Chemical Science Impact Factor rises to 9.211

We are delighted to announce that Chemical Science’s latest Impact Factor has soared to an impressive 9.211 this year, according to the 2014 Journal Citation Reports®.

C5SC90001HThank you to all our authors, referees, Associate Editors, and Editorial and Advisory Board members for contributing to the journal’s continued impact and success – this achievement would not have been possible without your support and trust. Chemical Science remains dedicated to publishing research of exceptional significance from across the chemical sciences – for us, it’s all about giving our authors the visibility and recognition their research deserves.

Chemical Science became a gold open access journal in January 2015, giving the global community free access to high quality research while waiving all Article Processing Charges (APCs), keeping articles free to publish, for at least two years.  This unique combination of open access, top quality articles, a flexible format and world-class Associate Editors makes it clear why so many leading scientists choose to publish in Chemical Science.

We invite you to submit your exceptional research to Chemical Science today.

Take a look at our most highly cited articles listed below.

Perspectives

Ruthenium-catalyzed direct oxidative alkenylation of arenes through twofold C–H bond functionalization
Sergei I. Kozhushkov and Lutz Ackermann
Chem. Sci., 2013, 4, 886-896
DOI: 10.1039/C2SC21524A, Perspective

Indole synthesis – something old, something new
Martyn Inman and Christopher J. Moody
Chem. Sci., 2013,4, 29-41
DOI: 10.1039/C2SC21185H, Perspective

Minireviews

Intriguing aspects of lanthanide luminescence
Jean-Claude G. Bünzli and Svetlana V. Eliseeva
Chem. Sci., 2013,4, 1939-1949
DOI: 10.1039/C3SC22126A, Minireview

Carbene-stabilized main group radicals and radical ions
Caleb D. Martin, Michele Soleilhavoup and Guy Bertrand
Chem. Sci., 2013,4, 3020-3030
DOI: 10.1039/C3SC51174J, Minireview

Edge articles

Slow magnetization dynamics in a series of two-coordinate iron(II) complexes
Joseph M. Zadrozny, Mihail Atanasov, Aimee M. Bryan, Chun-Yi Lin, Brian D. Rekken, Philip P. Power, Frank Neese and Jeffrey R. Long
Chem. Sci., 2013, 4, 125-138
DOI: 10.1039/C2SC20801F, Edge Article

Metal-free oxidative tandem coupling of activated alkenes with carbonyl C(sp2)–H bonds and aryl C(sp2)–H bonds using TBHP
Ming-Bo Zhou, Ren-Jie Song, Xuan-Hui Ouyang, Yu Liu, Wen-Ting Wei, Guo-Bo Deng and Jin-Heng Li
Chem. Sci., 2013,4, 2690-2694
DOI: 10.1039/C3SC50810B, Edge Article

Catalytic hydrotrifluoromethylation of styrenes and unactivated aliphatic alkenes via an organic photoredox system
Dale J. Wilger, Nathan J. Gesmundo and David A. Nicewicz
Chem. Sci., 2013,4, 3160-3165
DOI: 10.1039/C3SC51209F, Edge Article

Read more Impact Factor highlights for the Royal Society of Chemistry’s leading journals, including Chemical Communications and Chemical Society Reviews.

Find out how other RSC journals are ranked in the latest Impact Factor release

Chemical Science is the world’s first high-quality gold open access chemistry journal (open access from January 2015). Set up a personal account on the publishing platform to download articles for free.

*The Impact Factor provides an indication of the average number of citations per paper. Produced annually, Impact Factors are calculated by dividing the number of citations in a year, by the number of citeable articles published in the preceding two years. Data based on 2014 Journal Citation Reports®, (Thomson Reuters, 2015).

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Challenges in Chemical Renewable Energy: poster deadline 29 June

Challenges in Chemical Renewable Energy ISACS17 8-11 September 2015 Rio de Janeiro, Brazil

Poster abstract deadline 29 June 2015

The poster abstract deadline for Challenges in Chemical Renewable Energy (ISACS17) is fast approaching. This meeting will cover a broad range of topics from solar fuels and molecular catalysis to biofuels and much more besides.

