Chemical Communications Blog

Hot ChemComm articles for December

22 Dec 2015

Take a look at this selection of recently published referee-recommended articles – all are free to read* until 23 January.

Highly sensitive and selective bioluminescence based ozone probes and their applications to detect ambient ozone
Younseok Nam, Beom Seok Kim and Injae Shin
DOI: 10.1039/C5CC08622A, Communication

C5CC08622A GA

Transient electrochemistry: beyond simply temporal resolution
X.-S. Zhou, B.-W. Mao, C. Amatore, R. G. Compton, J.-L. Marignier, M. Mostafavi, J.-F. Nierengarten and E. Maisonhaute
DOI: 10.1039/C5CC07953E, Feature Article

C5CC07953E GA

Robust molecular representations for modelling and design derived from atomic partial charges
A. R. Finkelmann, A. H. Göller and G. Schneider
DOI: 10.1039/C5CC07887C, Communication

C5CC07887C GA

A novel multi-stimuli responsive gelator based on D-gluconic acetal and its potential applications
Xidong Guan, Kaiqi Fan, Tongyang Gao, Anping Ma, Bao Zhang and Jian Song
DOI: 10.1039/C5CC08615A, Communication

C5CC08615A GA

Enzyme encapsulation in zeolitic imidazolate frameworks: a comparison between controlled co-precipitation and biomimetic mineralisation
Kang Liang, Campbell J. Coghlan, Stephen G. Bell, Christian Doonan and Paolo Falcaro
DOI: 10.1039/C5CC07577G, Communication

C5CC07577G GA

Spotting and designing promiscuous ligands for drug discovery
P. Schneider, M. Röthlisberger, D. Reker and G. Schneider
DOI: 10.1039/C5CC07506H, Communication

C5CC07506H GA

*Access is free through a registered RSC account

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Molecules, materials, medicines – the story of pharmaceutical cocrystals

16 Dec 2015

By Iain Larmour, web science writer.

Iain Larmour is a guest web writer for ChemSci. He has researched a wide variety of topics during his years in the lab including nanostructured surfaces for water repellency and developing nanoparticle systems for bioanalysis by surface enhanced optical spectroscopies. He currently works in science management. In his spare time he enjoys reading, photography, art and inventing.

Pharmaceutical cocrystals – cocrystals that contain a drug molecule – can improve the physicochemical performance of drugs, making the prescription you take on doctor’s orders more effective. The properties of any crystal are inherently dependent upon composition and crystal packing, so if you have control over these two things you have control over the physicochemical properties.

Following an explosion of interest and work in this area over the last decade, Michael Zaworotko and colleagues from the Department of Chemical and Environmental Sciences at the University of Limerick review the current state of the literature on pharmaceutical cocrystals.

They cover four areas: nomenclature, design using hydrogen-bonded supramolecular synthons, methods of discovery, and synthesis and development of pharmaceutical cocrystals as drug products. Usefully, they present seven recent case studies on the clinical improvements that can be observed.

The three stages of early drug discovery and development: identify a molecule that is biologically active; create a material suitable for use in a drug product; formulate the material into a medicine with excipients.

A review in 2004 asked the question “Do pharmaceutical co-crystals represent a new path to improved medicines?” Zaworotko and colleagues, having reviewed the last decade of literature, can answer in the affirmative. To find out why the answer to this question is “yes” read this review today!

To read the details, check out the ChemComm article in full:

Pharmaceutical cocrystals: along the path to improved medicines
Naga Duggirala, Miranda Perry, Örn Almarsson and Michael Zaworotko
Chem. Commun., 2016, 52, Advanced Article
DOI: 10.1039/C5CC08216A

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Journal lectureships 2016 – nominations open!

15 Dec 2015

By Jeanne Therese Andres.

Nominations for the 2016 lectureships for ChemComm, Chem Soc Rev, and Chemical Science are open till Friday, 15 January 2016. Nominate now!

We are pleased to welcome nominations for the 2016 lectureships for ChemComm, Chem Soc Rev, and Chemical Science – the Royal Society of Chemistry’s flagship general chemistry journals.

