The challenging synthesis of B-seco limonoids has been achieved using an Ireland-Claisen rearrangement, report scientists in Germany.
Herbert Waldmann worked with a collaboration of scientists from various German science institutes on this project and believes that the synthetic strategy described here might facilitate the total synthesis of other natural products containing similar limonoid scaffolds and their analogues.
For more details on the reaction conditions used, download the ChemComm communication today, which will be free to access until the 24th June 2011.
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You may also be interested to know that Herbert Waldmann recently helped guest edit a web themed issue on ‘Enzymes and Proteins’ – A nice collection of articles from high profile scientists in this area of chemical biology, including some of Herbert’s very own research papers. |
