Purifying and picturing proteins

Device for fast nanopurification and imaging of biological entities

Do you spend your day running HPLC or other lengthy column chromatography to purify your proteins or other biological entities? 
 
Deborah F. Kelly and co-workers have found the perfect solution for a rapid purification of proteins and in-situ imaging using transmission electron microscopy (TEM). 
 
The purification of biological complexes such as proteins remains the rate-limiting step for structural studies in the electron microscopy (EM) field. In a recent RSC Advances article, the team led by Kelly developed an improved affinity capture device capable of purifying tagged biomacromolecules of interest while viewing them in a liquid-flow environment within a TEM column. The purification component of the device works at high specificity and nanogram sensitivity.  
 
“The method also lends itself for use with antibodies against cell surface proteins to isolate whole cells. The isolation of rare cells or cancer cells may be possible in combination with TEM imaging. This opens a new avenue for the visual screening of therapeutic interventions aimed at multiscale imaging—from the molecular to the cellular levels. Overall, the use of affinity capture devices and live TEM imaging provide a unique platform to view active biological processes at nanometer resolution,” say the US scienstists.   
 
Read the full article online. Free to access upon a simple registration process.   

The development of affinity capture devices—a nanoscale purification platform for biological in situ transmission electron microscopy
Katherine Degen ,  Madeline Dukes ,  Justin R. Tanner and Deborah F. Kelly
RSC Adv., 2012, Advance Article, DOI: 10.1039/C2RA01163H

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Nucleic Acids collection in RSC Advances

Below is a list of recently published articles involving nucleic acids:

Synthetic 5′-phosphorylated oligodeoxynucleotide purification through catching full-length sequences by polymerization
Yinan Yuan, Suntara Fueangfung, Xi Lin, Durga Pokharel and Shiyue Fang
RSC Adv., 2012, Advance Article
DOI: 10.1039/C2RA01357F, Paper

Label-free detection of target DNA sequence and single-base mismatch in hepatitis C virus corresponding to oligonucleotide by resonance light scattering technique
Zhanguang Chen, Sihua Qian, Xi Chen, Junhui Chen, Yuejuan Lin and Jinbin Liu
RSC Adv., 2012, Advance Article
DOI: 10.1039/C2RA01141G, Paper

Synthesis, characterization and DNA binding properties of rutin–iron complex
Stalin Selvaraj, Sridharan Krishnaswamy, Venkappayya Devashya, Swaminathan Sethuraman and Uma Maheswari Krishnan
RSC Adv., 2012, Advance Article
DOI: 10.1039/C2RA01319C, Paper

Base recognition by L-nucleotides in heterochiral DNA
Shuji Ogawa, Shun-ichi Wada and Hidehito Urata
RSC Adv., 2012, Advance Article
DOI: 10.1039/C2RA01013E, Communication

Printed conductive features for DNA chip applications prepared on PET without sintering
Albert R. Liberski, Joseph T. Delaney, Aleksandra Liberska, Jolke Perelaer, Martha Schwarz, Thomas Schüler, Robert Möller and Ulrich S. Schubert
RSC Adv., 2012, Advance Article
DOI: 10.1039/C2RA01191C, Paper

Co-delivery of genes and drugs with nanostructured calcium carbonate for cancer therapy
Si Chen, Dong Zhao, Feng Li, Ren-Xi Zhuo and Si-Xue Cheng
RSC Adv., 2012, Advance Article
DOI: 10.1039/C1RA00527H, Paper

Highly flexible and stable aptamer-caged nanoparticles for control of thrombin activity
Chia-Lun Hsu, Shih-Chun Wei, Jyun-Wei Jian, Huan-Tsung Chang, Wei-Hsi Chen and Chih-Ching Huang
RSC Adv., 2012, 2, 1577-1584