All nominations must be received by Friday, 15 January 2016.

Nominations are open for the following journal lectureships – only one entry needed per nominee, as each nomination will be considered for all three competitions as appropriate.

ChemComm Emerging Investigator Lectureship
• Recognises emerging scientists in the early stages of their independent academic career
• Eligible nominees should have completed their PhD on or after the 15th September 2007, and should also have published as least one article in ChemComm during the course of their independent career

Chem Soc Rev Emerging Investigator Lectureship
• Recognises emerging scientists who have made significant contributions to their research field
• Eligible nominees should have completed their PhD on or after the 15th September 2007

Chemical Science Lectureship
• Recognises sustained excellence in research by a mid-career scientist within the chemical sciences.
Previous recipients of this lectureship include Kevan Shokat (UC San Francisco; 2013), Gregory Fu (Caltech; 2014) and Yamuna Krishnan (University of Chicago; 2015).

Lectureship details
• Recipients of these lectureships will each be invited to present a lecture at three different locations over a 12-month period, with at least one of these events taking place at an international conference. Note: As part of this series of winners’ lectures, the Chemical Science Lectureship recipient will be invited to give a plenary lecture at a relevant ISACS (International Symposia on Advancing the Chemical Sciences) meeting.
• Each recipient will receive a contribution of £1500 towards travel and accommodation costs for their lectures, as well as a certificate.
• Recipients will be asked to contribute a review article for the specific journal awarding their lectureship.

How to nominate
Self-nomination is not permitted. Nominators must send the following to the editorial team via chemcomm-rsc@rsc.org by Friday, 15 January 2016. Each nomination will be considered for all appropriate lectureships.
• Recommendation letter, including the name, contact details and website URL of the nominee.
• A one-page CV for the nominee, including their date of birth, summary of education, career and key achievements, a list of up to five of their top independent publications, total numbers of publications and patents, and other indicators of esteem (and evidence of independence for nominees eligible for the emerging investigator lectureships).
• A copy of the candidate’s best publication to date (as judged by the nominator).
• Two supporting letters of recommendation from two independent referees. These should not be someone from the same institution or the candidate’s post doc or PhD supervisor.

The nominator and independent referees should comment on the candidate’s presenting skills.

Incomplete nominations or those not adhering to the above requirements will not be considered, and nominees will not be contacted regarding any missing or incorrect documents.

Selection procedure
• The editorial team will screen each nomination for eligibility and draw up a shortlist of candidates based on the nomination documents provided.
• Shortlisted candidates will be asked to provide a brief supporting statement summarising their key achievements, highlighting the impact of their work and justifying why they deserve the specific lectureship for which they have been entered.
• Recipients of each lectureship will then be selected and endorsed by a joint selection panel composed of members of each journal’s Editorial Board. Winners of the lectureships will be announced in spring 2016.

NB: Please note that members of the selection panel from the ChemComm, Chem Soc Rev and Chemical Science Editorial Boards are not eligible to nominate, provide references for or be nominated for these lectureships.

For any queries, please contact the editorial team at chemcomm-rsc@rsc.org.

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Nominate now for the 2016 Cram Lehn Pedersen Prize in Supramolecular Chemistry

10 Dec 2015

By Jeanne Therese Andres.

The International Committee of the International Symposium on Macrocyclic and Supramolecular Chemistry is pleased to invite nominations for the Cram Lehn Pedersen Prize for young supramolecular chemists.

The Cram Lehn Pedersen Prize, named in honour of the winners of the 1987 Nobel Prize in Chemistry, recognises significant original and independent work in supramolecular chemistry.

Previous winners include Feihe Huang, Oren Schermann, Tomoki Ogoshi, Jonathan Nitschke, and Amar Flood.

Those who are within 10 years of receiving their PhD on 31st December 2015 are eligible for the 2016 award. The winner will receive a prize of £2000 and free registration for the ISMSC meeting in Seoul, Korea. In addition to giving a lecture at ISMSC, a short lecture tour will be organised after the meeting in consultation with the Editor of Chemical Communications, the sponsor of the award.

