First nitrido–imido–amido complex made

Aurora Walshe writes about a hot Chemical Science article for Chemistry World

Almost 40 years after Schrock and Clark’s synthesis of a tungsten ‘yl-ene-yne’ complex in 1978, scientists in the US have made the first nitrogen analogue: a chromium nitrido–imido–amido complex.


Read more in Chemistry World, or read the original journal article in Chemical Science.

A complex with nitrogen single, double, and triple bonds to the same chromium atom: synthesis, structure, and reactivity
E P Beaumier et al, Chem. Sci., 2016, DOI: 10.1039/c5sc04608d

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Hot Chemical Science articles for December

Take a look at this selection of recently published referee-recommended articles – all are open access and free to read:

Latent harmony in dicarbon between VB and MO theories through orthogonal hybridization of 3σg and 2σu
Ronglin Zhong, Min Zhang, Hongliang Xu and Zhongmin Su
DOI: 10.1039/C5SC03437J, Edge Article

C5SC03437J GA

Rational design of a water-soluble, lipid-compatible fluorescent probe for Cu(I) with sub-part-per-trillion sensitivity
M. T. Morgan, A. M. McCallum and C. J. Fahrni
DOI: 10.1039/C5SC03643G, Edge Article

C5SC03643G GA

Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(I) complexes in A549 lung cancer cells
J. F. Arambula, R. McCall, K. J. Sidoran, D. Magda, N. A. Mitchell, C. W. Bielawski, V. M. Lynch, J. L. Sessler and K. Arumugam
DOI: 10.1039/C5SC03519H, Edge Article

C5SC03519H GA

Mesoporous Pt nanospheres with designed pore surface as highly active electrocatalyst
Bo Jiang, Cuiling Li, Victor Malgras, Masataka Imura, Satoshi Tominaka and Yusuke Yamauchi
DOI: 10.1039/C5SC03779D, Edge Article

C5SC03779D GA

Many Mg–Mg bonds form the core of the Mg16Cp*8Br4K cluster anion: the key to a reassessment of the Grignard reagent (GR) formation process?
T. Kruczyński, F. Henke, M. Neumaier, K. H. Bowen and H. Schnöckel
DOI: 10.1039/C5SC03914B, Edge Article

C5SC03914B GA

Thermodynamic synthesis of solution processable ladder polymers
Jongbok Lee, Bharath Bangalore Rajeeva, Tianyu Yuan, Zi-Hao Guo, Yen-Hao Lin, Mohammed Al-Hashimi, Yuebing Zheng and Lei Fang
DOI: 10.1039/C5SC02385H, Edge Article

C5SC02385H GA

*Access is free through a registered RSC account

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

ISACS18: Challenges in Organic Materials and Supramolecular Chemistry in Bangalore

Highlights from the very first ISACS meeting in India held on 19-21 November 2015

Over 160 delegates from 14 countries signed up for the first International Symposia on Advancing the Chemical Sciences (ISACS) meeting in India to discuss ground-breaking research in organic materials and supramolecular chemistry. Held at the Indian Institute of Science in Bangalore on 19-21 November, with an international scientific committee led by Professor S Ramakrishnan, this was the culmination of the ISACS series in 2015.



Professor Ramakrishnan, Chair of the Scientific Committee, delivers the opening remarks at ISACS18

Focusing on five key topic areas, all the scientific talks were extremely well-received, from engineering interfaces through the assembly of minerals and nutrients with Frank Caruso, to self-assembly and self-healing by molecular recognition with Akira Harada, to stimuli-responsive fluorescent molecular assemblies with Ayyappanpillai Ajayaghosh, and to rectification in single-molecule junctions with Latha Venkataraman. Exciting discussions also took place on the latest developments in bio-inspired and bio-relevant supramolecular systems, as the participants enjoyed outstanding contributions from Stefan Matile, Sijbren Otto and Jan van Esch, to name a few.

