October 2020 Reviews

Every month we update our Recent Reviews collection. This rolling collection showcases all of the review articles published in RSC Advances in the last 6 months. Don’t forget to come back next month to check out our latest reviews.

We hope you enjoy reading and as always, all of our articles are open access so you can easily share your favourites online and with your colleagues.

Check out the full collection!

Browse a selection of our October reviews below:

G-Protein coupled receptors: structure and function in drug discovery
Chiemela S. Odoemelam, Benita Percival, Helen Wallis, Ming-Wei Chang, Zeeshan Ahmad, Dawn Scholey, Emily Burton, Ian H. Williams, Caroline Lynn Kamerlin and Philippe B. Wilson
RSC Adv., 2020, 10, 36337-36348
DOI: 10.1039/D0RA08003A

Recent advances in additive manufacturing of engineering thermoplastics: challenges and opportunities
Maisyn Picard, Amar K. Mohanty and Manjusri Misra
RSC Adv., 2020, 10, 36058-36089
DOI: 10.1039/D0RA04857G

Integrating DNA damage response and autophagy signalling axis in ultraviolet-B induced skin photo-damage: a positive association in protecting cells against genotoxic stress
Sheikh Ahmad Umar and Sheikh Abdullah Tasduq
RSC Adv., 2020, 10, 36317-36336
DOI: 10.1039/D0RA05819J

Anisotropic quasi-one-dimensional layered transition-metal trichalcogenides: synthesis, properties and applications
Abhinandan Patra and Chandra Sekhar Rout
RSC Adv., 2020, 10, 36413-36438
DOI: 10.1039/D0RA07160A

Multicomponent crystals of anti-tuberculosis drugs: a mini-review
Eustina Batisai
RSC Adv., 2020, 10, 37134-37141
DOI: 10.1039/D0RA06478E

Homogeneous and heterogeneous molecular catalysts for electrochemical reduction of carbon dioxide
Maryam Abdinejad, M. Nur Hossain and Heinz-Bernhard Kraatz
RSC Adv., 2020, 10, 38013-38023
DOI: 10.1039/D0RA07973A

Nitroacetonitrile as a versatile precursor in energetic materials synthesis
Shannon E. Creegan and Davin G. Piercey
RSC Adv., 2020, 10, 39478-39484
DOI: 10.1039/D0RA07579E

 

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

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October HOT Articles

Every month we update our RSC Advances HOT Article Collection. This rolling collection features all of the articles selected by our reviewers and handling editors as HOT in the last 6 months. Don’t forget to come back next month to check out our latest HOT articles.

We hope you enjoy reading and as always, all of our articles are open access so you can easily share your favourites online and with your colleagues.

Check out the full collection!

Browse our October HOT articles below:

Hierarchical micro-/mesoporous zeolite microspheres prepared by colloidal assembly of zeolite nanoparticles
Walter Rosas-Arbelaez, Andreas J. Fijneman, Heiner Friedrich and Anders E. C. Palmqvist
RSC Adv., 2020, 10, 36459-36466
DOI: 10.1039/D0RA07394F

Deep eutectic solvent in water pickering emulsions stabilised by cellulose nanofibrils
Saffron J. Bryant, Marcelo A. da Silva, Kazi M. Zakir Hossain, Vincenzo Calabrese, Janet L. Scott and Karen J. Edler
RSC Adv., 2020, 10, 37023-37027
DOI: 10.1039/D0RA07575B

Network pharmacology-based study of the mechanisms of action of anti-diabetic triterpenoids from Cyclocarya paliurus
Zixin Lin, Yingpeng Tong, Na Li, Ziping Zhu and Junmin Li
RSC Adv., 2020, 10, 37168-37181
DOI: D0RA06846B

Nanocellulose enriches enantiomers in asymmetric aldol reactions
Naliharifetra Jessica Ranaivoarimanana, Xin Habaki, Takuya Uto, Kyohei Kanomata, Toshifumi Yui and Takuya Kitaoka
RSC Adv., 2020, 10, 37064-37071
DOI: 10.1039/D0RA07412H

Engineering of zeolite BEA crystal size and morphology via seed-directed steam assisted conversion
Tatiana O. Bok, Egor P. Andriako, Elena E. Knyazeva and Irina I. Ivanova
RSC Adv., 2020, 10, 38505-38514
DOI: 10.1039/D0RA07610D