Nanoporous carbon as a sensing platform for DNA detection: The use of impedance spectroscopy for hairpin-DNA based assay
Hwee Ling Poh, Alessandra Bonanni and Martin Pumera
RSC Adv., 2012, 2, 1021-1024
DOI: 10.1039/C1RA00812A, Paper

A pyridyl carboxamide molecule selectively stabilizes DNA G-quadruplex and regulates duplex–quadruplex competition
Liang Xu, Weixin Wu, Jie Ding, Shuo Feng, Xiwen Xing, Minggang Deng and Xiang Zhou
RSC Adv., 2012, 2, 894-899

Protein–dendron conjugates for DNA binding: understanding the effect of the protein core on multivalency
Giovanni M. Pavan, Mauri A. Kostiainen and Andrea Danani
RSC Adv., 2011, 1, 1677-1681

Fast repair of DNA radicals in the earliest stage of carcinogenesis suppresses hallmarks of cancer
Rongliang Zheng, Zhongjian Jia, Ji Li, Shuangsheng Huang, Ping Mu, Fangxin Zhang, Chunming Wang and Chengshan Yuan
RSC Adv., 2011, 1, 1610-1619

DNA hybridization of pathogenicity island of vancomycin-resistant Enterococcus faecalis with discretely functionalized gold nanoparticles in organic solvent mixtures
Chun-Pong Chak, Josie M. Y. Lai, Kathy W. Y. Sham, Christopher H. K. Cheng and Ken Cham-Fai Leung
RSC Adv., 2011, 1, 1342-1348

Detection of single-stranded nucleic acids by hybridization of probe oligonucleotides on polystyrene nanospheres and subsequent release and recovery of fluorescence
Lei Wang, Hailong Li, Yonglan Luo, Yingwei Zhang, Jingqi Tian and Xuping Sun
RSC Adv., 2011, 1, 1318-1323

Large-scale synthesis of coordination polymer microdendrites and their application as a sensing platform for fluorescent DNA detection
Hailong Li, Junfeng Zhai and Xuping Sun
RSC Adv., 2011, 1, 725-730
DOI: 10.1039/C1RA00359C, Paper

Control of synthesis and optical properties of DNA templated silver nanoclusters by varying DNA length and sequence
Guo-Yu Lan, Wei-Yu Chen and Huan-Tsung Chang
RSC Adv., 2011, 1, 802-807

A novel application of porphyrin nanoparticles as an effective fluorescent assay platform for nucleic acid detection
Junfeng Zhai, Hailong Li and Xuping Sun
RSC Adv., 2011, 1, 36-39

Target-induced biomolecular release for sensitive aptamer-based electrochemical detection of small molecules from magnetic graphene
Dianping Tang, Juan Tang, Qunfang Li, Bingqian Liu, Huanghao Yang and Guonan Chen
RSC Adv., 2011, 1, 40-43

All the above articles are free to access if you register by December 2012.

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Towards light-controllable anticoagulant drug

Aptamers are single-stranded oligonucleotides that fold into 3-D structures to specifically bind targets such as ions, small biological organic or inorganic molecules. Previously, it has been shown that thrombin binding aptamers (TBA) have good anticoagulant activity with high-affinity, non-immunogenicity, and non-toxicity.

In a recently published RSC Advances article, Huang et al. show that multivalent TBA bound to gold nanoparticles have 10000 times higher binding affinity than TBA15 (thrombin binding aptamer containing 15 bases). The anticoagulant activity of multivalent TBA-gold nanoparticles is reported to be extremely high, even better than the commercial drugs, argatroban and hirudin.

Moreover, the authors have also developed a photocleavable (PC) version of the multivalent TBA-gold nanoparticles. Upon irradiation with near UV light (365 nm), the 2-nitrobenzyl PC linker of the terminal-modified TBA can be cleaved resulting in the reversal of thrombin activity. The authors are confident that the light-controllable anticoagulant drug will be potentially useful in biomedical aplications.