The poster sessions were extremely lively with 84 presenters discussing their work. Three poster prizes were presented, sponsored by Chemical Science, ChemComm and Chemistry World.

ISACS18 poster prizes

Ajith Mallia (L) and Emmanuel Etim won the Chemical Science and Chemistry World poster prizes, respectively

The Chemical Science-sponsored poster prize went to Ajith Ravi Mallia (IISER-Thiruvananthapuram) for his poster on how light-harvesting vesicular donor-acceptor scaffold limits the rate of charge recombination in the presence of an electron donor, while the ChemComm poster prize was won by Pritam Mukhopadhyay (Jawaharlal Nehru University) for his research on highly ambient stable naphthalenediimide-based radicals and radical ions. PhD student Emmanuel Etim received the Chemistry World poster prize (together with the customary mug) for his work on interstellar hydrogen bonding.

A Chemistry World panel discussion on building successful industry-academia collaborations discussed the challenges and advantages of partnerships between these two groups.

Royal Society of Chemistry members and ISACS18 delegates also enjoyed a special reception and conference dinner at the Fairfield Marriott.

View more ISACS18 photos on Chemistry World’s album on Facebook.

The next instalment of the ISACS conference series on the theme of Challenges in Organic Materials and Supramolecular Chemistry will be held in conjuction with the International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC) meeting on 2-6 July 2017 in Cambridge, UK – more details on registration and abstract submission dates to be announced next year.

ISACS18 May Copsey

Chemical Science Executive Editor May Copsey (L) with an ISACS18 poster presenter

Get involved in our upcoming ISACS:

Challenges in Organic Chemistry
20 – 23 March 2016, Irvine, USA
Early bird registration deadline: 18 January 2016

Challenges in Nanoscience
10-13 November 2016, Beijing, China
Oral abstracts deadline: 11 July 2016

Challenges in Inorganic Chemistry and Materials
Chair: Richard Layfield (University of Manchester)
Details to be announced soon

ISACS18 members reception

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Jihong Yu elected Academician by the Chinese Academy of Sciences

Congratulations, Jihong!

We proudly congratulate Chemical Science Associate Editor Jihong Yu (Jilin University), who was officially elected as Academician by the Chinese Academy of Sciences (CAS) on 7 December 2015 – congratulations from the Royal Society of Chemistry, and especially from the whole Chemical Science team!

After rigorous selection and assessment, Jihong was awarded the title of Academician – widely regarded as one of the highest honours for scientists in China – together with eight other professors working in the chemical sciences. A total of 61 new Academicians from various science disciplines were selected by CAS in this round of biennial elections. As a CAS Academician, Jihong is now even better placed to help shape the nation’s science policy and influence significant decisions on the future of the chemical sciences in China.

Jihong’s research focuses on the synthesis and preparation chemistry of inorganic microporous materials, typically known as zeolites. In the course of her research, she has made significant contributions to the molecular engineering of zeolites by developing effective strategies for the structural design and rational synthesis of these materials.

As an Associate Editor for Chemical Science since 2012, Jihong welcomes submissions in the area of inorganic materials. Together with our dynamic international team of Associate Editors, she has been actively driving the journal’s scientific development by making direct decisions on its content – submit your best work to any of their Editorial Offices today!

Read Jihong Yu’s latest articles in Chemical Science* and its sister journals, published by the Royal Society of Chemistry:

Synthesis of new zeolite structures
Jiyang Li, Avelino Corma and Jihong Yu
Chem. Soc. Rev., 2015, 44, 7112-7127
DOI: 10.1039/C5CS00023H
From themed collection Recent Advances in Zeolite Chemistry and Catalysis

Coupling of chromophores with exactly opposite luminescence behaviours in mesostructured organosilicas for high-efficiency multicolour emission
Dongdong Li, Yuping Zhang, Zhiying Fan, Jie Chen and Jihong Yu
Chem. Sci., 2015, 6, 6097-6101
DOI: 10.1039/C5SC02044A, Edge Article
Open Access