Pyrazolo[1,5-a]pyrimidines-based fluorophores: a comprehensive theoretical-experimental study
Alexis Tigreros, Sandra-L. Aranzazu, Nestor-F. Bravo, Jhon Zapata-Rivera and Jaime Portilla
RSC Adv., 2020, 10, 39542-39552
DOI: 10.1039/D0RA07716J

 

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

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Editors’ Collection: Phthalocyanines by Associate Editor Fabienne Dumoulin

We are delighted to share with you our latest collection of recently published articles focusing on Phthalocyanines, handpicked by Associate Editor Fabienne Dumoulin.

These brightly coloured molecules belong to the porphyrinoids family, as do haemoglobin and chlorophyll. Their optical, magnetic, electronic (amongst others!) properties can be tailored by playing with the substitution and/or metalation pattern, with quasi-infinite combinations, giving the opportunity to perform enthralling structure-properties or structure-activities relationship analyses.

With an appropriate design, these fascinating compounds can act as photosensitisers for photodynamic therapy, take place in sensor devices, harvest light, catalyse, electro-catalyse or photo-catalyse either oxidation or reduction reactions. Their inclusion in materials such as MOFs and COFs and more generally in nanoscience enlarge again the possibilities to produce high-performance compounds and materials, should it be for pure fundamental research or more applied technologies.

As the world’s largest gold open access chemistry journal, all publications in RSC Advances are free to access. We hope you enjoy reading these articles.

We invite you to submit your research to this collection and give your work the global visibility it deserves.

 

Submit your research now

Featured articles:

Impact of photosensitizer orientation on the distance dependent photocatalytic activity in zinc phthalocyanine–nanoporous gold hybrid systems
David Steinebrunner, Günter Schnurpfeil, Mathis Kohröde, Alexander Epp, Khaetthariya Klangnog, Jorge Adrian Tapia Burgos, Andre Wichmann, Dieter Wöhrle and Arne Wittstock
RSC Adv., 2020,10, 23203-23211. DOI: 10.1039/D0RA03891A

Elucidating π–π interaction-induced extension effect in sandwich phthalocyaninato compounds
Xin Chen, Dongdong Qi, Chao Liu, Hailong Wang, Zheng Xie, Tse-Wei Chen, Shen-Ming Chen, Tien-Wen Tseng and Jianzhuang Jiang
RSC Adv., 2020,10, 317-322. DOI: 10.1039/C9RA07847A

Metal phthalocyanine organic thin-film transistors: changes in electrical performance and stability in response to temperature and environment
Nicholas T. Boileau, Rosemary Cranston, Brendan Mirka, Owen A. Melville and Benoît H. Lessard
RSC Adv., 2019,9, 21478-21485. DOI: 10.1039/C9RA03648B

 

Read the full collection here

Meet the Editor

Associate Professor Dr. Fabienne Dumoulin first started university studying biology, graduated in biochemistry and then completed her PhD in organic chemistry in Lyon, France in 2002. After post doctoral studies in Pisa, Italy, she was a faculty member at Chemistry Department of Gebze Technical University from 2005 to 2019. She is now associate professor at Acıbadem Mehmet Ali Aydinler University in Istanbul,Turkey.

Her research focuses on the chemistry, properties and applications of phthalocyanines, mainly for photodynamic therapy. She has authored so far 82 research articles, three book chapters, and supervised many Master and PhD students. Fabienne has also been the recipient of several Young Scientist Awards: TUBA-GEBİP from the Turkish Academy of Sciences, BAGEP from the Bilim Akademisi and the Mustafa N Parlar Foundation of METU. She was elected officer of the executive committee of the European Society for Photobiology in 2015 and 2017, is an Associate Editor for RSC Advances and the Journal of Porphyrins and Phthalocyanines, and is a Member of the Royal Society of Chemistry.

 

RSC Advances Royal Society of Chemistry

Submit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

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RSC Advances Science Communications: New advances in materials for electrodes of lithium batteries

Author: Cristian M. O. Lépori, Web Writer

Argentina, Bolivia and Chile make up the “Lithium Triangle”, where 70 % of the world’s lithium reserves are concentrated. These factors lead to the study in the development of lithium batteries being of great interest to my country and particularly to me, because I am beginning to research on this topic, so I am interested in reading articles on lithium batteries. During the last decades, numerous investigations have been carried out in the area of lithium batteries, in relation to their components such as electrodes, separators and electrolytes, to make them safer, environmentally friendly and economical.