“We believe that our described technique can be widely used to modify nanoparticles with other DNA or RNA aptamers for different proteins or cancer targets”, say Huang and co-workers from National Taiwan University.

The article was published in our latest issue of RSC Advances, issue 4, 2012. It is free to access by simply registering online before December 2012.

Highly flexible and stable aptamer-caged nanoparticles for control of thrombin activity
Chia-Lun Hsu, Shih-Chun Wei, Jyun-Wei Jian, Huan-Tsung Chang, Wei-Hsi Chen and Chih-Ching Huang
RSC Adv., 2012, 2, 1577-1584

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Top ten most accessed articles in December

This month sees the following articles in RSC Advances that are in the top ten most accessed:-

Graphene–inorganic nanocomposites
Song Bai and Xiaoping Shen
RSC Adv., 2012, 2, 64-98, DOI: 10.1039/C1RA00260K

Cucurbituril chemistry: a tale of supramolecular success
Eric Masson, Xiaoxi Ling, Roymon Joseph, Lawrence Kyeremeh-Mensah and Xiaoyong Lu
RSC Adv., 2012, Advance Article, DOI: 10.1039/C1RA00768H

Graphene-based photocatalytic composites
Xiaoqiang An and Jimmy C. Yu
RSC Adv., 2011, 1, 1426-1434, DOI: 10.1039/C1RA00382H

An electrochemically formed three-dimensional structure of polypyrrole/graphene nanoplatelets for high-performance supercapacitors
Peng Si, Shujiang Ding, Xiong-Wen (David) Lou and Dong-Hwan Kim
RSC Adv., 2011, 1, 1271-1278, DOI: 10.1039/C1RA00519G

Homogeneous and heterogeneous catalysts for multicomponent reactions
Maria José Climent, Avelino Corma and Sara Iborra
RSC Adv., 2012, 2, 16-58, DOI: 10.1039/C1RA00807B

Enhancement of electron field emission properties of TiO2-x nanoplatelets by N-doping
N. C. Raut, Tom Mathews, K. Panda, B. Sundaravel, S. Dash and A. K. Tyagi
RSC Adv., 2012, 2, 812-815, DOI: 10.1039/C2RA00905F

Effect of electrodeposition temperature on the electrochemical performance of a Ni(OH)2 electrode
Yin-Mei Wang, Dan-Dan Zhao, Yong-Qing Zhao, Cai-Ling Xu and Hu-Lin Li
RSC Adv., 2012, 2, 1074-1082, DOI: 10.1039/C1RA00613D

Synthesis of graphene nanosheets via oxalic acid-induced chemical reduction of exfoliated graphite oxide
Peng Song, Xiaoyan Zhang, Mingxuan Sun, Xiaoli Cui and Yuehe Lin
RSC Adv., 2012, 2, 1168-1173, DOI: 10.1039/C1RA00934F

Synthesis of WO3@Graphene composite for enhanced photocatalytic oxygen evolution from water
Jingjing Guo, Yao Li, Shenmin Zhu, Zhixin Chen, Qinglei Liu, Di Zhang, Won-Jin Moon and Deok-Min Song
RSC Adv., 2012, Advance Article , DOI: 10.1039/C1RA00621E, Paper

High performance three-dimensionally ordered macroporous composite cathodes for intermediate temperature solid oxide fuel cells
Naiqing Zhang, Juan Li, Wei Li, Dan Ni and Kening Sun
RSC Adv., 2012, 2, 802-804, DOI: 10.1039/C1RA00837D

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to RSC Advances? Then why not submit to us today or alternatively email us your suggestions.

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Biofunctionalised graphene as an anticoagulant

Scientists in China have come up with a green way to reduce graphene oxide so that it can be used in the biomedical field.

