Archive for the ‘Hot Articles’ Category

Bubble power: Driving self-propelled machines with acetylene bubbles

Self-propelled micro/nanomachines were once the thing of science-fiction, but as so often is the case, fiction has become reality in recent years. Such devices could in the future find uses in environmental remediation and biomedical applications. Researchers around the world have been making progress on designing these machines, and it is a novel fuel-free autonomous self-propelled motor which is the focus of this Chemical Communication by Martin Pumera and team from the School of Physical and Mathematical Sciences at Nanyang Technological University.

Rather than focus on oxygen bubble propulsion, which often requires the use of high levels of toxic hydrogen peroxide, they have developed an acetylene bubble based motor. To achieve this they utilised the reaction of water and calcium carbide, which produces acetylene and calcium hydroxide. This approach makes use of the water that will be found in the most common application environments, but does not require reactive metals such as magnesium and aluminium. The work expands the scope of bubble-propulsion beyond hydrogen and oxygen and gives designers of micro/nanomachines greater power unit choices in their designs.

Acetylene bubble powered motor in water.

The most important part of the research reported in this Communication is the optimisation of an encapsulation layer around the calcium carbide to control the reaction. However, to find out what this layer is made of and how to prepare it you will have to read the article today.

To read the details, check out the Chem Comm article in full:

Acetylene bubble-powered autonomous capsules: towards in situ fuel
James Guo Sheng Moo, Hong Wang and Martin Pumera
Chem. Commun., 2014, 50, Advance Article
DOI: 10.1039/C4CC07218A
   

    

    

    

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Just Mix – Zeolitic Imidazolate Framework Synthesis

Zeolitic-imidazolate frameworks (ZIFs) are a sub-class of metal-organic frameworks (MOFs) with a wide range of potential uses including: CO2 capture, storage, catalysis, sensing and biomedicine. Unfortunately their synthesis often requires additives or reaction activation, and if they can be made without these it often requires long reaction times or results in low yields, neither of which is ideal for a substance with such wide potential uses.

To overcome this bottleneck in ZIF synthesis, Roland Fischer and his team from the Inorganic Chemistry department in Ruhr Universitat Bochum in Germany have developed a rapid room temperature synthesis approach. I am a great believer in developing approaches that can be carried out at room temperature and pressure and this is one such elegant solution. The authors produce nanocrystals of ZIFs in a very narrow size distribution by careful selection of the precursors and the solvents they are dissolved in. The solutions are then mixed and stirred to create the ZIF crystals; it really is that elegant.

ZIF crystals showing very narrow size distribution

The authors then used these crystals to fabricate thin films on quartz crystal microbalances and used this device to detect volatile organic solvents. This demonstration leads the way into exploring other uses of these ZIFs – after all, they can now be easily made. But to find out which solvent and precursors you need to use, you’ll have to read the paper today!

To read the details, check out the ChemComm article in full:
Rapid room temperature synthesis of zeolitic-imidazolate framework (ZIF) nanocrystals
Min Tu, Christian Wiktor, Christoph Rosler and Roland Fischer
Chem. Commun., 2014, 50, 13258-13260
DOI: 10.1039/C4CC06491G  

    

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Ionic liquid-gas interfaces: more than a surface glance

Research by scientists in the UK suggests that small changes in the nature of binary ionic liquid systems can significantly alter their surface composition. The findings may aid the design of ionic liquid films for applications such as gas capture and supported catalysis, where surface adsorption is essential.

Studies on simple one-cation–one-anion mixtures have previously revealed that the outer layers contain a greater concentration of alkyl chains than in the bulk…


Read the full article in Chemistry World»

Read the original journal article in ChemComm – it’s free to access until 20 November:
Fine tuning the ionic liquid–vacuum outer atomic surface using ion mixtures
Ignacio J. Villar-Garcia, Sarah Fearn, Nur L. Ismail, Alastair J. S. McIntosh and Kevin R. J. Lovelock  
DOI: 10.1039/C4CC06307D

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FBNCO: all the 2p-block elements in one molecule

Scientists in Italy have made a molecule with one of each of the 2p-block elements. Well, almost. There’s no neon in FBNCO but it would be a bit unfair to expect them to include an element with no known chemistry.

