Archive for the ‘Uncategorized’ Category

Bioorthogonal & Bioresponsive Symposium 2019

The second Bioorthogonal & Bioresponsive symposium will be held at the Institute of Genetics & Molecular Medicine in Edinburgh on the 6th and 7th of June 2019. Chemical Science is proud to sponsor the symposium and our new Assistant Editor Amelia Newman will be attending.

The symposium aims to bring together chemists and biologists interested in the latest advances in bioorthogonal and bioresponsive strategies. Talks will highlight state-of-the-art work from leading UK and international experts, and speakers include Jason Chin, Ben Davis, Karen Faulds, Sarah Heilshorn, Ludovic Jullien and Vincent Rotello.

It’s not too late to join us at this exciting meeting – registration is still open at the RSC Events webpage. The registration deadline is 31st May 2019.

If you cannot attend the symposium next month, you can follow @BBSymposium1 on Twitter to stay updated.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

CPE Annual Symposium 2019

The Centre for Plastic Electronics is hosting its prestigious annual symposium on 10 and 11 June 2019. It will take place at Imperial College London and and will include talks from several high-profile speakers to discuss their latest advances in the science and technology of organic conducting materials and of organic/flexible electronics and photonics. The program includes a day of short talks and poster presentations by students and early career scientists giving them a platform to highlight their recent work.

More information and details of how to register is available at: http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/centres/plasticelectronics/eventssummary/event_20-2-2019-14-14-7. Abstracts submissions for poster presentations are open until the 31 May.

Imperial College London are delighted to host Prof Erwin Reisner of the University of Cambridge who will be giving his RSC Corday-Morgan Prize talk for his work on the development of solar-driven catalysis with molecularly engineered semiconductors and semi-artificial photosynthesis.

The symposium will cover all areas related to organic/plastic electronics and photonics, including chemistry, physics, materials science and device engineering. Confirmed speakers include:

  • Christine Luscombe, University of Washington
  • Andy Cooper, University of Liverpool
  • Iain McCulloch, KAUST and Imperial College London
  • Erwin Reisner, University of Cambridge
  • Kwanghee Lee, GIST, South Korea
  • Henry Yan, Hong Kong University of Science and Technology
  • Ji-Seon Kim, Imperial College London
  • Artem Bakulin, Imperial College London
  • Maria Ibáñez, Institute of Science and Technology, Austria
  • Rachel Evans, University of Cambridge
  • Oliver Dumele, Humboldt University of Berlin, Germany
  • Hyejeong Seong, Imperial College London
  • Rowena Brugge, Imperial College London
  • Ludmilla Steier, Imperial College London
  • Jess Wade, Imperial College London
  • Alex Clark, Imperial College London

With more speakers being confirmed in the coming weeks, this will be an event not to miss!

If you cannot attend the Symposium next month, you can follow the hashtag #CPESymp19 on Twitter.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

François Gabbaï joins Chemical Science as an Associate Editor

We are delighted to announce that Dr François Gabbaï has joined Chemical Science as our newest Associate Editor.

François Gabbaï was born in France and attended the University of Bordeaux before moving to UT Austin where he became a PhD student with Alan Cowley.  Upon completion of his Ph.D. in 1994, he joined the group of Hubert Schmidbaur at the Technical University of Munich, first as a postdoctoral fellow and later as an Habilitand.  Upon completion of his Habilitation in 1998, he moved to Texas A&M University where he now holds the Arthur E. Martell Chair of Chemistry.  His research interests revolve around the chemistry of p-block elements and late transition metals with applications in anion recognition, anion transport, and catalysis.  His is a Fellow of the American Chemical Society, a Fellow of the Royal Society of Chemistry and the recipient of the 2009 North American Dalton Lectureship. In 2016, he also received the ACS F. Albert Cotton Award in Synthetic Inorganic Chemistry.

François has selected 4 of his favourite Chemical Science articles that he has published over the years that he would like to share with you. We hope you enjoy reading them!