A battery is made up of a set of electrochemical cells, which are made up of three main components: cathode, anode and electrolyte. In the case of the lithium battery, when charging battery, the lithium ions move from the positive electrode (cathode) towards the negative electrode (anode), and in opposite way during the discharge process. In this type of battery, the negative electrode is mainly composed of carbonaceous materials and the positive electrode of metal oxides. There is an urgent need for better lithium-ion batteries in order to create sustainable solutions based on relatively limited resources with a long-term perspective, and to apply the knowledge of mesoporous based cathode materials to an exciting field of lithium-ion battery research.

The article “Electrochemical performance of nano-sized LiFePO4-embedded 3D-cubic ordered mesoporous carbon and nitrogenous carbon composites” focuses on generic principles applicable to more advanced materials and systems for the development of highly electroactive olivine structured cathode materials for high performance lithium-ion batteries. This research findings would open potential avenues for fundamental on state-of-the-art mesoporous carbon-based materials for energy storage systems. Exploitation of novel porous cathode materials and a strengthening of fundamental understanding of their textural property and electrochemical performance relationships have played a major role in developing the lithium-ion battery research field.

One way to overcome the limitations of commercial lithium batteries is to modify the active material used in the negative electrode. Current devices use mainly carbonaceous material, which has the advantage of operating at low potentials. During the charging and discharging process, the carbonaceous material undergoes a reversible volumetric variation of approximately 10% and maintains its structure, giving stability to the battery for many cycles. Although the storage capacity of this material has allowed for the development of current portable electronic devices, it translates into a low energy density when considering its application in electric vehicles. Therefore, much of the lithium battery research is focused on the development of next generation batteries with high energy density (i.e. lighter batteries). However, enabling stable cycling and high-power output is also desirable for next generation batteries. Operation of lithium batteries at high power often leads to a decrease in the cycle life. Often a high-power output is required for a short duration, for example for rapid vehicle acceleration. The developed electrode material is cheap and easy to make, and is applicable to these high power applications.

The article “A stable TiO2–graphene nanocomposite anode with high rate capability for lithium-ion batteries” focuses on the development of new electrode materials for lithium batteries that offers stable cycle performance at high power density. Titanium dioxide is an abundant metal oxide that is widely used as a pigment in paint, sunscreen, and food coloring. Titanium dioxide can be used as a stable negative electrode material, enabling long life for the battery. However, it has low electrical conductivity, thus combining the titanium dioxide with a conducting additive has been found to enhance its performance. In this study, the high power stable cycling performance of a titanium dioxide/graphene composite, prepared by a simple synthesis method, was demonstrated. The new electrode material could be used in the next generation batteries, which will be much safer and with higher power density and longer cycle life than ever before. It should be noted that this work was performed with the collaboration between battery research groups at the Helmholtz Institute of Ulm, the University of Waterloo, and the University of Calgary.

I thank Dr. Parasuraman Selvam and Dr. Edward P. L. Roberts for their cordial responses.

Read the articles:

Electrochemical performance of nano-sized LiFePO4-embedded 3D-cubic ordered mesoporous carbon and nitrogenous carbon composites
Sourav Khan, Rayappan Pavul Raj, Talla Venkata Rama Mohan and Parasuraman Selvam
RSC Adv., 2020, 10, 30406–30414

A stable TiO2–graphene nanocomposite anode with high rate capability for lithium-ion batteries
Umer Farooq, Faheem Ahmed, Syed Atif Pervez, Sarish Rehman, Michael A. Pope, Maximilian Fichtner and Edward P. L. Roberts
RSC Adv., 2020,10, 29975-29982

 

About the Web Writer:

Cristian M. O. Lépori is Doctor in Chemical Sciences and currently has a postdoctoral position at the “Enrique Gaviola” Institute of Physics, CONICET, National University of Córdoba (Argentina). He works in the area of nuclear magnetic resonance studying hybrid materials formed with porous matrices and ionic liquids for use in lithium batteries. He likes to plan, organize and carry out science dissemination activities. You can find him on Twitter at @cristianlepo.