Read the full article in Chemistry World»

You can read the original journal article in ChemComm – it’s free to access until 17th November 2014:
All the 2p-block elements in a molecule: experimental and theoretical studies of FBNCO and FBNCO+
Anna Troiani, Stefania Garzoli, Federico Pepi, Andreina Ricci, Marzio Rosi, Chiara Salvitti and Giulia de Petris  
DOI: 10.1039/C4CC05217J

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Hot ChemComm articles for October

All of the referee-recommended articles below are free to access until 9th November 2014

Relay cooperation of K2S2O8 and O2 in oxytrifluoromethylation of alkenes using CF3SO2Na
Qingquan Lu, Chao Liu, Zhiyuan Huang, Yiyang Ma, Jian Zhang and Aiwen Lei  
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4CC06328G, Communication

C4CC06328G GA


All the 2p-block elements in a molecule: experimental and theoretical studies of FBNCO and FBNCO+
Anna Troiani, Stefania Garzoli, Federico Pepi, Andreina Ricci, Marzio Rosi, Chiara Salvitti and Giulia de Petris  
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4CC05217J, Communication

C4CC05217J GA


Hierarchical porous metal–organic framework monoliths
Adham Ahmed, Mark Forster, Rob Clowes, Peter Myers and Haifei Zhang  
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4CC06967F, Communication

C4CC06967F GA


Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry
Kei Yamaura, Keiko Kuwata, Tomonori Tamura, Yoshiyuki Kioi, Yousuke Takaoka, Shigeki Kiyonaka and Itaru Hamachi  
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4CC05885B, Communication

C4CC05885B GA


Organic nanoparticles with aggregation-induced emission for tracking bone marrow stromal cells in the rat ischemic stroke model
Kai Li, Mie Yamamoto, Su Jing Chan, Mun Yee Chiam, Wei Qin, Peter Tsun Hon Wong, Evelyn King Fai Yim, Ben Zhong Tang and Bin Liu  
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4CC06921H, Communication

C4CC06921H GA


The coaction of tonic and phasic dopamine dynamics
Christopher W. Atcherley, Kevin M. Wood, Kate L. Parent, Parastoo Hashemi and Michael L. Heien  
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4CC06165A, Communication

C4CC06165A GA

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Assessing covalency in the hydrogen bond zoo

Covalency, a term describing bonding by sharing electrons, divides opinion when mentioned alongside hydrogen bonding. Worried that the concept of hydrogen bonding has been getting fuzzier over time, scientists in Germany have sought a fresh look at the very nature of these bonds, and how much covalency they involve.

Richard Dronskowski and colleagues at RWTH Aachen University collected evidence from hydrogen-bonded molecular crystals to elucidate how these crystals are held together and compare the covalency of long and short hydrogen bonds.


Read the full article in Chemistry World»

Read the original journal article in ChemComm – it’s free to access until 13th November:
Covalency of hydrogen bonds in solids revisited
Volker L. Deringer, Ulli Englert and Richard Dronskowski  
Chem. Commun., 2014,50, 11547-11549, DOI: 10.1039/C4CC04716H

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Hot ChemComm articles for September

All of the referee-recommended articles below are free to access until 15th October 2014

A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines
Ho Yin Li, Joachim Horn, Amanda Campbell, David House, Adam Nelson and Stephen P. Marsden  
Chem. Commun., 2014,50, 10222-10224
DOI: 10.1039/C4CC04940C, Communication
From themed collection In Celebration of Richard Taylor’s 65th Birthday


On-surface aryl–aryl coupling via selective C–H activation
Qiang Sun, Chi Zhang, Huihui Kong, Qinggang Tan and Wei Xu  
Chem. Commun., 2014,50, 11825-11828
DOI: 10.1039/C4CC05482B, Communication


A single molecular probe for multi-analyte (Cr3+, Al3+ and Fe3+) detection in aqueous medium and its biological application
Junfeng Wang, Yingbo Li, Nikul G. Patel, Ge Zhang, Demin Zhou and Yi Pang  
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4CC04731A, Communication


Disentangling scalar coupling patterns by real-time SERF NMR
Nina Gubensäk, Walter M. F. Fabian and Klaus Zangger  
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4CC05892E, Communication


Isolation of stable non cyclic 1,2-disulfoxides. Revisiting the thermolysis of S-aryl sulfinimines
José A. Souto, Willian Lewis and Robert A. Stockman  
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4CC05751A, Communication


Chemical Reaction-Induced Multi-molecular Polarization (CRIMP)
Youngbok Lee, Niki M Zacharias, David Piwnica-Worms and Pratip K Bhattacharya  
Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4CC06199C, Communication

 

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Antimalarial flow synthesis closer to commercialisation

Scientists in Germany have demonstrated the large scale and inexpensive production of a range of antimalarial drugs, using a continuous flow system.