Large-bite diboranes for the μ(1,2) complexation of hydrazine and cyanide
C. H. Chen, F. P. Gabbaï
Chem. Sci., 2018, 9, 6210-6218
DOI: 10.1039/c8sc01877d

Fluorinated Antimony(V) Derivatives: Strong Lewis Acidic Properties and Application to the Complexation of Formaldehyde in Aqueous Solutions
D. Tofan, F. P. Gabbaï
Chem. Sci., 2016, 7, 6768-6778
DOI: 10.1039/c6sc02558g

Lewis acidic stiborafluorenes for the fluorescence turn-on sensing of fluoride in drinking water at ppm concentrations
M. Hirai, F. P. Gabbaï
Chem. Sci., 2014, 5, 1886-1893
DOI: 10.1039/c4sc00343h

Lewis acid enhancement by juxtaposition with an onium ion: the case of a mercury stibonium complex
T.-P. Lin, R. C. Nelson, T. Wu, J. T. Miller, F. P. Gabbaï
Chem. Sci., 2012, 3, 1128-1136
DOI: 10.1039/c2sc00904h

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

ChemSci Pick of the Week video abstracts

We’ve produced video abstracts for our latest two ChemSci Pick of the Week articles! Check them out below – we hope you enjoy watching them!

 

Catalytic asymmetric allylation of aldehydes with alkenes through allylic C(sp3)–H functionalization mediated by organophotoredox and chiral chromium hybrid catalysis

Harunobu Mitsunuma, Shun Tanabe, Hiromu Fuse, Kei Ohkubo and Motomu Kanai

DOI:10.1039/C8SC05677C

 

An Al-doped SrTiO3 photocatalyst maintaining sunlight-driven overall water splitting activity for over 1000 h of constant illumination

Hao Lyu, Takashi Hisatomi, Yosuke Goto, Masaaki Yoshida, Tomohiro Higashi, Masao Katayama, Tsuyoshi Takata, Tsutomu Minegishi, Hiroshi Nishiyama, Taro Yamada, Yoshihisa Sakata, Kiyotaka Asakura and Kazunari Domen

DOI:10.1039/C8SC05757E

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Chemical Science prize winner at IPEROP19

Chemical ScienceSustainable Energy & Fuels, and Energy & Environmental Science were delighted to recently support the Perovskite, Organic Photovoltaics and Optoelectronics  (IPEROP19) conference that took place in Kyoto, Japan from 28-29th January 2019. On behalf of the Royal Society of Chemistry, we would like to congratulate the following prize winners who won a £200 book voucher each. A particular mention to the Chemical Science winner, Chieh-Ting Lin of Professor James Durrant’s group at Imperial College London:

Chemical Science winner: Lin, Chieh-Ting (Imperial College London)
“Probing the Enhanced Stability Against Oxygen Induced Photodegradation by Selection of Transport Layer and Defect Passivation”

Energy & Environmental Science winner: Yamaguchi, Mayu (Waseda University)
“Perovskite Precursor Solution Tuned with Polymer Addition for Effective Formation of the Photovoltaic Layer”

James Durrant (Sustainable Energy & Fuels Editor-in-Chief), Mayu Yamaguchi, Juan Bisquert (Energy & Environmental Science and Sustainable Energy & Fuels Advisory Board member)

Sustainable Energy & Fuels winner Mantulnikovs, Konstantins (EPFL)
“Differential Response of the Photoluminescence and Photocurrent of Polycrystalline CH3NH3PbI3 and CH3NH3PbBr3 to the Exposure to Oxygen and Nitrogen”

Juan Bisquert (Energy & Environmental Science and Sustainable Energy & Fuels Advisory Board member), James Durrant (Sustainable Energy & Fuels Editor-in-Chief), Konstantins Mantulnikovs, Hideo Ohkita and Atsushi Wakamiya

 

Awards presented by James Durrant, Editor-in-Chief of Sustainable Energy & Fuels

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Toshiharu Teranishi joins Chemical Science as an Associate Editor

We are delighted to announce that Professor Toshiharu Teranishi has joined Chemical Science as our newest Associate Editor.

