Top 25 most downloaded Chemical Science articles October–December 2014

Chemical Science Issue 1, 2015 front coverHave you read the 25 most downloaded Chemical Science articles from October–December 2014?

An anti-cancer trinuclear ruthenium(III) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling
Sharon Lai-Fung Chan, Raymond Wai-Yin Sun, Mei-Yuk Choi, Yibo Zeng, Lam Shek, Stephen Sin-Yin Chui and Chi-Ming Che  
DOI:10.1039/C1SC00203A

Selective affinity-based probe for oncogenic kinases suitable for live cell imaging
Claudio Zambaldo, Kalyan K. Sadhu, Ganesan Karthikeyan, Sofia Barluenga, Jean-Pierre Daguer and Nicolas Winssinger
DOI: 10.1039/C3SC21856B

De novo design and optimization of Aurora A kinase inhibitors
Tiago Rodrigues, Filip Roudnicky, Christian P. Koch, Takayuki Kudoh, Daniel Reker, Michael Detmar and Gisbert Schneider  
DOI: 10.1039/C2SC21842A

A high-spin square-planar Fe(II) complex stabilized by a trianionic pincer-type ligand and conclusive evidence for retention of geometry and spin state in solution
M. E. Pascualini, N. V. Di Russo, A. E. Thuijs, A. Ozarowski, S. A. Stoian, K. A. Abboud, G. Christou and A. S. Veige  
DOI: 10.1039/C4SC02634A
Open Access

Macrocycles: lessons from the distant past, recent developments, and future directions
Andrei K. Yudin
DOI: 10.1039/C4SC03089C
Open Access

Carbon–hydrogen (C–H) bond activation at PdIV: a Frontier in C–H functionalization catalysis
Joseph J. Topczewski and Melanie S. Sanford
DOI: 10.1039/C4SC02591A
Open Access

The application of chiroptical spectroscopy (circular dichroism) in quantifying binding events in lanthanide directed synthesis of chiral luminescent self-assembly structures
Oxana Kotova, Salvador Blasco, Brendan Twamley, John O’Brien, Robert D. Peacock, Jonathan A. Kitchen, Miguel Martínez-Calvo and Thorfinnur Gunnlaugsson  
DOI: 10.1039/C4SC02474E
Open Access

ITQ-54: a multi-dimensional extra-large pore zeolite with 20 × 14 × 12-ring channels
Jiuxing Jiang, Yifeng Yun, Xiaodong Zou, Jose Luis Jorda and Avelino Corma 
DOI: 10.1039/C4SC02577F
Open Access

Polycyclic aromatic azomethine ylides: a unique entry to extended polycyclic heteroaromatics
Reinhard Berger, Manfred Wagner, Xinliang Feng and Klaus Müllen  
DOI: 10.1039/C4SC02793K
Open Access

Enantioselective α-amination enabled by a BINAM-derived phase-transfer catalyst
H. M. Nelson, J. S. Patel, H. P. Shunatona and F. D. Toste  
DOI: 10.1039/C4SC02494J
Open Access

“Self-repairing” nanoshell for cell protection
Nan Jiang, Xiao-Yu Yang, Guo-Liang Ying, Ling Shen, Jing Liu, Wei Geng, Ling-Jun Dai, Shao-Yin Liu, Jian Cao, Ge Tian, Tao-Lei Sun, Shi-Pu Li and Bao-Lian Su  
DOI: 10.1039/C4SC02638A
Open Access

Reversible photo-induced trap formation in mixed-halide hybrid perovskites for photovoltaics
Eric T. Hoke, Daniel J. Slotcavage, Emma R. Dohner, Andrea R. Bowring, Hemamala I. Karunadasa and Michael D. McGehee  
DOI: 10.1039/C4SC03141E
Open Access

Diaryldichalcogenide radical cations
Ole Mallow, Monther A. Khanfar, Moritz Malischewski, Pamela Finke, Malte Hesse, Enno Lork, Timo Augenstein, Frank Breher, Jeffrey R. Harmer, Nadezhda V. Vasilieva, Andrey Zibarev, Artem S. Bogomyakov, Konrad Seppelt and Jens Beckmann 
DOI: 10.1039/C4SC02964J
Open Access