Don’t miss your chance to present your own research alongside some of the world’s leading experts in this important research area, including Daniel Nocera (Harvard University), Marc Fontecave (Collège de France), Karen Wilson (Aston University), Ernesto R. Gonzalez (University of São Paulo) and many more.

Submit your poster abstract today!

A provisional programme is now available on our website.Take advantage of our early bird discount and register now to secure your place at this exciting event. We look forward to welcoming you to Brazil.

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DNA inspires smart phospholipids

Carla Pegoraro writes about a hot Chemical Science article for Chemistry World

Researchers in China and Ireland have developed a simple way of building new stimuli-responsive phospholipids that can self-assemble into hollow spheres and trigger the release of anticancer drugs only when inside the cell lysosome.

Liposomes made from synthetic nucleoside phospholipids could benefit drug delivery

Liposomes are nanoscale three-dimensional hollow vesicles with a phospholipid-based outer shell. They are widely used as drug and gene delivery agents and have been approved for various clinical trials. Liposomes are easily internalised by cells and are sealed off from the rest of the cell by the endosome and later in the internalisation process by the lysosome. These compartments specifically isolate foreign objects from the cell and remove them. Controlled release from them can significantly enhance delivery of a therapeutic drug directly within the targeted cell. Since the internal lysosome environment is acidic, pH sensitive liposomes capable of braking up and releasing their cargo have been widely studied. Due to the covalent nature of most of the phospholipids used to prepare liposomes, the latter do not respond promptly to the acidic environment, limiting the fast release of their cargos, and require tedious covalent synthesis procedures. Read the full article in Chemistry World»


You can read the original journal article in Chemical Science – it’s open access and free to download:
Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery
Dali Wang, Chunlai Tu, Yue Su, Chuan Zhang, Udo Greiser, Xinyuan Zhu, Deyue Yan and Wenxin Wang 
Chem. Sci., 2015,6, 3775-3787
DOI: 10.1039/C5SC01188D, Edge Article

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Carsten Shultz joins Chemical Science as Associate Editor

In March this year Chemical Science was delighted to welcome Dr Carsten Schultz as an Associate Editor, further strengthening our Associate Editor team. He is now handling submissions in the area of Chemical Biology.

Biography
Dr Schultz received his PhD from the University of Bremen in 1989. He then spent some time as a postdoctoral researcher at the University of California, San Diego before returning to Germany to take up a position at the University of Bremen in 1997 for a few years. He has been a group leader at EMBL since 2001 and a Senior Scientist since 2008.

Research
Carsten leads the Schultz Group at the European Molecular Biology Laboratory (EMBL) in Heidelberg. The lab is interested in better understanding complex intracellular signalling networks relevant in diabetes, cancer, lung inflammation and metabolic diseases. For this purpose the group develops probes useful for visualizing intracellular events such as enzyme activities, lipid metabolism or protein translocation in intact cells. The Schultz lab also constructs tools to manipulate cell components and their activities.

Carsten and Chemical Science:
Carsten says that ”in Chemical Science I like to see articles that describe chemistry of the highest quality.” He enjoys reading papers on novel synthetic methods, natural compound syntheses, and mechanistic studies, and says that what excites him most is “when chemistry is used to solve highly relevant problems in biology, pharmacology, physiology or medicine; similarly important are applications of chemistry to material sciences and physics.”

You can submit your high quality research in the area of Chemical Biology to Carsten Schultz’s Editorial Office.

