Meet the Author
We are very pleased to introduce Peige Wang, co-author of the paper ‘A polypropylene mesh coated with interpenetrating double network hydrogel for local drug delivery in temporary closure of open abdomen‘ with Ze Li, Changliang Wu, Zhen Liu, Zhenlu Li, Xingang Peng, Jinjian Huang and Jianan Ren. His article has been very well received and handpicked by our reviewers and handling editors as one of our HOT articles. Peige was kind enough to tell us more about the work that went into this article and what he hopes to achieve in the future. You can find out more about Peige and his article below and find more HOT articles in our online collection.
Peige Wang is currently the Director of Emergency Department and Emergency Surgery at the Affiliated Hospital of Qingdao and works at the Department of Infectious Diseases and Critical Care, Chinese Medical Association Surgery Branch. He is also Vice Chairman of the Professional Committee of Parenteral Fistula of the Surgical Branch of Chinese Medical Association and Deputy Chief of the Perioperative Group, China Anorectal Board.
Could you briefly explain the focus of your article to the non-specialist (in one or two sentences only) and why it is of current interest?
The double-network hydrogel combined the stiffness and elastic ability as well as in situ forming property. It can significantly reduce the inflammatory irritation caused by temporary abdominal closure friction and greatly reduce complications of the open abdomen.
The double-network hydrogel has great potential for practical application in medicine, especially in the treatment of open abdomen through temporary abdominal closure.
How big an impact could your results potentially have?
Our study provides an advantagous temporary abdominal closure (TAC) biomaterial with good mechnical strength, drug releasing ability and wound healing for management of defected abdominal wall, and will have great potential clinical applications.
Could you explain the motivation behind this study?
Temporary abdominal closure (TAC) technology is prone to complications such as intestinal fistulas when treating open abdomen (OA). We hope to design hydrogels with appropriate stiffness and elasticity to reduce local inflammation and reduce the occurrence of complications in patients.
In your opinion, what are the key design considerations for your study?
The reaction substrate of the double-network hydrogel and appropriate reaction ratio.
Which part of the work towards this paper proved to be most challenging?
Results and discussion. Being a doctor requires knowledge of polymer material to process relevant data and conduct analysis and discussion.
What aspect of your work are you most excited about at the moment?
The emergence and commercialization of more related hydrogels can greatly reduce the incidence of complications of open abdomen (OA) in patients, speed up the recovery time of patients, reduce the length of hospital stay and medical costs.
What is the next step? What work is planned?
We will further study OA-related hydrogels and promote the commercialization of hydrogels for their use in OA patients.
A polypropylene mesh coated with interpenetrating double network hydrogel for local drug delivery in temporary closure of open abdomen
Ze Li, Changliang Wu, Zhen Liu, Zhenlu Li, Xingang Peng, Jinjian Huang, Jianan Ren and Peige Wang
RSC Adv., 2020, 10, 1331-1340
DOI: 10.1039/C9RA10455K Paper
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