Archive for June, 2022

Chemical Science Reviewer Spotlight – June 2022

To further thank and recognise the support from our excellent reviewer community, we are highlighting reviewers who have provided exceptional support to the journal over the past year.

This month, we’ll be highlighting Iwona Nierengarten, Ashlee Howarth, Jonathan Goodman and Stefan Matile. We asked our reviewers a few questions about what they enjoy about reviewing, and their thoughts on how to provide a useful review.

Iwona Nierengarten, CNRS and University of Strasbourg. My main research interests are concerned with supramolecular chemistry in general and with pillar[n]arenes and rotaxanes in particular. We also develop versatile scaffolds that are easy to functionalize for the construction of sophisticated nanomolecules for applications in materials science and biology.

 

Ashlee Howarth, Concordia University. The Howarth research group is focused on making new rare-earth cluster-based metal–organic frameworks for potential applications in wastewater treatment, catalysis, drug delivery, bioimaging, and sensing.

 

Jonathan Goodman, University of Cambridge. My research group is working on understanding organic chemistry better, by analysing chemical information and by calculating molecular properties. Our DP5 method enables us to get more information out of NMR spectra, our calculations help us to predict how molecules react, and our studies of toxicology tell us whether chemicals are likely to be poisonous.

 

Stefan Matile, University of Geneva. My research focuses on functional supramolecular chemistry, supramolecular systems in action, at work. The general vision is that offering different, at best new ways to get into contact on the molecular level will lead to new structures and functions that ultimately will allow us to tackle challenges in science and society that are otherwise beyond reach. Current topics of interest are systems catalysis with unorthodox interactions (anion-π interactions, chalcogen, pnictogen bonds), chemistry tools to image physical forces in living cells, and the search for new ways to enter into cells.

 

What would you recommend to new reviewers to ensure their report is helpful?

Ashlee Howarth: To always be kind. Remember that you are writing these reviews for real people, many of whom are trainees (it could be their first manuscript!). You can be thorough and constructive, while still being kind. Compliment aspects of the manuscript that are well-done or exciting and be constructive and reasonable with your critiques.

 

Do you have any advice to our readers seeking publication in Chemical Science on what makes a good paper?

Jonathan Goodman: Good papers say something new that is justified by the supporting data and analysis. Very good papers help us to think about chemistry in different ways.

Ashlee Howarth: The main thing I look for when I review a manuscript is thoroughness. Are new materials fully characterized? Are all necessary control experiments performed? Are all the conclusions made supported by data? In addition, the manuscript should be well-written, clear, and easy to follow.

 

What encouraged you to review for Chemical Science?

Stefan Matile: I review for journals that publish my research.  For publishing, I submit mostly to journals published by chemical societies.  Chemical Science thus deserves highest respect for pioneering thoughtful publishing with regard to all aspects.  This includes outstanding editors who always send me papers to reviewers that match my interests.  I can only congratulate Chemical Science, I hope it will continue to excel and am of course more than happy to make my contribution. 

Iwona Nierengarten: Chemical Science offers to the readers the possibility to stay informed on emerging trends in science and it is great to read papers before their publication. It is also very rewarding to help authors to improve the quality of their manuscripts and thus to contribute to the high quality of the papers published by the journal.

 

What do you enjoy most about reviewing?

Iwona Nierengarten: Reviewing is like discovering a first thought of the authors about their research, challenges and achievements. Writing a report offers the possibility to communicate with the authors and share with them your feelings about their work.

Stefan Matile: Reviewing is a lot of work but most enjoyable because it keeps me updated, forces me to catch up on topics different from, but close to, my own research interests – I learn so much, reviewing broadens my horizon.

 

Tune in next month to meet our next group of #ChemSciReviewers!

 

If you want to learn more about how we support our reviewers, check out our Reviewer Hub.

Interested in joining our ever-growing reviewer community? Send us your CV and a completed Reviewer Application Form to becomeareviewer@rsc.org.

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Chemical Science HOT Articles: January – June 2022

We are pleased to share a selection of our referee-recommended HOT articles for January to June 2022. We hope you enjoy reading these articles, congratulations to all the authors whose articles are featured! As always, Chemical Science is free for authors and readers.

You can explore our full 2022 Chemical Science HOT Article Collection here!

Browse a selection of our January to June HOT articles below:

January: 

Universal encoding of next generation DNA-encoded chemical libraries
Louise Plais, Alice Lessing, Michelle Keller, Adriano Martinelli, Sebastian Oehler, Gabriele Bassi, Dario Neri, and
Chem. Sci., 2022,13, 967-974

Solid-state 17O NMR study of α-d-glucose: exploring new frontiers in isotopic labeling, sensitivity enhancement, and NMR crystallography
Jiahui Shen, Victor Terskikh, Jochem Struppe, Alia Hassan, Martine Monette, Ivan Hung,  Zhehong Gan, Andreas Brinkmann, and Gang Wu
Chem. Sci., 2022,13, 2591-2603

February: 

Fluorescent supramolecular polymers of barbiturate dyes with thiophene-cored twisted π-system
Maika Kawaura, Takumi Aizawa, Sho Takahashi, Hiroshi Miyasaka, Hikaru Sotome, and Shiki Yagai
Chem. Sci., 2022,13, 1281-1287

Diboramacrocycles: reversible borole dimerisation–dissociation systems
Sonja Fuchs, Arumugam Jayaraman, Ivo Krummenacher, Laura Haley, Marta Baštovanović, Maximilian Fest, Krzysztof Radacki, Holger Helten and, Holger Braunschweig
Chem. Sci., 2022,13, 2932-2938