Methyl viologen-templated zinc gallophosphate zeolitic material with dual photo-/thermochromism and tuneable photovoltaic activity
Junbiao Wu, Chunyao Tao, Yi Li, Jiyang Li and Jihong Yu
Chem. Sci., 2015, 6, 2922-2927
DOI: 10.1039/C5SC00291E, Edge Article
Open Access

Ultrafast synthesis of nano-sized zeolite SAPO-34 with excellent MTO catalytic performance
Qiming Sun, Ning Wang, Guanqi Guo and Jihong Yu
Chem. Commun., 2015, 51, 16397-16400
DOI: 10.1039/C5CC07343J, Communication

With thanks to Guanqun Song, our Editorial Development Manager based in Beijing, for contributing to this blog post.

*Access is free through a registered RSC account

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Hitching a ride on DNA

In the congested intracellular environment, scientists in the Netherlands and the US have found a way for molecules to manoeuvre through the crowds and arrive at their destination faster, increasing the efficiency of lengthy laboratory processes, such as polymerase chain reactions (PCRs).

Biomolecules must find and associate with other biomolecules to carry out basic processes within a cell. To do so, many will randomly diffuse within the cell’s three-dimensional space, which is very time-consuming. Some proteins have evolved to glide along DNA and sample positions in a one-dimensional fashion in search of their target, akin to driving down a highway and stopping to sightsee along the way. This has the potential to speed up these processes. Read the full article in Chemistry World»

Read the original journal article in Chemical Science – it’s open access and free to read:
Speeding up biomolecular interactions by molecular sledding
Alexander Turkin, Lei Zhang, Alessio Marcozzi, Walter F. Mangel, Andreas Herrmann and Antoine M. van Oijen
DOI: 10.1039/C5SC03063C, Edge Article

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Highlights from Chemical Science

Here is some of the latest research from Chemical Science to be highlighted in Chemistry World magazine

Eucalyptus bears both catalyst and biofuel
by Elisabeth Ratcliffe 

Leftovers from the catalytic conversion of biomass into biofuels and biochemicals need not go to waste. So say Japanese researchers who have devised a method using eucalyptus trees that regenerates residue from the process into fresh catalyst. Read the full  article in Chemistry World» 


Read the original journal article in Chemical Science:
Hydrolysis of woody biomass by a biomass-derived reusable heterogeneous catalyst
Hirokazu Kobayashi, Hiroyuki Kaiki, Abhijit Shrotri, Kota Techikawara and Atsushi Fukuoka
DOI: 10.1039/C5SC03377B, Edge Article 

Add more peroxide to stabilise new drug molecules
by Michaela Muehlberg 

Scientists in the US and Russia have performed theoretical calculations to better understand the well-known instability of peroxides as well as the astonishing higher stability of bis- and tris-peroxides. For the latter, they found that multiple O–O bonds appear to exert a stabilising stereoelectronic effect on each other, which boosts stability. Read the full article in Chemistry World» 


Read the original journal article in Chemical Science:
Stereoelectronic source of the anomalous stability of bis-peroxides
Gabriel dos Passos Gomes, Vera Vil’, Alexander Terent’ev and Igor V. Alabugin
DOI: 10.1039/C5SC02402A, Edge Article

Gold cluster bends between two isomers
by Sage Bowser

Collaborating research groups in the US and China have observed a rare type of isomerism in a gas phase Au2I3– cluster. The cluster exhibits two stable structures with the same electronic configuration and potential energy surface that vary in only their Au–I–Au bond angles, a phenomenon that the researchers have dubbed ‘bond-bending isomerism’. Read the full article in Chemistry World» 


Read the original journal article in Chemical Science:
Bond-bending isomerism of Au2I3: competition between covalent bonding and aurophilicity
Wan-Lu Li, Hong-Tao Liu, Tian Jian, Gary V. Lopez, Zachary A. Piazza, Dao-Ling Huang, Teng-Teng Chen, Jing Su, Ping Yang, Xin Chen, Lai-Sheng Wang and Jun Li
DOI: 10.1039/C5SC03568F, Edge Article

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

ISACS19: Challenges in Organic Chemistry – deadline extended

Submit an oral abstract by 22 November

We are excited to announce that the deadline for oral abstract submission for Challenges in Organic Chemistry (ISACS19) has been extended to 22 November.