Nomination Details:

You may nominate yourself or someone else. Please send your CV, list of publications (divided into publications from your PhD and post-doc, and those from your independent work), and if desired, a letter of support, or these materials for someone you wish to nominate, to Prof. Roger Harrison (ISMSC Secretary) at rgharris@chem.byu.edu by 31st January 2016.

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H2-free route to actinide hydrides

18 Nov 2015

By Bethany Johnson.

Aurora Walshe writes about a hot ChemComm article for Chemistry World

Scientists in the US have shown that phenylsilane is a safer and more convenient replacement for hydrogen gas when synthesising uranium and thorium hydrides.

Thorium and uranium are the most abundant actinoid elements. Although many stable thorium and uranium oxides and minerals are found in nature, the other actinoids are almost exclusively found in nuclear waste. Understanding actinoid chemistry has important practical applications in the nuclear industry but it is also fundamentally fascinating as the actinoid f electrons are so unlike those of the lanthanoids. Scientists need to make and study actinoid complexes with different oxidation states and with different ligands to understand their chemistry. Unfortunately, organometallic actinide chemistry can be quite challenging as organoactinide complexes will react – sometimes violently – with air or water, meaning that specialist equipment is needed to make and store them safely. Read the full article in Chemistry World»

Read the original journal article in ChemComm – it’s free to access until 23 December 2015:
Phenylsilane as a safe, versatile alternative to hydrogen for the synthesis of actinide hydrides
Justin K. Pagano, Jacquelyn M. Dorhout, Rory Waterman, Kenneth R. Czerwinski and Jaqueline L. Kiplinger
DOI: 10.1039/C5CC06856H, Communication

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Oral delivery of anticancer drug

10 Nov 2015

By Bethany Johnson.

Suzanne Howson writes about a hot ChemComm article for Chemistry World

Scientists in China have unveiled a way to deliver a platinum-based anticancer drug orally. The system, which works by protecting a prodrug from activation until it reaches the cancer cells, could help avoid the drug’s side effects.

The researchers incoporated an asplatin-cholesterol complex into biocompatible nanoparticles, which protect the drug from degrading before reaching the cancer cells

Platinum(IV)-based drugs are used to treat a range of cancers, often combined with other drugs. They are only reduced to the active platinum(II) drug once inside a cancer cell. Currently, healthcare workers administer platinum anticancer drugs through intravenous injections, which results in uncontrolled levels of the drug in the body and associated side effects. Administrating these drugs orally, however, would sustain an optimum concentration of the drug whilst boosting patient comfort and compliance. However, a downside is the prodrugs would be vulnerable to premature reduction into the active drug in the gastrointestinal tract. Read the full article in Chemistry World»

Read the original journal article in ChemComm – it’s free to read until 16 December:
Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles
Qinqin Cheng, Hongdong Shi, Hai Huang, Zhiting Cao, Jun Wang and Yangzhong Liu
Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5CC07853A, Communication

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Sharpening up super-resolution images by getting heavy

04 Nov 2015

By Iain Larmour, web science writer.

Iain Larmour is a guest web writer for Chemical Science and ChemComm. He has researched a wide variety of topics during his years in the lab including nanostructured surfaces for water repellency and developing nanoparticle systems for bioanalysis by surface enhanced optical spectroscopies. He currently works in science management. In his spare time he enjoys reading, photography, art and inventing.

Single molecule super-resolution microscopy is the technique which takes advantage of the photoconversion of fluorescent probes and single molecule dyes to image cellular ultrastructures beyond the diffraction limit of light. The most common approach for this technique is to genetically fuse photoactivatable fluorescent proteins (PA-FPs) to the biomolecules of interest. However, PA-FPs do not emit as much light as organic dyes, which poses a problem since this technique relies heavily on the number of photons that are collected. If you can increase the amount of photons emitted, you can increase the amount collected, which leads to higher localization and ultimately a higher resolution image.

Bo Huang and colleagues from the Department of Pharmaceutical Chemistry at the University of California, San Francisco set out to investigate ways to make the PA-FPs brighter. It was previously shown that heavy water (D2O) increased the photon count from popular small molecule dyes¹; would the same effect be seen in the PA-FPs? The answer was yes: as the heavy water component increased, the photon count also increased.

