Synthesising cyclic carbonates could become easier and more efficient thanks to a sequential flow system developed by scientists in the US.
Cyclic carbonates are used as fuel additives and in lithium-ion batteries, and are key intermediates for pharmaceuticals. However, many current synthesis methods require expensive starting reagents and result in unwanted side products.
The method developed by Tim Jamison, of Massachusetts Institute of Technology in Boston, and coworkers, avoids many of these problems by starting from easily obtainable alkenes, rather than the corresponding epoxides, and the cheap and readily available carbon dioxide. The starting alkene is treated with water and N-bromosuccinimide (NBS), a source of bromide ions, which converts the alkene to a bromohydrin. 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), a base, is then added, followed by CO2, leading to the formation of the cyclic carbonate.
Read the full article in Chemistry World»
Read the original journal article in Chemical Science:
Mechanism-guided design of flow systems for multicomponent reactions: conversion of CO2 and olefins to cyclic carbonates
Jie Wu, Jennifer A. Kozak, Fritz Simeon, T. Alan Hatton and Timothy F. Jamison
Chem. Sci., 2014, Advance Article, DOI: 10.1039/C3SC53422G, Edge Article