The team has used the anticoagulant heparin, a straight-chain anionic glycosaminoglycan and a natural polymer, to reduce and stabilise the graphene oxide. The heparin–reduced graphene oxide sheets show excellent biocompatibility and activity as a blood anticoagulant, according to the researchers. They also say that the heparin–reduced graphene oxide could bind strongly to anticancer drugs for highly efficient loading.

In order to read more about this work, please download the full article for free by simply registering here:

Green and easy synthesis of biocompatible graphene for use as an anticoagulant
Yi Wang, Pu Zhang, Chun Fang Liu, Lei Zhan, Yuan Fang Li and Cheng Zhi Huang
RSC Adv., 2012, Advance Article, DOI: 10.1039/C2RA00841F, Paper

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Articles from Oz

RSC Advances wishes to celebrate Australia Day by highlighting all of our articles that are written by authors from Australia. Please note that all the articles are free to download upon a simple registration process.

Articles from Down Under:

Research progress and materials selection guidelines on mixed conducting perovskite-type ceramic membranes for oxygen production
Kun Zhang, Jaka Sunarso, Zongping Shao, Wei Zhou, Chenghua Sun, Shaobin Wang and Shaomin Liu
RSC Adv., 2011, 1, 1661-1676, Review 

Effect of different additives on the hydrogen storage properties of the MgH2-LiAlH4 destabilized system
M. Ismail, Y. Zhao, X. B. Yu and S. X. Dou
RSC Adv., 2011, 1, 408-414

Graphene–V2O5·nH2O xerogel composite cathodes for lithium ion batteries
Guodong Du, Kuok Hau Seng, Zaiping Guo, Jun Liu, Wenxian Li, Dianzeng Jia, Chris Cook, Zongwen Liu and Huakun Liu
RSC Adv., 2011, 1, 690-697

Ultraflexible plasmonic nanocomposite aerogel
Yi Chen, Khee Chaw Ng, Wenyi Yan, Yue Tang and Wenlong Cheng
RSC Adv., 2011, 1, 1265-1270

Copper(I) speciation in mixed thiosulfate-chloride and ammonia-chloride solutions: XAS and UV-Visible spectroscopic studies
Barbara E. Etschmann, Jay R. Black, Pascal V. Grundler, Stacey Borg, Dale Brewe, D. C. McPhail, Leone Spiccia and Joël Brugger
RSC Adv., 2011, 1, 1554-1566

Formation of a chrome-free and coloured conversion coating on AA6063 aluminium alloy
Tingyi Chen, Wenfang Li and Jackie Cai
RSC Adv., 2011, 1, 607-610

Controlled hydrolysis of aryltellurium trichlorides using 2-pyrrolidinones: isolation and structural characterization of monomeric aryltellurium(IV) monohydroxides
Shafalika Misra, Ashok K. S. Chauhan, Ramesh C. Srivastava, Andrew Duthie and R. J. Butcher
RSC Adv., 2011, 1, 808-816

Dispersion of SnO2 nanocrystals on TiO2(B) nanowires as anode material for lithium ion battery applications
Zunxian Yang, Guodong Du, Qing Meng, Zaiping Guo, Xuebin Yu, Zhixin Chen, Tailiang Guo and Rong Zeng
RSC Adv., 2011, 1, 1834-1840

A novel bath lily-like graphene sheet-wrapped nano-Si composite as a high performance anode material for Li-ion batteries
Yu-Shi He, Pengfei Gao, Jun Chen, Xiaowei Yang, Xiao-Zhen Liao, Jun Yang and Zi-Feng Ma
RSC Adv., 2011, 1, 958-960 

Selective adsorption and photocatalysis of low-temperature base-modified anatase nanocrystals
Manoj A. Lazar and Walid A. Daoud
RSC Adv., 2012, 2, 447-452

Analytical-scale purification of trichostatin A from bacterial culture in a single step and with high selectivity using immobilised metal affinity chromatography
Najwa Ejje, Ernest Lacey and Rachel Codd
RSC Adv., 2012, 2, 333-337