Photon counts seen from 8 fluorescent proteins in PBS and D2O PBS

One possible concern is that heavy water in live cells can slow down cell growth and even cause cell death. However, in real life this happens on significantly longer time-scales than it does in an experimental environment, therefore, any adverse effects on live cells would be minimal.

If you use PA-FPs in your work and you want to sharpen up your images then this paper is worth a read.

To find out the details, read the ChemComm article in full:
Heavy Water: A Simple Solution to Increasing Brightness of Fluorescence Proteins in Super-resolution Imaging
Wei Qiang Ong, Y. Rose Citron, Joerg Schnitzbauer, Daichi Kamiyama and Bo Huang
Chem. Commun., 2015, 51, Advance Article
DOI: 10.1039/C5CC04575D

¹S. van de Linde, A. Loschberger, T. Klein, M. Heidbreder, S. Wolter, M. Heilemann and M. Sauer, Nat. Protoc., 2011, 6, 991

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Shanti Swarup Bhatnagar Prize for Chemical Sciences awarded

04 Nov 2015

By Mina Roussenova, Development Editor.

Professor Pradyut Ghosh wins the 2015 Shanti Swarup Bhatnagar Prize for Chemical Sciences

Professor Pradyut Ghosh, IACS, India

The Shanti Swarup Bhatnagar Prize for chemical sciences is awarded annually by the Council of Scientific and Industrial Research (CSIR) to two Indian scientists, recognizing outstanding research in the applied and fundamental chemical sciences. This year, one of the winners of this prestigious award was Professor Pradyut Ghosh (Indian Association for the Cultivation of Science, Kolkata), who received the prize for his notable work in the fields of inorganic and supramolecular chemistry. A frequent contributor to ChemComm, Professor Ghosh’s work spans many key areas including anion recognition chemistry, molecular encapsulation, chemical sensing of ions, extraction of inorganic salts and supramolecular aggregates. To celebrate Professor Ghosh’s remarkable achievements, we are delighted to present a collection of his recent ChemComm articles below.

In relation to the broad themes of Professor Ghosh’s work, we would like to highlight the upcoming ISACS18: Challenges in Organic Materials and Supramolecular Chemistry conference which will be held in India for the very first time on 19-21 November 2015 in Bangalore. On behalf of the ISACS18 Chair and ChemComm Associate Editor Professor S Ramakrishnan (Indian Institute of Science) and Dr May Copsey (Executive Editor), we warmly invite you to come to this historic and significant event, which will also be attended by our India representatives, Dr Aparna Ganguly and Dr Deeksha Gupta.

Read Professor Ghosh’s latest ChemComm articles below:

Artificial receptors for nitrate: a comprehensive overview
Ranjan Dutta and Pradyut Ghosh
Chem. Commun., 2015, 51, 9070-9084
DOI: 10.1039/C5CC01266J, Feature Article

Selective recognition and extraction of KBr via cooperative interactions with a urea functionalized crown ether dual-host
Bidyut Akhuli and Pradyut Ghosh
Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5CC07291C, Communication

Halogen bonding assisted selective removal of bromide
Sourav Chakraborty, Ranjan Dutta and Pradyut Ghosh
Chem. Commun., 2015, 51, 14793-14796
DOI: 10.1039/C5CC05495H, Communication

Recent developments in anion induced capsular self-assemblies
Ranjan Dutta and Pradyut Ghosh
Chem. Commun., 2014, 50, 10538-10554
DOI: 10.1039/C4CC02957G, Feature Article

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Top 25 ChemComm articles July–September 2015

29 Oct 2015

By Bethany Johnson.