 

 

 

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

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RSC Advances Science Communications: Investigating the water splitting reaction

Author: Jifang Zhang, Web Writer

Recalling my early days as a PhD student, our lab was just setting up equipment for tests, which involved a group of devices that could evaluate the efficiency of our electrodes for splitting water into hydrogen and oxygen using sunlight. For that, we needed a “sun” in the lab to give out consistent irradiation, which was a powerful Xe lamp (Fig. 1). Only when our sample electrodes were illuminated with this big bulb would they get excited, generate electric current and produce gas.

The more interesting part was, however, something called a monochromator. When I was doing physics module as an undergraduate and first came across this instrument in textbook, I mumbled, ‘What’s the big deal?’ But as different colours of light came out one after another in front of my eyes (with special safety goggles on, of course), it was like seeing some kind of magic unfolding. This was even cooler than ‘The Dark Side of The Moon’! But what the expensive monochromator really did was to allow us to evaluate how well our samples respond to each wavelength of light, technically called incident photon-to-current conversion efficiency (IPCE).

Another measurement we did was called intensity modulated photocurrent spectroscopy (IMPS), which has been gaining increasing popularity over the years. This test involved superimposing an AC signal on a DC signal and giving it as input to an LED so that the light intensity changed sinusoidally around a constant level. When the experiment started and you would see the light start to jiggle, at all sorts of frequencies from kHz to mHz, just like stage lights. Suddenly, we were like: It’s party time! Now back to business, we had to take recordings of the current generated by our electrodes and calculate a couple of rate constants to understand the kinetics of the water splitting reaction.

These fun experiments led our group to a number of publications (1, 2), including one in RSC Advances. Moving on to a different university as a postdoc, I’m planning to buy them again!

Fig 1. Lab setup at University of Bath (2017). Now at Imperial College London under group of Salvador Eslava.

References

1. J. Zhang et al., RSC Adv., 2017, 7, 35221
2. J. Zhang et al., Energy Environ. Sci., 2018, 11, 2972

 

About the Web Writer: 

Jifang Zhang completed his BEng at Beijing Institute of Technology, before moving to the UK for MSc at the University of Edinburgh and PhD at University of Bath. Now he is back in Beijing as a postdoc researcher at Tsinghua University.

Outside working hours, he is always juggling between karate, running, drumming and photography. You can find him on Instagram @jifang_zhang.

 

 

 

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

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Feature interview with RSC Advances Executive Editor Laura Fisher

Laura Fisher is Executive Editor for RSC Advances at the Royal Society of Chemistry. She is responsible for the strategic development of the journal, working with members of the Editorial Board and Associate Editors to ensure RSC Advances upholds its standards of quality and impact, and supports the global chemistry community. She kindly agreed to talk about her career in publishing and her aspirations for RSC Advances in the future.

You started as Managing Editor for RSC Advances in June 2019 and in January this year, you were appointed as Executive Editor. Going forward, what is your vision for the journal? What can authors and readers expect of RSC Advances in the future?

I’ve really enjoyed working with the RSC Advances team for the past year. My previous role was across five journals, all of which were much smaller and more subject-specific, as well as not being open access. RSC Advances offers completely different challenges in terms of the size of the journal and engaging with authors across a much broader subject range, and I have learned a lot in the past year! I have really enjoyed the Open Access focus, and working with our huge team of Associate Editors who cover so many different subjects and geographies, but are all so engaged with what we are doing.

In the future I would like us to engage with more and more early career researchers, and give them opportunities to be involved in the journal, whether it is as web writers on our blog, as reviewers, or as Associate Editors. I’d also really like to engage with more people who are really passionate about open access publishing, as I really believe it is the future of our field.

Soon after you started as Executive Editor, the COVID-19 pandemic hit the world. How has this affected you and the journal? What has been most challenging?

From a personal standpoint the biggest transitions have been working from home rather than seeing my colleagues and teammates in the office every day, and also the lack of international travel. I was lucky to get out to China and meet some of the community there last November, but it has been really strange not getting to meet authors and readers in person at conferences over the past year.

From a journal point of view we saw a big spike in submissions at the start of lockdown, when I guess more people had time for writing, and more recently a slight dip as labs are opening up and people are focussing on getting their research back on track. We are also seeing funding being limited in certain regions, which can be challenging for open access.

