Rapid natural product synthesis

A strategy for regiochemical reversal of reductive macrocyclisations of aldehydes and terminal alkynes has been developed by US researchers. Using an advanced synthetic intermediate directed towards the methymycin/neomethymycin class of macrolides, selective endocyclisation provides the natural twelve-membered ring series, whereas ligand alteration enables selective exocyclisation to provide access to the  unnatural eleven-membered ring series. The twelve-membered ring adduct was converted to 10- deoxymethynolide, completing an efficient total synthesis of this natural product.

Graphical abstract: Nickel-catalyzed regiodivergent approach to macrolide motifs

Reference:
Nickel-Catalyzed Regiodivergent Approach to Macrolide Motifs
A-R Shareef, D H Sherman and J Montgomery, Chem. Sci., 2012
DOI: 10.1039/c2sc00866a

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

One Response to “Rapid natural product synthesis”

  1. Wonderful article! This is the type of information that are supposed to be shared around the
    web. Shame on the search engines for now not positioning this post higher!
    Come on over and visit my website . Thank you =)

    Feel free to surf to my web page Office 2010 Download

    (Report comment)

Leave a Reply