The 25 most-downloaded ChemComm articles in the third quarter of 2015 were as follows:

Copper-catalyzed oxidative decarboxylative C–H arylation of benzoxazoles with 2-nitrobenzoic acids
Lijun Chen, Lin Ju, Katelyn A. Bustin and Jessica M. Hoover
DOI: 10.1039/C5CC06645J, Communication

Unactivated C(sp³)–H hydroxylation through palladium catalysis with H₂O as the oxygen source
Jiantao Hu, Tianlong Lan, Yihua Sun, Hui Chen, Jiannian Yao and Yu Rao
DOI: 10.1039/C5CC04952K, Communication

TMSBr/InBr₃-promoted Prins cyclization/homobromination of dienyl alcohol with aldehyde to construct cis-THP containing an exocyclic E-alkene
Linjie Li, Xianwei Sun, Yanyang He, Lu Gao and Zhenlei Song
DOI: 10.1039/C5CC06270E, Communication

Organocatalytic amination of alkyl ethers via n-Bu₄NI/t-BuOOH-mediated intermolecular oxidative C(sp³)–N bond formation: novel synthesis of hemiaminal ethers
Longyang Dian, Sisi Wang, Daisy Zhang-Negrerie, Yunfei Du and Kang Zhao
DOI: 10.1039/C4CC05758A, Communication

Visible light-driven water oxidation catalyzed by a highly efficient dinuclear ruthenium complex
Yunhua Xu, Lele Duan, Lianpeng Tong, Björn Åkermark and Licheng Sun
DOI: 10.1039/C0CC01250E, Communication

Multifunctional catalysis by Pd-polyoxometalate: one-step conversion of acetone to methyl isobutyl ketone
Robert D. Hetterley, Elena F. Kozhevnikova and Ivan V. Kozhevnikov
DOI: 10.1039/B515325E, Communication

A facile solvothermal growth of single crystal mixed halide perovskite CH₃NH₃Pb(Br_1−xCl_x)₃
Taiyang Zhang, Mengjin Yang, Eric E. Benson, Zijian Li, Jao van de Lagemaat, Joseph M. Luther, Yanfa Yan, Kai Zhu and Yixin Zhao
DOI: 10.1039/C5CC01835H, Communication

Nanostructured electrochromic smart windows: traditional materials and NIR-selective plasmonic nanocrystals
Evan L. Runnerstrom, Anna Llordés, Sebastien D. Lounis and Delia J. Milliron
DOI: 10.1039/C4CC03109A, Feature Article

Surface modification of MoS₂ nanoparticles with ionic liquid–ligands: towards highly dispersed nanoparticles
Wilton Osim, Anja Stojanovic, Johanna Akbarzadeh, Herwig Peterlik and Wolfgang H. Binder
DOI: 10.1039/C3CC45305G, Communication

The surface chemistry of metal–organic frameworks
Christina V. McGuire and Ross S. Forgan
DOI: 10.1039/C4CC04458D, Feature Article

Catalytic meta-selective C–H functionalization to construct quaternary carbon centres
Andrew J. Paterson, Sahra St John-Campbell, Mary F. Mahon, Neil J. Press and Christopher G. Frost
DOI: 10.1039/C5CC03951G, Communication

Production of few-layer phosphorene by liquid exfoliation of black phosphorus
Jack R. Brent, Nicky Savjani, Edward A. Lewis, Sarah J. Haigh, David J. Lewis and Paul O’Brien
DOI: 10.1039/C4CC05752J, Communication

Graphene quantum dots: emergent nanolights for bioimaging, sensors, catalysis and photovoltaic devices
Jianhua Shen, Yihua Zhu, Xiaoling Yang and Chunzhong Li
DOI: 10.1039/C2CC00110A, Feature Article

Reduction of graphene oxide via L-ascorbic acid
Jiali Zhang, Haijun Yang, Guangxia Shen, Ping Cheng, Jingyan Zhang and Shouwu Guo
DOI: 10.1039/B917705A, Communication

Few-layer, large-area, 2D covalent organic framework semiconductor thin films
Jeremy I. Feldblyum, Clara H. McCreery, Sean C. Andrews, Tadanori Kurosawa, Elton J. G. Santos, Vincent Duong, Lei Fang, Alexander L. Ayzner and Zhenan Bao
DOI: 10.1039/C5CC04679C, Communication

Copper-catalyzed oxidative C–H/C–H cross-coupling of benzamides and thiophenes
Sheng Zhao, Jun Yuan, Yi-Chen Li and Bing-Feng Shi
DOI: 10.1039/C5CC05058H, Communication

