The inhibition effect of Naringenin

With the help of two single-molecule techniques, the inhibitor effects of Naringenin become apparent

Chinese scientists have confirmed that Naringenin inhibits transforming growth factor-β (TGF-β) signaling in living cells.

Naringenin is a natural predominant flavanone with many pharmacology activities

TGF-β signalling plays a crucial role in a wide variety of biological processes, such as cell growth, differentiation, apoptosis, and embryonic development. Xiaohong Fang and colleagues from the Chinese Academy of Sciences, in Beijing, and co-workers from nearby Peking University, believe that developing TGF-β signalling inhibitors will help create new therapeutic reagents and anticancer drugs of the future. Here, Fang and his team have shown that Naringenin, a natural flavonone, inhibits this important signalling receptor, evidence supported by single-molecule fluorescence microscopy and single molecule force spectroscopy techniques.

Fancy reading about the techniques used, or finding out more on the inhibition mechanism? Then download the ChemComm communication, which is free to access until the 3rd June 2011!

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