Scientists in Japan and Germany have made the first efficient catalyst to enable the synthesis of hindered heterobiaryls by direct C–H coupling. Hindered biaryls have numerous applications such as catalysts/ligands for asymmetric synthesis and chiral materials, and are often found in biologically active natural products.
Link to journal article
Hindered Biaryls by C-H Coupling: Bisoxazoline-Pd Catalysis Leading to Enantioselective C-H Coupling
K Yamaguchi et al
Chem. Sci., 2012, DOI: 10.1039/c2sc20277h
