A cheaper way to catalyse the oxidative annulation of alkynes

The first ruthenium-catalysed oxidative annulation of alkynes with air as an oxidant has been done by scientists in Germany.

The team used an inexpensive ruthenium catalyst for aerobic C-H bond functionalisations, providing novel access to structural motifs of bioactive alkaloids.

Oxidative annulations reactions of alkynes by C-H bond cleavages provides a route to polycyclic heteroarenes. Ruthenium-catalysed methods use stoichiometric amount of copper(II) or silver(II) salts, but these lead to heavy metal by-products. Rhodium-catalysed methods are known but this ruthenium method is cheaper with improved scope and chemoselectivity.


Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles

L Ackermann, L Wang and A V Lygin, Chem. Sci., 2011,
: 10.1039/c1sc00619c

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One Response to “A cheaper way to catalyse the oxidative annulation of alkynes”

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