Join Chemical Science Associate Editor Vy Dong and an excellent line-up of invited speakers at University of California, Irvine, USA from 20–23 March to discuss challenges in organic chemistry, from catalysis, proteins, sugars and total synthesis to theory and mechanisms.

Confirmed speakers include:

  • Ashraf Brik, Technion – Israel Institute of Technology, Israel
  • Seth Herzon, Yale University, United States
  • Kami Hull, University of Illinois, Urbana-Champaign, United States
  • James Nowick, University of California, Irvine, United States
  • RB Sunoj, IIT, Mumbai, India
  • Jin-Quan Yu, Scripps University, United States
  • Darren Dixon, University of Oxford, United Kingdom
  • Ning Jiao, Peking University, China
  • Nicola Pohl, Indiana University, United States
  • Peter Seeberger, Max-Planck Institute, Germany
  • Kyoko Nozaki, University of Tokyo, Japan
  • Michelle Chang, University of California, Berkeley, United States
  • Yamuna Krishnan, University of Chicago, United States


Submit your oral abstract by 22 November and get involved


Check out these recent reviews and original research articles on related topics in Chemical Science. As of 2015 Chemical Science is fully Gold Open Access so all articles published since then are free to read:

Macrocycles: lessons from the distant past, recent developments, and future directions
Andrei K. Yudin
Chem. Sci., 2015,6, 30-49
DOI: 10.1039/C4SC03089C, Perspective
Open Access

A catalytic asymmetric total synthesis of (−)-perophoramidine
B. M. Trost, M. Osipov, S. Krüger and Y. Zhang
Chem. Sci., 2015,6, 349-353
DOI: 10.1039/C4SC01826E, Edge Article
Open Access

NHC-catalysed benzoin condensation – is it all down to the Breslow intermediate?
Julia Rehbein, Stephanie-M. Ruser and Jenny Phan
Chem. Sci., 2015,6, 6013-6018
DOI: 10.1039/C5SC02186C, Edge Article
Open Access

Stereocontrolled 1,2-cis glycosylation as the driving force of progress in synthetic carbohydrate chemistry
Swati S. Nigudkar and Alexei V. Demchenko
Chem. Sci., 2015,6, 2687-2704
DOI: 10.1039/C5SC00280J, Perspective
Open Access

Organocatalytic asymmetric chlorinative dearomatization of naphthols
Qin Yin, Shou-Guo Wang, Xiao-Wei Liang, De-Wei Gao, Jun Zheng and Shu-Li You
Chem. Sci., 2015,6, 4179-4183
DOI: 10.1039/C5SC00494B, Edge Article
From themed collection Celebrating the 2015 RSC Prize and Award Winners
Open Access

Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA–protein interactions
Jana Balintová, Jan Špaček, Radek Pohl, Marie Brázdová, Luděk Havran, Miroslav Fojta and Michal Hocek
Chem. Sci., 2015,6, 575-587
DOI: 10.1039/C4SC01906G, Edge Article
Open Access

Mechanistic investigation of aziridine aldehyde-driven peptide macrocyclization: the imidoanhydride pathway
Serge Zaretsky, Jennifer L. Hickey, Joanne Tan, Dmitry Pichugin, Megan A. St. Denis, Spencer Ler, Benjamin K. W. Chung, Conor C. G. Scully and Andrei K. Yudin
Chem. Sci., 2015,6, 5446-5455
DOI: 10.1039/C5SC01958C
Open Access

