Hot Article: Architecture effects on L-selectin shedding induced by polypeptide-based multivalent ligands

Architecture effects on L-selectin shedding induced by polypeptide-based multivalent ligands: Polymers can be used as multivalent backbones to probe cell surface receptor arrangement and cell signalling. In this hot paper Shuang Liu and Kristi Kiick synthesize a series of polypeptide-based multivalent ligands and study the architecture effects on L-selectin shedding using by L-selectin shedding assay and ELISA. The team claim that these polypeptide-based multivalent ligands may have potential physiological and pathological applications as cell biology tools, and in the regulation of cell functions or inflammatory responses. (Polym. Chem., 2011, DOI: 10.1039/C1PY00063B, Advance Article)

Graphical abstract: Architecture effects on L-selectin shedding induced by polypeptide-based multivalent ligands

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