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Yi-Tao Long selects his Editor’s Choice in analytical chemistry and sensors

Photo of Yitao Long in a circle

Professor Yi-Tao Long, Nanjing University

Professor Yi-Tao Long’s Editor’s Choice

We are delighted to share with you our latest Editor’s Choice collection that presents a selection of notable research contributions in analytical chemistry and sensors in Chemical Science from 2023 to 2024.

The featured articles selected by Chemical Science Associate Editor, Yi-Tao, demonstrate 18 cutting-edge papers in analytical chemistry and sensors, highlighting innovations in imaging, diagnostics, phototherapy, mass spectroscopy, AI-powered detection and more.

From photodynamic therapy to high-throughput proteomics, these studies showcase key advances in analytical chemistry and the creativity and interdisciplinary strength of chemical research published in Chemical Science.

 

Professor Long considers work at the forefront of analytical chemistry, including significant advances in spectroscopic analysis and electrochemistry. Submit your best manuscripts on these topics to Chemical Science for Professor Long’s consideration.

We hope you enjoy reading this selection of articles chosen by Professor Yi-Tao Long.

A mitochondria-localized iridium(III) photosensitizer for two-photon photodynamic immunotherapy against melanoma

Lili Wang, Johannes Karges, Fangmian Wei, Lina Xie, Zhuoli Chen, Gilles Gasser, Liangnian Ji and Hui Chao

Chem. Sci., 2023, 14, 1461-1471

Graphical abstract: A mitochondria-localized iridium(iii) photosensitizer for two-photon photodynamic immunotherapy against melanoma

Rational design of mesoporous chiral MOFs as reactive pockets in nanochannels for enzyme-free identification of monosaccharide enantiomers

Graphical abstract: Rational design of mesoporous chiral MOFs as reactive pockets in nanochannels for enzyme-free identification of monosaccharide enantiomers

Ligand engineering of Au44 nanoclusters for NIR-II luminescent and photoacoustic imaging-guided cancer photothermal therapy

Chem. Sci., 2023, 14, 4308-4318

Graphical abstract: Ligand engineering of Au44 nanoclusters for NIR-II luminescent and photoacoustic imaging-guided cancer photothermal therapy

Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy

Chem. Sci., 2023, 14, 2901-2909

Graphical abstract: Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy

Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells

Chem. Sci., 2023, 14, 2318-2324

Graphical abstract: Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells

The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination

Chem. Sci., 2023, 14, 2159-2167

Graphical abstract: The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination

Automatic materials characterization from infrared spectra using convolutional neural networks

Chem. Sci., 2023, 14, 3600-3609

Graphical abstract: Automatic materials characterization from infrared spectra using convolutional neural networks

Oxidization enhances type I ROS generation of AIE-active zwitterionic photosensitizers for photodynamic killing of drug-resistant bacteria

Chem. Sci., 2023, 14, 4863-4871

Graphical abstract: Oxidization enhances type I ROS generation of AIE-active zwitterionic photosensitizers for photodynamic killing of drug-resistant bacteria

All-in-One digital microfluidics pipeline for proteomic sample preparation and analysis

Chem. Sci., 2023, 14, 2887-2900

Graphical abstract: All-in-One digital microfluidics pipeline for proteomic sample preparation and analysis

Selective FRET nano probe based on carbon dots and naphthalimide–isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury

Chem. Sci., 2024, 15, 757-764

Graphical abstract: Selective FRET nano probe based on carbon dots and naphthalimide–isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury

Lanthanide MOF-based luminescent sensor arrays for the detection of castration-resistant prostate cancer curing drugs and biomarkers

Chem. Sci., 2024, 15, 6488-6499

Graphical abstract: Lanthanide MOF-based luminescent sensor arrays for the detection of castration-resistant prostate cancer curing drugs and biomarkers

Redox-mediated electrochemiluminescence enhancement for bead-based immunoassay

Chem. Sci., 2024, 15, 1150-1158

Graphical abstract: Redox-mediated electrochemiluminescence enhancement for bead-based immunoassay

Ratiometric near-infrared fluorescent probe for nitroreductase activity enables 3D imaging of hypoxic cells within intact tumor spheroids

Chem. Sci., 2024, 15, 3633-3639

Graphical abstract: Ratiometric near-infrared fluorescent probe for nitroreductase activity enables 3D imaging of hypoxic cells within intact tumor spheroids

Dynamic surface reconstruction of individual gold nanoclusters by using a co-reactant enables color-tunable electrochemiluminescence

Chem. Sci., 2024, 15, 3255-3261

Graphical abstract: Dynamic surface reconstruction of individual gold nanoclusters by using a co-reactant enables color-tunable electrochemiluminescence

High-throughput single-cell mass spectrometry enables metabolic network analysis by resolving phospholipid C[double bond, length as m-dash]C isomers

Chem. Sci., 2024, 15, 6314-6320

Graphical abstract: High-throughput single-cell mass spectrometry enables metabolic network analysis by resolving phospholipid C [[double bond, length as m-dash]] C isomers