I also think there have been some positives though, such as the way we have learned to communicate with each other remotely through various means, and that could have a really big benefit going forwards both in terms of collaboration, but also in limiting the amount of international travel for conferences, which is a big part of both my role as an Executive Editor, as well as those of our authors, editors, and readers.

It is the International Open Access Week and you are leading one of the largest gold open access chemistry journals in the world. What makes RSC Advances an important journal in the work towards open research?

The main thing for me is that we are really trying to make open access publishing as inclusive as possible. Our APCs are some of the lowest in the industry, and we offer waivers and discounts to authors from developing countries. To me that shows that we really are doing this for the researchers, and to make chemical science more accessible for everyone.

What would you say to researchers who are on the fence about open access?

It really depends on their reasoning. For those who have concerns about whether the research is reliable and of high quality, I would highlight the fact that at RSC Advances our standards have not changed since before we were open access. Our reject rate has been steady at ~55% for the past 7 years, and this shows that we are applying the same quality standards to open access work as we were previously. 

It is also important to clarify that at the RSC we keep our editorial decisions very separate from any decisions about discounts or waivers. We do that for a good reason – so that we are only judging people’s research on the research itself, and not on the author’s ability to pay an APC. That is the way it should always be.

Finally I would tell people that one of the main benefits of open access is that your research can be read by more people. Under the subscription model only people at institutions with subscription access, or those who pay per article, can read articles, whereas with Open Access anyone can read your work. That includes people at institutions with lower budgets, people in developing countries who don’t generally have broad access to research, and people working in different fields. This means more opportunities for citation and collaboration.

You have a background in research yourself, a PhD in chemistry. Please could you tell us about that?

I did my undergraduate degree and my PhD at the University of Bath. Technically my PhD is in chemical engineering, but it had a quite heavy chemistry focus – synthesising and characterising MOFs, and then measuring their hydrogen adsorption capacity for potential use in fuel cells. After leaving Bath I completed a postdoc at Stellenbosch University, South Africa. However, I have to say I was never a very good practical chemist, and my accident-prone nature made me realise that being in the lab probably wasn’t the best career path for me. I really wanted to stay involved in science though, which is why I applied to work at the Royal Society of Chemistry.

In the past, you have worked on several different journals as well as been involved in the launching of new journals. What made you interested in a career in publishing in the first place? What do you find most exciting with RSC Advances?

As I said in the previous question, it was mostly wanting to stay involved in science but recognising that a career in research didn’t really suit me. I also really enjoy writing, and initially was attracted to the language editing side of the role – helping authors improve their papers. As my career developed I realised I was better at the more outward-facing side of the editor role, and I really enjoy getting to work directly with members of the scientific community on a daily basis. The breadth of scope in RSC Advances makes that even better, because there are so many people who have published in, reviewed for, or read the journal, and each has a different insight.

What is the most common question people ask you about RSC Advances and what is your response to it?

I get a lot of questions from people who have been offered a transfer to RSC Advances from another RSC journal, asking why this is. The main reason is that we get a lot of really great work submitted to all of our journals at the RSC, but sometimes that work isn’t suitable for the journal it was submitted to, whether that is because it isn’t in scope, or because it doesn’t meet the novelty or impact standards of that journal. However, that doesn’t mean it isn’t great work, and we want to keep as much of that great work as we can at the RSC, by offering the authors the option to publish in a more suitable journal. 

We see this as a service for authors, because the transfer is automatic once they approve it, so they don’t have to go through the submission process from the beginning again, and if their paper has already been through peer review, we can often use the same referees, or even the same referee reports, saving the authors time.

Sometimes a transfer offer will be made to one of our subscription journals, and sometimes it will be an open access journal, such as RSC Advances. The only criterion driving transfer offers is the suitability of the venue for the paper in question. And of course, these transfer offers are always optional! 

Do you have any favourite RSC Advances articles? If so, which ones and why?

There was a paper earlier in the year where the authors had been inspired by the way beetles capture water from the air in deserts, and had used the same concept to design a surface that could capture water from fog, with the potential to generate drinking water in arid regions. I really do love how nature can inspire scientists in so many ways!