Professor Teranishi is a Professor at the Institute for Chemical Research at Kyoto University. He received his PhD from The University of Tokyo under the direction of Prof. Naoki Toshima in 1994, and spent seven and a half years at Japan Advanced Institute of Science and Technology as an Assistant Professor and an Associate Professor. In 2004, he moved to University of Tsukuba as a Full Professor, and moved to Kyoto University in 2011. He is a vice president of the Society of Nano Science and Technology, Japan, and an associate member of Science Council of Japan.

His current research interests include the precise structural control of inorganic nanomaterials and structure-specific functions for high-performance devices and photo-energy conversion and welcomes submissions in these areas.

Toshiharu has selected 5 fantastic Chemical Science articles that he would like to share with you. We hope you enjoy reading them!

Perspective 

Plasmon-induced charge separation: chemistry and wide applications
Tetsu Tatsuma, Hiroyasu Nishi and Takuya Ishida
Chem. Sci., 2017, 8, 3325-3337
DOI: 10.1039/C7SC00031F

Edge Articles

Bio-inspired design: bulk iron–nickel sulfide allows for efficient solvent-dependent CO2 reduction
Stefan Piontek, Kai junge Puring, Daniel Siegmund, Mathias Smialkowski, Ilya Sinev, David Tetzlaff, Beatriz Roldan Cuenya and Ulf-Peter Apfel
Chem. Sci., 2019, 10, 1075-1081
DOI: 10.1039/C8SC03555E

Understanding the visible-light photocatalytic activity of GaN:ZnO solid solution: the role of Rh2−yCryO3 cocatalyst and charge carrier lifetimes over tens of seconds
Robert Godin, Takashi Hisatomi, Kazunari Domen and James R. Durrant
Chem. Sci., 2018, 9, 7546-7555
DOI: 10.1039/C8SC02348D

Efficient cleavage of aryl ether C–O linkages by Rh–Ni and Ru–Ni nanoscale catalysts operating in water
Safak Bulut, Sviatlana Siankevich, Antoine P. van Muyden, Duncan T. L. Alexander, Georgios Savoglidis, Jiaguang Zhang, Vassily Hatzimanikatis, Ning Yan and Paul J. Dyson
Chem. Sci., 2018, 9, 5530-5535
DOI: 10.1039/C8SC00742J

Visualizing the bidirectional electron transfer in a Schottky junction consisting of single CdS nanoparticles and a planar gold film
Zhimin Li, Yimin Fang, Yongjie Wang, Yingyan Jiang, Tao Liu and Wei Wang
Chem. Sci., 2017, 8, 5019-5023
DOI: 10.1039/C7SC00990A

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Infographics – ChemSci Pick of the Week

As part of our ChemSci Pick of the Week scheme, two of our newest Picks now come with handy infographics! Check them out below:

Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

Paolo Destito, Ana Sousa-Castillo, José R. Couceiro, Fernando López, Miguel A. Correa-Duarte and José L. Mascareñas

10.1039/C8SC04390F

 

Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media

 

A Molecular Picture of Surface Interactions of Organic Compounds on Prevalent Indoor Surfaces: Limonene Adsorption on SiO2

Yuan Fang, Pascale Lakey, Saleh Riahi, Andrew McDonald, Mona Shrestha, Douglas J Tobias, Manabu Shiraiwa and Vicki Grassian

10.1039/C8SC05560B


A Molecular Picture of Surface Interactions of Organic Compounds on Prevalent Indoor Surfaces: Limonene Adsorption on SiO2

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT Chemical Science articles for October

We are happy to present a selection of our HOT articles over the past month. To see all of our HOT referee-recommended articles from 2018, please find the collection here.

As always, Chemical Science articles are free to access.

