By building methotrexate – a potent leukaemia drug – into nanoscale coordination polymers as bridging ligands, scientists have achieved high drug loadings of 79 wt% and selective delivery to cancer cells, where the drug is released. The polymers have superior in vitro efficacy to the free drug and the toxic side effects of the free drug are avoided.
Reference:
Lipid-Coated Nanoscale Coordination Polymers for Targeted Delivery of Antifolates to Cancer Cells
R C Huxford, K E deKrafft, W S Boyle, D Liu and W Lin, Chem. Sci., 2011
DOI : 10.1039/c1sc00499a
