An efficient stereoselective synthesis of 1-alkenylphosphonates has been developed by Gwilherm Evano and colleagues at CNRS in France. Its advantages over other methods are the starting materials, which are readliy avaiable. For example, dibromo alkene is an attractive synthetic equivalent to alkenyl bromides.
- Synthesis of 1-alkenylphosphonates
The team plan to do further studies on the applications of this method, particularly investigating its use with other nucleophiles and reaction mechanisms that are still unclear and undoubtedly more complicated than the one reported here.
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