Archive for the ‘Uncategorized’ Category

HPLC-free synthesis slashes protein production time

Chemists in Germany have devised a faster, cheaper and greener way to synthesise proteins which avoids the need to use high pressure liquid chromatography (HPLC).

Being able to chemically synthesise proteins from scratch allows them to be modified with atom-by-atom precision, and in ways that are not possible in nature. For example, researchers can introduce non-natural amino acids into proteins or tag them with fluorescent markers.

Graphical Abstract

Read the full article in Chemistry World >>>

S. F. Loibl, Z. Harpaz, R. Zitterbart and O. Seitz
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC01883A, Edge Article

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Shape-shifting hydrogel can heal itself

A shape-memory hydrogel that also has self-healing properties has been developed by scientists in China. The new material can repair itself and return to its original shape even after being cut into segments.
Both self-healing and shape-memory polymers have many potential uses, including in aerospace, textiles and biomedicine. Now, a team lead by Tao Chen and Jiawei Zhang from the Ningbo Institute of Material Technology and Engineering has developed a material that combines both of these useful properties.

The hydrogel is produced by polymerising acrylamide in the presence of a boronic acid-grafted alginate and poly(vinyl alcohol). After immersion in calcium chloride solution, the polymer is strengthened by the reversible double network of boronic acid-diol ester bonds, and chelation of the alginate chains with the calcium cations.

Graphical Abstract

Read the full article in Chemistry World >>>

Stretchable supramolecular hydrogels with triple shape memory effect
Xiaoxia Le, Wei Lu, Jing Zheng, Dingyi Tong, Ning Zhao, Chunxin Ma, He Xiao, Jiawei Zhang, Youju Huang and Tao Chen
Chem. Sci., 2016, Advance Article
DOI: 10.1039/C6SC02354A, Edge Article

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Top 25 Chemical Science articles July–September 2015

The 25 most-downloaded Chemical Science articles in the third quarter of 2015 were as follows: 

Sulfonyl fluorides as privileged warheads in chemical biology
Arjun Narayanan and Lyn H. Jones
DOI: 10.1039/C5SC00408J Perspective

A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy
Victor Sans, Luzian Porwol, Vincenza Dragonea and Leroy Cronin
DOI: 10.1039/C4SC03075C Edge Article

Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp3)–H bonds
José A. Fernández-Salas, Enrico Marelli and Steven P. Nolan
DOI: 10.1039/C5SC01589H, Edge Article

Evaluating metal–organic frameworks for natural gas storage
Jarad A. Mason, Mike Veenstra and Jeffrey R. Long
DOI: 10.1039/C3SC52633J, Perspective

Macrocycles: lessons from the distant past, recent developments, and future directions
Andrei K. Yudin
DOI: 10.1039/C4SC03089C, Perspective

Reversible photo-induced trap formation in mixed-halide hybrid perovskites for photovoltaics
Eric T. Hoke, Daniel J. Slotcavage, Emma R. Dohner, Andrea R. Bowring, Hemamala I. Karunadasa and Michael D. McGehee
DOI: 10.1039/C4SC03141E, Edge Article

Impacts of gold nanoparticle charge and ligand type on surface binding and toxicity to Gram-negative and Gram-positive bacteria
Vivian Feng, Ian L. Gunsolus, Tian A. Qiu, Katie R. Hurley, Lyle H. Nyberg, Hilena Frew, Kyle P. Johnson, Ariane M. Vartanian, Lisa M. Jacob, Samuel E. Lohse, Marco D. Torelli, Robert J. Hamers, Catherine J. Murphy and Christy L. Haynes
DOI: 10.1039/C5SC00792E, Edge Article

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user’s guide
David S. Surry and Stephen L. Buchwald
DOI: 10.1039/C0SC00331J, Perspective

Rethinking the term “pi-stacking”
Chelsea R. Martinez and Brent L. Iverson
DOI: 10.1039/C2SC20045G, Perspective

Computational discovery and experimental verification of tyrosine kinase inhibitor pazopanib for the reversal of memory and cognitive deficits in rat model neurodegeneration
Yongliang Yang, Guohui Li, Dongyu Zhao, Haoyang Yu, Xiliang Zheng, Xiangda Peng, Xiaoe Zhang, Ting Fu, Xiaoqing Hu, Mingshan Niu, Xuefei Ji, Libo Zou and Jin Wang
DOI: 10.1039/C4SC03416C, Edge Article

Unified approach to prenylated indole alkaloids: total syntheses of (−)-17-hydroxy-citrinalin B, (+)-stephacidin A, and (+)-notoamide I
Eduardo V. Mercado-Marin and Richmond Sarpong
DOI: 10.1039/C5SC01977J, Edge Article

Computational design of molecules for an all-quinone redox flow battery
Süleyman Er, Changwon Suh, Michael P. Marshak and Alán Aspuru-Guzik
DOI: 10.1039/C4SC03030C, Edge Article

Molecular understandings on the activation of light hydrocarbons over heterogeneous catalysts
Zhi-Jian Zhao, Cheng-chau Chiu and Jinlong Gong
DOI: 10.1039/C5SC01227A, Perspective

