Scientists in Germany have prepared gold conjugates with mitochondria-localising peptides. Using these conjugates, the team studied the mechanism of action of gold-based anti-cancer drug candidates.
The team showed that the conjugates were able to break resistance against the commonly used anti-cancer drug cisplatin in p53 mutant cells lines.
Link to journal article
A Spontaneous Gold(I)-Azide Alkyne Cycloaddition Reaction Yields Gold-Peptide Bioconjugates which Overcome Cisplatin Resistance in a p53-Mutant Cancer Cell Line
S D Koster et al
Chem. Sci., 2012, DOI: 10.1039/c2sc01127a