Enhanced annihilation electrochemiluminescence by nanofluidic confinement
Hanan Al-Kutubi, Silvia Voci, Liza Rassaei, Neso Sojic and Klaus Mathwig
Chem. Sci., 2018, Advance Article
DOI: 10.1039/C8SC03209B, Edge Article

______________________________________________________

Mechanistic investigation into the C(sp3)–H acetoxylation of morpholinones
Cornelia S. Buettner, Darren Willcox, Ben. G. N. Chappell and Matthew J. Gaunt
Chem. Sci., 2018, Advance Article
DOI: 10.1039/C8SC03434F, Edge Article

______________________________________________________

Ir(III)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents
Xiao-Yang Chen and Erik J. Sorensen
Chem. Sci., 2018, Advance Article
DOI: 10.1039/C8SC03606C, Edge Article

______________________________________________________

Direct observation of the intermediate in an ultrafast isomerization
Tyler M. Porter, Jiaxi Wang, Yingmin Li, Bo Xiang, Catherine Salsman, Joel S. Miller, Wei Xiong and Clifford P. Kubiak
Chem. Sci., 2018, Advance Article
DOI: 10.1039/C8SC03258K, Edge Article

______________________________________________________

Structural control of polyelectrolyte/microemulsion droplet complexes (PEMECs) with different polyacrylates
Miriam Simon, Patrick Krause, Leonardo Chiappisi, Laurence Noirez and Michael Gradzielski
Chem. Sci., 2019, Advance Article
DOI: 10.1039/C8SC04013C, Edge Article

______________________________________________________

Reversibility and reactivity in an acid catalyzed cyclocondensation to give furanochromanes – a reaction at the ‘oxonium-Prins’ vs. ‘ortho-quinone methide cycloaddition’ mechanistic nexus
Christian D.-T. Nielsen, Wouter J. Mooij, David Sale, Henry S. Rzepa, Jordi Burés and Alan C. Spivey
Chem. Sci., 2018, Advance Article
DOI: 10.1039/C8SC04302G, Edge Article

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Mutant Enzymes and Frankenstein Catalysts

I know what you’re thinking: “Autumn is here! Who needs sunny weather and optimism? Sign me up for grey skies and vitamin D supplements!”. Oh you weren’t thinking that? Me neither. Well perhaps Halloween gives you more joy, along with the chance to see one of your colleagues dressed up like Freddy Mercury (‘Hg’ emblazoned on their chest, classic) at the departmental party?

In the spirit of Halloween, Simone Morra and Anca Pordea at the University of Nottingham have synthesized a mutant alcohol dehydrogenase enzyme turned Frankenstein catalyst, by replacing the zinc catalytic site with a covalently-bound rhodium(III) complex. The resulting mutant/transition-metal composite was used in combination with the wild-type enzyme to synthesize the chiral alcohol (S)-4-phenyl-2-butanol.

Like many hybrid systems, the purpose of combining enzymatic with transition metal catalysis is to take advantage of the benefits of each. Millions of years of evolution have produced enzymatic catalysts that function under mild conditions, in aqueous solvents, with impressive selectivity and high catalytic efficiency. But the narrow range of conditions that enzymes operate under can be disadvantageous in a synthetic setting. On the other hand, transition metal catalysts are versatile and can be easily customised, reacting with a liberty that would make the most promiscuous of enzymes blush.

Unfortunately, developing multi-component systems that utilise both transition metal and enzymatic catalysis is not as simple as combining them in a single mixture, as mutual deactivation often results. The authors found that encasing the transition metal complex in an enzyme provided a physical shield against inhibition, and preserved the activity of both the wild type enzyme and the rhodium(III) complex.

Synthesis of chiral alcohols via two interconnected cycles: the wild type enzyme (native ADH) reduces the ketone to the alcohol using NADPH as a reducing agent. NADPH is regenerated using the mutant enzyme containing a rhodium active site (chemically modified ADH) with formic acid as the terminal reductant. Alcohol dehydrogenase

Synthesis of chiral alcohols via two interconnected cycles: the wild type enzyme (native ADH) reduces the ketone using NADPH as a reducing agent. NADPH is regenerated by the mutant enzyme containing a catalytically-active rhodium complex (chemically modified ADH) with formic acid as the terminal reductant.