Rh-catalyzed desymmetrization of α-quaternary centers by isomerization-hydroacylation
Jung-Woo Park, Kevin G. M. Kou, Daniel K. Kim and Vy M. Dong
DOI: 10.1039/C5SC01553G, Edge Article

A single crystalline porphyrinic titanium metal–organic framework
Shuai Yuan,Tian-Fu Liu,Dawei Feng,Jian Tian,Kecheng Wang,Junsheng Qin,Qiang Zhang, Ying-Pin Chen,Mathieu Bosch,Lanfang Zou,Simon J. Teat,Scott J. Dalgarno and Hong-Cai Zhou
DOI: 10.1039/C5SC00916B, Edge Article

Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery
Dali Wang, Chunlai Tu, Yue Su, Chuan Zhang, Udo Greiser, Xinyuan Zhu, Deyue Yan and Wenxin Wang
DOI: 10.1039/C5SC01188D, Edge Article

Near-infrared fluorescence activation probes based on disassembly-induced emission cyanine dye
Tai-Cheng Hou, Ying-Yi Wu, Po-Yi Chiang and Kui-Thong Tan
DOI: 10.1039/C5SC01330E, Edge Article

Thin metal nanostructures: synthesis, properties and applications
Zhanxi Fan, Xiao Huang, Chaoliang Tana and Hua Zhang
DOI: 10.1039/C4SC02571G, Minireview

Supramolecular hydrogel microcapsules via cucurbit[8]uril host–guest interactions with triggered and UV-controlled molecular permeability
Ziyi Yu, Jing Zhang, Roger J. Coulston, Richard M. Parker, Frank Biedermann, Xin Liu, Oren A. Scherman and Chris Abell
DOI: 10.1039/C5SC01440A, Edge Article

Bioinspired design of redox-active ligands for multielectron catalysis: effects of positioning pyrazine reservoirs on cobalt for electro- and photocatalytic generation of hydrogen from water
Jonah W. Jurss, Rony S. Khnayzer, Julien A. Panetier, Karim A. El Roz, Eva M. Nichols, Martin Head-Gordon, Jeffrey R. Long, Felix N. Castellano and Christopher J. Chang
DOI: 10.1039/C5SC01414J, Edge Article

Ligand-enabled Ir-catalyzed intermolecular diastereoselective and enantioselective allylic alkylation of 3-substituted indoles
Xiao Zhang, Wen-Bo Liu, Hang-Fei Tu and Shu-Li You
DOI: 10.1039/C5SC01772F, Edge Article

Boron chemistry in a new light
Guillaume Duret, Robert Quinlan, Philippe Bisseret and Nicolas Blanchard
DOI: 10.1039/C5SC02207J, Minireview

Porous ionic liquids: synthesis and application
Shiguo Zhang, Kaoru Dokko and Masayoshi Watanabe
DOI: 10.1039/C5SC01374G, Minireview

Chemical sensing in two dimensional porous covalent organic nanosheets
Gobinda Das, Bishnu P. Biswal, Sharath Kandambeth, V. Venkatesh, Gagandeep Kaur, Matthew Addicoat, Thomas Heine, Sandeep Verma and Rahul Banerjee
DOI: 10.1039/C5SC00512D, Edge Article

Carbon–hydrogen (C–H) bond activation at PdIV: a Frontier in C–H functionalization catalysis
Joseph J. Topczewski and Melanie S. Sanford
DOI: 10.1039/C4SC02591A, Minireview

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Small Molecule Mimics of Transport Proteins

Many diseases are caused by faulty anion transport across cell membranes, such as faulty chloride transport leading to cystic fibrosis. Therefore, in recent years interest has grown in developing small molecule mimics of transport proteins that can be used to restore or disrupt the chemical processes within cells and thus cure or kill a range of diseases.

Researchers from the University of Southampton and the University of Sydney have produced a series of thiosquaramides which investigate pH dependent chloride transport properties. It was observed that the anion transport ability of the thiosquaramides was completely turned on below a pH of 7.2 but fully switched off at a pH value of 7.2 or higher. The developed thiosquaramides can promote chloride efflux mainly via a chloride/nitrate antiport process.

One of the thiosquaramide derivative with bound chloride anion

This paper provides one of the few examples of truly controllable and switchable anion transport by small synthetic molecules. Thiosquaramides form interesting targets for developing future biologically active anion transporters –  read the paper today to find out how to make them!

To read the details, check out the Chem Sci article in full for free:

Nathalie Busschaert, Robert B. P. Elmes, Dawid D. Czech, Xin Wu, Isabelle L. Kirby, Evan M. Peck, Kevin D. Hendzel, Scott K. Shaw, Bun Chan, Bradley D. Smith, Katrina A. Jolliffe and Philip A. Gale
DOI: 10.1039/C4SC01629G
About the Webwriter
Iain Larmour is a guest web writer for ChemSci. He has researched a wide variety of topics during his years in the lab including nanostructured surfaces for water repellency and developing nanoparticle systems for bioanalysis by surface enhanced optical spectroscopies. He currently works in science management. In his spare time he enjoys reading, photography, art and inventing.

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