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ZIF-8 disrupts ionic liquid deep freeze

Emma Stephen writes about a hot Chemical Science article for Chemistry World

Ionic liquid conductivity decreases at low temperature. To overcome this, a team of researchers from across Japan have combined an ionic liquid with a metal–organic framework (MOF) to produce an unusual material that retains its conductivity below –20°C. This low-temperature conductivity, together with the attractive ionic liquid properties of non-flammability and negligible volatility, could open up the potential for safe battery and capacitor materials for use in extremely cold conditions. Read the full article in Chemistry World»


Read the full article in Chemical Science – it’s open access and free to download:
Low temperature ionic conductor: ionic liquid incorporated within a metal–organic framework
Kazuyuki Fujie, Kazuya Otsubo, Ryuichi Ikeda, Teppei Yamada and Hiroshi Kitagawa  
Chem. Sci., 2015, Advance Article, DOI: 10.1039/C5SC01398D, Edge Article

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Crystalline sponge method strikes again

Victoria Richards writes about a hot Chemical Science article for Chemistry World

Scientists from Japan report that their revolutionary crystallographic technique has determined the stereochemistries of molecules with axial and planar chiralities, where classical methods had failed.

A team led by Makoto Fujita from the University of Tokyo captured the chemistry community’s attention just a few years ago when they reported a crystallographic technique capable of analysing compounds without first needing to crystallise them. Read the full article in Chemistry World»

 


You can read the original journal article in Chemical Science – it’s open access and free to download:
Absolute structure determination of compounds with axial and planar chirality using the crystalline sponge method
Shota Yoshioka, Yasuhide Inokuma, Manabu Hoshino, Takashi Sato and Makoto Fujita  
Chem. Sci., 2015, Advance Article, DOI: 10.1039/C5SC01681A, Edge Article

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Hot Chemical Science articles for June

Here are some of the latest referee-recommended hot articles in Chemical Science:

Can the study of self-assembly in solution lead to a good model for the nucleation pathway? The case of tolfenamic acid.
W. Du, A. J. Cruz-Cabeza, S. Woutersen, R. J. Davey and Q. Yin 
Chem. Sci., 2015,6, 3515-3524, DOI: 10.1039/C5SC00522A, Edge Article

C5SC00522A GA


Chemical principles underpinning the performance of the metal–organic framework HKUST-1
Christopher H. Hendon and Aron Walsh 
Chem. Sci., 2015, Advance Article, DOI: 10.1039/C5SC01489A, Perspective

C5SC01489A GA


The role of capsule stiffness on cellular processing
Huanli Sun, Edgar H. H. Wong, Yan Yan, Jiwei Cui, Qiong Dai, Junling Guo, Greg G. Qiao and Frank Caruso 
Chem. Sci., 2015,6, 3505-3514, DOI: 10.1039/C5SC00416K, Edge Article

C5SC00416K GA


Fluoride binding to an organoboron wire controls photoinduced electron transfer
Jing Chen and Oliver S. Wenger 
Chem. Sci., 2015,6, 3582-3592, DOI: 10.1039/C5SC00964B, Edge Article

C5SC00964B GA


Absolute structure determination of compounds with axial and planar chirality using the crystalline sponge method
Shota Yoshioka, Yasuhide Inokuma, Manabu Hoshino, Takashi Sato and Makoto Fujita 
Chem. Sci., 2015, Advance Article, DOI: 10.1039/C5SC01681A, Edge Article

C5SC01681A GA


Highly efficient near ultraviolet organic light-emitting diode based on a meta-linked donor–acceptor molecule
Haichao Liu, Qing Bai, Liang Yao, Haiyan Zhang, Hai Xu, Shitong Zhang, Weijun Li, Yu Gao, Jinyu Li, Ping Lu, Hongyan Wang, Bing Yang and Yuguang Ma 
Chem. Sci., 2015, Advance Article, DOI: 10.1039/C5SC01131K, Edge Article

C5SC01131K GA

Chemical Science is an Open Access journal, and all articles from 2015 onwards are free to access through a registered RSC account – click here to register

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Top 25 Chemical Science articles January–March 2015

The 25 most-downloaded Chemical Science articles in the first quarter of 2015 were as follows: 

