A racemic Au(I)-catalysed three-component reaction has been developed by US scientists to prepare cyclic carbamimidates from imines, terminal alkynes and sulfonylisocyanates. This reaction exploits the carbophilic π-acidity of gold catalysts to first activate an alkyne toward deprotonation and then to activate the internal alkyne generated toward intramolecular O-cyclisation.
Unlike similar previously reported multicomponent gold-catalysed reactions, the stereocentre generated during the alkynylation is preserved in the product. This trait was exploited by developing an enantioselective variant, using an unusual trans-1-diphenylphosphino-2-arylsulfamidocyclohexane ligand.
Moderate to excellent levels of enantioselectivity were obtained using a variety of N-arylbenzylidene anilines.
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M J Campbell and F D Toste, Chem. Sci., 2011, DOI: 10.1039/c1sc00160d
On Monday I attended the 
Scientists have laid the foundations for a high-performance ‘molecular fridge’ capable of reaching temperatures within a few thousandths of a degree of absolute zero (0K) with a high degree of efficiency. Such ultracoolers could have applications in areas such as ultra-low temperature physics, where alternative technologies such as those that rely on expensive and rare helium-3 could be unsuitable or too costly.
