Computational studies have unpicked the surprising stability behind high-energy fluorinating reagent Togni reagent I.
Togni reagents – named after creator Antonio Togni – are trifluoromethylating agents that introduce the CF3 group often found in pharmaceuticals and agrochemicals. They’re members of a family of benziodoxole-based hypervalent iodine reagents that transfer atoms or functional groups loaded onto their oxygen and hypervalent iodine-containing five-membered ring. Read the full article in Chemistry World»
Read the original journal article in ChemComm – it’s free to access until 21 April 2016:
Why does Togni’s reagent I exist in the high-energy hypervalent iodine form? Re-evaluation of benziodoxole based hypervalent iodine reagents
Tian-Yu Sun, Xiao Wang, Hao Geng, Yaoming Xie, Yun-Dong Wu, Xinhao Zhang and Henry F. Schaefer III
DOI: 10.1039/C6CC00384B, Communication