K0.25Mn2O4 nanofiber microclusters as high power cathode materials for rechargeable lithium batteries
Chaofeng Zhang, Chuanqi Feng, Peng Zhang, Zaiping Guo, Zhixin Chen, Sean Li and Huakun Liu
RSC Adv., 2012, Advance Article, DOI: 10.1039/C1RA00510C, Paper

Enhanced hydrogen storage properties of NaAlH4 co-catalysed with niobium fluoride and single-walled carbon nanotubes
Jianfeng Mao, Zaiping Guo and Huakun Liu
RSC Adv., 2012, Advance Article, DOI: 10.1039/C1RA00645B, Paper

Clicking dendritic peptides onto single walled carbon nanotubes
Eli Moore, Peng-Yuan Wang, Andrew P. Vogt, Christopher T. Gibson, Vattekat Haridas and Nicolas H. Voelcker
RSC Adv., 2012, Advance Article, DOI: 10.1039/C2RA00791F, Communication

Self assembly of bivalent glycolipids on single walled carbon nanotubes and their specific molecular recognition properties
Bandaru Narasimha Murthy, Susanne Zeile, Monessha Nambiar, Matthew R. Nussio, Christopher T. Gibson, Joseph G. Shapter, Narayanaswamy Jayaraman and Nicolas H. Voelcker
RSC Adv., 2012, Advance Article, DOI: 10.1039/C2RA01192A, Communication

Design of low-charge peptide sequences for high-yield formation of titania nanoparticles
Chun-Xia Zhao, Lei Yu and Anton P. J. Middelberg
RSC Adv., 2012, Advance Article, DOI: 10.1039/C2RA00726F, Communication

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The power of the dragon

The dragon year begins on the 23rd January and the Chinese believe it to be an auspicious and prosperous year. The dragon is a mythical creature often associated with intelligence and great energy and power.

Here at RSC Advances, we wish to celebrate Chinese new year by highlighting some of our recently published articles on energy and power generation

Sustainable power generation 

Chinese Dragon in a dragon dance. Image reproduced from wikipedia.

Supercritical fluid extraction (SFE) as an effective tool in reducing auto-oxidation of dried pine sawdust for power generation
Mehrdad Arshadi, Andrew J. Hunt and James H. Clark
RSC Adv., 2012, Advance Article, DOI: 10.1039/C1RA00715G, Paper 

Bioelectrochemical systems (BES) for sustainable energy production and product recovery from organic wastes and industrial wastewaters
Deepak Pant, Anoop Singh, Gilbert Van Bogaert, Stig Irving Olsen, Poonam Singh Nigam, Ludo Diels and Karolien Vanbroekhoven
RSC Adv., 2012, Advance Article, DOI: 10.1039/C1RA00839K, Review 

A new outlook on solubility of carbohydrates and sugar alcohols in ionic liquids
Lucinda J. A. Conceiçao, Ewa Bogel-Łukasik and Rafał Bogel-Łukasik
RSC Adv., 2012, Advance Article, DOI: 10.1039/C1RA01006A, Paper 

Lithium ion batteries 

Facile preparation of hydrated vanadium pentoxide nanobelts based bulky paper as flexible binder-free cathodes for high-performance lithium ion batteries
Xianhong Rui, Jixin Zhu, Weiling Liu, Huiteng Tan, Daohao Sim, Chen Xu, Hua Zhang, Jan Ma, Huey Hoon Hng, Tuti Mariana Lim and Qingyu Yan
RSC Adv., 2011, 1, 117-122 

Magnetite/graphene nanosheet composites: interfacial interaction and its impact on the durable high-rate performance in lithium-ion batteries
Jisheng Zhou, Huaihe Song, Lulu Ma and Xiaohong Chen
RSC Adv., 2011, 1, 782-791 

