Surface plasmon resonance measures biomolecular interactions

Calcium plays a central role in many signalling pathways, including neuronal and sensory function. Now scientists in Germany have shown that surface plasmon resonance can be used to monitor Ca2+-induced conformational changes in a Ca2+-sensor protein immobilised on a chip.

Graphical abstract: Quantitative detection of conformational transitions in a calcium sensor protein by surface plasmon resonance

Daniele Dell’Orco and colleagues at the University of Oldenburg, Germany describe their study in a recently published ChemComm communication. Download the article for free until 25th October.

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