Mechanisms and energetics of free radical initiated disulfide bond cleavage in model peptides and insulin by mass spectrometry
Chang Ho Sohn, Jinshan Gao, Daniel A. Thomas, Tae-Young Kim, William A. Goddard III and J. L. Beauchamp
Chem. Sci., 2015,6, 4550-4560
DOI: 10.1039/C5SC01305D
Open Access

The effect of host structure on the selectivity and mechanism of supramolecular catalysis of Prins cyclizations
William M. Hart-Cooper, Chen Zhao, Rebecca M. Triano, Parastou Yaghoubi, Haxel Lionel Ozores, Kristen N. Burford, F. Dean Toste, Robert G. Bergman and Kenneth N. Raymond
Chem. Sci., 2015,6, 1383-1393
DOI: 10.1039/C4SC02735C, Edge Article
Open Access

We hope you can join us for Challenges in Organic Chemistry (ISACS19). Vy Dong and the rest of the Scientific Committee look forward to welcoming you and your colleagues to California.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Top 25 Chemical Science articles July–September 2015

The 25 most-downloaded Chemical Science articles in the third quarter of 2015 were as follows: 

Sulfonyl fluorides as privileged warheads in chemical biology
Arjun Narayanan and Lyn H. Jones
DOI: 10.1039/C5SC00408J Perspective

A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy
Victor Sans, Luzian Porwol, Vincenza Dragonea and Leroy Cronin
DOI: 10.1039/C4SC03075C Edge Article

Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp3)–H bonds
José A. Fernández-Salas, Enrico Marelli and Steven P. Nolan
DOI: 10.1039/C5SC01589H, Edge Article

Evaluating metal–organic frameworks for natural gas storage
Jarad A. Mason, Mike Veenstra and Jeffrey R. Long
DOI: 10.1039/C3SC52633J, Perspective

Macrocycles: lessons from the distant past, recent developments, and future directions
Andrei K. Yudin
DOI: 10.1039/C4SC03089C, Perspective

Reversible photo-induced trap formation in mixed-halide hybrid perovskites for photovoltaics
Eric T. Hoke, Daniel J. Slotcavage, Emma R. Dohner, Andrea R. Bowring, Hemamala I. Karunadasa and Michael D. McGehee
DOI: 10.1039/C4SC03141E, Edge Article

Impacts of gold nanoparticle charge and ligand type on surface binding and toxicity to Gram-negative and Gram-positive bacteria
Vivian Feng, Ian L. Gunsolus, Tian A. Qiu, Katie R. Hurley, Lyle H. Nyberg, Hilena Frew, Kyle P. Johnson, Ariane M. Vartanian, Lisa M. Jacob, Samuel E. Lohse, Marco D. Torelli, Robert J. Hamers, Catherine J. Murphy and Christy L. Haynes
DOI: 10.1039/C5SC00792E, Edge Article

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user’s guide
David S. Surry and Stephen L. Buchwald
DOI: 10.1039/C0SC00331J, Perspective

Rethinking the term “pi-stacking”
Chelsea R. Martinez and Brent L. Iverson
DOI: 10.1039/C2SC20045G, Perspective

Computational discovery and experimental verification of tyrosine kinase inhibitor pazopanib for the reversal of memory and cognitive deficits in rat model neurodegeneration
Yongliang Yang, Guohui Li, Dongyu Zhao, Haoyang Yu, Xiliang Zheng, Xiangda Peng, Xiaoe Zhang, Ting Fu, Xiaoqing Hu, Mingshan Niu, Xuefei Ji, Libo Zou and Jin Wang
DOI: 10.1039/C4SC03416C, Edge Article

Unified approach to prenylated indole alkaloids: total syntheses of (−)-17-hydroxy-citrinalin B, (+)-stephacidin A, and (+)-notoamide I
Eduardo V. Mercado-Marin and Richmond Sarpong
DOI: 10.1039/C5SC01977J, Edge Article

Computational design of molecules for an all-quinone redox flow battery
Süleyman Er, Changwon Suh, Michael P. Marshak and Alán Aspuru-Guzik
DOI: 10.1039/C4SC03030C, Edge Article