Electrospun carbon nanofibers decorated with various amounts of electrochemically-inert nickel nanoparticles for use as high-performance energy storage materials
Liwen Ji, Zhan Lin, Mataz Alcoutlabi, Ozan Toprakci, Yingfang Yao, Guanjie Xu, Shuli Li and Xiangwu Zhang
RSC Adv., 2012, 2, 192-198, Paper 

K0.25Mn2O4 nanofiber microclusters as high power cathode materials for rechargeable lithium batteries
Chaofeng Zhang, Chuanqi Feng, Peng Zhang, Zaiping Guo, Zhixin Chen, Sean Li and Huakun Liu
RSC Adv., 2012, Advance Article, DOI: 10.1039/C1RA00510C, Paper 

Stabilized cycling performance of silicon oxide anode in ionic liquid electrolyte for rechargeable lithium batteries
Jin-Woo Song, Cao Cuong Nguyen and Seung-Wan Song
RSC Adv., 2012, Advance Article, DOI: 10.1039/C2RA01183B, Paper 

Capacitors and supercapacitors 

Electrochemical capacitors utilising transition metal oxides: an update of recent developments
Wentao Deng, Xiaobo Ji, Qiyuan Chen and Craig E. Banks
RSC Adv., 2011, 1, 1171-1178, DOI: 10.1039/C1RA00664A, Review 

An electrochemically formed three-dimensional structure of polypyrrole/graphene nanoplatelets for high-performance supercapacitors
Peng Si, Shujiang Ding, Xiong-Wen (David) Lou and Dong-Hwan Kim
RSC Adv., 2011, 1, 1271-1278, Paper 

High-performance aqueous supercapacitors based on hierarchically porous graphitized carbon
Zheng Chen, Ding Weng, Hiesang Sohn, Mei Cai and Yunfeng Lu
RSC Adv., 2012, Advance Article, DOI: 10.1039/C2RA00887D, Communication 

Fuel Cells 

Robust solid oxide cells for alternate power generation and carbon conversion
Xiaoming Ge, Lan Zhang, Yanan Fang, Jie Zeng and Siew Hwa Chan
RSC Adv., 2011, 1, 715-724
DOI: 10.1039/C1RA00355K, Paper 

Symmetric and reversible solid oxide fuel cells
Juan Carlos Ruiz-Morales, David Marrero-López, Jesús Canales-Vázquez and John T. S. Irvine
RSC Adv., 2011, 1, 1403-1414, DOI: 10.1039/C1RA00284H, Review 

Electrochemical growth of gold nanostructures on carbon paper for alkaline direct glucose fuel cell
Sze-Ping Tung, Ting-Kai Huang, Chi-Young Lee and Hsin-Tien Chiu
RSC Adv., 2012, 2, 1068-1073, Paper 

Solar Cells 

Large scale two-dimensional nanobowl array high efficiency polymer solar cell
Szu-Ying Chen, Yu-Ting Yen, Yi-Yang Chen, Chain-Shu Hsu, Yu-Lun Chueh and Lih-Juann Chen
RSC Adv., 2012, Advance Article, DOI: 10.1039/C2RA01258H, Communication 

Efficient Small Molecule Organic Semiconductor containing Bis-dimethylfluorenyl Amino Benzo[b]thiophene for High Open Circuit Voltage in High Efficiency Solution Processed Organic Solar Cell
Jooyoung Kim, Haye Min Ko, Nara Cho, Sanghyun Paek, Jae Kwan Lee and Jaejung Ko
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA01271E, Communication 

A bilayer structure of a titania nanoparticle/highly-ordered nanotube array for low-temperature dye-sensitized solar cells
Jianqiang Luo, Lian Gao, Jing Sun and Yangqiao Liu
RSC Adv., 2012, Advance Article, DOI: 10.1039/C2RA00731B, Paper 

More energy-related articles can be read here. Please note that all of our articles are free to download upon a simple registration process. 

