A platinum(II)-based major groove binder was identified as a potent human topoisomerase IIα poison, showing anti-proliferation activities in human cancer cells.
Chi-Ming Che and colleagues from the University of Hong Kong were able to stabilise the covalent TopoIIα–DNA cleavage complex and induce cancer cell death with its high potency – apparently it’s significantly higher than a clinically used TopoIIα poison.
Fancy reading more? Then why not download the article today and blog some comments below. The communication, published in ChemComm will be free to access until the 24th December.