High-throughput drug target discovery using a fully automated proteomics sample preparation platform

Chem. Sci., 2024, 15, 2833-2847

 

Graphical abstract: High-throughput drug target discovery using a fully automated proteomics sample preparation platform

A simplified and efficient extracellular vesicle-based proteomics strategy for early diagnosis of colorectal cancer

Chem. Sci., 2024, 15, 18419-18430

Graphical abstract: A simplified and efficient extracellular vesicle-based proteomics strategy for early diagnosis of colorectal cancer

Calibration-free reaction yield quantification by HPLC with a machine-learning model of extinction coefficients

Chem. Sci., 2024, 15, 10092-10100

Graphical abstract: Calibration-free reaction yield quantification by HPLC with a machine-learning model of extinction coefficients

 

If you are interested in research in similar areas, explore our most popular 2024 analytical chemistry articles collection and our related Imaging, biosensing and diagnostics: 2025 Chemical Science symposium collection.

Chemical Science is the flagship journal of the Royal Society of Chemistry, publishing exceptional research across the chemical sciences. As a diamond open access journal, all of our articles are free to read and free to publish – find out more and browse our latest articles on our webpage.

Keep up to date with our latest articles, reviews, collections & more by following us on Bluesky, LinkedIn or by signing up to our E-Alerts.

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2025 Chemical Science Lectureship awarded to Chris Chang

Chemical Science is delighted to announce the winner of our 2025 Lectureship, Professor Christopher Chang!

Launched in our 15th anniversary year, the Chemical Science Lectureship celebrates leading, independent researchers at all career stages who have made exceptional discoveries and innovations in their field within the last five years. This annual lectureship focuses on a specific subject area that aligns with the Chemical Science symposium each year, rotating to cover the breadth of the journal and all areas of the chemical sciences.

This year, the Lectureship focused on the chemistry of imaging, biosensing and diagnostics and Professor Chris Chang was selected as the winner for his recent research on activity-based sensing and transition metal signalling. Chris will deliver the Lectureship at the 2025 Chemical Science Symposium on the same theme on 18-19 November in London, UK.

About our 2025 winner:

Photograph of Chris Chang, by David Kelly CrowChristopher Chang, Princeton University

Chris Chang is the Edward and Virginia Taylor Professor of Bioorganic Chemistry at Princeton University. He completed his B.S. and M.S. degrees from Caltech in 1997 with Harry Gray, a Fulbright scholarship with Jean-Pierre Sauvage, a Ph.D. from MIT in 2002 with Dan Nocera, and a postdoc at MIT with Steve Lippard. Chris started his independent career at UC Berkeley in 2004 before moving to Princeton in 2024.

The Chang laboratory studies the chemistry and biology of the elements. His group has pioneered the concept of activity-based sensing, showing that selectivity in sensor design is achievable by reaction-based methods that go beyond traditional binding-based approaches that operate by lock-and-key molecular recognition.

Christopher’s work has also changed dogma in the inorganic and chemical biology communities by showing that transition metals are not merely active site cofactors in proteins but also serve as dynamic transition metal signals that operate as allosteric regulators of protein function through metalloallostery, giving rise to new metal-dependent cell growth and proliferation pathways such as cuproplasia and ferroplasia.

He has mentored nearly 150 graduate, postdoc, and undergraduate researchers, with 46 alumni who are now faculty leading their own laboratories. He currently serves as Editor-in-Chief for Accounts of Chemical Research.

Read Chris’ recent Chemical Science articles:

A mitochondrial-targeted activity-based sensing probe for ratiometric imaging of formaldehyde reveals key regulators of the mitochondrial one-carbon pool
Logan Tenney, Vanha N. Pham, Thomas F. Brewer and Christopher J. Chang*
Chem. Sci., 2024, 15, 8080-8088

A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells
Zeming Wang, Tyler C. Detomasi and Christopher J. Chang
Chem. Sci., 2021, 12, 1720-1729

 

Find out more about the 2025 Chemical Science Symposium on the chemistry of imaging, biosensing and diagnostics where Chris will deliver the 2025 Lectureship on our event webpage.

Promotional banner for symposium, with graphical background image relating to imaging chemistry

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Most popular 2024 article collections

Here at Chemical Science, we are pleased to share subject-specific collections of our most popular Chemical Science content published in the last year. These collections are designed to highlight some of the exceptional research published in Chemical Science – and like all Chemical Science articles, they are free to access and read from anywhere in the world with no restrictions.

We hope you enjoy reading our selections of 2024 most popular articles in the collections below.

Analytical Chemistry

Featuring nanotechnology and molecular imaging, revolutionizing diagnostics, therapy, real-time biological monitoring and more.

 

Energy & Environment

Including work on perovskite solar cells, supercapacitors, materials for different types of batteries, plastic recycling and more.

 

Physical & Theoretical Chemistry

Ranging from insights into delocalization errors within the density-functional many-body expansion to visible-light-driven stiff-stilbene photoswitches.

Catalysis

Including articles on photocatalytic plastic upcycling, switchable molecular electrocatalysis and much more.