The processes yields several artemisinin-derived APIs that are key components in Artemisinin Combination Therapies

An important starting material for various anti-malarial drugs is artemisinin, which until recently could only be obtained by extraction from the plant Artemisia annua. As Peter Seeberger, from the Max Planck Institute for Colloids and Interfaces in Potsdam, explains, ‘the problem is that the drug is too expensive, such that in Africa and south east Asia between 40 and 50% of the artemisinin combination therapies are fake.’


Read the full article in Chemistry World»

Read the original journal article in ChemComm:
Continuous synthesis of artemisinin-derived medicines
Kerry Gilmore, Daniel Kopetzki, Ju Weon Lee, Zoltán Horváth, D. Tyler McQuade, Andreas Seidel-Morgenstern and Peter H. Seeberger  
Chem. Commun., 2014, Advance Article, DOI: 10.1039/C4CC05098C

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Optimising multi-enzyme reactions – enabling enzymatic encoding

The ability to mimic cascade and linked enzyme reactions has potential applications for disease diagnosis and pharmaceutical manufacturing, to name just two. However, the optimisation of the ratios of the interacting enzymes can be a time consuming step when carried out using standard solution based enzyme assays. With the problem becoming exponentially more difficult with the number of enzymes in the system, Jun Ge and Zheng Liu of the Department of Chemical Engineering at Tsinghua University, with colleagues, have looked to overcome this hurdle by developing a simple, fast and high throughput method based on ink-jet printing. 

The team replaced the colour inks in a standard inkjet printer with enzyme and substrate solutions. The ratio of these solutions could be controlled by varying the overall colour that was printed. Optimisation of cascade and coupled enzymatic reactions could be carried out rapidly and inexpensively compared to the standard solution based method. 

Enzymatic encryption, decoding and deletion of information

Precise two-dimensional control of enzyme placement via ink-jet printing also raises the possibility of creating 2D codes with enzymatic encryption built in, as the figure demonstrates. I don’t want to give the secret of this encryption technique away so you’ll have to read the paper today. 

To read the details, check out the ChemComm article in full: 

Ink-jet printing an optimal multi-enzyme system
Yifei Zhang, Fengjiao Lyu, Jun Ge, Zheng Liu
Chem. Commun., 2014, Accepted Article
DOI: 10.1039/C4CC06158F 

 

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Improvements to a selective hydrogenation process using ionic liquids

In this ChemComm communication, Peter Claus and co-workers describe an interesting application of room temperature ionic liquids to the selective hydrogenation of 2-hexyne. Unlike many reports in the literature, where an ionic liquid acting as a solvent may enhance a particular reaction, this report outlines a solid supported catalyst system modified with an ionic liquid layer.

Such materials, known as SCILLS, (solid catalyst with an ionic liquid layer) have been investigated in a variety of hydrogenation reactions. In this work the desired reaction is the reduction of 2-hexyne to cis-2-hexene. The catalyst is 1 wt% palladium on silica, modified with various loadings of 3 common ionic liquids: BMIM hexafluorophosphate, BMIM bis(triflouoromethanesulfonyl)imide and N-butyl-N-methylpyrrolidinium dicyanamide ([BMPL][DCA]). The performance of the unmodified catalyst was compared with the yield and selectivity afforded by the SCILL systems. The best results were reported with the dicyanamide ionic liquid SCILL, ([BMPL][DCA]) at 30 wt% ionic liquid loading.

In such a process, there are several reactions that must be suppressed. As the product is an olefin, isomerisation to the trans product must be controlled, as must further hydrogenation to the fully reduced material, hexane. For a number of reasons, based on the nature and amount of chemisorbed hydrogen, and favourable dicyanamide anion interactions with palladium, the dicyanamide SCILL system is particularly effective.

Notably, this system gives improved performance in terms of selectivity and yield over the two best performing commercial catalysts for this task. For example, Lindlar´s catalyst, palladium on calcium carbonate, deactivated with lead, cannot match its performance. In this work, the authors give an example of how ionic liquids can add value to a commercial process, while also offering considerable process improvements, in terms of toxicity and arguably, simplicity. The group’s focus now turns to SCILL activity and stability in a continuous hydrogenation process.

Read this RSC Chemical Communication today!

ionic-liquid layer
Frederick Schwab, Natascha Weidler, Martin Lucas and Peter Claus
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