Polymer Chemistry Blog

Professor Runhui Liu obtained Ph.D in organic chemistry 2009 at Purdue University. Afterward, he took postdoctoral trainings at California Institute of Technology and University of Wisconsin-Madison during 2010-2014. At the end of 2014, he took a professor position in the School of Materials Science and Engineering at East China University of Science and Technology (ECUST). His current research focuses on peptide polymer-based biomaterials for antimicrobial and tissue engineering applications.

Read Runhui’s article ‘Facile Synthesis of Polypeptoid Bearing Bulky Sidechains via Urea Accelerated Ring-Opening Polymerization of a-Amino Acid N-Substituted N-Carboxyanhydrides’.

How do you feel about Polymer Chemistry as a place to publish research on this topic?

Polymer Chemistry is a wonderful place to publish our work on polymer synthesis.

What aspect of your work are you most excited about at the moment and what do you find most challenging about your research?

I am most excited in exploring new chemistry for polymer synthesis, especially to tackle the long-lasting challenges.

The most challenging things for me as a professor are in two folds: keeping the lab running efficiently and productively with minimum amount of funding; inspiring/encouraging students to work on long-standing challenges but not hot topics, and persuading students to give up results that look interesting and publishable at first glance.

Can you share one piece of career-related advice or wisdom with other early career scientists?

As long as the start-up funding can support the lab for the first 3-4 years, focus on science is more productive eventually; as long as the PI and students can survive, no rush to publish or publish a lot at the first 3 years.

Matthias Hartlieb received his PhD in Chemistry in 2015 at the Friedrich Schiller-University in Jena. He proceeded to work as a DFG-funded postdoctoral research fellow at the University of Warwick followed by a research position at the Helmholtz Zentrum Geesthacht. He joined the University of Potsdam in 2019 as an Open-Topic Postdoc and, since 2021, he leads an Emmy Noether research group at Potsdam. His research interests are the design of functional polymeric (bio)materials, specifically in the areas of antimicrobial polymers and supramolecular polymers, using tools such as (photo)-RAFT polymerization or solid phase synthesis. More information can be found on his group website and on Twitter @PolyBioPotsdam.

Read Matthias’ article ‘The role of reversible deactivation in photo-iniferter RAFT polymerization: high livingness enables the straightforward synthesis of multiblock copolymers’.

How do you feel about Polymer Chemistry as a place to publish research on this topic?

A significant share of my publications are in Polymer Chemistry and there are reasons for that. Of course, it is one of the leading journals in macromolecular chemistry, and in my opinion, it presents the broadest overview in this area. So, it’s a great journal for researchers to see and be seen. I am also in favor of the uncomplicated and open reviewing process. Waiting times are relatively short and usually feedback is extremely constructive. It might also be a result of my time in the UK, but for me Polymer Chemistry is the journal where I feel most “at home” with my research.

What aspect of your work are you most excited about at the moment and what do you find most challenging about your research?

There are actually at least two aspects I am currently equally excited about. On the one hand there is photo-iniferter RAFT polymerization, which is also the topic of the publication in the special issue. This method has a tremendous potential, both for polymer synthesis as well as for material design. On the other hand, I am very keen on developing new antimicrobial polymers. At some point in the future antibiotics might fail us and then we need to have something to replace them to avoid a drastic decrease in health care quality and life expectancy.

We are looking at the impact of polymer architecture and on the membrane interaction of these polymers, among other things in order to get closer to an application. For the development of new antimicrobial polymers, we are currently implementing PI-RAFT as well.

In your opinion, what are the most important questions to be asked/answered in this field of research?

When it comes to antimicrobial polymers, the most important question is how we can improve their properties to bring them closer to an actual clinical application. However, this contains a lot of other questions, as there are many parameters, influencing the bioactivity of these polymers. Overall, their selectivity (targeting bacterial cells over mammalian cells) requires improvement but its not entirely clear how to achieve optimal performance.

We are looking into the polymer architecture, a parameter that hasn’t received much attention. We are also probing different targeting strategies and want to understand the mechanism of membrane interaction of these polymers in more detail.

Can you share one piece of career-related advice or wisdom with other early career scientists?

I am happy to forward something that has helped me staying on track: a fellow early career researcher did show me his folder with failed grant applications from the last few years, which had well over 30 items in it. However, he also had one successful one, and that was enough to kick start his career. The same thing happened to me. A lot of failed grant applications, not always with helpful feedback, sometimes without any feedback at all. It is easy to get frustrated at this stage but its important to continue trying. For me eventually, the DFG (Deutsche Forschungsgemeinschaft) thought my ideas regarding antimicrobial polymers were worth funding, which was the start of my independent research group. The lesson seems to be: don’t get discouraged by failure, because there will be a lot of that. Have a plan B but stay on track and try everything you can to follow your goal. Persistence is key (among other things like good mentoring, a supportive family, etc.).

