Scientists in the US have used restriction endonucleases to detect nucleic acids that do not contain restriction endonuclease recognition sites. Herman Sintim and colleagues at the University of Maryland, College Park, show that the topology of DNA probes used in this detection strategy remarkably affects the efficiency of RNA/DNA detection.
This article is also part of the ‘Emerging Investigators’ issue, due to be published later on this year.
This issue will highlight the very best work from scientists in the early stages of their independent career
from across the chemical sciences.