Structural study of a small molecule receptor bound to dimethyllysine in lysozyme
Róise E. McGovern, Brendan D. Snarr, Joseph A. Lyons, James McFarlane, Amanda L. Whiting, Irina Paci, Fraser Hof and Peter B. Crowley   
DOI: 10.1039/C4SC02383H
Open Access

Ligand design for Rh(III)-catalyzed C–H activation: an unsymmetrical cyclopentadienyl group enables a regioselective synthesis of dihydroisoquinolones
Todd K. Hyster, Derek M. Dalton and Tomislav Rovis 
DOI: 10.1039/C4SC02590C
Open Access

Annihilation electrogenerated chemiluminescence of mixed metal chelates in solution: modulating emission colour by manipulating the energetics
Emily Kerr, Egan H. Doeven, Gregory J. Barbante, Conor F. Hogan, David J. Bower, Paul S. Donnelly, Timothy U. Connell and Paul S. Francis 
DOI: 10.1039/C4SC02697G
Open Access

Selecting reactions and reactants using a switchable rotaxane organocatalyst with two different active sites
Jack Beswick, Victor Blanco, Guillaume De Bo, David A. Leigh, Urszula Lewandowska, Bartosz Lewandowski and Kenji Mishiro  
DOI: 10.1039/C4SC03279A
Open Access

Tailored chondroitin sulfate glycomimetics via a tunable multivalent scaffold for potentiating NGF/TrkA-induced neurogenesis
Pei Liu, Liwei Chen, Jerry K. C. Toh, Yi Li Ang, Joo-Eun Jee, Jaehong Lim, Su Seong Lee and Song-Gil Lee  
DOI: 10.1039/C4SC02410A
Open Access

Optical and electronic properties of air-stable organoboron compounds with strongly electron-accepting bis(fluoromesityl)boryl groups
Zuolun Zhang, Robert M. Edkins, Jörn Nitsch, Katharina Fucke, Andreas Steffen, Lauren E. Longobardi, Douglas W. Stephan, Christoph Lambert and Todd B. Marder 
DOI: 10.1039/C4SC02410A
Open Access

Ligand functionalization as a deactivation pathway in a fac-Ir(ppy)3-mediated radical addition
James J. Devery III, James J. Douglas, John D. Nguyen, Kevin P. Cole, Robert A. Flowers II and Corey R. J. Stephenson  
DOI: 10.1039/C4SC03064H
Open Access

In vivo visible light-triggered drug release from an implanted depot
Carl-Johan Carling, Mathieu L. Viger, Viet Anh Nguyen Huu, Arnold V. Garcia and Adah Almutairi   
DOI: 10.1039/C4SC02651A
Open Access

Non-equilibrium cobalt(III) “click” capsules
P. R. Symmers, M. J. Burke, D. P. August, P. I. T. Thomson, G. S. Nichol, M. R. Warren, C. J. Campbell and P. J. Lusby  
DOI: 10.1039/C4SC03036B
Open Access

Ultrafast infrared spectroscopy reveals water-mediated coherent dynamics in an enzyme active site
Katrin Adamczyk, Niall Simpson, Gregory M. Greetham, Andrea Gumiero, Martin A. Walsh, Michael Towrie, Anthony W. Parker and Neil T. Hunt  
DOI: 10.1039/C4SC02752C
Open Access

A counteranion triggered arylation strategy using diaryliodonium fluorides
L. Chan, A. McNally, Q. Y. Toh, A. Mendoza and M. J. Gaunt
DOI: 10.1039/C4SC02856B
Open Access

Transition-metal-free controlled polymerization for poly(p-aryleneethynylene)s
Takanobu Sanji, Asahi Motoshige, Hideaki Komiyama, Junko Kakinuma, Rie Ushikubo, Satoru Watanabe and Tomokazu Iyoda 
DOI: 10.1039/C4SC02872D
Open Access


Chemical Science is the Royal Society of Chemistry’s flagship journal, publishing research articles of exceptional significance and high-impact reviews from across the chemical sciences. It has been Gold Open Access since January 2015. The journal’s latest (2013) Impact Factor is 8.6. Research in Chemical Science is not only of the highest quality but also has excellent visibility: this is reflected in our latest citation profile.