Rhodium-catalyzed C–H functionalization-based approach to eight-membered lactams
Shangze Wu, Rong Zeng, Chunling Fu, Yihua Yu, Xue Zhang and Shengming Ma
Chem. Sci., 2015,6, 2275-2285, DOI: 10.1039/C5SC00092K, Edge Article 

Exploiting parameter space in MOFs: a 20-fold enhancement of phosphate-ester hydrolysis with UiO-66-NH2
Michael J. Katz, Su-Young Moon, Joseph E. Mondloch, M. Hassan Beyzavi, Casey J. Stephenson, Joseph T. Hupp and Omar K. Farha
Chem. Sci., 2015,6, 2286-2291, DOI: 10.1039/C4SC03613A, Edge Article 

Metal oxidation states in biological water splitting
Vera Krewald, Marius Retegan, Nicholas Cox, Johannes Messinger, Wolfgang Lubitz, Serena DeBeer, Frank Neese and Dimitrios A. Pantazis
Chem. Sci., 2015,6, 1676-1695, DOI: 10.1039/C4SC03720K, Edge Article 

Solid state organic amine detection in a photochromic porous metal organic framework
Arijit Mallick, Bikash Garai, Matthew A. Addicoat, Petko St. Petkov, Thomas Heine and Rahul Banerjee
Chem. Sci., 2015,6, 1420-1425, DOI: 10.1039/C4SC03224A, Edge Article 

C–H arylation of triphenylene, naphthalene and related arenes using Pd/C
Karl D. Collins, Roman Honeker, Suhelen Vásquez-Céspedes, Dan-Tam D. Tang and Frank Glorius
Chem. Sci., 2015,6, 1816-1824, DOI: 10.1039/C4SC03051F, Edge Article 

Adaptive binding and selection of compressed 1,ω-diammonium-alkanes via molecular encapsulation in water
Dan Dumitrescu, Yves-Marie Legrand, Eddy Petit, Arie van der Lee and Mihail Barboiu
Chem. Sci., 2015,6, 2079-2086, DOI: 10.1039/C4SC03945A, Edge Article 

Thymine functionalised porphyrins, synthesis and heteromolecular surface-based self-assembly
Anna G. Slater, Ya Hu, Lixu Yang, Stephen P. Argent, William Lewis, Matthew O. Blunt and Neil R. Champness
Chem. Sci., 2015,6, 1562-1569, DOI: 10.1039/C4SC03531C, Edge Article 

Structure–activity relationship studies of cyclopropenimines as enantioselective Brønsted base catalysts
Jeffrey S. Bandar, Alexandre Barthelme, Alon Y. Mazori and Tristan H. Lambert
Chem. Sci., 2015,6, 1537-1547, DOI: 10.1039/C4SC02402H, Edge Article 

Reversible photo-induced trap formation in mixed-halide hybrid perovskites for photovoltaics
Eric T. Hoke, Daniel J. Slotcavage, Emma R. Dohner, Andrea R. Bowring, Hemamala I. Karunadasa and Michael D. McGehee
Chem. Sci., 2015,6, 613-617, DOI: 10.1039/C4SC03141E, Edge Article 

Macrocycles: lessons from the distant past, recent developments, and future directions
Andrei K. Yudin
Chem. Sci., 2015,6, 30-49, DOI: 10.1039/C4SC03089C, Perspective 

Rh(III)-catalyzed C–H olefination of N-pentafluoroaryl benzamides using air as the sole oxidant
Yi Lu, Huai-Wei Wang, Jillian E. Spangler, Kai Chen, Pei-Pei Cui, Yue Zhao, Wei-Yin Sun and Jin-Quan Yu
Chem. Sci., 2015,6, 1923-1927, DOI: 10.1039/C4SC03350G, Edge Article 

A family of N-heterocyclic carbene-stabilized borenium ions for metal-free imine hydrogenation catalysis
Jeffrey M. Farrell, Roy T. Posaratnanathan and Douglas W. Stephan
Chem. Sci., 2015,6, 2010-2015, DOI: 10.1039/C4SC03675A, Edge Article 

