Oren Scherman and co-workers at the University of Cambridge, UK, have used diffusion NMR and solution viscometry to probe cucurbituril-mediated host–guest polymer self assembly. The polymer studied was a 5-component supramolecular ABA triblock copolymer in aqueous solution.
![Graphical abstract: Probing cucurbit[8]uril-mediated supramolecular block copolymer assembly in water using diffusion NMR](https://blogs.rsc.org/py/files/2010/10/NNCAJWITQ3CA65OY3CCAD7BD1XCAI6NT9ICAW3ZTGSCA6UKW2OCABNZQMDCAULS386CA6FMIXMCAB11870CARE9YIDCA7KR95BCA2FI983CAR2LVGNCAIAGBWUCAOVSEOBCAL2S7RFCAZX9DLKCA272FMF.gif "NNCAJWITQ3CA65OY3CCAD7BD1XCAI6NT9ICAW3ZTGSCA6UKW2OCABNZQMDCAULS386CA6FMIXMCAB11870CARE9YIDCA7KR95BCA2FI983CAR2LVGNCAIAGBWUCAOVSEOBCAL2S7RFCAZX9DLKCA272FMF")
The team showed the utility of DOSY NMR for probing the multi-component assembly of supramolecular block copolymers formed through host–guest chemistry. The NMR approach offers a non-invasive, and in situ method to visualise the multi-component assembly process.
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