Molecular understandings on the activation of light hydrocarbons over heterogeneous catalysts
Zhi-Jian Zhao, Cheng-chau Chiu and Jinlong Gong
DOI: 10.1039/C5SC01227A, Perspective

Rh-catalyzed desymmetrization of α-quaternary centers by isomerization-hydroacylation
Jung-Woo Park, Kevin G. M. Kou, Daniel K. Kim and Vy M. Dong
DOI: 10.1039/C5SC01553G, Edge Article

A single crystalline porphyrinic titanium metal–organic framework
Shuai Yuan,Tian-Fu Liu,Dawei Feng,Jian Tian,Kecheng Wang,Junsheng Qin,Qiang Zhang, Ying-Pin Chen,Mathieu Bosch,Lanfang Zou,Simon J. Teat,Scott J. Dalgarno and Hong-Cai Zhou
DOI: 10.1039/C5SC00916B, Edge Article

Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery
Dali Wang, Chunlai Tu, Yue Su, Chuan Zhang, Udo Greiser, Xinyuan Zhu, Deyue Yan and Wenxin Wang
DOI: 10.1039/C5SC01188D, Edge Article

Near-infrared fluorescence activation probes based on disassembly-induced emission cyanine dye
Tai-Cheng Hou, Ying-Yi Wu, Po-Yi Chiang and Kui-Thong Tan
DOI: 10.1039/C5SC01330E, Edge Article

Thin metal nanostructures: synthesis, properties and applications
Zhanxi Fan, Xiao Huang, Chaoliang Tana and Hua Zhang
DOI: 10.1039/C4SC02571G, Minireview

Supramolecular hydrogel microcapsules via cucurbit[8]uril host–guest interactions with triggered and UV-controlled molecular permeability
Ziyi Yu, Jing Zhang, Roger J. Coulston, Richard M. Parker, Frank Biedermann, Xin Liu, Oren A. Scherman and Chris Abell
DOI: 10.1039/C5SC01440A, Edge Article

Bioinspired design of redox-active ligands for multielectron catalysis: effects of positioning pyrazine reservoirs on cobalt for electro- and photocatalytic generation of hydrogen from water
Jonah W. Jurss, Rony S. Khnayzer, Julien A. Panetier, Karim A. El Roz, Eva M. Nichols, Martin Head-Gordon, Jeffrey R. Long, Felix N. Castellano and Christopher J. Chang
DOI: 10.1039/C5SC01414J, Edge Article

Ligand-enabled Ir-catalyzed intermolecular diastereoselective and enantioselective allylic alkylation of 3-substituted indoles
Xiao Zhang, Wen-Bo Liu, Hang-Fei Tu and Shu-Li You
DOI: 10.1039/C5SC01772F, Edge Article

Boron chemistry in a new light
Guillaume Duret, Robert Quinlan, Philippe Bisseret and Nicolas Blanchard
DOI: 10.1039/C5SC02207J, Minireview

Porous ionic liquids: synthesis and application
Shiguo Zhang, Kaoru Dokko and Masayoshi Watanabe
DOI: 10.1039/C5SC01374G, Minireview

Chemical sensing in two dimensional porous covalent organic nanosheets
Gobinda Das, Bishnu P. Biswal, Sharath Kandambeth, V. Venkatesh, Gagandeep Kaur, Matthew Addicoat, Thomas Heine, Sandeep Verma and Rahul Banerjee
DOI: 10.1039/C5SC00512D, Edge Article

Carbon–hydrogen (C–H) bond activation at PdIV: a Frontier in C–H functionalization catalysis
Joseph J. Topczewski and Melanie S. Sanford
DOI: 10.1039/C4SC02591A, Minireview

Chemical Science is the Royal Society of Chemistry’s flagship journal, publishing research articles of exceptional significance and high-impact reviews from across the chemical sciences. It has been Gold Open Access since January 2015. 

Submit your exceptional research to Chemical Science today!