Dr. Wen-Ming Wan is a Professor at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences. He received his B.E. degree in Polymer Material and Engineering from Harbin Institute of Technology. He received a Ph.D. degree in Polymer Chemistry and Physics from University of Science and Technology of China, where he developed polymerization-induced self-assembly (PISA) method under the supervision of Prof. Cai-Yuan Pan. He completed postdocs at UT Southwestern Medical Center (Dallas) with Prof. Wen-Hong Li, The University of Southern Mississippi with Prof. Charles L. McCormick, and Rutgers University (Newark) with Prof. Frieder Jäkle. He started his independent research career as an Assistant Professor at Centre for Bioengineering and Biotechnology at China University of Petroleum (East China) in 2014, and then moved to Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences in 2018. His current research interests focus on the development of novel polymerization methodologies, including but not limited to Barbier polymerization, living polymerization, polymerization-induced emission (PIE), single-atom polymerization (SAP) and PISA.

Read Wen-Ming’s article ‘Room-temperature Barbier single-atom polymerization induced emission as a versatile approach for the utilization of monofunctional carboxylic acid resources’.

How do you feel about Polymer Chemistry as a place to publish research on this topic?

Polymer chemistry is of significance in polymer science. So, Polymer Chemistry journal is a significant platform to publish important research work in polymer science, including synthesis, functionality and applications of polymers.

What aspect of your work are you most excited about at the moment and what do you find most challenging about your research?

Carbonyl chemistry is fundamental and plays cornerstone roles in synthetic chemistry. Meanwhile, carbonyl compounds are widely and readily available from fossil fuels and biomass, which are important resources on Earth. However, corresponding carbonyl polymerization is rarely investigated. My most excited work at the moment is Barbier polymerization, which successfully realizes the utilization of a varieties of carbonyls as polymerizable groups for the molecular design of nonconjugated luminescent polymers through polymerization-induced emission (PIE) strategy. Currently, the most challenging about my research is to demonstrate the advantages and importance of carbonyl polymerization in both scientific and industrial aspects, which will ultimately allow us to exploit Earth’s carbonyl resources more efficiently and functionally.

In your opinion, what are the most important questions to be asked/answered in this field of research?

Since Staudinger proposed the concept of polymerization in 1920, generations of polymer chemists have spent considerable efforts to develop different kinds of polymerization methods, resulting in prosperous polymer science with abundant synthetic polymer materials in the forms of plastics, fibers, rubbers, etc. In comparison with previous polymerization methods, whether can Barbier polymerization survive throughout the history of polymer chemistry? How far can Barbier polymerization go? Whether can the prepared polymers via Barbier polymerization be recyclable? Whether is the concept of PIE applicable to other polymerization methods?

For many years Polymer Chemistry has showcased special collections dedicated to work carried out by researchers in the earlier stages of their research careers in our Emerging Investigator collections, most recently in our 2020 Emerging Investigators collection.

We hope that the polymer chemistry community has found these issues to be valuable, both in the high quality of the articles and in drawing attention to newer voices in the community. The journal editors and Editorial Board consider these to have been highly successful.

In light of disruption to research programmes worldwide, we have taken the opportunity to reassess the format of this initiative, and we are now excited to announce the launch of the Polymer Chemistry Emerging Investigators Series.

What is changing?

In place of a dedicated journal issue, Emerging Investigators papers will be published throughout the year. We anticipate the following benefits to this change:

• No fixed submission deadlines allowing more flexibility for authors
• Continual exposure of exciting work from early-career members of the community
• Greater emphasis and focus on individual authors and research groups

We hope for this to offer a better service to our authors and readers well into the future.

What is not changing?

While we will no longer dedicate a specific journal issue to our Emerging Investigators, all other aspects of this initiative will remain the same. This includes:

• Eligibility criteria (see below)
• A dedicated web page for published articles alongside our other collections
• Rigour and speed in peer review
• An overall objective to showcase the full diversity of cutting-edge research carried out from polymer chemists in the early stages of their independent careers worldwide

What happens now?

The Polymer Chemistry Editorial Office will contact nominated Emerging Investigators throughout the year.

Regarding eligibility, contributors must:

• Publish research within the journal scope
• Currently be an independent research leader
• Have not been featured as an Emerging Investigator in a previous Polymer Chemistry Emerging Investigators article
• Have either no more than 12 years of post-PhD research experience in the year of submission when taking into account any career breaks

Do you fit the criteria above, and wish to be featured as an Emerging Investigator in the journal? Get in touch with us at polymers-rsc@rsc.org