Manganese oxide nanoparticles with a hydrophilic coating show promise as a contrast agent for Magnetic Resonance Imaging (MRI) due to the nanoparticles efficient water-surface interaction resulting in prominent T1 contrast.
Xiaoyuan Chen, at Stanford University, in the US and colleagues in China, have carried out a proof-of-concept study, where they’ve coupled the nanoparticles with 64Cu radioisotope and performed PET/MRI dual imaging in a U87MG xenograft model. It showed good tumor accumulation for both imaging modalities.
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