Platinum-decorated carbon nanotubes for hydrogen oxidation and proton reduction in solid acid electrochemical cells
V. Sara Thoi, Robert E. Usiskin and Sossina M. Haile
Chem. Sci., 2015,6, 1570-1577, DOI: 10.1039/C4SC03003F, Edge Article 

Electrophilic bis-fluorophosphonium dications: Lewis acid catalysts from diphosphines
Michael H. Holthausen, Rashi R. Hiranandani and Douglas W. Stephan
Chem. Sci., 2015,6, 2016-2021, DOI: 10.1039/C5SC00051C, Edge Article 

Computational design of molecules for an all-quinone redox flow battery
Süleyman Er, Changwon Suh, Michael P. Marshak and Alán Aspuru-Guzik
Chem. Sci., 2015,6, 885-893, DOI: 10.1039/C4SC03030C, Edge Article 

Topochemical conversion of a dense metal–organic framework from a crystalline insulator to an amorphous semiconductor
S. Tominaka, H. Hamoudi, T. Suga, T. D. Bennett, A. B. Cairns and A. K. Cheetham
Chem. Sci., 2015,6, 1465-1473, DOI: 10.1039/C4SC03295K, Edge Article 

A comprehensive test set of epoxidation rate constants for iron(IV)–oxo porphyrin cation radical complexes
Mala A. Sainna, Suresh Kumar, Devesh Kumar, Simonetta Fornarini, Maria Elisa Crestoni and Sam P. de Visser
Chem. Sci., 2015,6, 1516-1529, DOI: 10.1039/C4SC02717E, Edge Article 

Carbon–hydrogen (C–H) bond activation at PdIV: a Frontier in C–H functionalization catalysis
Joseph J. Topczewski and Melanie S. Sanford
Chem. Sci., 2015,6, 70-76, DOI: 10.1039/C4SC02591A, Minireview 

Synthesis by extrusion: continuous, large-scale preparation of MOFs using little or no solvent
Deborah Crawford, José Casaban, Robert Haydon, Nicola Giri, Tony McNally and Stuart L. James
Chem. Sci., 2015,6, 1645-1649, DOI: 10.1039/C4SC03217A, Edge Article 

Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging
Qiang Zhao, Xiaobo Zhou, Tianye Cao, Kenneth Yin Zhang, Lijuan Yang, Shujuan Liu, Hua Liang, Huiran Yang, Fuyou Li and Wei Huang
Chem. Sci., 2015,6, 1825-1831, DOI: 10.1039/C4SC03062A, Edge Article 

Cu-catalyzed transannulation reaction of pyridotriazoles with terminal alkynes under aerobic conditions: efficient synthesis of indolizines
V. Helan, A. V. Gulevich and V. Gevorgyan
Chem. Sci., 2015,6, 1928-1931, DOI: 10.1039/C4SC03358B, Edge Article 

Highly efficient one-pot/one-step synthesis of multiblock copolymers from three-component polymerization of carbon dioxide, epoxide and lactone
Yang Li, Jiali Hong, Renjian Wei, Yingying Zhang, Zaizai Tong, Xinghong Zhang, Binyang Du, Junting Xu and Zhiqiang Fan
Chem. Sci., 2015,6, 1530-1536, DOI: 10.1039/C4SC03593C, Edge Article 

A hydrazone-based covalent organic framework for photocatalytic hydrogen production
Linus Stegbauer, Katharina Schwinghammer and Bettina V. Lotsch
Chem. Sci., 2014,5, 2789-2793, DOI: 10.1039/C4SC00016A, Edge Article 

Formation of a C–C double bond from two aliphatic carbons. Multiple C–H activations in an iridium pincer complex
Alexey V. Polukeev, Rocío Marcos, Mårten S. G. Ahlquist and Ola F. Wendt
Chem. Sci., 2015,6, 2060-2067, DOI: 10.1039/C4SC03839H, Edge Article 

On the formation of anions: frequency-, angle-, and time-resolved photoelectron imaging of the menadione radical anion
James N. Bull, Christopher W. West and Jan R. R. Verlet
Chem. Sci., 2015,6, 1578-1589, DOI: 10.1039/C4SC03491K, Edge Article 

These articles are all free to download until 6th July. Access is free through a registered RSC account – click here to register 


 

Chemical Science is the Royal Society of Chemistry’s flagship journal, publishing research articles of exceptional significance and high-impact reviews from across the chemical sciences. It has been Gold Open Access since January 2015. The journal’s latest (2013) Impact Factor is 8.6. 