Interview with Ben L. Feringa
DOI: 10.1039/C4CC90068E, Profile

Aggregation-induced emission: phenomenon, mechanism and applications
Yuning Hong, Jacky W. Y. Lam and Ben Zhong Tang
DOI: 10.1039/B904665H, Feature Article

Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives
Pankaj Chauhan, Suruchi Mahajan and Dieter Enders
DOI: 10.1039/C5CC04930J, Feature Article

A MOF platform for incorporation of complementary organic motifs for CO₂ binding
Pravas Deria, Song Li, Hongda Zhang, Randall Q. Snurr, Joseph T. Hupp and Omar K. Farha
DOI: 10.1039/C5CC04808G, Communication

Strongly green-photoluminescent graphene quantum dots for bioimaging applications
Shoujun Zhu, Junhu Zhang, Chunyan Qiao, Shijia Tang, Yunfeng Li, Wenjing Yuan, Bo Li, Lu Tian, Fang Liu, Rui Hu, Hainan Gao, Haotong Wei, Hao Zhang, Hongchen Sun and Bai Yang
DOI: 10.1039/C1CC11122A, Communication

Cerium-based metal organic frameworks with UiO-66 architecture: synthesis, properties and redox catalytic activity
Martin Lammert, Michael T. Wharmby, Simon Smolders, Bart Bueken, Alexandra Lieb, Kirill A. Lomachenko, Dirk De Vos and Norbert Stock
DOI: 10.1039/C5CC02606G, Communication

A facile synthesis of UiO-66, UiO-67 and their derivatives
Michael J. Katz, Zachary J. Brown, Yamil J. Colón, Paul W. Siu, Karl A. Scheidt, Randall Q. Snurr, Joseph T. Hupp and Omar K. Farha
DOI: 10.1039/C3CC46105J, Communication

Red, far-red, and near infrared photoswitches based on azonium ions
M. Dong, A. Babalhavaeji, M. J. Hansen, L. Kálmán and G. A. Woolley
DOI: 10.1039/C5CC02804C, Communication

A ratiometric fluorescent system for carboxylesterase detection with AIE dots as FRET donors
Yinglong Wu, Shuailing Huang, Fang Zeng, Jun Wang, Changmin Yu, Jing Huang, Huiting Xie and Shuizhu Wu
DOI: 10.1039/C5CC04771D, Communication

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In celebration of the 2015 Nobel Prize in Chemistry

27 Oct 2015

By Mina Roussenova, Development Editor.

The 2015 Nobel Prize in Chemistry was jointly awarded to Tomas Lindahl, former director of Cancer Research UK’s Clare Hall Laboratories, Paul Modrich from Duke University in the US and Aziz Sancar from the University of North Carolina in the US for their “mechanistic studies of DNA repair”.

nobel laureates
Tomas Lindahl, Paul Modrich and Aziz Sancar © Inserm-P. Latron, Mary Schwalm/AP/Press Association, Max Englund/UNC School of Medicine.

Tomas Lindahl’s research pieced together a molecular image of how base excision repairs DNA when a base of a nucleotide is damaged and subsequently managed to recreate the human repair process in vitro. The mechanism known as nucleotide excision repair, which excises damage from UV and carcinogenic substances, was then mapped by Aziz Sancar – the molecular details of this process changed the entire research field. Paul Modrich also studied the human version of the repair system. His work focused on DNA mismatch repair, a natural process which corrects mismatches that occur when DNA is copied during cell division.

The research carried out by the three 2015 Nobel Laureates in Chemistry has not only revolutionised our knowledge of how we function but also lead to the development of life – saving treatments. To celebrate these remarkable achievements, we are delighted to present a collection of recent Chemical Communications, Chemical Science and Chemical Society Reviews articles on DNA repair, FREE to read until 1 December 2015!

We invite you to submit your best research related to DNA repair mechanisms to Chemical Communications, Chemical Science and Chemical Society Reviews!