Submit your exceptional research to Chemical Science today!

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Prize awarded at Postgraduate Solar Fuels Symposium

SFN 3rd UK Solar Fuels Symposium 19th and 20th January, 2015 Edinburgh Conference CentreChemical Science and Energy & Environmental Science were delighted to sponsor the Postgraduate Solar Fuels Symposium which took place in Edinburgh last month.

The winner of the prize for best oral presentation  was Jan Rongé, University of Cambridge for his talk “Solar fuel from air and sunlight”.

Emily Glover of University College London and Wei Li of the University of Liverpool both received honourable mentions for their talks.

The best poster prize was awarded to Mark Forster from the University of Liverpool, for his poster titled “Elucidating charge carrier dynamics on advanced hematite (Fe2O3) photoelectrodes”.

Congratulations to the winners!

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Challenges in Chemical Renewable Energy – join us in Rio!

Challenges in Chemical Renewable Energy ISACS17 8-11 September 2015 Rio de Janeiro, Brazil

Call for oral abstracts – deadline 27 April 2015

We invite you to join us at Challenges in Chemical Renewable Energy (ISACS17), which will be held in Rio de Janeiro, Brazil from 8-11 September 2015.

This conference will bring together leading scientists from across the world to share scientific developments in renewable energy generation and storage. The broad subject scope will provide an excellent overview of some of the key challenges within cutting edge aspects of this important, fast-moving research field, with plenty of opportunities for networking.

Themes include:

  • Solar Fuels and molecular catalysis
  • Photovoltaics
  • Biofuels
  • Battery technology and energy storage
  • Fuel cells


Submit your abstract today via our submission system.

You can find more details about submitting your abstract here.


Invited speakers:

James Durrant, Imperial College London, United Kingdom

Eduardo Falabella, Federal University of Rio de Janeiro and PETROBRAS, Brazil

Marc Fontecave, Collège de France, France

Ernesto R. Gonzalez, University of São Paulo, Brazil

Can Li, Dalian Institute of Chemical Physics, China

Daniel Nocera, Harvard University, United States

Erwin Reisner, University of Cambridge, United Kingdom

Keith Waldron, Institute of Food Research, United Kingdom

Karen Wilson, Aston University, United Kingdom


Chemical Science cover imageThe ISACS symposia are organised in partnership with Chemical Science. From 2015 all our content is Open Access so you can check out some of the latest freely accessible research in the broad field of Chemical Renewable Energy today:

Reversible photo-induced trap formation in mixed-halide hybrid perovskites for photovoltaics
Eric T. Hoke, Daniel J. Slotcavage, Emma R. Dohner, Andrea R. Bowring, Hemamala I. Karunadasa and Michael D. McGehee
DOI: 10.1039/C4SC03141E

Long-lived charge carrier generation in ordered films of a covalent perylenediimide–diketopyrrolopyrrole–perylenediimide molecule
Patrick E. Hartnett, Scott M. Dyar, Eric A. Margulies, Leah E. Shoer, Andrew W. Cook, Samuel W. Eaton, Tobin J. Marks and Michael R. Wasielewski
DOI: 10.1039/C4SC02551B

Ultrafast delocalization of excitation in synthetic light-harvesting nanorings
Chaw-Keong Yong, Patrick Parkinson, Dmitry V. Kondratuk, Wei-Hsin Chen, Andrew Stannard, Alex Summerfield, Johannes K. Sprafke, Melanie C. O’Sullivan, Peter H. Beton, Harry L. Anderson and Laura M. Herz
DOI: 10.1039/C4SC02424A