Stepwise assembly and reversible structural transformation of ligated titanium coated bismuth-oxo cores: shell morphology engineering for enhanced chemical fixation of CO2
Qing-Rong Ding, Yinghua Yu, Changsheng Cao, Jian Zhang, and Lei Zhang
Chem. Sci., 2022,13, 3395-3401

Photocytotoxicity and photoinduced phosphine ligand exchange in a Ru(ii) polypyridyl complex
Sean J. Steinke, Sayak Gupta, Eric J. Piechota, Curtis E. Moore, Jeremy K. Kondanko, and Claudia Turro
Chem. Sci., 2022,13, 1933-1945

March:

Catalytic asymmetric synthesis of enantioenriched α-deuterated pyrrolidine derivatives
Xin Chang, Xiang Cheng, and Chun-Jiang Wang
Chem. Sci., 2022,13, 4041-4049

Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters
Liyin Jiang, Pau Sarró, Wei Jie Teo, Jordi Llop, and Marcos G. Suero
Chem. Sci., 2022,13, 4327-4333

Chiral molecular nanosilicas
Zhaohui Zong, Aiyou Hao, Pengyao Xing, and Yanli Zhao
Chem. Sci., 2022,13, 4029-4040

Bioinspired superwettable electrodes towards electrochemical biosensing
Qinglin Zhu, Yuemeng Yang, Hongxiao Gao, Li-Ping Xu, and Shutao Wang
Chem. Sci., 2022,13, 5069-5084

Stronger together for in-cell translation: natural and unnatural base modified mRNA
Lisa Bornewasser, Christof Domnick, and Stephanie Kath-Schorr
Chem. Sci., 2022,13, 4753-4761

April: 

Multi-component self-assembled molecular-electronic films: towards new high-performance thermoelectric systems
Troy L. R. Bennett, Majed Alshammari, Sophie Au-Yong, Ahmad Almutlg, Xintai Wang, Luke A. Wilkinson, Tim Albrecht, Samuel P. Jarvis, Lesley F. Cohen, Ali Ismael, Colin J. Lambert, Benjamin J. Robinson, and Nicholas J. Long
Chem. Sci., 2022,13, 5176-5185

Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to develop N-glycan modulators as anticancer agents
Wei-An Chen, Yu-Hsin Chen, Chiao-Yun Hsieh, Pi-Fang Hung, Chiao-Wen Chen, Chien-Hung Chen, Jung-Lee Lin, Ting-Jen R. Cheng, Tsui-Ling Hsu, Ying-Ta Wu, Chia-Ning Shen, and Wei-Chieh Cheng
Chem. Sci., 2022,13, 6233-6243

May:

Insights into electrochemiluminescence dynamics by synchronizing real-time electrical, luminescence, and mass spectrometric measurements
Xuemeng Zhang, Weifeng Lu, Cheng Ma, Tao Wang, Jun-Jie Zhu, Richard N. Zare, and Qianhao Min
Chem. Sci., 2022,13, 6244-6253

Cagearenes: synthesis, characterization, and application for programmed vapour release
Shuai Fang, Mengbin Wang, Yating Wu, Qing-Hui Guo, Errui Li, Hao Li, and Feihe Huang
Chem. Sci., 2022,13, 6254-6261

 

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Strategies for improved fabrication of polysaccharide nanofibers

Cellulose nanofibers (CNFs) are used in large amounts in the paper and biomedical industry. The synthesis process, the nature of the catalyst used, and the recyclability of the catalyst has a direct impact on the cost effectiveness of industrial grade CNFs. CNF production follows carboxylation of the primary alcohol groups at the surface of the cellulose fibres mediated by catalyst 2,2,6,6-tetramethyl-1-piperidine-N-oxy radicals (TEMPO). The genotoxic nature of TEMPO suggests the requirement of a lower concentration of the catalyst used during the reaction.

Scheme for different synthesis strategies and characterization of TEMPO mediated CNFs.

Researchers across the world tried a green synthetic approach for CNFs preparation. This also includes successful removal of the catalyst from the product after completion of the reaction. One of the processes employs oxidation of wood pulp fibres using the magnetically recoverable Karimi’s catalyst (TEMPO@SiO2@Fe3O4). The products obtained using the modified catalyst is 5 nm thick cellulose nanofibrils like those obtained in the oxidation mediated by TEMPO in solution. Whereas, the catalyst was easily recovered with a magnet and successfully reused in 4 successive reaction cycles.

Differently modulated TEMPO like SiliaCat TEMPO (a commercial immobilized TEMPO catalyst) and others, show that hybrid sol–gel catalyst allows the synthesis of insoluble polysaccharide nanofibers of superior quality, eliminating waste.

New production strategies involve TEMPO-mediated oxidation followed by homogenisation. The residual hypochlorite can be quenched with 0.3% ascorbic acid to produce chloride and subsequently CNF is separated from the solid catalyst via simple filtration. This dramatically reduced the polysaccharide nanofiber production costs opening the route to large-scale production of functional products where their use has been limited by high cost.

For details: please visit https://pubs.rsc.org/en/content/articlelanding/2021/sc/d1sc03114g

 

About the blogger:

Dr. Damayanti Bagchi is a postdoctoral researcher in Irene Chen’s lab at University of California, Los Angeles, United States. She has obtained her PhD in Physical Chemistry from Satyendra Nath Bose National Centre for Basic Sciences, India. Her research is focused on spectroscopic studies of nano-biomaterials. She is interested in exploring light enabled therapeutics. She enjoys travelling and experimenting with various cuisines.

You can find her on Twitter at @DamayantiBagchi.

Please note this blog post was originally posted on the Chemical Communications Blog.

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