 

Materials Chemistry

Ranging from recent advances in phosphorescent and fluorescent organic materials, non-linear optical materials, advances in MOFs, HOFs, and porous cages, organic photoswitches, and many other topics.

 

Inorganic Chemistry

Ranging from optical fluoride materials to insights into [FeFe] hydrogenases.

Chemical Biology

Featuring photodynamic therapy, polypeptide folding, and much more.

 

Supramolecular & Polymers Chemistry

Including polymer and supramolecular synthesis, recycling strategies, biomedical and catalytic applications and more.

 

Organic Chemistry

Featuring peptide macrocyclisation, coupling reactions, continuous flow synthesis, and much more.

 

Be sure to also browse our most popular all time article collection we have specially selected for our 15th anniversary in 2025 and find out more in our blog post.

 

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Submit to Chemical Science today! Check out our author guidelines for information on our article types and find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on social media (BlueSky, LinkedIn, Facebook, X), and browse the articles in our latest issues by signing up to our E-Alerts.

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How can Chemical Science increase confidence in research?

Publishing practices you can rely on

Open access research benefits everyone around the planet. It makes research more widely accessible, which can lead to positive change in many areas of daily life. As a diamond open access journal, Chemical Science makes this form of publishing an easy option. We cover all publication costs, so our community can read and publish with us for free.

We are real advocates for open access, and in this blog post, we will explain how it can improve research culture and benefit every single one of us. Interested in learning more? Explore our research or submit your article today.

 

Discover what you could achieve with open access

Greater impact for you

As a researcher, you will find that the biggest benefit of publishing open access is increasing the discoverability of your work. The number of potential readers of your publications increases significantly with open access. If anyone can access your research – including other scientists, funders, policymakers and the general public – then it is more likely to be cited and make an impact.

Every article we publish is diamond open access, but we don’t only rely on our publications being available to all to make an impact. We celebrate our community, offering promotional opportunities like #ChemSciVoices where our authors can discuss their research in a video or blog post. When you publish with us, you can trust that your research will find the communities it needs to.

Better research culture for all

The benefits of open access for individual researchers are clear – but how can it improve research culture too? Open access helps make sure that publications are visible, reliable and reproducible. Ensuring research findings are available to everyone, in any part of the world is the key to building a fairer, more equitable society – one where everyone can access and benefit from discoveries. Open access can also encourage greater multi-disciplinary collaboration, as scientists in all disciplines and subjects can access and inspire each other, so driving scientific progress faster. Chemical Science harnesses these benefits of open access for everyone, by publishing leading-edge articles that have undergone rigorous peer review, at no cost to the author.

 

What makes Chemical Science different?

Our diamond open access policy sets us apart from other journals. This policy means that our community can read our articles and publish with us for free. We cover all of the publication costs, so everyone can choose an open access path for their research. And this is only a possibility because we are a society publisher with a mission to disseminate scientific knowledge.

Fair and rigorous peer review

We see open access as part of a larger vision to improve research culture. It’s not enough to increase the accessibility of articles – we need to make sure that our publications are reliable and reproducible too. Providing a robust peer review process is one way we make sure our publications are reliable. In every submission, our peer reviewers are looking for novel ideas, progressive thinking and research that can make a real-world difference. This approach means that Chemical Science is a home to both accessible and impactful work.

The choice of transparent peer review

We are continually looking for ways in which we can increase the quality of our peer-review. For this reason, we now offer our authors the choice of transparent peer review, which aims to cultivate a more open and robust peer-review process. If an author chooses this option, the peer reviewers’ reports, authors’ responses and editors’ decision letters are published alongside the accepted article. Transparent peer review can:

  • encourage fair and rigorous peer review
  • amplify the hard work of our editors and reviewers
  • allow scientists to learn from the published reports
  • promote more constructive reviewer comments

Transparent peer review is compatible with both single- and double-anonymised peer review. And if you are a reviewer, you will stay anonymous during the process by default. As an author, you can opt in for transparent peer review at any stage before publication.

FAIR publications

Reproducibility is a key part of the open access picture for Chemical Science. We encourage our authors to make sure that the data in publications is FAIR (Findable, Accessible, Interoperable and Reusable), and we also ask authors to provide a data availability statement in their article. This can improve research culture by:

  • supporting the validity of data and maintaining research reproducibility
  • increasing transparency and encouraging trust in the scientific process
  • enabling and encouraging the reuse of new findings
  • giving authors credit through the formal citation of data

Author Contributions

We also ask all authors to provide an Author Contribution Statement as part of their article as standard. Author contribution statements are important as they can:

  • provide transparency about who contributed to the research and in what capacity. It allows readers to understand the specific roles of each author in the study, which can be helpful for assessing the validity and reliability of the research findings. 
  • promote inclusion and diversity by acknowledging the different types of contributions made by each author. 
  • ensure that all authors are given credit for their work, and that those who did not contribute significantly are not listed as authors. 

Start your journey

We are ready when you are. Explore some of these resources to get started with confidence and inspire a global audience.

 

Read our how to publish guide Learn more about open access Watch #ChemSciVoices

 

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