Glycan-protein interactions represent an important class of mechanisms underlying numerous biological and pathological events that include cell recognition, trafficking, signalling and infection. Glycodendrimers of tunable saccharide loading levels using different types and generations of dendritic substrates were prepared using thio-urea linkage and click chemistries. Luo et al report a general approach to synthesize saccharide modified dendrimers via direct conjugation of underivatized reducing saccharides to hydrazide functionalized dendrimers.
Facile glycosylation of dendrimers for eliciting specific cell-material interactions by Xiaopeng Liu, Jie Liu and Ying Luo Polym. Chem. 2012, 3, 310-313.