RSC Advances wishes a happy chinese new year to all our authors, referees, readers and editors.

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Choose to publish on accept

Authors can now choose to publish their manuscripts as soon as it is accepted after peer review, prior to editing and proof-reading.

It means your research is readily available, in a citable form, even more rapidly. Once the finishing touches are done during the editing and proof-reading stage, the “Accepted” version is replaced with the latest version called “Advance Article”.

When submitting your manuscript to RSC Advances, authors can opt for their manuscript to be published as soon as it is accepted after the peer review process. You may want to join the other authors who have already selected this option.

RSC Advances “Accepted Manuscripts” are:

Biotemplated Synthesis of Catalytic Au-Pd Nanoparticles
Simon Hall, Andrew Collins, Natalie J Wood, Wataru Ogasawara, Moataz Morad, Peter Miedziak, Meenakshisundaram Sankar, D W Knight and Graham Hutchings
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA01336C

Columnar mesophases of luminescent polycatenar liquid crystals incorporating a 1,3-substituted benzene ring interconnecting two 1,3,4-oxadiazoles
Jianchuan Tang, Rong Huang, Hongfei Gao, Xiaohong Cheng, Marko Prehm,and Carsten Tschierske
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA01362B

Additional bioactive guanidine alkaloids from the Mediterranean sponge Crambe crambe
Stéphanie Bondu, Grégory Genta-Jouve, Marta Leirόs, Carmen Vale, Jean-Marie Guigonis, Luis M. Botana, and Olivier P. Thomas
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA00045H

Efficient Small Molecule Organic Semiconductor containing Bis-dimethylfluorenyl Amino Benzo[b]thiophene for High Open Circuit Voltage in High Efficiency Solution Processed Organic Solar Cell
Jooyoung Kim, Haye Min Ko, Nara Cho, Sanghyun Paek, Jae Kwan Lee and Jaejung Ko
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA01271E

Decoupling of CVD Graphene by controlled Oxidation of Recrystallized
Cu Ang-Yu Lu, Sung-Yen Wei, Chih-Yu Wu, Yenny Hernandez, Tzu-Yin Chen, Te-Huan Liu, Chun-Wei Pao, Fu-Rong Chen, Lain-Jong Li and Zhen-Yu Juang
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA01281B

Phase selective carbohydrate gelator
Somnath Mukherjee and Balaram Mukhopadhyay
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA00036A

Synthesis, Structural Characterization, Solvatochromism, and Ion-binding Studies of a Ditopic Receptor Based on 2-(4-[2,2′: 6′,2′′]Terpyridin-4′-yl-phenyl)-1H-phenanthro[9,10-d] imidazole (tpy-HImzphen) Unit
Chanchal Bhaumik, Dinesh Maity, Shyamal Das, and Sujoy Baitalik
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA00023G

Different types of phase separation in binary monolayers of long chain alkyltrichlorosilanes on silicon oxide
Simon Desbief, Lionel Patrone, Didier Goguenheim, Dominique Vuillaume
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA01327D

Collision-Induced Dissociation of Singly and Doubly Charged CuII-Cytidine Complexes in the Gas Phase: an Experimental and Computational Study
Shuqin Zhang, Li Xu, Junguo Dong, Ping Cheng, Zhen Zhou
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA01293F

Stabilization of poly-iodides: structural influences of the cationic disulfides of 2-mercapto-3,4,5,6-tetrahydro-pyrimidine and 2-mercatpo-pyrimidine.
Anita M. Owczarzak, Maciej Kubicki, Nikolaos Kourkoumelis, Sotiris K. Hadjikakou
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA00013J

Synthetic 5′-phosphorylated oligodeoxynucleotide purification through catching full-length sequences by polymerization
Yinan Yuan, Fueangfung Suntara, Xi Lin, Durga Pokharel and Shiyue Fang
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA01357F