Two interconnected catalytic cycles were responsible for synthesis of the chiral alcohol. In the first, the wild type enzyme effected reduction of 4-phenyl-2-butanol, a process that relies on the biological reductant nicotinamide adenine dinucleotide phosphate (NADPH). In the second cycle, NADPH was recycled using the composite rhodium(III) complex/mutant enzyme, with formic acid as the stoichiometric reductant. The rate of alcohol formation was slow (turnover frequency of 0.02 s-1) and the transition-metal catalysed process was deemed to be rate limiting (compare to turnover frequencies of 4.8 s-1 for enzymatic systems). However, near perfect enantioselectivity was obtained (>99% ee).

This research demonstrates one way that transition metal catalysts can augment the scope of co-factor-dependent enzymes. Furthermore, devising strategies to prepare metal-complex/enzyme bioconjugates might have value for small molecule synthesis due to the second coordination sphere that enzymes offer; an encased steric environment to guide the reaction outcome is a valuable approach to improving selectivity in catalytic reactions.

To find out more please read:

Biocatalyst-artifical metalloenzyme cascade based on alcohol dehydrogenase

Simone Morra, Anca Pordea.
Chem. Sci., 2018, 9, 7447-7454
DOI: 10.1039/c8sc02371a

About the author

Zoë Hearne is a PhD candidate in chemistry at McGill University in Montréal, Canada, under the supervision of Professor Chao-Jun Li. She hails from Canberra, Australia, where she completed her undergraduate degree. Her current research focuses on transition metal catalysis to effect novel transformations, and out of the lab she is an enthusiastic chemistry tutor and science communicator.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT Chemical Science articles for September

We are happy to present a selection of our HOT articles over the past month. To see all of our HOT referee-recommended articles from 2018, please find the collection here.

As always, Chemical Science articles are free to access.

Selective and catalytic carbon dioxide and heteroallene activation mediated by cerium N-heterocyclic carbene complexes
Polly Louise Arnold, Ryan Kerr, Catherine Weetman, Scott Doherty, Julia Rieb, Kai Wang, Christian Jandl, Max McMullon, Alexander Pöthig, Fritz Elmar Kühn and Andrew D Smith
Chem. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8SC03312A, Edge Article

______________________________________________________________________

Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice
Xinfu Zhang, Weiyu Zhao, Bin Li, Wenqing Li, Chengxiang Zhang, Xucheng Hou, Justin Jiang and Yizhou Dong
Chem. Sci., 2018, Advance Article
DOI: 10.1039/C8SC03226B, Edge Article

______________________________________________________________________

Surprising solvent-induced structural rearrangements in large [N⋯I+⋯N] halogen-bonded supramolecular capsules: an ion mobility-mass spectrometry study
Ulrike Warzok, Mateusz Marianski, Waldemar Hoffmann, Lotta Turunen, Kari Rissanen, Kevin Pagel and Christoph A. Schalley
Chem. Sci., 2018, Advance Article
DOI: 10.1039/C8SC03040E, Edge Article

______________________________________________________________________

Advanced microRNA-based cancer diagnostics using amplified time-gated FRET
Xue Qiu, Jingyue Xu, Jiajia Guo, Akram Yahia-Ammar, Nikiforos-Ioannis Kapetanakis, Isabelle Duroux-Richard, Julia J. Unterluggauer, Nicole Golob-Schwarzl, Christophe Regeard, Catherine Uzan, Sébastien Gouy, Michael DuBow, Johannes Haybaeck, Florence Apparailly, Pierre Busson and Niko Hildebrandt
Chem. Sci., 2018, Advance Article
DOI: 10.1039/C8SC03121E, Edge Article

______________________________________________________________________

Atomic structure of boron resolved using machine learning and global sampling
Si-Da Huang, Cheng Shang, Pei-Lin Kang and Zhi-Pan Liu
Chem. Sci., 2018, Advance Article
DOI: 10.1039/C8SC03427C, Edge Article

______________________________________________________________________

Spontaneous growth of 2D coordination polymers on functionalized ferromagnetic surfaces 
Michele Mattera, Víctor Rubio-Giménez, Sophie Delprat, Richard Mattana, Pierre Seneor, Sergio Tatay, Alicia Forment-Aliaga and Eugenio Coronado
Chem. Sci., 2018, Advance Article
DOI: 10.1039/C8SC03067G, Edge Article

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)