Submit your exceptional research to Chemical Science today!

Stay up to date with Chemical Science

Be among the first to hear about the newest articles being published – Sign-up to our journal news alert to receive information about most read articles, journal news, as well as calls for papers and invitations.

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Chemical Science welcomes Alán Aspuru-Guzik as Associate Editor

Chemical Science is delighted to announce the addition of another Associate Editor: Professor Alán Aspuru-Guzik of Harvard University, who is now handling submissions in the area of theoretical chemistry.

Biography
Professor Aspuru-Guzik joined Harvard University in 2006 and has been a full professor there since 2013 (the same year in which he received the ACS Early Career Award in Theoretical Chemistry). Prior to joining Harvard, Alán spent a couple of years as a postdoctoral researcher at the University of California, Berkeley, where he also completed his PhD in Physical Chemistry. He holds a BSc in Chemistry from the Universidad Nacional Autónoma de México.

Research
Alán leads the Aspuru-Guzik Research Group, a theoretical physical chemistry group in the Department of Chemistry and Chemical Biology at Harvard University. The group’s research focuses on:

  • The Clean Energy Project: a theory-driven search for the next generation of organic solar cell materials
  • Excitonics: aiming to understand, control, and harness electronic excitations in nanoscale environments
  • Quantum Simulation: developing digital and analogue quantum simulators for quantum chemistry, in order to enhance understanding of complicated electronic structures and molecules
  • Open Quantum Systems and Quantum Algorithms: developing efficient quantum algorithms for quantum simulation of chemical systems, reaction dynamics, and state preparation, and developing methods by which these algorithms can be successfully carried out on quantum computers
  • Electronic Structure Theory: developing methods to apply quantum chemical calculations to the description of new types of quantum processes

Alán is very interested in the design of novel materials for renewable energy in general. He recently had a breakthrough in screening for practical organic molecules for flow batteries. The theoretical aspects related to that work were published in Chemical Science as a cover article.

Chemical Science: Alan’s choice
We asked Alan to send us his pick of Chemical Science articles in the area of theoretical chemistry. His choices are listed below and you can read them by clicking on the links - all are free to access* until 24th May.

van der Waals dispersion interactions in molecular materials: beyond pairwise additivity
Anthony M. Reilly and Alexandre Tkatchenko 
Chem. Sci., 2015, Advance Article
DOI: 10.1039/C5SC00410A, Perspective
Open Access
C5SC00410A GA
Novel metal–organic framework linkers for light harvesting applications
Michael E. Foster, Jason D. Azoulay, Bryan M. Wong and Mark D. Allendorf 
Chem. Sci., 2014, 5, 2081-2090
DOI: 10.1039/C4SC00333K, Edge Article
C4SC00333K GA
Polymethine dyes for all-optical switching applications: a quantum-chemical characterization of counter-ion and aggregation effects on the third-order nonlinear optical response
Sukrit Mukhopadhyay, Chad Risko, Seth R. Marder and Jean-Luc Brédas 
Chem. Sci., 2012,3, 3103-3112
DOI: 10.1039/C2SC20861J, Edge Article
 C2SC20861J GA
Thermodynamic analysis of Xe/Kr selectivity in over 137 000 hypothetical metal–organic frameworks
Benjamin J. Sikora, Christopher E. Wilmer, Michael L. Greenfield and Randall Q. Snurr 
Chem. Sci., 2012, 3, 2217-2223
DOI: 10.1039/C2SC01097F, Edge Article
From themed collection Physical Chemistry
 C2SC01097F GA
Estimating chemical reactivity and cross-influence from collective chemical knowledge
Siowling Soh, Yanhu Wei, Bartlomiej Kowalczyk, Chris M. Gothard, Bilge Baytekin, Nosheen Gothard and Bartosz A. Grzybowski 
Chem. Sci., 2012, 3, 1497-1502
DOI: 10.1039/C2SC00011C, Edge Article
C2SC00011C GA

