ChemComm’s 60th Anniversary – Daisuke Miyoshi

ChemComm is publishing its 60th volume in 2024. Over the past 60 years, ChemComm has been the RSC’s most cited journal, and one of the most trusted venues for rapid publication of short communications. In our anniversary year, we recognise the important contributions ChemComm has made, and continues to make, in advancing the chemical sciences.

As part of our anniversary celebrations, we’ve brought together a collection featuring the latest research from some of our most loyal and dedicated authors. From those marking the beginning of their independent academic career by publishing their first article with us, to the rising stars and established leaders publishing in our yearly ‘Emerging Investigators’ and ‘Pioneering Investigators’ collections, this collection champions the contributions of our worldwide author community. We are proud many authors choose to support our journal by regularly publishing their best work with us. This collection also features papers from our ChemComm Emerging Investigator Lectureship winners, and our Outstanding Reviewer awardees, whose invaluable feedback has shaped our published content through the years.

To accompany the collection, we’ll be publishing interviews with contributing authors where they provide further insight into their research and reflect on their journey with ChemComm.

Check out our interview with Daisuke Miyoshi (Konan University, Japan) below!​​​

Daisuke Miyoshi is a professor at Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University. He obtained his BA, MS, and Ph. D (2003) from Konan University in Natural Sciences, conducting his research in the group of Professor Naoki Sugimoto. He then moved to University of Illinois at Urbana-Champaign to join the group of Professor Yi Lu as a postdoctoral fellow, working on a development of functional nucleic acids. In 2004, he returned to Konan University to take up an assistant professor position at Frontier institute of biomolecular Engineering Research (FIBER), Konan University. He moved to FIRST in 2009 and promoted to be a professor in 2014. His research interests are mainly biochemical and biophysical properties of non-canonical nucleic acid structures, such as G-quadruplex, i-motif, triplex, and junction. Especially, he has studied how molecular crowding affects structure and stability of nucleic acids. Currently, he is also focusing on roles of non-canonical nucleic acid structures on biomolecular liquid-liquid and liquid-solid phase separations.

 

What is your favourite thing about ChemComm?

I like ChemComm from a variety of perspectives. The publications in the ChemComm are very general and broad in chemistry-related fields. The length of the paper is perfect to read, and the graphical abstract helps a lot to find out the must read papers. The Feature and Highlight articles are also useful to start studying the related field and to keep updated about the latest research in the field.

In what ways do you think ChemComm stands out among other journals in your field?

In my opinion, ChemComm is open not only to applied science but also to basic science. I ask all my lab members to check and read the latest research without added hype, because of the great peer review process by the editors and reviewers.

How would you describe the peer review process and interaction with the editorial team at ChemComm?

The peer review process of ChemComm is very rapid and reliable. I have submitted around ten original articles and one FEATURE ARTICLE to ChemComm. I believe that the editors and the reviewers have provided comprehensive support with the constructive and positive feedback. These feedback was very useful to improve my manuscripts.

Could you provide a brief summary of your recent ChemComm publication?

Since it is now generally accepted that there are huge number of G-quadruplex-forming sequences on our genome, it is essential to develop G-quadruplex ligands which bind the target G-quadruplex in a sequence-selective manner for their cellular applications. In the recent publication in ChemComm, we developed a new screening system for sequence-selective G-quadruplex ligands, targeting a cancer related NRAS gene. The G-quadruplex ligands identified in this study maintained their binding affinity even in the presence of excess other DNA G-quadruplexes and inhibited a series of enzymes in a sequence-selective manner. I believe that the results obtained here stimulate development of G-quadruplex ligands not only with high affinity but also with high selectivity.

 

Be sure to read Daisuke’s full article, “NRAS DNA G-quadruplex-targeting molecules for sequence-selective enzyme inhibition” to learn more!

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