Stay up to date with Chemical Science

Be among the first to hear about the newest articles being published – Sign-up to our journal news alert to receive information about most read articles, journal news, as well as calls for papers and invitations.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

A macrocyclic ‘hole’ that fits round AND square molecular ‘pegs’

Researchers from the South University of Science and Technology of China have developed a structurally dynamic macrocycle, which is able to modulate the dimensions of its internal cavity and show binding affinities for molecular guests of a range of shapes and sizes.

As children, we learn very early on about the concept of shape and size complementarity. No matter how many times you try, the square peg doesn’t fit in the round hole, and that second (or third!) piece of cake just wasn’t a good idea. This same concept also extends to supramolecular interactions, especially when we consider the arena of host–guest chemistry.

Generally speaking, the conformation of a macrocyclic host is relatively rigid, which means that the scope of host molecules it can encase is also somewhat limited. Whilst this feature of host–guest chemistry and molecular recognition is the basis for a range of catalytic events and the template-directed synthesis of mechanically interlocked molecules, it would be advantageous in expanding the scope of this field if a macrocycle existed that could happily host a wide range of guest molecules.

Wei Jiang and his team from the South University of Science and Technology of China have achieved this feat in the synthesis of a naphthalene-based macrocycle, oxatub[4]arene, that has the rigidity required of host–guest interactions, but, in addition, the flexibility necessary to adapt to and accommodate the chemical shape and size of a variety of guest molecules. Its naphthalene units are able to rotate, and in doing so generate four predominant conformers, each with different cavity depths and diameters, as well as different binding affinities for molecular guest molecules.

The dynamic nature of this unique macrocycle is an important step forward in the construction of host–guest complexes, especially as we look to introduce further complexity into the arsenal of supramolecular interactions we have at our disposal, and particularly in the development of increasingly multifaceted stimuli-responsive and molecular machines.

Read this hot ChemSci article in full – it’s open access and free to download:

Oxatub[4]arene: A smart macrocyclic receptor with multiple interconvertible cavities
Fei Jia, Zhenfeng He, Liu-Pan Yang, Zhi-Sheng Pan, Min Yi, Ren-Wang Jiang and Wei Jiang
Chem. Sci., 2015, Advance Article.
DOI: 10.1039/C5SC03251B, Edge Article

About the Writer:

Anthea Blackburn is a guest web writer for Chemical Science. Anthea is a recent graduate student hailing from New Zealand. She studied at Northwestern University in the US under the tutelage of Prof. Fraser Stoddart (a Scot), where she exploited supramolecular chemistry to develop multidimensional systems and study the emergent properties that arise in these superstructures. When time and money allowed, she ambitiously attempted to visit all 50 US states.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Hot Chemical Science articles for October

Take a look at this selection of recently published referee-recommended articles – all are open access and free to download.

Connecting electrodes with light: one wire, many electrodes
Moinul H. Choudhury, Simone Ciampi, Ying Yang, Roya Tavallaie, Ying Zhu, Leila Zarei, Vinicius R. Gonçales and J. Justin Gooding
DOI: 10.1039/C5SC03011K, Edge Article

C5SC03011K GA

Linear scaling relationships and volcano plots in homogeneous catalysis – revisiting the Suzuki reaction
Michael Busch, Matthew D. Wodrich and Clémence Corminboeuf
DOI: 10.1039/C5SC02910D, Edge Article

C5SC02910D GA

IspH–RPS1 and IspH–UbiA: “Rosetta stone” proteins
Guodong Rao, Bing O’Dowd, Jikun Li, Ke Wang and Eric Oldfield
DOI: 10.1039/C5SC02600H, Edge Article

C5SC02600H GA

An optoelectronic nose for identification of explosives
Jon R. Askim, Zheng Li, Maria K. LaGasse, Jaqueline M. Rankin and Kenneth S. Suslick
DOI: 10.1039/C5SC02632F, Edge Article

C5SC02632F GA

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)