Back in 2016–2018 when I was working on the journal Soft Matter there was a series of papers in RSC Advances and Soft Matter where the authors were engineering edible microballoons that could be used to deliver nutritional supplements to babies in developing countries. The work they had published with us helped them secure a Bill & Melinda Gates Foundation grant. It’s really great when publications in our journals lead to work that can make such a difference in the world.

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest HOT articles, Reviews, Collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

 

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RSC Advances Science Communications: Open Access

Author: Lee Birchall, Web Writer

In my recent blog post, I discussed the benefits of online conferences for inclusion and wide participation. Access to science without barriers like money and travel is always appreciated and fosters greater interest and collaboration within communities.

As a PhD student at the University of Kent in the UK, I am privileged because my institution has subscriptions to most of the journals needed to progress with my research and understanding. This level of access is quite normal in the UK and therefore it can be easy to forget that not everyone has this luxury. But it is important for this imbalance to be recognized and over the last few years it has been pleasant to see the increased use of open access publishing. I was pleased to publish my first paper as open access because I believe that the dissemination of research will be increasingly important as the world faces new problems.

Scientific innovation can take huge leaps forward when working to overcome challenges. We have seen evidence of this with COVID-19 and the incredible response from scientists all over the world. However, COVID-19 is not the only issue that the world faces. Each country has its own characteristics such as climate, agriculture and infrastructure which results in specific and unique challenges that may light the spark for scientific innovation. However, lack of access to key research can result in missed opportunities and ideas that would benefit the entire world. Issues such as climate change and antimicrobial resistance, pose serious threats to our way of life, with consequences worse than we have seen with the ongoing COVID-19 pandemic, which has shocked the world. Therefore, it is increasingly important that the global scientific community can work collaboratively and with fewer barriers through open access so that we can be better prepared for what the future holds.

It is also important to recognise that misinformation and misunderstanding surrounding science is becoming increasingly common, resulting in a disconnect with the public. With the adoption of open access, factual and reliable scientific information will be much easier to find by anyone if they so wish.

Unfortunately, publishing open access does not come without issues. It can be expensive, and the existence of predatory journals can result in published science that has not been through the same rigorous peer-review process that is used by reputable journals. But choosing to publish open access in trusted journals, providing funds are available, will help to advance the progress and inclusivity of science, which is important now more than ever.

About the Web Writer:

Lee Birchall has recently started his PhD under the supervision of Dr. Helena Shepherd at the University of Kent, where he also completed his MSc under the supervision of Dr. Stefano Biagini. He obtained a first class BSc at University College London. He enjoys music, languages and windsurfing and you can find him on Twitter at @LTBIRCH.

 

 

 

 

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

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RSC Advances HOT articles – a feature interview with Mitsuru Ando

We are very pleased to introduce Dr Mitsuru Ando, first author of the paper ‘Preparation of cationic proteoliposomes using cell-free membrane protein synthesis: the chaperoning effect of cationic liposomes‘. His article has been very well received and handpicked by our reviewers and handling editors as one of our September HOT articles. Mitsuru told us more about the work that went into this article and what he hopes to achieve in the future. You can find out more about the author and his article below and find more HOT articles in our online collection.

Meet the authors

Dr Mitsuru Ando received his undergraduate degree in Polymer Science and Engineering in 2007 from Kyoto Institute of Technology by under the supervision of Professor Akira Murakami. He received his master degree and Ph.D. in Pharmaceutical Sciences from Kyoto University by under the supervision of Professor Yoshinobu Takakura in 2010 and 2013, respectively. After graduation, Dr. Ando has been a postdoctoral fellow at Graduate school of pharmaceutical sciences (2013-2014) and at the Department of Polymer Chemistry, Graduate school of Engineering, Kyoto University (2014-date). His research project focuses on membrane protein science, drug delivery system and synthetic biology.

 

 

 

 

Could you briefly explain the focus of your article to the non-specialist (in one or two sentences only) and why it is of current interest?
Our article describes the investigation of the effect of cationic liposome, one of the drug delivery system scaffolds, on cell-free membrane protein synthesis and the preparation method of the bioactive membrane protein reconstituted cationic liposomes.

How big an impact could your results potentially have?
Our study provides the advanced drug delivery system based on combination of membrane protein-guide with cationic liposomes. This cationic proteoliposome has the potential of highly specific interaction with target ligand on plasma membrane and more efficient delivery of encapsulated liposomal content through improvements to cellular attachment, fusion and ultimately delivery.