Oxygen evolution on well-characterized mass-selected Ru and RuO2 nanoparticles
Elisa A. Paoli, Federico Masini, Rasmus Frydendal, Davide Deiana, Christian Schlaup, Mauro Malizia, Thomas W. Hansen, Sebastian Horch, Ifan E. L. Stephens and Ib Chorkendorff
DOI: 10.1039/C4SC02685C

Metal oxidation states in biological water splitting
Vera Krewald, Marius Retegan, Nicholas Cox, Johannes Messinger, Wolfgang Lubitz, Serena DeBeer, Frank Neese and Dimitrios A. Pantazis
DOI: 10.1039/C4SC03720K

Computational design of molecules for an all-quinone redox flow battery
Süleyman Er, Changwon Suh, Michael P. Marshak and Alán Aspuru-Guzik
DOI: 10.1039/C4SC03030C

A noble metal-free proton-exchange membrane fuel cell based on bio-inspired molecular catalysts
P. D. Tran, A. Morozan, S. Archambault, J. Heidkamp, P. Chenevier, H. Dau, M. Fontecave, A. Martinent, B. Jousselme and V. Artero
DOI: 10.1039/C4SC03774J

A facile route to electronically conductive polyelectrolyte brushes as platforms of molecular wires
Karol Wolski, Michał Szuwarzyński and Szczepan Zapotoczny
DOI: 10.1039/C4SC04048A

Catalysis of water oxidation in acetonitrile by iridium oxide nanoparticles
Jonnathan C. Hidalgo-Acosta, Manuel A. Méndez, Micheál D. Scanlon, Heron Vrubel, Véronique Amstutz, Wojciech Adamiak, Marcin Opallo and Hubert H. Girault
DOI: 10.1039/C4SC02196G

Tandem redox mediator/Ni(II) trihalide complex photocycle for hydrogen evolution from HCl
Seung Jun Hwang, David C. Powers, Andrew G. Maher and Daniel G. Nocera
DOI: 10.1039/C4SC02357A

Durable hydrogen evolution from water driven by sunlight using (Ag,Cu)GaSe2 photocathodes modified with CdS and CuGa3Se5
Li Zhang, Tsutomu Minegishi, Mamiko Nakabayashi, Yohichi Suzuki, Kazuhiko Seki, Naoya Shibata, Jun Kubota and Kazunari Domen
DOI: 10.1039/C4SC02346C

Magnetic MOF microreactors for recyclable size-selective biocatalysis
Jia Huo, Jordi Aguilera-Sigalat, Samir El-Hankari and Darren Bradshaw
DOI: 10.1039/C4SC03367A

We hope you can join us for Challenges in Chemical Renewable Energy (ISAC17). Claudio Mota, Roberto Torresi and the rest of the Scientific Committee look forward to welcoming you and your colleagues to Rio de Janeiro!

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Christopher Hunter joins Chemical Science as Associate Editor

Chemical Science is pleased to welcome Christopher Hunter as Associate Editor for Physical Organic chemistry.  

Biography
Christopher Hunter is Herchel Smith Professor of Organic Chemistry at the University of Cambridge. Originally from New Zealand, he moved to Northern Ireland at the age of four and completed his early education there.  After receiving his undergraduate degree and PhD from Churchill College, Cambridge, he returned to his native New Zealand for a couple of years to lecture at the University of Otago. In 1991 he moved back to the UK, joining the University of Sheffield first as Lecturer and then as Professor, before taking up his current post at the University of Cambridge in September 2014.  

Research
The Hunter Group’s aim is to establish a reliable set of rules that can be used for the design of non-covalent systems. Their research focuses on four main areas of development:
1. Fundamental investigations of the nature of intermolecular interactions
2. Molecular design of functional assemblies
3. Development of new methods for studying solvation and co-operativity
4. Computer modelling of intermolecular interactions  

Awards
Chris’s recent awards include the RSC Physical Organic Chemistry Award (2011) and the RSC Tilden Prize (2009). In 2008 he was elected a Fellow of the Royal Society.  