ß-Lactam-host defence peptide conjugates as antibiotic prodrug candidates targeting resistant bacteria
Stephane Desgranges, Carol Ruddle, Liam Burke, Tara Mary Mc Fadden, John E O’Brien, Deirdre Fitzgerald -Hughes, Hilary Humphreys, Timothy P Smyth and Marc Devocelle
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA01351G

Indirect Hydrodesulfurization of Gasoline via Sodium Borohydride Reduction with Nickel Catalysis under Ambient Conditions
Yafei Shen, Tonghua Sun and Jinping Jia
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA01313D

Diffusion-diffraction using singlet spin states and various NMR coherences in a J-coupled AX spin system
Allan M. Torres, Bahman Ghadirian and William S. Price
RSC Adv., 2012, Accepted Manuscript, DOI: 10.1039/C2RA20063E

All 2011 and 2012 articles published in RSC Advances are free to download upon a simple registration process.

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Some of the most accessed articles in 2011 are…

Below is a list containing some of the most downloaded RSC Advances articles in 2011:

A novel bath lily-like graphene sheet-wrapped nano-Si composite as a high performance anode material for Li-ion batteries
Yu-Shi He, Pengfei Gao, Jun Chen, Xiaowei Yang, Xiao-Zhen Liao, Jun Yang and Zi-Feng Ma
RSC Adv., 2011, 1, 958-960

Electrochemistry of graphene: not such a beneficial electrode material?
Dale A. C. Brownson, Lindsey J. Munro, Dimitrios K. Kampouris and Craig E. Banks
RSC Adv., 2011, 1, 978-988

CO2 chemistry: task-specific ionic liquids for CO2 capture/activation and subsequent conversion
Zhen-Zhen Yang, Ya-Nan Zhao and Liang-Nian He
RSC Adv., 2011, 1, 545-567

Incorporation of pyridazine rings in the structure of functionalized π-conjugated materials
Sylvain Achelle, Nelly Plé and Alain Turck
RSC Adv., 2011, 1, 364-388

Fe3O4@SiO2@Pd-Au: a highly efficient and magnetically separable catalyst for liquid-phase hydrodechlorination of 4-chlorophenol
Zhijie Wu, Chongxia Sun, Yan Chai and Minghui Zhang
RSC Adv., 2011, 1, 1179-1182

Modulation of the photophysical properties of BODIPY dyes by substitution at their meso position
Jorge Bañuelos, Ismael J. Arroyo-Córdoba, Ismael Valois-Escamilla, Alejandro Alvarez-Hernández, Eduardo Peña-Cabrera, Rongrong Hu, Ben Zhong Tang, Ixone Esnal, Virginia Martínez and Iñigo López Arbeloa
RSC Adv., 2011, 1, 677-684

All the articles are free to download upon a simple registration process.

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Selecting chiral nanotubes using phage display

“Peptides with an affinity for carbon nanotubes with specific chiralities have been selected by phage display for the first time”, claim scientists from Singapore and China. Phage display is a selection technique in which a combinatorial library of polypeptides allows identification of peptides with desired binding specificities to various target molecules.

Separation of single walled carbon nanotubes (SWCNTs) with a specific chirality is important in the field of carbon nanotube research and a prerequisite for their applications in nanoelectronics. “The availability of single-chirality SWCNT components is still a formidable challenge, although remarkable progress has been made in obtaining narrow chirality distributions of SWCNTs in the past few years”, explain Liao and co-workers.

The figure on the right shows the “biopanning” procedure designed to retain the desired phage and eliminate the undesired phages in the phage display library. More information  about “biopanning” can be obtained by reading the full article online.

Free to access article reference:

Recognition of carbon nanotube chirality by phage display
Ting Yu, Yingxue Gong, Tingting Lu, Li Wei, Yuanqing Li, Yuguang Mu, Yuan Chen and Kin Liao

RSC Adv., 2012, Advance Article, DOI: 10.1039/C1RA00581B

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