Could you explain the motivation behind this study?
Since membrane proteins in modulating cellular homeostasis, they are expected for their use in advanced applications. However, compared with the soluble protein science, the membrane protein science is still quite preliminary. We hope to use membrane proteins as a membrane protein-conducted drug delivery targeting materials and biosensor chips.

In your opinion, what are the key design considerations for your study?
A key point for this study is to control the surface positive charge of liposome and the concentration of cationic lipids.

Which part of the work towards this paper proved to be most challenging?
The most challenging aspect is the optimization of cationic lipid contents and concentrations under cell-free protein synthesis to control droplet-like polyion complexes.

What aspect of your work are you most excited about at the moment?
At this moment, we are very excited in establishing the preparation method of cationic proteoliposomes to open the advanced drug delivery system pivoted membrane protein science.

What is the next step? What work is planned?
In the next step, we plan and performe to use other membrane protein-reconstituted cationic liposomes in the membrane protein-conducted drug delivery strategy.

 

Preparation of cationic proteoliposomes using cell-free membrane protein synthesis: the chaperoning effect of cationic liposomes
Mitsuru Ando, Yoshihiro Sasaki and Kazunari Akiyoshi
RSC Adv., 2020,10, 28741-28745
DOI: 10.1039/D0RA05825D, Paper

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RSC Advances HOT articles – a feature interview with Hamdy M. Abdel-Rahman and his team

We are very pleased to introduce Professor Hamdy M. Abdel-Rahman, Dr Asmaa M. AboulMagd and Mr Mostafa A. Mansour, the authors of the paper ‘Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins‘. Their article has been very well received and handpicked by our reviewers and handling editors as one of our September HOT articles. The authors told us more about the work that went into this article and what they hope to achieve in the future. You can find out more about the authors and their article below and find more HOT articles in our online collection.

Meet the authors

Prof. Hamdy M. Abdel-Rahman received the Ph.D. degree in medicinal chemistry in 1999 in a joint supervision system between Faculty of Pharmacy Assiut University, Egypt and Kyoto Pharmaceutical University, Japan. After Two postdoctoral positions, from 2002-2004, at Kyoto Pharmaceutical University, Japan and from 2006-2009 at institute of cancer therapeutics, Bradford University, UK; he returned back to Assiut University, Egypt where he promoted to full professor in 2012. From 2014 he joined the Faculty of Pharmacy, Nahda University, Egypt, where he is the dean from 2018 till now.

 

 

 

 

 

Dr. Asmaa M. AboulMagd received the Ph.D. degree in pharmaceutical chemistry in 2016 from Faculty of Pharmacy, Ain Shams University. She is interested in design and synthesis of small molecules with potential biological activities and the use of computer aided drug design. Since 2017, she has been a lecturer of pharmaceutical chemistry at Faculty of Pharmacy, Nahda University, Egypt, till now.

 

 

 

 

Mr. Mostafa A. Mansour graduated from Faculty of pharmacy, Nahda University, Egypt in 2013 and received the Master degree in medicinal chemistry in 2020 from Faculty of Pharmacy, Beni-Suef University, Egypt. Interested in computer aided drug design techniques.

 

 

 

 

 

 

 

Could you briefly explain the focus of your article to the non-specialist (in one or two sentences only) and why it is of current interest?
The focus of this article is to find a drug for treatment of coronavirus diseases COVID-19.

How big an impact could your results potentially have?
Reaching to a therapeutic drug against coronavirus will have a social, economic, and political impact.

Could you explain the motivation behind this study?
In a previous work, we have designed and synthesized a class of synthetic compounds and were evaluated against PDE 4B activity (anti-inflammatory in chest diseases), we thought that this would be ideal pharmaceutical therapy against COVID-19 disease.

In your opinion, what are the key design considerations for your study?
The key design considerations in this study is to find out that these compounds could be used as potential therapeutic agents for COVID-19.

Which part of the work towards this paper proved to be most challenging?
COVID-19 pandemic is considered as a global health crisis of our time and the greatest challenge we have faced nowadays.

What aspect of your work are you most excited about at the moment?
Using computer modeling softwares, we proved that these compounds have a potential therapeutic effect on coronavirus by several mechanisms.

