Chemists in Denmark have developed a procedure for modifying the surface of SU-8 microparticles and then using it for quantitative multi-step organic synthesis.
SU-8 is a novolac-epoxy resin used in the field of microfabrication and micropatterning. Thomas Nielsen, at Technical University of Denmark, and colleagues demonstrated how common linkers can be attached to the support surface and effectively used for solid-supported synthesis.
They report transformations including reduction, oxidation, multi-step peptide synthesis and metal-catalysed cycloaddition and cross-coupling reactions in their ChemComm communication, free to download until 24th December.