Publications
You can read some of the most recent work from the Hunter group in Chemical Science – click on the links below to get to the articles. All are either Open Access or free to access until 24th March: 

The flexibility–complementarity dichotomy in receptor–ligand interactions
Hongmei Sun, Christopher A. Hunter and Eva Marina Llamas  
Chem. Sci., 2015, 6, 1444-1453
DOI: 10.1039/C4SC03398A, Edge Article
OA icon Open Access
 
pH-dependent binding of guests in the cavity of a polyhedral coordination cage: reversible uptake and release of drug molecules
William Cullen, Simon Turega, Christopher A. Hunter and Michael D. Ward  
Chem. Sci., 2015, 6, 625-631
DOI: 10.1039/C4SC02090A, Edge Article
OA icon Open Access
 
Applications of dynamic combinatorial chemistry for the determination of effective molarity
Maria Ciaccia, Irene Tosi, Laura Baldini, Roberta Cacciapaglia, Luigi Mandolini, Stefano Di Stefano and Christopher A. Hunter  
Chem. Sci., 2015, 6, 144-151
DOI: 10.1039/C4SC02347A, Edge Article
OA icon Open Access
 
A solvent-resistant halogen bond
Craig C. Robertson, Robin N. Perutz, Lee Brammer and Christopher A. Hunter  
Chem. Sci., 2014, 5, 4179-4183
DOI: 10.1039/C4SC01746C, Edge Article
OA icon Open Access
 
Quantification of solvent effects on molecular recognition in polyhedral coordination cage hosts
Martina Whitehead, Simon Turega, Andrew Stephenson, Christopher A. Hunter and Michael D. Ward  
Chem. Sci., 2013, 4, 2744-2751
DOI: 10.1039/C3SC50546D, Edge Article 
OA icon Open Access

A surface site interaction model for the properties of liquids at equilibrium
Christopher A. Hunter  
Chem. Sci., 2013, 4, 1687-1700
DOI: 10.1039/C3SC22124E, Edge Article
From themed collection Physical Chemistry  

van der Waals interactions in non-polar liquids
Christopher A. Hunter  
Chem. Sci., 2013, 4, 834-848
DOI: 10.1039/C2SC21666C, Edge Article
From themed collection Physical Chemistry  

Chris is now accepting submissions to Chemical Science in the area of physical organic chemistry.  Submit your high-impact research to his Editorial Office.  


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Chemical Science welcomes Vy Dong as Associate Editor

Chemical Science is delighted to welcome Vy Dong of UC Irvine as Associate Editor in the area of Organic Chemistry.

Vy DongBiography
Vy Dong grew up in Big Spring, Texas and Anaheim, California. After graduating from the University of California, Irvine, she joined David MacMillan’s group at UC Berkeley, moving with his group to Caltech to complete her doctoral studies. She began her independent academic career at the University of Toronto in 2006, where she was promoted with tenure and named the Adrian Brook Professor. After six years in Canada, Vy returned to the United States to assume a professorship at her alma mater, UC Irvine.

In 2013 we interviewed Vy for Chemistry Worldread the full interview to find out why Vy chose to pursue a career in chemistry, how she comes up with ideas for new projects, and what she loves about her job.

Research
Professor Dong’s research group at UC Irvine is interested in new reaction methods, enantioselective catalysis, and natural product synthesis. Specifically, the group looks at finding ways to directly convert carbon-hydrogen bonds into other functional groups, use carbon dioxide as a raw material, and make biologically active heterocycles.

Publications
We’ve made some of the Dong Research Group’s Chemical Science articles free to access until 18th March – click on the titles below to get to the articles*:

Mechanistic insights into hydroacylation with non-chelating aldehydes
Stephen K. Murphy, Achim Bruch and Vy M. Dong
Chem. Sci., 2015,6, 174-180, DOI: 10.1039/C4SC02026J, Edge Article
OA icon Open Access

β-hydroxy ketones prepared by regioselective hydroacylation
Stephen K. Murphy, Matthew M. Coulter and Vy M. Dong
Chem. Sci., 2012,3, 355-358, DOI: 10.1039/C1SC00634G, Edge Article