What is the next step? What work is planned?
The in-vitro evaluation of the biological activity of the synthesized derivatives is our next step in an attempt to discover a potential multi-target agent against coronavirus.

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Mostafa A. Mansour, Asmaa M. AboulMagd and Hamdy M. Abdel-Rahman
RSC Adv., 2020,10, 34033-34045
DOI: 10.1039/D0RA06424F, Paper

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest HOT articles, Reviews, Collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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RSC Advances HOT articles – a feature interview with Shuntaro Takahashi and Naoki Sugimoto

We are very pleased to introduce Dr Shuntaro Takahashi and Professor Naoki Sugimoto, first author and corresponding author of the paper ‘Molecular crowding induces primer extension by RNA polymerase through base stacking beyond Watson–Crick rules‘. Their article has been very well received and handpicked by our reviewers and handling editors as one of our September HOT articles. The authors told us more about the work that went into this article and what they hope to achieve in the future. You can find out more about the authors and their article below and find more HOT articles in our online collection.

Meet the authors

Shuntaro Takahashi is an Associate Professor at the Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, Japan. Dr. Takahashi earned his PhD degree at Tokyo Institute of Technology in 2007. After a period of research at Tokyo Institute of Technology as an Assistant Professor, he joined FIBER in 2012. He is currently studying the biophysics of nucleic acids in cells and the mechanism of molecular crowding for nucleic acid structures that affect cellular metabolism.

 

 

 

 

 

Professor Sugimoto received his PhD in 1985 from Kyoto University, Japan. After completing his postdoctoral work at the University of Rochester in the U.S.A., he became a faculty member at Konan University in Kobe, Japan in 1988. He has been a full professor since 1994 and a director at the Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University since 2003. He received The Imbach-Townsend Award from IS3NA in 2018. In 2020, he was awarded CSJ Awards from the Chemical Society of Japan. His research interests include biophysical chemistry, biomaterials, biofunctional chemistry, and biotechnology in the field of nucleic acid chemistry.

 

 

 

 

Could you briefly explain the focus of your article to the non-specialist (in one or two sentences only) and why it is of current interest?
We investigated the effect of chemical environments on gene replication of the virus RNA polymerase. This article provides insight into not only the evolution of life but also the mechanism of mutation of the virus genome including SARS-CoV-2.

How big an impact could your results potentially have?
Our results provide one story that the molecular environment could take part in the evolution of life by enhancing the replication error of genome sequences. Moreover, this study suggests the significance of molecular environments of patients’ cells for spreading viruses.

Could you explain the motivation behind this study?
The stability of the Watson-Crick base pair is NOT always the most stable, which can be perturbed by molecular environments. Therefore, we speculated that the replication of nucleic acids in the enzyme could also be affected by molecular environments and cause replication errors.

In your opinion, what are the key design considerations for your study?
The key design consideration of our study is to quantitatively understand the effect of molecular environments on the replication fidelity because the stability of nucleic acids structures depends on the physicochemical properties of the solution such as dielectric constant and water activity.

Which part of the work towards this paper proved to be most challenging?
For the reagents for the molecular environments, we used poly(ethylene glycol)s. Although these reagents were easy to tune the solution properties, the effect on RNA and protein were different and complex. The choice of suitable condition was very important for this kind of research.

What aspect of your work are you most excited about at the moment?
We were excited to find the replication rules became dependent on the stacking interactions more than Watson-Crick base pairing under molecular crowding conditions. This indicates that the replication error can be simply explained by the changes in dielectric constant.

What is the next step? What work is planned?
This study suggests that the rule of the base pairings can be differentiated under molecular crowding conditions. Thus, we will pursue the biological role of non-Watson-Crick base pairings such as Hoogsteen base pairs under different cellular conditions. We are also interested in the effect of molecular environments on the reaction of RNA-dependent RNA polymerase of Covid-19.

Molecular crowding induces primer extension by RNA polymerase through base stacking beyond Watson–Crick rules
Shuntaro Takahashi, Hiromichi Okura, Pallavi Chilka, Saptarshi Ghosh and Naoki Sugimoto
RSC Adv., 2020,10, 33052-33058
DOI: 10.1039/D0RA06502A, Paper

RSC Advances Royal Society of ChemistrySubmit to RSC Advances today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest HOT articles, Reviews, Collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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