Reviews

Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules
Anton Granzhan, Naoko Kotera and Marie-Paule Teulade-Fichou
Chem. Soc. Rev., 2014, 43, 3630-3665
DOI: 10.1039/C3CS60455

The chemical biology of sirtuins
Bing Chen, Wenwen Zang, Juan Wang, Yajun Huang, Yanhua He, Lingling Yan, Jiajia Liu and Weiping Zheng
Chem. Soc. Rev., 2015, 44, 5246-5264
DOI: 10.1039/C4CS00373J

Luminescent oligonucleotide-based detection of enzymes involved with DNA repair
Chung-Hang Leung, Hai-Jing Zhong, Hong-Zhang He, Lihua Lu, Daniel Shiu-Hin Chan and Dik-Lung Ma
Chem. Sci., 2013, 4, 3781-3795
DOI: 10.1039/C3SC51228B

Research articles

A label-free and sensitive fluorescent method for the detection of uracil-DNA glycosylase activity
Jing Tao, Panshu Song, Yusuke Sato, Seiichi Nishizawa, Norio Teramae, Aijun Tong and Yu Xiang
Chem. Commun., 2015, 51, 929-932
DOI: 10.1039/C4CC06170E

DNA-mediated supercharged fluorescent protein/graphene oxide interaction for label-free fluorescence assay of base excision repair enzyme activity
Zhen Wang, Yong Li, Lijun Li, Daiqi Li, Yan Huang, Zhou Nie and Shouzhuo Yao
Chem. Commun., 2015, 51, 13373-13376
DOI: 10.1039/C5CC04759E

A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity
Chang Yeol Lee, Ki Soo Park and Hyun Gyu Park
Chem. Commun., 2015, 51, 13744-13747
DOI: 10.1039/C5CC05010C

A chemical probe targets DNA 5-formylcytosine sites and inhibits TDG excision, polymerases bypass, and gene expression
Liang Xu, Ying-Chu Chen, Satoshi Nakajima, Jenny Chong, Lanfeng Wang, Li Lan, Chao Zhang and Dong Wang
Chem. Sci., 2014, 5, 567-574
DOI: 10.1039/C3SC51849C

Sensitive detection of polynucleotide kinase using rolling circle amplification-induced chemiluminescence
Wei Tang, Guichi Zhu and Chun-yang Zhang
Chem. Commun., 2014, 50, 4733-4735
DOI: 10.1039/C4CC00256C

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase
Alhosna Benjdia, Korbinian Heil, Andreas Winkler, Thomas Carell and Ilme Schlichting
Chem. Commun., 2014, 50, 14201-14204
DOI: 10.1039/C4CC05158K

Expanding DNAzyme functionality through enzyme cascades with applications in single nucleotide repair and tunable DNA-directedassembly of nanomaterials
Yu Xiang, Zidong Wang, Hang Xing and Yi Lu
Chem. Sci., 2013, 4, 398-404
DOI: 10.1039/C2SC20763J

Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe
Ka-Ho Leung, Hong-Zhang He, Victor Pui-Yan Ma, Hai-Jing Zhong, Daniel Shiu-Hin Chan, Jun Zhou, Jean-Louis Mergny, Chung-Hang Leung and Dik-Lung Ma
Chem. Commun., 2013, 49, 5630-5632
DOI: 10.1039/C3CC41129J

Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: constructing DNA sensing platforms with extremely high selectivity
Xianjin Xiao, Yang Liu and Meiping Zhao
Chem. Commun., 2013, 49, 2819-2821
DOI: 10.1039/C3CC40902C

Also of interest: Find out more about the three Chemistry Nobel Laureates and their research.

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Chemical Communications Blog

Hot ChemComm articles for December

Molecules, materials, medicines – the story of pharmaceutical cocrystals

Journal lectureships 2016 – nominations open!

Nominate now for the 2016 Cram Lehn Pedersen Prize in Supramolecular Chemistry

H2-free route to actinide hydrides

Oral delivery of anticancer drug

Sharpening up super-resolution images by getting heavy

Shanti Swarup Bhatnagar Prize for Chemical Sciences awarded

In celebration of the 2015 Nobel Prize in Chemistry

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