Amine behind mask hides its reactivity

Written by Andrea McGhee for Chemistry World

Graphical AbstractChemists mask amines’ unwanted reactivity with carbon dioxide and overcome limitations of amide formation

Chemists at Imperial College London, UK, have overcome limitations that afflict a specific class of amidation reactions, used to produce a range of compounds from drugs to valuable materials. Their simple trick was to add carbon dioxide, which masks the reagent’s reactivity, making sure it only reacts when they want it to.

Read the full article in Chemistry World >>>


Robert W. M. Davidson and Matthew J. Fuchter
Chem. Commun., 2016, Advance Article
DOI: 10.1039/C6CC04639H, Communication
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