Making Bispirin: A new drug to fight both indigestion and pain

Until now, drugs which fight gastrointestinal infections and those which treat acute inflammation have been found to interfere with each other.  For instance, people infected with the Helicobacter pylori bacterium have needed to deal with the additional risk of gastrointestinal bleeding associated with the use of aspirin and other inflammatory drugs.

Australian research chemists, led by Philip C. Andrews of Monash University, have designed a new drug which treats gastrointestinal infections and acute inflammation at the same time.  They have successfully synthesized bispirin, a bismuth acetylsalicylate complex which combines the effectiveness of bismuth carboxylate compounds as anti-infection agents with that of acetyl­salicylic acid (aspirin) as an anti-inflammatory drug.  Their initial tests have shown that bispirin’s antibacterial effects are comparable or better than those of current bismuth drugs, and investigations of bispirin’s anti-inflammatory activity are currently in progress.

Making Bispirin_graphical abstract

This journal article has also been recently featured on C&ENread it here.

Read this ‘HOT’ ChemComm article in full:

Philip C. Andrews, Victoria L. Blair, Richard L. Ferrero, Peter C. Junk and Ish Kumar
Chem. Commun., 2013, 49, 2870-2872
DOI: 10.1039/C3CC40645H

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One Response to “Making Bispirin: A new drug to fight both indigestion and pain”

  1. mrtran says:

    thanks you for sharing !

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