Ru-catalyzed activation of sp3 C–O bonds: O- to N-alkyl migratory rearrangement in pyridines and related heterocycles
Charles S. Yeung, Tom H. H. Hsieh and Vy M. Dong
Chem. Sci., 2011,2, 544-551, DOI: 10.1039/C0SC00498G, Edge Article

Nitrogen-directed ketone hydroacylation: Enantioselective synthesis of benzoxazecinones
Hasan A. Khan, Kevin G. M. Kou and Vy M. Dong
Chem. Sci., 2011,2, 407-410, DOI: 10.1039/C0SC00469C, Edge Article

Vy is now accepting submissions to Chemical Science in the area of organic chemistry. Submit your high-impact research to her Editorial Office.

*Access is free through a registered RSC account

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Photosynthesis takes the high road

Jason Woolford writes about a hot Chemical Science article for Chemistry World

Understanding biological water oxidation is central to achieving artificial photosynthesis and providing cheap and efficient hydrogen production. However, cracking the mystery of such a complex system has resulted in two competing oxidation state schemes, accompanied by controversy and debate over which is correct. Now, Dimitrios Pantazis, of the Max Planck Institute for Chemical Energy Conversion in Germany, and his colleagues feel they have proven one scheme more valid than the other.


Read the full article in Chemistry World»

Read the original journal article in Chemical Science – it’s Open Access and free to read:
Metal oxidation states in biological water splitting

Vera Krewald, Marius Retegan, Nicholas Cox, Johannes Messinger, Wolfgang Lubitz, Serena DeBeer, Frank Neese and Dimitrios A. Pantazis  
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC03720K, Edge Article

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Hot Chemical Science articles for January

We hope you enjoy reading some of the most recent referee-recommended articles from Chemical Science – all Open Access unless otherwise stated   

Solid state organic amine detection in a photochromic porous metal organic framework
Arijit Mallick, Bikash Garai, Matthew A. Addicoat, Petko St. Petkov, Thomas Heine and Rahul Banerjee  
Chem. Sci., 2015, 6, 1420-1425
DOI: 10.1039/C4SC03224A, Edge Article
Open Access    

C4SC03224A ga   


Synergistic cascade catalysis by metal nanoparticles and Lewis acids in hydrogen autotransfer
Gerald C. Y. Choo, Hiroyuki Miyamura and Shū Kobayashi  
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC03627A, Edge Article
Open Access   

C4SC03627A ga   


Critical analysis of the limitations of Bleaney’s theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes
Alexander M. Funk, Katie-Louise N. A. Finney, Peter Harvey, Alan M. Kenwright, Emily R. Neil, Nicola J. Rogers, P. Kanthi Senanayake and David Parker  
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C4SC03429E, Edge Article
Open Access   

C4SC03429E ga   


The role of πσ* states in the photochemistry of heteroaromatic biomolecules and their subunits: insights from gas-phase femtosecond spectroscopy
Gareth M. Roberts and Vasilios G. Stavros 
Journal Article
Chem. Sci., 2014, 5, 1698-1722
DOI: 10.1039/C3SC53175A, Perspective
Free to access until 2nd March   

C3SC53175A ga   


Thermoresponsive organometallic arene ruthenium complexes for tumour targeting
Catherine M. Clavel, Emilia Păunescu, Patrycja Nowak-Sliwinska and Paul J. Dyson  
Chem. Sci., 2014, 5, 1097-1101
DOI: 10.1039/C3SC53185F, Edge Article
Open Access   

C3SC53185F ga   


Polyunsaturated fatty acid biosynthesis in myxobacteria: different PUFA synthases and their product diversity
Katja Gemperlein, Shwan Rachid, Ronald O. Garcia, Silke C. Wenzel and Rolf Müller  
Chem. Sci., 2014, 5, 1733-1741
DOI: 10.1039/C3SC53163E, Edge Article
Free to access until 2nd March   

C3SC53163E ga

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Challenges in Chemical Biology – oral abstract deadline: 23 February

Don’t miss your chance to be part of this significant event – submit today!


