramolecular hosts to form inclusion complexes with suitable guests. They can be easily assembled on the surface of azobenzene-functionalized MSNs via host–guest interactions to obtain MSN@PGMA–β-CD hybrid nanoparticles. The experimental results showed that these types of inorganic–organic hybrid mesoporous nanocomposites possess good cargo encapsulation and release properties, as compared with the simple supramolecular nanovalves with β-CD itself as the gating component, upon activation by light, temperature variation, and competitive binding agents. In addition, the extremely low cytotoxicity of the nanocomposites demonstrated by MTT assay can further broaden their applications in controlled drug release.

Stimuli-responsive biocompatible nanovalves based on β-cyclodextrin modified poly(glycidyl methacrylate) by Qing-Lan Li, Lizhi Wang, Xi-Long Qiu, Yu-Long Sun, Pei-Xi Wang, Yu Liu, Feng Li, Ai-Di Qi, Hui Gao and Ying-Wei Yang Polym. Chem. 2014, 5, 3389-3395.

Julien Nicolas is a web-writer and advisory board member for Polymer Chemistry. He currently works at Univ. Paris-Sud (FR) as a CNRS researcher.

In this article, Kamigaito and co-workers cationically polymerized (−)-β-pinene, a major constituent of pine tree oil,  to generate a high-molecular-weight polymer that were subsequently hydrogenated via metal catalysts to give a high-performance, bio-based cycloolefin polymer with an alicyclic backbone. To obtain the high-molecular-weight polymer, the controlled/living cationic polymerization of (−)-β-pinene was investigated by an initiating system, consisting of a protonic acid, a Lewis acid, and an added base, along with an incremental monomer addition technique. These reactions could be performed even at relatively large scales to produce several hundred grams of the polymer, which can be then processed through injection-molding. The synthesized bio-based cycloolefin polymers demonstrated promising potential properties as high performance optical plastics with good processability, low density, high optical transparency, low birefringence, non-hygroscopicity, high mechanical strength, and excellent thermal properties.

Sustainable cycloolefin polymer from pine tree oil for optoelectronics material: living cationic polymerization of β-pinene and catalytic hydrogenation of high-molecular-weight hydrogenated poly(β-pinene) by Kotaro Satoh, Atsuhiro Nakahara, Kazunori Mukunoki, Hiroko Sugiyama, Hiromu Saito and Masami Kamigaito Polym. Chem. 2014, 5, 3222-3230.

Julien Nicolas is a web-writer and advisory board member for Polymer Chemistry. He currently works at Univ. Paris-Sud (FR) as a CNRS researcher.

To overcome these drawbacks, Berthelot and co-workers proposed here an innovative process, based on VUV irradiation, which proved efficient not only for surface modification, but also for the bulk modification of industrially relevant polymers such as β-polyvinylidene fluoride (β-PVDF), polyethylene (PE) or fluorinated ethylene propylene (FEP). The authors assumed that VUV irradiation of a PVDF film can induce radical active species at depths up to 50 micrometers, as demonstrated by ESR. Those active species were able to initiate the radical polymerization of a vinylic or acrylate monomer such as acrylic acid through the polymer film, as confirmed by the EDX profile of the film thickness. Similar results were obtained on PE and FEP films, while aromatic polymers such as PET strongly absorbed VUV energy and dissipated it along other pathways. By mixing this process and photolithographic masks, 3D structuration of commercial polymer films was also obtained.

VUV grafting: an efficient method for 3D bulk patterning of polymer sheets by Cecile Baudin, Jean-Philippe Renault, Stephane Esnouf, Serge Palacin and Thomas Berthelot Polym. Chem. 2014, 5, 2990-2996.

Julien Nicolas is a web-writer and advisory board member for Polymer Chemistry. He currently works at Univ. Paris-Sud (FR) as a CNRS researcher.