 

Alán is now accepting submissions to Chemical Science in the area of theoretical chemistry.  He is keen to emphasize that he is interested not only in exceptional applications of theoretical methods, but also in the top methods-development manuscripts. He is also very interested in articles that are at the interface of theoretical chemistry and other fields.

Submit your high-impact research to Alán’s Editorial Office.

*Access is free with a registered RSC account.

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Beyond the Mizoroki-Heck Reaction: Palladium-catalyzed Synthesis of α-Aryl Dicarbonyls via 1,2-Migration

Web writer Tezcan Guney writes for the blog about a recent Chemical Science Edge Article.

The utility of palladium-catalyzed coupling has grown extensively as it has become one of the most powerful tools available to synthetic chemists.  By playing a strategic role in the formation of carbon-carbon and carbon-heteroatom bonds, this synthetic technology has provided numerous opportunities to access diverse molecular architectures. 

C5SC00505A GA

In this recently published Chemical Science Edge Article, Professor Uttam K. Tambar and colleague from the University of Texas Southwestern Medical Center at Dallas set out to determine whether the Mizoroki–Heck reaction could be extended to generate dicarbonyl species while circumventing the usual alkene products.  They envisioned that under the modified reaction conditions the initial coupling of substituted allylic alcohols and organohalides would be followed by the key 1,2-migration step, instead of the conventional β-hydride elimination.

After screening various reaction conditions, the Tambar group found that the desired aryl dicarbonyls were furnished in good yield when a catalytic amount of  bis(benzonitrile)dichloropalladium(II) was combined with a silver salt in the presence of 1,1-diphenylallyl alcohol and ethyl bromoacetate

An investigation of the scope revealed that the aryl groups substituted with electron-rich and electron-deficient groups, as well as geminal-disubstituted allylic alcohols provided the desired coupling products.  Based on the preliminary mechanistic studies, they proposed that the reactions proceeded through the acyclic free radical pathway.

Furthermore, Prof. Tambar and his coworker also tested the possibility of producing additional acyclic 1,5-dicarbonyl compounds containing multiple stereogenic centers.  For instance, when they utilized the piperidine-substituted methyl bromoamide as the reaction partner with 1,1-diphenylallyl alcohol, the researchers found that the coupling reaction yielded the diketone product with diastereomeric ratio of 5:1.

Because acyclic stereocontrol remains a challenging research area in stereoselective free radical reactions, the 5:1 ratio is notably the highest reported level of 1,3-stereoinduction in 1,2-aryl migrations. 

This exciting article was just published in Chemical Science as an Edge Article. Read “Palladium-catalyzed cross-coupling of α-bromocarbonyls and allylic alcohols for the synthesis of α-aryl dicarbonyl compounds” (DOI: 10.1039/C5SC00505A) by Professor Uttam K. Tambar and Yang Yu to learn more about their chemistry. The article is free to access until 20th May 2015*.

*Access is free through a registered RSC account


Dr. Tezcan Guney is a web writer for Chemical Society Reviews, Chemical Science and Chemical Communications. Dr. Guney received his Ph.D. from the Department of Chemistry at Iowa State University with Prof. George Kraus, where he focused on the synthesis of biologically active polycyclic natural products and multifunctional imaging probes. Currently, he is a postdoctoral research scholar at the Memorial Sloan-Kettering Cancer Center in New York with Prof. Derek Tan, contributing to the efforts to access biologically active small molecules using the diversity-oriented synthetic approach.

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