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Oral abstract submission – deadline extended to 23 February 2015

We invite you to join us at Challenges in Chemical Biology (ISACS16), the 16th conference in the highly successful International Symposia on Advancing the Chemical Sciences (ISACS) series.

The conference will be held at the ETH, Zurich, Switzerland from 15-18 June 2015.

Take advantage of this excellent opportunity to showcase your latest research alongside the following leading scientists from across the globe - submit your abstract today.

Confirmed invited speakers:

Shankar Balasubramanian, University of Cambridge, UK
Annette Beck-Sickinger, Leipzig University, Germany
Peng Chen, Peking University, China
Dorothea Fiedler, Princeton University, USA
Kai Johnsson, EPFL Switzerland, Switzerland
Carsten Schultz, European Molecular Biology Laboratory, Germany
Scott Sternson, Howard Hughes Medical Institute, USA
John Sutherland, MRC Laboratory of Molecular Biology, UK
David Tirrell, California Institute of Technology, USA
Yasuteru Urano, University of Tokyo, Japan
Wilfred van der Donk, University of Illinois, USA

We look forward to welcoming you to Zurich in June 2015.

Professor Hema Wennemers
Conference Chair
Dr Heather Montgomery
Deputy Editor, Chemical Science
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Smart nanoparticles take aim at cancer cells

Thadchajini Retneswaran writes about a hot Chemical Science article for Chemistry World

Scientists in China have developed an intelligent nanoparticle system that delivers a chemotherapeutic and radiosensitiser drug directly to the nucleus of cancer cells. Tests suggest this intranuclear radiosensitisation technique could intensify the effects of radiotherapy.

Along with radiotherapy, chemotherapy assumes a frontline position in the battle against cancer. However, many drugs fail to enter cancer cell nuclei when they should. This often leads to multidrug resistance in tumours and a diminished response to radiotherapy.


Read the full article in Chemistry World»

Read the original journal article for free in Chemical Science:
Design of An Intelligent Sub-50 nm Nuclear-targeting Nanotheranostic System for Imaging Guided Intranuclear Radiosensitization
Wenpei Fan, Bo Shen, Wenbo Bu, Xiangpeng Zheng, Qianjun He, Zhaowen Cui, Kuaile Zhao, Shengjian Zhang and Jianlin Shi  
 Chem. Sci., 2014, Accepted Manuscript
DOI: 10.1039/C4SC03080J, Edge Article

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Daniel Nocera – our new Chemical Science Editor-in-Chief

We are delighted to announce Professor Daniel Nocera as the new Editor-in-Chief of Chemical Science. Daniel Nocera, the Patterson Rockwood Professor of Energy at Harvard University, has a diverse research programme and is recognised, internationally, as a pioneer and leading expert in the field of solar energy conversion.

Professor Nocera’s group has recently accomplished a solar fuels process that captures many of the elements of photosynthesis – he has now translated this science to produce the artificial leaf. This exciting discovery sets the stage for a storage mechanism for the distributed deployment of solar energy.

As we thank Professor David MacMillan for his valuable contributions to Chemical Science since its launch in 2010, we extend a warm welcome to Professor Nocera as he leads the journal towards continued success and excellence.

Professor Nocera joins us in inviting you to read Chemical Science’s first Open Access articles in Issue 1 for 2015 – one hundred cutting-edge articles showcasing exceptional research across the chemical sciences. For a limited time, these have been gathered under broad subject areas to show significant breakthroughs in each field:

Analytical Chemistry

Chemical Biology and Medicinal Chemistry

Organic Chemistry

Catalysis

Energy and Physical Chemistry

Materials

Nanoscience

Inorganic Chemistry

Chemical Science is the Royal Society of Chemistry’s flagship journal, publishing research articles of exceptional significance and high-impact reviews from across the chemical sciences. The journal’s latest (2013) Impact Factor is 8.6. Research in Chemical Science is not only of the highest quality but also has excellent visibility; this is reflected in our latest citation profile.

Submit your exceptional research to Chemical Science today!

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